spiperone has been researched along with Vomiting in 4 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, compound 57b was free from dopamine D2 receptor antagonistic activity in both in vitro ([3H]spiperone binding) and in vivo (apomorphine-induced emesis in dogs) tests." | 3.68 | Novel benzamides as selective and potent gastrokinetic agents. III. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]-benzamides. ( Harada, H; Kato, S; Matsumoto, J; Morie, T; Yoshida, N, 1992) |
| "Remoxipride was shown to be a selective dopamine D2 receptor antagonist since it displaced [3H]spiperone (IC50 = 1570 nM) but not [3H]flupentixol (IC50 greater than 100 000 nM) in rat striatum, and did not inhibit striatal DA-sensitive adenylate cyclase in vitro (IC50 greater than 100 000 nM)." | 1.27 | Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain. ( Angeby, K; Florvall, L; Hall, H; Köhler, C; Lindbom, LO; Magnusson, O; Ogren, SO, 1984) |
| " (+)-PHNO was well absorbed when given p." | 1.27 | Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]. ( Clineschmidt, BV; Jones, JH; Martin, GE; Pettibone, DJ; Williams, M; Yarbrough, GG, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ogren, SO | 1 |
| Hall, H | 1 |
| Köhler, C | 1 |
| Magnusson, O | 1 |
| Lindbom, LO | 1 |
| Angeby, K | 1 |
| Florvall, L | 1 |
| Martin, GE | 1 |
| Williams, M | 1 |
| Pettibone, DJ | 1 |
| Yarbrough, GG | 1 |
| Clineschmidt, BV | 1 |
| Jones, JH | 1 |
| Verimer, T | 1 |
| Long, JP | 1 |
| Bhatnagar, RK | 1 |
| Koble, DL | 1 |
| Cannon, JG | 1 |
| Flynn, JR | 1 |
| Goodale, DB | 1 |
| Arnerić, SP | 1 |
| Kato, S | 1 |
| Morie, T | 1 |
| Harada, H | 1 |
| Yoshida, N | 1 |
| Matsumoto, J | 1 |
4 other studies available for spiperone and Vomiting
| Article | Year |
|---|---|
Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzamides; Binding | 1984 |
Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO].
Topics: Adenylyl Cyclases; Animals; Apomorphine; Binding, Competitive; Body Temperature; Brain Stem; Female; | 1984 |
Dopamine receptor stimulating activity of 5-hydroxy-6-methyl-2-aminotetralin derivatives.
Topics: Animals; Behavior, Animal; Blood Pressure; Cats; Dihydroxyphenylalanine; Female; Ganglia, Sympatheti | 1981 |
Novel benzamides as selective and potent gastrokinetic agents. III. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]-benzamides.
Topics: Animals; Benzamides; Dogs; Dopamine Antagonists; Gastric Emptying; Male; Mice; Morpholines; Rats; Re | 1992 |