spiperone has been researched along with Schizophrenia in 100 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phencyclidine (PCP), a non-competitive NMDA-receptor antagonist, is able to induce schizophrenia-like symptoms in animals and in humans." | 3.70 | Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory. ( Sabel, BA; Schroeder, H; Schroeder, U; Schwegler, H, 2000) |
| "The dopamine hypothesis of schizophrenia received strong support when a two- to three-fold elevation of D2 receptor densities was demonstrated by positron emission tomography (PET) and [11C]N-methylspiperone ([11C]NMSP)." | 3.69 | No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone. ( Eriksson, L; Farde, L; Halldin, C; Nordström, AL, 1995) |
| "An increased spiperone binding capacity in lymphocytes has been proposed as a possible biological marker for schizophrenia while in previous studies patients with alcohol dependence were shown to have a normal binding capacity." | 3.69 | Spiperone binding capacity in lymphocytes of patients with alcohol- and drug-induced psychosis: preliminary results. ( Ackenheil, M; Bondy, B; Peuker, B; Soyka, M, 1994) |
| " There is an ongoing controversy, if increased binding of 3H-spiperone to lymphocytes might discriminate between schizophrenia and other psychiatric diseases or even be a genetic vulnerability marker for schizophrenia, or predict the response to neuroleptic treatment." | 3.69 | 3H-spiperone binding to peripheral mononuclear cells in psychiatric in-patients. ( Fritze, J; Riederer, P; Wodarz, N, 1996) |
| " Using positron emission tomography and constrained analysis of the brain uptake of the radioligand N-[11C]methyl-spiperone ([11C]NMSP), we tested four questions: Were the assumptions underlying the quantitation valid? Is there an age decline of the density of D2-like dopamine receptors in drug-naive schizophrenia and bipolar illness? If so, is it different from that observed in normal aging? Are D2-like dopamine receptors elevated at any age in either drug-naive schizophrenic or psychotic bipolar illness patients? NMSP and haloperidol partition volumes and plasma protein fractions were not significantly different among patient groups and normal volunteers." | 3.69 | Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. ( Dannals, RF; Gjedde, A; Kuhar, MJ; Meltzer, CC; Pearlson, GD; Ravert, HT; Reith, J; Tune, LE; Wong, DF; Young, LT, 1997) |
| "Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h." | 3.67 | Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls. ( Crawley, JC; Crow, TJ; Johnstone, EC; Oldland, SR; Owen, F; Owens, DG; Smith, T; Veall, N; Zanelli, GD, 1986) |
| "To test the dopamine hypothesis of schizophrenia the authors measured specific 3H-neuroleptic/dopamine binding sites in three dopamin-rich regions of 59 postmortem normal human brains and 50 postmortem brains from schizophrenic patients using 3H-haloperidol and 3H-spiperone." | 3.66 | Elevation of brain neuroleptic/dopamine receptors in schizophrenia. ( Lee, T; Seeman, P, 1980) |
| "In order to test the dopamine hypothesis of schizophrenia, the neuroleptic/dopamine receptors in three dopamine-rich regions of 53 postmortem normal human brains and 42 schizophrenic brains were measured using 3H-haloperidol and 3H-spiperone." | 3.66 | Abnormal neuroleptic/dopamine receptors in schizophrenia. ( Lee, T; Seeman, P, 1980) |
| " The role of the reported increase in dopamine receptors (measured as 3H-spiperone binding sites) in post-mortem brain tissue from patients with schizophrenia in the aetiology of the disease is, however, unclear." | 3.66 | Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action. ( Iversen, LL; Reynolds, GP; Rossor, MN, 1983) |
| " A steady-state treatment condition was ensured by dosing the patients with 750 mg quetiapine daily during 3 weeks followed by a period of tapering off the dose." | 2.69 | N-[11C]methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic. ( Bergström, M; Gefvert, O; Hagberg, G; Långström, B; Lindström, L; Wiesel, FA; Wieselgren, IM, 1998) |
| "Treatment with risperidone, 6 mg/day, is likely to induce unnecessarily high D2 receptor occupancy, with a consequent risk of extrapyramidal side effects." | 2.69 | Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. ( Eriksson, B; Farde, L; Halldin, C; Nyberg, S; Oxenstierna, G, 1999) |
| " The atypical antipsychotic clozapine exhibited an "inverted-U" shaped dose-response curve, reversing the apomorphine-induced loss of PPI at low doses but not at high doses." | 1.28 | Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. ( Braff, DL; Geyer, MA; Keith, VA; Swerdlow, NR, 1991) |
| "[3H]-spiperone was used as a ligand for the binding studies and previous drug treatment was recorded." | 1.27 | Alteration of dopamine receptors in the caudate nucleus and the putamen in schizophrenic brain. ( Mjörndal, T; Winblad, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (53.00) | 18.7374 |
| 1990's | 37 (37.00) | 18.2507 |
| 2000's | 8 (8.00) | 29.6817 |
| 2010's | 2 (2.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, H | 1 |
| Zhu, L | 1 |
| Yang, H | 1 |
| Qian, W | 1 |
| Guo, L | 1 |
| Zhou, S | 1 |
| Gao, B | 1 |
| Li, Z | 1 |
| Zhou, Y | 1 |
| Jiang, H | 1 |
| Chen, K | 1 |
| Zhen, X | 1 |
| Liu, H | 1 |
| Cao, X | 1 |
| Zhang, Y | 1 |
| Chen, Y | 1 |
| Qiu, Y | 1 |
| Yu, M | 1 |
| Xu, X | 1 |
| Liu, X | 1 |
| Liu, BF | 1 |
| Zhang, L | 1 |
| Zhang, G | 1 |
| BOBON, J | 1 |
| COLLARD, J | 1 |
| DELREE, C | 1 |
| GERNAY, JM | 1 |
| Dean, B | 1 |
| Pavey, G | 1 |
| Scarr, E | 1 |
| Goeringer, K | 1 |
| Copolov, DL | 1 |
| Moresco, RM | 1 |
| Cavallaro, R | 1 |
| Messa, C | 1 |
| Bravi, D | 1 |
| Gobbo, C | 1 |
| Galli, L | 1 |
| Lucignani, G | 1 |
| Colombo, C | 1 |
| Rizzo, G | 1 |
| Velonà, I | 1 |
| Smeraldi, E | 1 |
| Fazio, F | 1 |
| Park, WK | 1 |
| Jeong, D | 1 |
| Cho, H | 1 |
| Lee, SJ | 1 |
| Cha, MY | 1 |
| Pae, AN | 1 |
| Choi, KI | 1 |
| Koh, HY | 1 |
| Kong, JY | 1 |
| Lee, T | 3 |
| Seeman, P | 6 |
| Creese, I | 4 |
| Pedigo, NW | 1 |
| Reisine, TD | 2 |
| Schallert, T | 1 |
| Overstreet, DH | 1 |
| Ling, NC | 1 |
| Ragan, P | 1 |
| Yamamura, HI | 2 |
| Reynolds, GP | 5 |
| Reynolds, LM | 1 |
| Riederer, P | 6 |
| Jellinger, K | 3 |
| Gabriel, E | 3 |
| Snyder, SH | 3 |
| Ciaranello, RD | 1 |
| Boehme, RE | 1 |
| Le Fur, G | 1 |
| Zarifian, E | 1 |
| Phan, T | 1 |
| Cuche, H | 1 |
| Flamier, A | 1 |
| Bouchami, F | 1 |
| Burgevin, MC | 1 |
| Loo, H | 3 |
| Gérard, A | 1 |
| Uzan, A | 1 |
| Owen, F | 8 |
| Baker, HF | 1 |
| Ridley, RM | 1 |
| Cross, AJ | 6 |
| Crow, TJ | 7 |
| Ferrier, IN | 2 |
| Johnstone, EC | 4 |
| McCreadie, RM | 1 |
| Owens, DG | 4 |
| Poulter, M | 5 |
| Rossor, MN | 1 |
| Iversen, LL | 5 |
| Owen, R | 1 |
| Wagner, HN | 4 |
| Rossor, M | 2 |
| Spokes, E | 2 |
| Rotrosen, J | 2 |
| Stanley, M | 1 |
| Lautin, A | 1 |
| Wazer, D | 1 |
| Gershon, S | 1 |
| Rotstein, E | 1 |
| Mishra, RK | 1 |
| Singal, DP | 1 |
| Barone, D | 1 |
| Mackay, AV | 3 |
| Bird, E | 2 |
| Arregui, A | 1 |
| Synder, SH | 1 |
| Waddington, JL | 2 |
| Kaneno, S | 1 |
| Shimazono, Y | 1 |
| Stevens, JR | 1 |
| Bird, ED | 2 |
| Spokes, EG | 2 |
| Gjedde, A | 5 |
| Reith, J | 2 |
| Wong, D | 1 |
| Nordström, AL | 3 |
| Farde, L | 5 |
| Eriksson, L | 1 |
| Halldin, C | 4 |
| Nyberg, S | 2 |
| Karlsson, P | 1 |
| Sedvall, G | 2 |
| Yousef, KA | 1 |
| Volkow, ND | 2 |
| Schlyer, DJ | 2 |
| Fowler, JS | 4 |
| Wolf, AP | 4 |
| Wang, GJ | 1 |
| Smith, MR | 1 |
| Brodie, JD | 3 |
| Warner, D | 1 |
| Pearlson, GD | 3 |
| Wong, DF | 8 |
| Tune, LE | 4 |
| Ross, CA | 1 |
| Chase, GA | 1 |
| Links, JM | 3 |
| Dannals, RF | 5 |
| Wilson, AA | 4 |
| Ravert, HT | 5 |
| Pearlson, G | 2 |
| Strauss, M | 1 |
| Young, T | 1 |
| Shaya, EK | 1 |
| Sapp, J | 1 |
| Soyka, M | 1 |
| Bondy, B | 4 |
| Peuker, B | 2 |
| Ackenheil, M | 4 |
| Meltzer, HY | 4 |
| Sommer, SS | 1 |
| Lind, TJ | 1 |
| Heston, LL | 1 |
| Sobell, JL | 1 |
| Guan, HC | 2 |
| Van Tol, HH | 1 |
| Niznik, HB | 2 |
| Wodarz, N | 3 |
| Fritze, J | 3 |
| Beckmann, H | 2 |
| Ertl, M | 1 |
| Minelli, G | 1 |
| Mundt, C | 1 |
| Schleuning, G | 1 |
| Sauer, H | 1 |
| Bardgett, ME | 1 |
| Jackson, JL | 1 |
| Taylor, GT | 1 |
| Csernansky, JG | 1 |
| Flores, G | 1 |
| Barbeau, D | 1 |
| Quirion, R | 1 |
| Srivastava, LK | 1 |
| Bossé, R | 1 |
| DiPaolo, T | 1 |
| Odou, P | 1 |
| Vaiva, G | 1 |
| Luyckx, M | 1 |
| Brunet, C | 1 |
| Dine, T | 1 |
| Gressier, B | 1 |
| Cazin, M | 1 |
| Cazin, JC | 1 |
| Goyer, PF | 1 |
| Berridge, MS | 1 |
| Morris, ED | 1 |
| Semple, WE | 1 |
| Compton-Toth, BA | 1 |
| Schulz, SC | 1 |
| Miraldi, F | 1 |
| Young, D | 1 |
| Wilson, PD | 1 |
| Meltzer, CC | 2 |
| Young, LT | 1 |
| Kuhar, MJ | 3 |
| Hagberg, G | 1 |
| Gefvert, O | 1 |
| Bergström, M | 1 |
| Wieselgren, IM | 1 |
| Lindström, L | 1 |
| Wiesel, FA | 1 |
| Långström, B | 1 |
| Eriksson, B | 1 |
| Oxenstierna, G | 1 |
| Schroeder, U | 1 |
| Schroeder, H | 1 |
| Schwegler, H | 1 |
| Sabel, BA | 1 |
| Okubo, Y | 1 |
| Suhara, T | 1 |
| Suzuki, K | 1 |
| Kobayashi, K | 1 |
| Inoue, O | 1 |
| Terasaki, O | 1 |
| Someya, Y | 1 |
| Sassa, T | 1 |
| Sudo, Y | 1 |
| Matsushima, E | 1 |
| Iyo, M | 1 |
| Tateno, Y | 1 |
| Toru, M | 1 |
| Govitrapong, P | 1 |
| Chagkutip, J | 1 |
| Turakitwanakan, W | 1 |
| Srikiatkhachorn, A | 1 |
| Lee, MJ | 1 |
| Breese, CR | 1 |
| Strook, ML | 1 |
| Leonard, S | 1 |
| Zavitsanou, K | 1 |
| Huang, XF | 1 |
| Longden, A | 1 |
| Riley, GJ | 1 |
| Goode, DJ | 1 |
| Schyve, PM | 1 |
| Young, M | 1 |
| Fang, VS | 1 |
| Tourtellotte, WW | 1 |
| Farley, IJ | 1 |
| Hornykeiwicz, O | 1 |
| Doble, A | 1 |
| Quik, M | 1 |
| Bischoff, S | 1 |
| Bruinink, A | 1 |
| Gunst, F | 1 |
| Krauss, J | 1 |
| Schaub, M | 1 |
| Vassout, A | 1 |
| Maitre, L | 1 |
| Kornhuber, J | 2 |
| Griffiths, RS | 1 |
| Chung-a-on, KO | 1 |
| Griffiths, KD | 1 |
| Payne, JW | 1 |
| Davies, JI | 1 |
| Shiue, CY | 3 |
| Dewey, SL | 1 |
| Bendriem, B | 1 |
| Logan, J | 1 |
| Raulli, R | 1 |
| Hitzemann, R | 1 |
| Coppens, HJ | 1 |
| Slooff, CJ | 1 |
| Paans, AM | 1 |
| Wiegman, T | 1 |
| Vaalburg, W | 1 |
| Korf, J | 1 |
| Arora, RC | 1 |
| Swerdlow, NR | 1 |
| Keith, VA | 1 |
| Braff, DL | 1 |
| Geyer, MA | 1 |
| Karbe, H | 1 |
| Wienhard, K | 2 |
| Hamacher, K | 1 |
| Huber, M | 1 |
| Herholz, K | 1 |
| Coenen, HH | 2 |
| Stöcklin, G | 2 |
| Lövenich, A | 1 |
| Heiss, WD | 2 |
| Grodzicki, J | 1 |
| Pardo, M | 1 |
| Schved, G | 1 |
| Schlosberg, A | 1 |
| Fuchs, S | 1 |
| Kanety, H | 1 |
| Pawlik, G | 1 |
| Rudolf, J | 1 |
| Laufer, P | 1 |
| Jovkar, S | 1 |
| Martinot, JL | 2 |
| Peron-Magnan, P | 2 |
| Huret, JD | 2 |
| Mazoyer, B | 1 |
| Baron, JC | 3 |
| Boulenger, JP | 1 |
| Loc'h, C | 2 |
| Maziere, B | 2 |
| Caillard, V | 2 |
| Rao, ML | 1 |
| Deister, A | 1 |
| Roth, A | 1 |
| Elbers, R | 1 |
| Fröhler, M | 1 |
| Wolkin, A | 2 |
| Barouche, F | 2 |
| Cooper, TB | 1 |
| Mazoyer, BM | 1 |
| Syrota, A | 1 |
| Itzchaky, S | 1 |
| Lerer, B | 1 |
| Ebstein, RP | 1 |
| Johnson, JA | 1 |
| Pimoule, C | 1 |
| Schoemaker, H | 1 |
| Langer, SZ | 1 |
| Ko, GN | 1 |
| Korpi, ER | 1 |
| Linnoila, M | 1 |
| Krska, J | 1 |
| Sampath, G | 1 |
| Shah, A | 1 |
| Soni, SD | 1 |
| Shimogawa, S | 1 |
| Kaku, H | 1 |
| Yoshimoto, S | 1 |
| Nakane, Y | 1 |
| Tamminga, CA | 1 |
| Broussolle, EP | 1 |
| Toung, JK | 1 |
| Malat, J | 1 |
| Williams, JA | 1 |
| O'Tuama, LA | 1 |
| Mjörndal, T | 1 |
| Winblad, B | 1 |
| Crawley, JC | 1 |
| Oldland, SR | 1 |
| Smith, T | 1 |
| Veall, N | 1 |
| Zanelli, GD | 1 |
| Mita, T | 1 |
| Hanada, S | 1 |
| Nishino, N | 1 |
| Kuno, T | 1 |
| Nakai, H | 1 |
| Yamadori, T | 1 |
| Mizoi, Y | 1 |
| Tanaka, C | 1 |
| Hess, EJ | 1 |
| Bracha, HS | 1 |
| Kleinman, JE | 1 |
| Smith, M | 1 |
| Arnett, CD | 1 |
| Russell, JA | 1 |
| MacGregor, RR | 1 |
| Joyce, JN | 1 |
| Lexow, N | 1 |
| Winokur, A | 1 |
| Andreasen, NC | 1 |
| Carson, R | 1 |
| Diksic, M | 1 |
| Evans, A | 1 |
| Hakim, A | 1 |
| Lal, S | 1 |
| Nair, N | 1 |
| Crawley, J | 1 |
| von Kirchbach, A | 1 |
| Fischer, EG | 1 |
| Kornhuber, HH | 1 |
| Sethi, BB | 1 |
| Kumar, P | 1 |
| Agarwal, AK | 1 |
| Seth, PK | 1 |
| Trivedi, JK | 1 |
| Sgouropoulos, P | 1 |
| Duquesnoy, N | 1 |
| D'Antona, R | 1 |
| Cambon, H | 1 |
| Suneja, S | 1 |
| Bjorvvinssen, E | 1 |
3 reviews available for spiperone and Schizophrenia
| Article | Year |
|---|---|
Central nervous system dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Dopamine; Guanine Nucleotides; Haloperidol; | 1980 |
On the clinical relevance and methods of quantification of plasma concentrations of neuroleptics.
Topics: Animals; Antipsychotic Agents; Binding Sites; Chromatography, Gas; Corpus Striatum; Ethnicity; Follo | 1985 |
Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
Topics: Adult; Corpus Striatum; Haloperidol; Humans; National Institute of Mental Health (U.S.); Raclopride; | 1988 |
4 trials available for spiperone and Schizophrenia
| Article | Year |
|---|---|
Cerebral D2 and 5-HT2 receptor occupancy in Schizophrenic patients treated with olanzapine or clozapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Double-Blind Method; Female; Fluorin | 2004 |
High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agonists; Female; Humans; Male; Middle Aged; Prefro | 1993 |
N-[11C]methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic.
Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Cerebellum; Dibenzothiazepines; Dopamine; Dose-Respons | 1998 |
Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Brain; Carbon Radioisotopes; Dose-Response Rela | 1999 |
93 other studies available for spiperone and Schizophrenia
| Article | Year |
|---|---|
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.
Topics: Animals; Antipsychotic Agents; Berberine; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Do | 2013 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Topics: Animals; Antipsychotic Agents; Body Weight; Chemistry Techniques, Synthetic; Drug Design; Ether-A-Go | 2018 |
[SPIROPERIDOL].
Topics: Catatonia; Geriatrics; Hallucinations; Haloperidol; Humans; Hypnotics and Sedatives; Paranoid Disord | 1963 |
Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Autopsy; Autoradiography; Case-Control Studies; Caudate Nucleus; | 2004 |
KKHA-761, a potent D3 receptor antagonist with high 5-HT1A receptor affinity, exhibits antipsychotic properties in animal models of schizophrenia.
Topics: Animals; Antipsychotic Agents; Body Temperature; Catalepsy; Cell Line; Dopamine Uptake Inhibitors; G | 2005 |
Elevation of brain neuroleptic/dopamine receptors in schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Brain; Butyrophenones; Caudate Nucleus; Haloperidol; | 1980 |
Abnormal neuroleptic/dopamine receptors in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Apomorphine; Brain; Caudate Nucleus; Haloperidol; Humans; Middle | 1980 |
Possible role of opiate receptors and des-tyrosine1-gamma-endorphin in schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain; Endorphins; Humans; Mice; Peptide Fragments; | 1980 |
Dopamine receptors and schizophrenia: drug effect or illness.
Topics: Binding Sites; Brain; Butyrophenones; Humans; Receptors, Dopamine; Schizophrenia; Spiperone | 1980 |
Dopamine receptors, neuroleptics, and schizophrenia.
Topics: Adenylyl Cyclases; Antipsychotic Agents; Apomorphine; Brain; Brain Chemistry; Caudate Nucleus; Dopam | 1981 |
Dopamine receptors and schizophrenia: the neuroleptic drug problem.
Topics: Antipsychotic Agents; Brain; Humans; Kinetics; Receptors, Dopamine; Schizophrenia; Spiperone | 1981 |
Genetic regulation of neurotransmitter enzymes and receptors: relationship to the inheritance of psychiatric disorders.
Topics: Animals; Bipolar Disorder; Brain; Dopamine; Dopamine beta-Hydroxylase; Enzymes; Female; Humans; Male | 1982 |
[3H]spiroperidol binding on lymphocytes: changes in two different groups of schizophrenic patients and effect of neuroleptic treatment.
Topics: Adult; Age Factors; Antipsychotic Agents; Butyrophenones; Female; Humans; Lymphocytes; Male; Recepto | 1983 |
Effect of chronic amphetamine administration on dopaminergic systems in the vervet brain: relationship to findings in the brains of schizophrenics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamines; Animals; Brain; Chlorocebus aethiops; Dopa Decarboxyla | 1983 |
Dopamine receptor changes in schizophrenia in relation to the disease process and movement disorder.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; Humans; Nucleus Accumbens; Putamen; Receptors, Dopam | 1983 |
Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action.
Topics: Antipsychotic Agents; Cerebral Cortex; Humans; Ketanserin; Piperidines; Receptors, Serotonin; Schizo | 1983 |
Dopamine D2 receptors in substantia nigra in schizophrenia.
Topics: Aged; Antipsychotic Agents; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopam | 1984 |
Imaging CNS receptors: the dopaminergic system.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Brain; Carbon Radioisotopes; Deoxyglucose | 1984 |
Opiate and neuroleptic receptor alterations in human schizophrenic brain tissue.
Topics: Brain; Caudate Nucleus; Corpus Striatum; Frontal Lobe; Humans; Naloxone; Putamen; Receptors, Dopamin | 1980 |
Discrimination of functionally heterogeneous receptor subpopulations: antipsychotic and antidopaminergic properties of metoclopramide [proceedings].
Topics: Animals; Apomorphine; Binding Sites; Humans; Metoclopramide; Rats; Receptors, Dopamine; Receptors, N | 1981 |
Lymphocyte 3H-spiroperidol binding in schizophrenia: preliminary findings.
Topics: Adult; Binding, Competitive; Butyrophenones; Female; Humans; Lymphocytes; Male; Receptors, Dopamine; | 1983 |
Increased brain dopamine and dopamine receptors in schizophrenia.
Topics: Adolescent; Adult; Age Factors; Aged; Autopsy; Brain Chemistry; Caudate Nucleus; Dopamine; Humans; M | 1982 |
Abnormal involuntary movements in schizophrenia: are they related to the disease process or its treatment? Are they associated with changes in dopamine receptors?
Topics: Adult; Aged; Brain; Dyskinesia, Drug-Induced; Female; Flupenthixol; Humans; Male; Middle Aged; Mouth | 1982 |
Decreased in vivo [3H]spiroperidol binding in rat brain after repeated methamphetamine administration.
Topics: Animals; Brain; Butyrophenones; Drug Tolerance; Humans; Male; Methamphetamine; Motor Activity; Rats; | 1981 |
Receptor supersensitivity: relationships to cerebral anatomy and histopathology of schizophrenia.
Topics: Afferent Pathways; Apomorphine; Brain; Corpus Striatum; Gliosis; Haloperidol; Humans; Receptors, Dop | 1981 |
Dopaminergic abnormalities in postmortem schizophrenic brain.
Topics: Aging; Brain Chemistry; Caudate Nucleus; Dopamine; Humans; Kinetics; Nucleus Accumbens; Schizophreni | 1980 |
Dopamine receptors in schizophrenia.
Topics: Antipsychotic Agents; Corpus Striatum; Dopamine Antagonists; Female; Humans; Male; Putamen; Receptor | 1995 |
No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.
Topics: Adult; Carbon Radioisotopes; Cerebellum; Dopamine Agonists; Female; Frontal Lobe; Haloperidol; Human | 1995 |
D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients.
Topics: Adult; Benzazepines; Brain; Clozapine; Female; Humans; Male; Middle Aged; Raclopride; Receptors, Dop | 1995 |
Haloperidol blocks the uptake of [18F]N-methylspiroperidol by extrastriatal dopamine receptors in schizophrenic patients.
Topics: Adult; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spipe | 1995 |
In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Carbon Radioisotopes; Caudate Nucleus; Female; Haloperidol; Humans; | 1995 |
Dopamine D2 receptor density estimates in schizophrenia: a positron emission tomography study with 11C-N-methylspiperone.
Topics: Adult; Carbon Radioisotopes; Chronic Disease; Cohort Studies; Corpus Striatum; Dopamine Agents; Fema | 1993 |
Spiperone binding capacity in lymphocytes of patients with alcohol- and drug-induced psychosis: preliminary results.
Topics: Adult; Diagnosis, Differential; Female; Hallucinations; Humans; Lymphocytes; Male; Middle Aged; Neur | 1994 |
Serotonin2A receptors in schizophrenia: relation to suicide.
Topics: Cause of Death; Frontal Lobe; Humans; Ligands; Receptors, Serotonin; Schizophrenia; Spiperone; Suici | 1994 |
Dopamine D4 receptor variants in unrelated schizophrenic cases and controls.
Topics: Adult; Aged; Alleles; Binding, Competitive; Case-Control Studies; Chi-Square Distribution; Clozapine | 1993 |
Low density of dopamine D4 receptors in Parkinson's, schizophrenia, and control brain striata.
Topics: Animals; Benzamides; Corpus Striatum; Dopamine D2 Receptor Antagonists; Humans; In Vitro Techniques; | 1993 |
3H-spiroperidol binding to peripheral mononuclear cells in schizophrenic and healthy subjects.
Topics: Adult; Binding, Competitive; Clozapine; Dose-Response Relationship, Drug; Female; Haloperidol; Human | 1993 |
3H-spiperone binding capacity in mononuclear cells: a family study.
Topics: Adult; Biomarkers; Female; Humans; Kinetics; Male; Middle Aged; Monocytes; Phenotype; Psychiatric St | 1993 |
Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: an animal model of schizophrenia.
Topics: Animals; Brain Mapping; Caudate Nucleus; Cell Count; Disease Models, Animal; Dose-Response Relations | 1995 |
Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus.
Topics: Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Benzazepines; Disease Models, Animal; | 1996 |
The modulation of brain dopamine and GABAA receptors by estradiol: a clue for CNS changes occurring at menopause.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Benzazepines; Binding Sites; Brain; Brain Chemistry; | 1996 |
3H-spiperone binding to peripheral mononuclear cells in psychiatric in-patients.
Topics: Adult; Binding, Competitive; Clozapine; Female; Haloperidol; Hospitalization; Humans; Lymphocytes; M | 1996 |
Neuroleptic monitoring: relation between antipsychotic efficiency and radioreceptor assay of serum haloperidol.
Topics: Adult; Antipsychotic Agents; Binding, Competitive; Dopamine D2 Receptor Antagonists; Double-Blind Me | 1996 |
PET measurement of neuroreceptor occupancy by typical and atypical neuroleptics.
Topics: Adult; Antipsychotic Agents; Basal Ganglia; Bipolar Disorder; Carbon Radioisotopes; Case-Control Stu | 1996 |
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine A | 1997 |
Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
Topics: Adult; Aged; Aging; Basal Ganglia; Bipolar Disorder; Brain Chemistry; Caudate Nucleus; Chromatograph | 1997 |
Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid | 2000 |
Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography.
Topics: Adult; Carbon Isotopes; Cerebral Cortex; Humans; Receptors, Serotonin; Schizophrenia; Spiperone; Tom | 2000 |
Platelet 5-HT(2A) receptors in schizophrenic patients with and without neuroleptic treatment.
Topics: Adult; Antipsychotic Agents; Blood Platelets; Case-Control Studies; Dopamine Antagonists; Dose-Respo | 2000 |
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain.
Topics: Aconitine; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Antagonists; | 2001 |
Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study.
Topics: Adult; Aged; Antipsychotic Agents; Binding Sites; Binding, Competitive; Butaclamol; Down-Regulation; | 2002 |
Change in the charactertistics of 3H-spiperone binding to rat striatal membranes after acute chlorpromazine administration: effects of buffer washing of membranes.
Topics: Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Corpus Striatum; Histological Techniq | 1979 |
Increased dopamine-receptor sensitivity in schizophrenia.
Topics: Aged; Brain; Caudate Nucleus; Dopamine; Female; Humans; Male; Putamen; Receptors, Dopamine; Schizoph | 1978 |
Effect of clozapine on human serum prolactin levels.
Topics: Animals; Binding, Competitive; Chlorpromazine; Clozapine; Dibenzazepines; Female; Humans; Male; Prol | 1979 |
Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains.
Topics: Adult; Aged; Apomorphine; Brain; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Female; Haloperid | 1978 |
3H-Spiperone binding in normal and schizophrenic post-mortem human brain.
Topics: Animals; Binding, Competitive; Brain; Butyrophenones; Humans; In Vitro Techniques; Radioligand Assay | 1978 |
Can brain region-selective dopamine (DA) receptor blockers preferentially act on schizophrenia subtypes?
Topics: Animals; Antipsychotic Agents; Benzazepines; Binding, Competitive; Brain; Dopamine Antagonists; In V | 1992 |
PET studies of neuroreceptors in schizophrenia. Commentary on "The current status of PET scanning with respect to schizophrenia".
Topics: Brain; Carbon Radioisotopes; Dopamine Antagonists; Humans; Raclopride; Receptors, Dopamine; Receptor | 1992 |
3H-spiroperidol binding to human peripheral mononuclear cells: methodological aspects.
Topics: Adult; Binding, Competitive; Humans; Lymphocytes; Male; Receptors, Dopamine; Receptors, Dopamine D2; | 1992 |
The sequestration of [3H]spiperone by lymphocytes in schizophrenics and their first-degree relatives: a limited vulnerability marker?
Topics: Adolescent; Adult; Aged; Binding, Competitive; Female; Humans; Lymphocytes; Male; Middle Aged; Recep | 1992 |
Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol.
Topics: Adult; Animals; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Male; Mice; Schizophrenia; Spipe | 1992 |
High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Brain; Dyskinesia, Drug-Induced; Female; Humans; Male; Psychiatric Stat | 1991 |
Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Female; Frontal Lobe; Humans; Ligands; Lysergic Acid Diethylamide; Male | 1991 |
Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat.
Topics: Analysis of Variance; Animals; Apomorphine; Benzazepines; Clozapine; Male; Raclopride; Rats; Rats, I | 1991 |
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Human | 1991 |
Differences in [3H]-spiperone binding to peripheral blood lymphocytes from neuroleptic responsive and nonresponsive schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Brain; Humans; Lymphocytes; Male; Psychiatric Status Rating Scales; Rec | 1990 |
PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system.
Topics: Adolescent; Adult; Aged; Brain; Caudate Nucleus; Female; Humans; Male; Middle Aged; Nervous System D | 1990 |
Elevation of dopamine D2 receptors in schizophrenia is underestimated by radioactive raclopride.
Topics: Animals; Brain; Carbon Radioisotopes; Caudate Nucleus; Cerebellum; Corpus Striatum; Dopamine; Dopami | 1990 |
Striatal D2 dopaminergic receptors assessed with positron emission tomography and [76Br]bromospiperone in untreated schizophrenic patients.
Topics: Adult; Age Factors; Bromine Radioisotopes; Cerebellum; Corpus Striatum; Dopamine; Humans; Male; Midd | 1990 |
Lymphocytes of healthy subjects and schizophrenic patients possess no high-affinity binding sites for spiroperidol.
Topics: Adult; Cell Membrane; Corpus Striatum; Half-Life; Humans; Indicators and Reagents; Iodine Radioisoto | 1990 |
Binding of 3H-spiperone to human lymphocytes: a biological marker in schizophrenia?
Topics: Acute Disease; Adult; B-Lymphocytes; Binding Sites; Butaclamol; Butyrophenones; Female; Humans; Lymp | 1985 |
3H-spiperone binding sites in post-mortem brains from schizophrenic patients: relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dyskinesia, Drug-Induced; Female; Humans; Male; Middl | 1989 |
Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia.
Topics: Adolescent; Adult; Cerebellum; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Fluorine Radi | 1989 |
Striatal D2 dopaminergic receptor status ascertained in vivo by positron emission tomography and 76Br-bromospiperone in untreated schizophrenics.
Topics: Adult; Antipsychotic Agents; Bromine Radioisotopes; Cerebellum; Chronic Disease; Corpus Striatum; Hu | 1989 |
Uptake of 3H-spiperone by lymphocytes in schizophrenia.
Topics: Adult; Chronic Disease; Female; Humans; Male; Psychiatric Status Rating Scales; Receptors, Dopamine; | 1989 |
Chemical and structural changes in the brain in patients with movement disorder.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Antipsychotic Agents; Brain; Choline O-Acetyltransfer | 1985 |
[3H]SCH 23390 labeled D1 dopamine receptors are unchanged in schizophrenia and Parkinson's disease.
Topics: Aged; Antipsychotic Agents; Benzazepines; Cocaine; Humans; In Vitro Techniques; Middle Aged; Parkins | 1985 |
Radio receptor assay of serum neuroleptic levels in psychiatric patients.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Dose-Response Relationship, Drug; Halo | 1986 |
[Association between uptake to lymphocytes from schizophrenic patients and therapeutic efficacy].
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Brief Psychiatric Rating Scale; Female; Humans | 1986 |
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Haloperidol; Humans; Kinetics; Receptors, Dopamine; Re | 1986 |
Alteration of dopamine receptors in the caudate nucleus and the putamen in schizophrenic brain.
Topics: Adult; Aged; Antipsychotic Agents; Caudate Nucleus; Female; Humans; Male; Middle Aged; Putamen; Rece | 1986 |
Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.
Topics: Adult; Aged; Aged, 80 and over; Cerebellum; Corpus Striatum; Female; Humans; Male; Middle Aged; Rece | 1986 |
Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics.
Topics: Adult; Aged; Caudate Nucleus; Chronic Disease; Female; Frontal Lobe; Humans; Ketanserin; Male; Middl | 1986 |
Dopamine receptor subtype imbalance in schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Brain; Female; Humans; Male; Middle Aged; Recep | 1987 |
Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients.
Topics: Adult; Binding, Competitive; Chlorpromazine; Corpus Striatum; Haloperidol; Humans; Male; Middle Aged | 1988 |
Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophrenia.
Topics: Aged; Autoradiography; Benzazepines; Corpus Striatum; Female; Humans; Huntington Disease; Male; Midd | 1988 |
Brain dopamine receptors in schizophrenia and tardive dyskinesia.
Topics: Acetylcholine; Animals; Brain; Caudate Nucleus; Dopamine; Dyskinesia, Drug-Induced; Humans; Kinetics | 1985 |
3H-spiperone binding sites in lymphocytes as possible vulnerability marker in schizophrenia.
Topics: Adolescent; Adult; Aged; Female; Genetic Markers; Humans; Lymphocytes; Male; Middle Aged; Receptors, | 1987 |
Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.
Topics: Bromine; Corpus Striatum; Humans; Radioisotopes; Radionuclide Imaging; Schizophrenia; Spiperone | 1987 |
Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients. Short note.
Topics: Autoantibodies; Binding, Competitive; Haloperidol; Humans; Immunoglobulin G; Receptors, Dopamine; Sc | 1987 |
3H-spiperone binding in platelet membranes: a possible biological marker for schizophrenia.
Topics: Adolescent; Adult; Blood Platelets; Butyrophenones; Cell Membrane; Female; Humans; Male; Middle Aged | 1986 |
In vivo quantitative imaging of dopamine receptors in human brain using positron emission tomography and [76Br]bromospiperone.
Topics: Adult; Aged; Biological Transport, Active; Brain; Butyrophenones; Cerebellum; Cerebral Cortex; Corpu | 1985 |
Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.
Topics: Adult; Bipolar Disorder; Butyrophenones; Caudate Nucleus; Humans; Receptors, Dopamine; Schizophrenia | 1985 |