spiperone has been researched along with Retinoblastoma in 4 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the release of melatonin and the production of its precursors, 5-hydroxytryptophan and serotonin, in cultured Y79 human retinoblastoma cells." | 7.68 | Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate. ( Deng, MH; Lopez G-Coviella, I; Lynch, HJ; Wurtman, RJ, 1991) |
| "We studied the release of melatonin and the production of its precursors, 5-hydroxytryptophan and serotonin, in cultured Y79 human retinoblastoma cells." | 3.68 | Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate. ( Deng, MH; Lopez G-Coviella, I; Lynch, HJ; Wurtman, RJ, 1991) |
| " In membranes prepared from the WERI 27 human retinoblastoma cell line, specific receptor binding of the D2 antagonists [3H]methylspiperone and [125I]NAPS was observed." | 3.67 | Identification and characterization of D1 and D2 dopamine receptors in cultured neuroblastoma and retinoblastoma clonal cell lines. ( Brassard, DL; Monsma, FJ; Sibley, DR, 1989) |
| " The dopamine dose-response curve for inducing desensitization exhibits an EC50 of approximately 2-3 microM and a maximal response at approximately 0." | 1.28 | Agonist-induced desensitization of D2 dopamine receptors in human Y-79 retinoblastoma cells. ( Barton, AC; Black, LE; Sibley, DR, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barton, AC | 2 |
| Black, LE | 1 |
| Sibley, DR | 3 |
| Deng, MH | 1 |
| Lopez G-Coviella, I | 1 |
| Lynch, HJ | 1 |
| Wurtman, RJ | 1 |
| Monsma, FJ | 2 |
| Brassard, DL | 1 |
4 other studies available for spiperone and Retinoblastoma
| Article | Year |
|---|---|
Agonist-induced desensitization of D2 dopamine receptors in human Y-79 retinoblastoma cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Cell Differentiation; Dopamine; Dopamine Agent | 1991 |
Melatonin and its precursors in Y79 human retinoblastoma cells: effect of sodium butyrate.
Topics: 5-Hydroxytryptophan; Analysis of Variance; Butyrates; Butyric Acid; Cell Line; Colforsin; Dopamine; | 1991 |
Expression of functional D2 dopamine receptors following differentiation of Y-79 human retinoblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Binding, Competitive; Cell Membrane; Colforsin; Dopamine; Dopamine Agen | 1990 |
Identification and characterization of D1 and D2 dopamine receptors in cultured neuroblastoma and retinoblastoma clonal cell lines.
Topics: Animals; Benzazepines; Binding, Competitive; Cell Line; Dopamine Antagonists; Humans; Mice; Neurobla | 1989 |