spiperone has been researched along with Pulmonary Fibrosis in 3 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antifibrotic properties of spiperone and its effect on stem and progenitor cells were studied on the model of reversible bleomycin-induced pulmonary fibrosis in C57Bl/6 mice." | 7.80 | Effect of spiperone on mesenchymal multipotent stromal and hemopoietic stem cells under conditions of pulmonary fibrosis. ( Dygai, AM; Ermakova, NN; Khmelevskaya, ES; Krupin, VA; Pershina, OV; Reikhart, DV; Reztsova, AM; Reztsova, VM; Skurikhin, EG; Stepanova, IE, 2014) |
| "The antifibrotic properties of spiperone and its effect on stem and progenitor cells were studied on the model of reversible bleomycin-induced pulmonary fibrosis in C57Bl/6 mice." | 3.80 | Effect of spiperone on mesenchymal multipotent stromal and hemopoietic stem cells under conditions of pulmonary fibrosis. ( Dygai, AM; Ermakova, NN; Khmelevskaya, ES; Krupin, VA; Pershina, OV; Reikhart, DV; Reztsova, AM; Reztsova, VM; Skurikhin, EG; Stepanova, IE, 2014) |
| "Spiperone is a selective D2 dopamine receptor antagonist." | 1.42 | Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice. ( Artamonov, AV; Bekarev, AA; Dygai, AM; Ermakova, NN; Khmelevskaya, ES; Krupin, VA; Madonov, PG; Pershina, OV; Reztsova, AM; Skurikhin, EG; Stepanova, IE, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skurikhin, EG | 3 |
| Ermakova, NN | 3 |
| Reztsova, AM | 3 |
| Pershina, OV | 3 |
| Khmelevskaya, ES | 3 |
| Krupin, VA | 3 |
| Stepanova, IE | 3 |
| Reztsova, VM | 2 |
| Reihard, DV | 1 |
| Artamonov, AV | 2 |
| Bekarev, AA | 2 |
| Madonov, PG | 2 |
| Kinsht, DN | 1 |
| Goldberg, VE | 1 |
| Dygai, AM | 3 |
| Reikhart, DV | 1 |
3 other studies available for spiperone and Pulmonary Fibrosis
| Article | Year |
|---|---|
Anti-inflammatory and antifibrotic effects of a combination of spiperone and immobilized hyaluronidase on partially reversible and irreversible toxic pneumofibrosis.
Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Collagen; Drug Evaluation, Preclinical; Drug Therapy, | 2013 |
Effect of spiperone on mesenchymal multipotent stromal and hemopoietic stem cells under conditions of pulmonary fibrosis.
Topics: Animals; Antigens, CD; Biomarkers; Bleomycin; Bone Marrow Cells; Cell Lineage; Dopamine Antagonists; | 2014 |
Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice.
Topics: Animals; Bleomycin; Dopamine Antagonists; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hyaluro | 2015 |