spiperone has been researched along with Pregnancy in 39 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dopaminergic turnover was measured by 3,4-dihyroxyphenilacetic acid content and 3H-Spiperone binding has been carried out to determine dopaminergic receptor alterations induced by chronic ethanol consumption during pregnancy." | 3.66 | Effects of ethanol, given during pregnancy, on the offspring dopaminergic system. ( Covelli, V; Lucchi, L; Petkov, VV; Spano, PF; Trabucchi, M, 1983) |
| " A dose-response curve demonstrated that the dopamine D1 receptor agonist, SKF 38393, produced a maximal response in 6-OHDA-treated rats at a dose of 0." | 1.28 | Supersensitized D1 receptors mediate enhanced oral activity after neonatal 6-OHDA. ( Gong, L; Kostrzewa, RM, 1991) |
| "Phencyclidine is a widely used drug of abuse and is known to produce a wide variety of psychoactive effects." | 1.28 | Effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brain. ( Ahmad, G; Ali, SF; Bondy, SC; Slikker, W, 1989) |
| " Pregnant rats were dosed with 0, 0." | 1.27 | Prenatal reserpine exposure in rats decreases caudate nucleus dopamine receptor binding in female offspring. ( Ali, SF; Buelke-Sam, J; Slikker, W, 1986) |
| " There were no signs of maternal toxicity in dosed mothers as evaluated by their body weights or general appearance." | 1.26 | Effects of acrylamide given during gestation on dopamine receptor binding in rat pups. ( Agrawal, AK; Squibb, RE, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (61.54) | 18.7374 |
| 1990's | 13 (33.33) | 18.2507 |
| 2000's | 2 (5.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weinshank, RL | 1 |
| Zgombick, JM | 1 |
| Macchi, MJ | 1 |
| Branchek, TA | 1 |
| Hartig, PR | 1 |
| Serguera, C | 1 |
| Triaca, V | 1 |
| Kelly-Barrett, J | 1 |
| Banchaabouchi, MA | 1 |
| Minichiello, L | 1 |
| Moon, SL | 2 |
| Lucchi, L | 2 |
| Covelli, V | 1 |
| Petkov, VV | 1 |
| Spano, PF | 2 |
| Trabucchi, M | 2 |
| Rotten, D | 1 |
| Cronin, MJ | 2 |
| Laherty, RF | 1 |
| Weiner, RI | 1 |
| Jaffe, RB | 1 |
| Pasqualini, C | 1 |
| Lenoir, V | 1 |
| El Abed, A | 1 |
| Kerdelhué, B | 1 |
| Bruinink, A | 1 |
| Lichtensteiger, W | 1 |
| Schlumpf, M | 1 |
| Koritnik, DR | 1 |
| Rosengarten, H | 1 |
| Friedman, E | 1 |
| Friedhoff, AJ | 1 |
| Madsen, JR | 1 |
| Campbell, A | 1 |
| Baldessarini, RJ | 1 |
| Heiman, ML | 1 |
| Ben-Jonathan, N | 1 |
| Agrawal, AK | 1 |
| Squibb, RE | 1 |
| Flores, G | 1 |
| Barbeau, D | 1 |
| Quirion, R | 1 |
| Srivastava, LK | 1 |
| Benson, KA | 1 |
| Ali, SF | 4 |
| Wilson, MC | 1 |
| Chen, Y | 1 |
| Hillefors-Berglund, M | 1 |
| Herrera-Marschitz, M | 1 |
| Bjelke, B | 1 |
| Gross, J | 1 |
| Andersson, K | 1 |
| von Euler, G | 1 |
| Arai, F | 1 |
| Kishimoto, Y | 1 |
| Tada, K | 1 |
| Kondo, Y | 1 |
| Kudo, T | 1 |
| Engel, J | 1 |
| Lundborg, P | 1 |
| Peris, J | 1 |
| Coleman-Hardee, M | 1 |
| Millard, WJ | 1 |
| Schmidt, MH | 1 |
| Lee, T | 1 |
| Burke, RE | 1 |
| Reches, A | 1 |
| Kostrzewa, RM | 3 |
| Gong, L | 1 |
| Brus, R | 1 |
| Kalbfleisch, J | 1 |
| Gagnon, C | 1 |
| Bédard, PJ | 1 |
| Rioux, L | 1 |
| Gaudin, D | 1 |
| Martinoli, MG | 1 |
| Pelletier, G | 1 |
| Di Paolo, T | 1 |
| Hamdi, A | 1 |
| Petit, A | 1 |
| Vaillancourt, C | 1 |
| Bellabarba, D | 1 |
| Lehoux, JG | 1 |
| Gallo-Payet, N | 1 |
| Bélisle, S | 1 |
| Scalzo, FM | 1 |
| Frambes, NA | 1 |
| Spear, LP | 1 |
| Ahmad, G | 1 |
| Slikker, W | 2 |
| Bondy, SC | 2 |
| Fung, YK | 2 |
| Reed, JA | 1 |
| Lau, YS | 2 |
| Breese, GR | 1 |
| Duncan, GE | 1 |
| Napier, TC | 1 |
| Iorio, LC | 1 |
| Mueller, RA | 1 |
| Felder, RA | 1 |
| Nakamura, KT | 1 |
| Robillard, JE | 1 |
| Kanadjian, M | 1 |
| Jose, PA | 1 |
| Peters, DA | 2 |
| Lancaster, FE | 1 |
| Selvanayagam, PF | 1 |
| Hsu, LL | 1 |
| Buelke-Sam, J | 1 |
| Govoni, S | 1 |
| Missale, C | 1 |
| Memo, M | 1 |
| Takagi, S | 1 |
| Alleva, FR | 1 |
| Seth, PK | 1 |
| Balazs, T | 1 |
| De Ceballos, ML | 1 |
| Benedi, A | 1 |
| De Felipe, C | 1 |
| Del Rio, J | 1 |
39 other studies available for spiperone and Pregnancy
| Article | Year |
|---|---|
Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
Topics: Amino Acid Sequence; Animals; Brain; Cattle; Cell Membrane; Cloning, Molecular; DNA Probes; Female; | 1992 |
Increased dopamine after mating impairs olfaction and prevents odor interference with pregnancy.
Topics: Animals; Cues; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Embryo Implantation | 2008 |
Prenatal haloperidol alters striatal dopamine and opiate receptors.
Topics: Animals; Corpus Striatum; Female; Haloperidol; Maternal-Fetal Exchange; Naloxone; Pregnancy; Rats; R | 1984 |
Effects of ethanol, given during pregnancy, on the offspring dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Ethanol; Fema | 1983 |
Monkey placenta, decidua, amnion or chorion does not contain measurable dopamine receptors.
Topics: Amnion; Animals; Binding, Competitive; Cattle; Chorion; Decidua; Dihydroalprenolol; Extraembryonic M | 1984 |
Anterior pituitary dopamine receptors during the rat estrous cycle. A detailed analysis of proestrus changes.
Topics: Animals; Binding Sites; Estrogens; Estrus; Female; Pituitary Gland, Anterior; Pregnancy; Prolactin; | 1984 |
Pre- and postnatal ontogeny and characterization of dopaminergic D2, serotonergic S2, and spirodecanone binding sites in rat forebrain.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Brain; Butyrophenones; Female; Fetus; Kinetics; | 1983 |
Dopamine receptors of the monkey anterior pituitary in various endocrine states.
Topics: Animals; Binding, Competitive; Body Weight; Female; Lactation; Macaca fascicularis; Male; Menstruati | 1983 |
Sensitive periods for the effect of haloperidol on development of striatal dopamine receptors.
Topics: alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; Female; Gestational Age; Haloperidol; Levo | 1983 |
Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain.
Topics: Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain; Female; Haloperidol; Humans; Kineti | 1981 |
Dopaminergic receptors in the rat anterior pituitary change during the estrous cycle.
Topics: Animals; Cell Membrane; Estrus; Female; Pituitary Gland, Anterior; Pregnancy; Proestrus; Prolactin; | 1982 |
Effects of acrylamide given during gestation on dopamine receptor binding in rat pups.
Topics: Acrylamides; Animals; Corpus Striatum; Female; Gestational Age; Male; Maternal-Fetal Exchange; Pregn | 1981 |
Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus.
Topics: Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Benzazepines; Disease Models, Animal; | 1996 |
The effects of prenatal cocaine exposure on dopaminergic challenge and receptor binding in Wistar rats.
Topics: Animals; Avoidance Learning; Benzazepines; Cocaine; Dopamine; Dopamine Agonists; Female; Male; Motor | 1996 |
Perinatal asphyxia induces long-term changes in dopamine D1, D2, and D3 receptor binding in the rat brain.
Topics: Animals; Apomorphine; Asphyxia Neonatorum; Benzazepines; Brain; Cesarean Section; Dopamine Agonists; | 1997 |
The presence and role of the dopamine DA-2 receptor in the human decidua.
Topics: Decidua; Dopamine; Female; Humans; Pregnancy; Prostaglandins F; Radioligand Assay; Receptors, Dopami | 2000 |
Increased mesolimbic 3H-spiroperidol binding in 4 week old offspring of nursing rat mothers treated with penfluridol.
Topics: Animal Population Groups; Animals; Animals, Suckling; Butyrophenones; Female; Lactation; Limbic Syst | 1979 |
Cocaine in utero enhances the behavioral response to cocaine in adult rats.
Topics: Animals; Body Weight; Cocaine; Corpus Striatum; Female; Male; Motor Activity; Nucleus Accumbens; Pre | 1992 |
Investigation of striatal dopamine D2 receptor acquisition following prenatal neuroleptic exposure.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Corpus Striatum; Dose-Response Relationship, Dr | 1991 |
Preserved striatal tyrosine hydroxylase activity, assessed in vivo, following neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apomorphine; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; B | 1991 |
Supersensitized D1 receptors mediate enhanced oral activity after neonatal 6-OHDA.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Benzazepines; | 1991 |
Ontogenetic homologous sensitization to the antinociceptive action of quinpirole in rats.
Topics: Aging; Analgesics; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Erg | 1991 |
Regional changes of striatal dopamine receptors following denervation by 6-hydroxydopamine and fetal mesencephalic grafts in the rat.
Topics: Amphetamine; Animals; Benzazepines; Brain Tissue Transplantation; Corpus Striatum; Female; Fetal Tis | 1991 |
Potentiation of spiperone-induced oral activity in rats after neonatal 6-hydroxydopamine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Brain Chemistry; Corpus Striatum; Dopamin | 1991 |
Presence of D2-dopamine receptors in human term placenta.
Topics: Dopamine; Female; Humans; Labor, Obstetric; Placenta; Pregnancy; Prolactin; Receptors, Dopamine; Rec | 1990 |
Weanling rats exposed prenatally to cocaine exhibit an increase in striatal D2 dopamine binding associated with an increase in ligand affinity.
Topics: Animals; Benzazepines; Cocaine; Corpus Striatum; Female; Nucleus Accumbens; Pregnancy; Prenatal Expo | 1990 |
Effects of gestational exposure to phencyclidine: distribution and neurochemical alterations in maternal and fetal brain.
Topics: Animals; Brain; Brain Chemistry; Female; Fetus; Gestational Age; Nerve Tissue Proteins; Neurotransmi | 1989 |
Prenatal cocaine exposure fails to modify neurobehavioral responses and the striatal dopaminergic system in newborn rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Cocaine; Corpus Striatum; Dopamine; Drinki | 1989 |
Effects of prenatal nicotine exposure on rat striatal dopaminergic and nicotinic systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Body Weight; Corpus Striatum; Cotinine; Female; Gestational | 1989 |
Consequences of perinatal drug administration on brain development: striatal opiate receptors and dopamine.
Topics: Animals; Autoradiography; Brain; Caudate Nucleus; Corpus Striatum; Female; Haloperidol; Nucleus Accu | 1985 |
6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1987 |
Dopamine receptors in the developing sheep kidney.
Topics: Animals; Animals, Newborn; Benzazepines; Binding Sites; Binding, Competitive; Dopamine Antagonists; | 1988 |
Effects of maternal stress during different gestational periods on the serotonergic system in adult rat offspring.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Female; Gestational Age; Male; Methoxydimethyltryptamine | 1988 |
Lactational ethanol exposure: brain enzymes and [3H]spiroperidol binding.
Topics: Animals; Animals, Newborn; Choline O-Acetyltransferase; Corpus Striatum; Ethanol; Female; Glutamate | 1986 |
Prenatal stress: effect on development of rat brain serotonergic neurons.
Topics: Aging; Animals; Circadian Rhythm; Female; Kinetics; Motor Activity; Neurons; Pregnancy; Prenatal Exp | 1986 |
Prenatal reserpine exposure in rats decreases caudate nucleus dopamine receptor binding in female offspring.
Topics: Animals; Butyrophenones; Caudate Nucleus; Female; Male; Maternal-Fetal Exchange; Pregnancy; Rats; Re | 1986 |
Effect of lead exposure on dopaminergic receptors in rat striatum and nucleus accumbens.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Corpus Striatum; Female; Haloperidol; Lead Poisoni | 1986 |
Delayed development of reproductive functions and alteration of dopamine receptor binding in hypothalamus of rats exposed prenatally to phenytoin and phenobarbital.
Topics: Animals; Female; Hypothalamus; Male; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed | 1986 |
Prenatal exposure of rats to antidepressants enhances agonist affinity of brain dopamine receptors and dopamine-mediated behaviour.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Dopamine; Female; Kinetics; Motor | 1985 |