spiperone has been researched along with Parkinson Disease in 44 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied." | 5.27 | [3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987) |
| "[3H]Spiperone binding was investigated in the caudate nucleus, substantia nigra (s." | 5.26 | Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease. ( Bannister, R; Mackay, AV; Quik, M; Spokes, EG, 1979) |
| "In order to investigate the diagnostic value of 3H-spiperone binding capacity to lymphocytes in the differential diagnosis of de novo Parkinson's disease (idiopathic Parkinson syndrome, PD), we performed a double blind prospective study of spiperone binding capacity of 123 patients and 23 healthy control persons, belonging to different diagnostic groups (PD, Parkinsonian syndrome due to vascular lesions, multiple system atrophy [MSA], essential tremor)." | 5.07 | 3H-spiperone binding to lymphocytes fails in the differential diagnosis of de novo Parkinson syndromes. ( Arnold, G; Bandmann, O; Bondy, B; Gasser, T; Oertel, WH; Poewe, W; Schwarz, J; Trenkwalder, C; Wagner, M, 1993) |
| "Dopamine D2 receptor binding potential (BP) was measured by C-11 N-methylspiperone (NMSP) and PET in normal healthy volunteers and patients with various neurodegenerative diseases including Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Huntington disease (HD) and so on." | 4.79 | [Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET]. ( Momose, T; Sasaki, Y, 1997) |
| "The primary etiology of Parkinson's disease is still unknown, although the aging process may be an important predisposing factor." | 2.36 | Parkinson's disease as a model for changes in dopamine receptor dynamics with aging. ( Rinne, UK, 1982) |
| "Patients with amyotrophic lateral sclerosis (ALS) sometimes exhibit parkinsonism, but the lesion responsible for parkinsonism has not been extensively studied." | 1.33 | A positron emission tomography study on the role of nigral lesions in parkinsonism in patients with amyotrophic lateral sclerosis. ( Hideyama, T; Kwak, S; Momose, T; Shimizu, J; Tsuji, S, 2006) |
| "Seven patients with early Parkinson's disease and 5 healthy volunteers were studied." | 1.31 | Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone. ( Kaasinen, V; Lehikoinen, P; Någren, K; Oikonen, V; Rinne, JO; Ruottinen, HM, 2000) |
| "All the patients with Parkinson's disease also demonstrated symmetrical basal ganglia uptake in the late SPECT images, but it was diminished in parkinsonism and Wilson's disease." | 1.29 | Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography. ( Fukuyama, H; Iida, Y; Iwasaki, Y; Konishi, J; Magata, Y; Saji, H; Shimatsu, A; Tsuchida, T; Yokoyama, A; Yonekura, Y, 1995) |
| " These results indicate that chronic administration of either bromocriptine or L-Dopa will reverse the DA receptor denervation supersensitivity in striatum seen following 6-OHDA lesion." | 1.27 | Dopamine receptors: effects of chronic L-dopa and bromocriptine treatment in an animal model of Parkinson's disease. ( Deupree, JD; Murrin, LC; Pfeiffer, RF; Schneider, MB, 1984) |
| "[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied." | 1.27 | [3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987) |
| "Although the cause of Parkinson's disease is still unknown it has become clear that dopaminergic cell loss in the substantia nigra is a prominent feature of the disease." | 1.27 | Parkinson's disease and PET tracer studies. ( Leenders, KL, 1988) |
| "[3H]Spiperone binding was investigated in the caudate nucleus, substantia nigra (s." | 1.26 | Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease. ( Bannister, R; Mackay, AV; Quik, M; Spokes, EG, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (63.64) | 18.7374 |
| 1990's | 11 (25.00) | 18.2507 |
| 2000's | 4 (9.09) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishibashi, K | 1 |
| Ishii, K | 1 |
| Oda, K | 1 |
| Mizusawa, H | 1 |
| Ishiwata, K | 1 |
| Hideyama, T | 1 |
| Momose, T | 2 |
| Shimizu, J | 1 |
| Tsuji, S | 1 |
| Kwak, S | 1 |
| Zhang, H | 1 |
| Ma, L | 1 |
| Wang, F | 1 |
| Chen, J | 1 |
| Zhen, X | 1 |
| Mastroeni, D | 1 |
| Grover, A | 1 |
| Leonard, B | 1 |
| Joyce, JN | 2 |
| Coleman, PD | 1 |
| Kozik, B | 1 |
| Bellinger, DL | 1 |
| Rogers, J | 1 |
| Rinne, UK | 3 |
| Lönnberg, P | 2 |
| Koskinen, V | 1 |
| Wagner, HN | 1 |
| Mishra, RK | 1 |
| Winkler, MH | 1 |
| Berl, S | 1 |
| Whetsell, WO | 1 |
| Yahr, MD | 1 |
| Schneider, MB | 1 |
| Murrin, LC | 1 |
| Pfeiffer, RF | 1 |
| Deupree, JD | 1 |
| Maloteaux, JM | 1 |
| Laterre, CE | 1 |
| Hens, L | 1 |
| Laduron, PM | 1 |
| Bédard, P | 1 |
| Boucher, R | 1 |
| Di Paolo, T | 1 |
| Labrie, F | 1 |
| Bokobza, B | 1 |
| Ruberg, M | 3 |
| Scatton, B | 1 |
| Javoy-Agid, F | 3 |
| Agid, Y | 4 |
| Titeler, M | 1 |
| Seeman, P | 3 |
| Le Fur, G | 2 |
| Meininger, V | 2 |
| Baulac, M | 2 |
| Phan, T | 2 |
| Uzan, A | 2 |
| Gérard, A | 1 |
| Arnold, G | 1 |
| Bondy, B | 1 |
| Bandmann, O | 1 |
| Gasser, T | 1 |
| Schwarz, J | 1 |
| Trenkwalder, C | 1 |
| Wagner, M | 1 |
| Poewe, W | 1 |
| Oertel, WH | 1 |
| Guan, HC | 1 |
| Van Tol, HH | 1 |
| Niznik, HB | 1 |
| Przedborski, S | 1 |
| Goldman, S | 1 |
| Levivier, M | 1 |
| Giladi, N | 1 |
| Bidaut, LM | 1 |
| Hildebrand, J | 1 |
| Stanus, E | 1 |
| Labar, D | 1 |
| Luxen, A | 1 |
| Yonekura, Y | 1 |
| Saji, H | 1 |
| Iwasaki, Y | 1 |
| Tsuchida, T | 1 |
| Fukuyama, H | 1 |
| Shimatsu, A | 1 |
| Iida, Y | 1 |
| Magata, Y | 1 |
| Konishi, J | 1 |
| Yokoyama, A | 1 |
| Efange, SM | 1 |
| Langason, RB | 1 |
| Khare, AB | 1 |
| Low, WC | 1 |
| Perlmutter, JS | 2 |
| Stambuk, MK | 1 |
| Markham, J | 1 |
| Black, KJ | 1 |
| McGee-Minnich, L | 1 |
| Jankovic, J | 1 |
| Moerlein, SM | 1 |
| Sasaki, Y | 1 |
| Kaasinen, V | 1 |
| Ruottinen, HM | 1 |
| Någren, K | 2 |
| Lehikoinen, P | 1 |
| Oikonen, V | 1 |
| Rinne, JO | 2 |
| Goldstein, M | 1 |
| Lew, JY | 1 |
| Nakamura, S | 1 |
| Battista, AF | 1 |
| Lieberman, A | 1 |
| Fuxe, K | 1 |
| Quik, M | 1 |
| Spokes, EG | 1 |
| Mackay, AV | 1 |
| Bannister, R | 1 |
| Ahlskog, JE | 1 |
| Richelson, E | 1 |
| Nelson, A | 1 |
| Kelly, PJ | 1 |
| Okazaki, H | 1 |
| Tyce, GM | 1 |
| van Heerden, JA | 1 |
| Stoddard, SL | 1 |
| Carmichael, SW | 1 |
| Laihinen, A | 1 |
| Marjamäki, P | 1 |
| Wienhard, K | 1 |
| Coenen, HH | 1 |
| Pawlik, G | 1 |
| Rudolf, J | 1 |
| Laufer, P | 1 |
| Jovkar, S | 1 |
| Stöcklin, G | 1 |
| Heiss, WD | 1 |
| Pimoule, C | 1 |
| Schoemaker, H | 1 |
| Reynolds, GP | 1 |
| Langer, SZ | 1 |
| Cash, R | 1 |
| Raisman, R | 2 |
| Ploska, A | 1 |
| Hägglund, J | 2 |
| Aquilonius, SM | 2 |
| Bergström, K | 1 |
| Eckernäs, SA | 2 |
| Hartvig, P | 2 |
| Lundqvist, H | 1 |
| Långström, B | 2 |
| Malmborg, P | 1 |
| Lundquist, H | 1 |
| Gullberg, P | 1 |
| Członkowska, A | 1 |
| Jachowicz-Jeszka, J | 1 |
| Członkowski, A | 1 |
| Pierot, L | 1 |
| Desnos, C | 1 |
| Blin, J | 1 |
| Scherman, D | 1 |
| Bonnet, AM | 1 |
| Raichle, ME | 1 |
| Leenders, KL | 2 |
| Quinn, N | 1 |
| Frackowiak, RS | 1 |
| Marsden, CD | 1 |
| Koller, W | 1 |
| Herbster, G | 1 |
| Anderson, D | 1 |
| Wack, R | 1 |
| Gordon, J | 1 |
| Rutgers, AW | 1 |
| Lakke, JP | 1 |
| Paans, AM | 1 |
| Vaalburg, W | 1 |
| Korf, J | 1 |
| Guttman, M | 1 |
| Bennett, JP | 1 |
| Wooten, GF | 1 |
4 reviews available for spiperone and Parkinson Disease
| Article | Year |
|---|---|
CNS dopamine receptors: effect of prolyl-leucyl-glycinamide and solubilization.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Brain; Cattle; Dopamine; Dopamine Antagonists; Dyskinesia | 1984 |
Radioreceptor labeling of pre- and postsynaptic dopamine receptors.
Topics: Animals; Apomorphine; Binding Sites; Haloperidol; Humans; Parkinson Disease; Radioligand Assay; Rece | 1980 |
Parkinson's disease as a model for changes in dopamine receptor dynamics with aging.
Topics: Aged; Aging; Brain; Corpus Striatum; Humans; Models, Biological; Parkinson Disease; Receptors, Dopam | 1982 |
[Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET].
Topics: Aging; Biomarkers; Carbon Radioisotopes; Corpus Striatum; Diagnosis, Differential; Dopamine Agonists | 1997 |
1 trial available for spiperone and Parkinson Disease
| Article | Year |
|---|---|
3H-spiperone binding to lymphocytes fails in the differential diagnosis of de novo Parkinson syndromes.
Topics: Adult; Aged; Butaclamol; Diagnosis, Differential; Double-Blind Method; Female; Humans; Kinetics; Lev | 1993 |
39 other studies available for spiperone and Parkinson Disease
| Article | Year |
|---|---|
Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease.
Topics: Aged; Binding, Competitive; Carbon Radioisotopes; Case-Control Studies; Dopamine; Female; Humans; Li | 2010 |
A positron emission tomography study on the role of nigral lesions in parkinsonism in patients with amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Cerebrovascular Circulation; Female; Humans; Levodopa; Male; Mi | 2006 |
Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Disease M | 2007 |
Microglial responses to dopamine in a cell culture model of Parkinson's disease.
Topics: Aged; Aging; Antineoplastic Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Coculture Te | 2009 |
Dopamine receptors in the Parkinsonian brain.
Topics: Aged; Antipsychotic Agents; Brain; Caudate Nucleus; Female; Humans; Kinetics; Levodopa; Male; Parkin | 1981 |
Imaging CNS receptors: the dopaminergic system.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Brain; Carbon Radioisotopes; Deoxyglucose | 1984 |
Spiroperidol binding in the human caudate nucleus.
Topics: Binding, Competitive; Butaclamol; Butyrophenones; Caudate Nucleus; Humans; In Vitro Techniques; Park | 1980 |
Dopamine receptors: effects of chronic L-dopa and bromocriptine treatment in an animal model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bromocriptine; Corpus Striatum; Disease Models, Animal; Dop | 1984 |
Failure of a peripheral dopaminergic marker in Parkinson's disease.
Topics: Adult; Aged; Humans; Levodopa; Lymphocytes; Middle Aged; Parkinson Disease; Receptors, Dopamine; Spi | 1983 |
Interaction between estradiol, prolactin, and striatal dopaminergic mechanisms.
Topics: Animals; Corpus Striatum; Domperidone; Dopamine; Estradiol; Female; Haloperidol; Macaca fascicularis | 1984 |
[3H]spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy.
Topics: Aged; Brain; Butyrophenones; Caudate Nucleus; Dopamine; Homovanillic Acid; Humans; Levodopa; Nucleus | 1984 |
[Dopaminergic receptors on lymphocytes in idiopathic Parkinson's disease (author's transl)].
Topics: Adult; Aged; Female; Humans; Lymphocytes; Male; Middle Aged; Parkinson Disease; Receptors, Dopamine; | 1981 |
Decrease in lymphocyte [3H]spiroperidol binding sites in Parkinsonism.
Topics: Aged; Butyrophenones; Female; Humans; Kinetics; Lymphocytes; Male; Middle Aged; Parkinson Disease; R | 1980 |
Low density of dopamine D4 receptors in Parkinson's, schizophrenia, and control brain striata.
Topics: Animals; Benzamides; Corpus Striatum; Dopamine D2 Receptor Antagonists; Humans; In Vitro Techniques; | 1993 |
Brain glucose metabolism and dopamine D2 receptor analysis in a patient with hemiparkinsonism-hemiatrophy syndrome.
Topics: Aged; Basal Ganglia; Brain; Corpus Striatum; Diagnosis, Differential; Female; Functional Laterality; | 1993 |
Differential response of striatal dopamine and muscarinic cholinergic receptor subtypes to the loss of dopamine. III. Results in Parkinson's disease cases.
Topics: Aged; Aged, 80 and over; Autoradiography; Benzazepines; Dopamine; Female; Humans; Male; Mazindol; Mi | 1993 |
Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography.
Topics: Adenoma; Basal Ganglia; Brain; Frontal Lobe; Hepatolenticular Degeneration; Humans; Iodine Radioisot | 1995 |
The vesamicol receptor ligand (+)-meta-[125I]iodobenzyltrozamicol [(+)-[125I]-MIBT] reveals blunting of the striatal cholinergic response to dopamine D2 receptor blockade in the 6-hydroxydopamine (6-OHDA)-lesioned rat: possible implications for Parkinson'
Topics: Animals; Brain Diseases; Cholinergic Fibers; Corpus Striatum; Disease Models, Animal; Dopamine Antag | 1996 |
Decreased [18F]spiperone binding in putamen in idiopathic focal dystonia.
Topics: Adult; Aged; Basal Ganglia; Blepharospasm; Cerebrovascular Circulation; Dopamine; Dystonia; Facial M | 1997 |
Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone.
Topics: Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Female; Humans; Male; Middle Aged; Pa | 2000 |
Dopaminephilic properties of ergot alkaloids.
Topics: Acetonitriles; Animals; Bromocriptine; Corpus Striatum; Ergolines; Ergot Alkaloids; Haplorhini; Huma | 1978 |
Alterations in [3H]spiperone binding in human caudate nucleus, substantia nigra and frontal cortex in the Shy-Drager syndrome and Parkinson's disease.
Topics: Binding Sites; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Frontal Lobe; Humans; Levodopa; Mus | 1979 |
Reduced D2 dopamine and muscarinic cholinergic receptor densities in caudate specimens from fluctuating parkinsonian patients.
Topics: Adult; Brain Tissue Transplantation; Bromocriptine; Caudate Nucleus; Down-Regulation; Humans; Levodo | 1991 |
A post-mortem study on striatal dopamine receptors in Parkinson's disease.
Topics: Aged; Autopsy; Benzazepines; Caudate Nucleus; Corpus Striatum; Humans; Kinetics; Parkinson Disease; | 1991 |
PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system.
Topics: Adolescent; Adult; Aged; Brain; Caudate Nucleus; Female; Humans; Male; Middle Aged; Nervous System D | 1990 |
[3H]SCH 23390 labeled D1 dopamine receptors are unchanged in schizophrenia and Parkinson's disease.
Topics: Aged; Antipsychotic Agents; Benzazepines; Cocaine; Humans; In Vitro Techniques; Middle Aged; Parkins | 1985 |
Dopamine D-1 receptor and cyclic AMP-dependent phosphorylation in Parkinson's disease.
Topics: Aged; Benzazepines; Brain; Cyclic AMP; Humans; Parkinson Disease; Phosphoproteins; Phosphorylation; | 1987 |
Regional kinetics of [11C]methylspiperone in the brain studied by positron emission tomography in patients with Parkinson's disease.
Topics: Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Humans; Huntington Disease; Kinetics; Parkinson | 1987 |
Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using 11C-N-methyl-spiperone.
Topics: Aged; Caudate Nucleus; Corpus Striatum; Female; Frontal Lobe; Humans; Huntington Disease; Kinetics; | 1987 |
[3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging.
Topics: Adult; Aged; Aging; Antiparkinson Agents; Female; Hepatolenticular Degeneration; Humans; Lymphocytes | 1987 |
D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy.
Topics: Adenylyl Cyclases; Adult; Aged; Benzazepines; Caudate Nucleus; Dopamine Antagonists; Humans; Middle | 1988 |
Pathophysiology of L-dopa-induced abnormal involuntary movements.
Topics: Brain; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Humans; Levodopa; Neural Pathways; Parki | 1985 |
In vitro or in vivo receptor binding: where does the truth lie?
Topics: Animals; Corpus Striatum; Histological Techniques; Humans; In Vitro Techniques; Parkinson Disease; R | 1986 |
Parkinson's disease and PET tracer studies.
Topics: Animals; Carbon Radioisotopes; Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenylalanine; | 1988 |
Brain dopaminergic system studied in patients with dystonia using positron emission tomography.
Topics: Adult; Brain; Dopamine; Dystonia; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Sp | 1988 |
Quinpirole hydrochloride, a potential anti-parkinsonism drug.
Topics: Animals; Benzazepines; Corpus Striatum; Dogs; Dose-Response Relationship, Drug; Ergolines; Grooming; | 1987 |
Tracing of dopamine receptors in hemiparkinsonism with positron emission tomography (PET).
Topics: Adult; Aged; Brain; Female; Functional Laterality; Humans; Male; Middle Aged; Parkinson Disease; Rec | 1987 |
Dopamine receptor elevation in denervated tissues.
Topics: Animals; Corpus Striatum; Humans; Parkinson Disease; Receptors, Dopamine; Spiperone | 1987 |
Dopamine denervation does not alter in vivo 3H-spiperone binding in rat striatum: implications for external imaging of dopamine receptors in Parkinson's disease.
Topics: Animals; Autoradiography; Brain; Butyrophenones; Corpus Striatum; Denervation; Dopamine; Filtration; | 1986 |