spiperone has been researched along with Neuroblastoma in 12 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells." | 7.66 | [3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983) |
| " In contrast, ectopically expressed D2 receptor or endogenous D2-like receptor activation of ERKs in NS20Y neuroblastoma cells, which express little or no PDGF receptor, or in rat neostriatal neurons was largely dependent on transactivation of the epidermal growth factor (EGF) receptor, as demonstrated using the EGF receptor inhibitor AG 1478 and by quinpirole-induced phosphorylation of the EGF receptor." | 3.73 | Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. ( Buck, DC; Macey, TA; Neve, KA; Wang, C; Yang, R, 2005) |
| " In membranes prepared from the WERI 27 human retinoblastoma cell line, specific receptor binding of the D2 antagonists [3H]methylspiperone and [125I]NAPS was observed." | 3.67 | Identification and characterization of D1 and D2 dopamine receptors in cultured neuroblastoma and retinoblastoma clonal cell lines. ( Brassard, DL; Monsma, FJ; Sibley, DR, 1989) |
| " Similar results were obtained with other intact cells, fibroblasts, hepatocytes and neuroblastoma cells using [3H]spiperone and other ligands, such as [3H]haloperidol, [3H]pyrilamine and [3H]ketanserin." | 3.66 | Trapping of labelled ligands in intact cells: a pitfall in binding studies. ( Gossuin, A; Laduron, PM; Maloteaux, JM; Waterkeyn, C, 1983) |
| "Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells." | 3.66 | [3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983) |
| " The dopamine antagonists domperidone, pimozide, and spiroperidol inhibited macromolecular synthesis in vitro as demonstrated by decreased [3H]TdR and [14C]leu incorporation in a dose-response fashion; 56, 49, and 43% inhibition was noted at 10(-6) M concentration of each drug, respectively, with no loss of cell viability." | 1.27 | Inhibition of murine neuroblastoma growth by dopamine antagonists. ( McGrath, PC; Neifeld, JP, 1984) |
| " In four HNB cell lines the dopamine antagonists domperidone, pimozide, and spiroperidol inhibited macromolecular synthesis in vitro as indicated by decreased 3H-TdR and 14C-leu incorporation in a dose-response fashion with at least 50% inhibition noted at 10(-6)M concentration of each drug." | 1.27 | Inhibition of human neuroblastoma by dopamine antagonists. ( McGrath, PC; Neifeld, JP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Tol, HH | 1 |
| Bunzow, JR | 1 |
| Guan, HC | 1 |
| Sunahara, RK | 1 |
| Seeman, P | 2 |
| Niznik, HB | 1 |
| Civelli, O | 1 |
| Wang, C | 1 |
| Buck, DC | 1 |
| Yang, R | 1 |
| Macey, TA | 1 |
| Neve, KA | 1 |
| Mastroeni, D | 1 |
| Grover, A | 1 |
| Leonard, B | 1 |
| Joyce, JN | 1 |
| Coleman, PD | 1 |
| Kozik, B | 1 |
| Bellinger, DL | 1 |
| Rogers, J | 1 |
| Hartley, EJ | 1 |
| Spuhler, K | 1 |
| Prasad, KN | 1 |
| Berry-Kravis, E | 1 |
| Freedman, SB | 1 |
| Dawson, G | 1 |
| Maloteaux, JM | 1 |
| Gossuin, A | 1 |
| Waterkeyn, C | 1 |
| Laduron, PM | 1 |
| McGrath, PC | 2 |
| Neifeld, JP | 2 |
| Severson, JA | 1 |
| de Vellis, JS | 1 |
| Finch, CE | 1 |
| Safa, AR | 1 |
| Agresti, M | 1 |
| Bryk, D | 1 |
| Tamai, I | 1 |
| Alberts, GL | 1 |
| Pregenzer, JF | 1 |
| Im, WB | 1 |
| Monsma, FJ | 1 |
| Brassard, DL | 1 |
| Sibley, DR | 1 |
12 other studies available for spiperone and Neuroblastoma
| Article | Year |
|---|---|
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cloning, M | 1991 |
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.
Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Dopamine Agonists; Dopamine Antagonis | 2005 |
Microglial responses to dopamine in a cell culture model of Parkinson's disease.
Topics: Aged; Aging; Antineoplastic Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Coculture Te | 2009 |
A neuroblastoma clone which has dopamine-sensitive adenylate cyclase but which lacks stereospecific binding sites for the neuroleptic [3H]spiperone.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Butaclamol; Butyrophenones; Clone Cells; Dopamine; | 1980 |
Specific receptor-mediated inhibition of cyclic AMP synthesis by dopamine in a neuroblastoma X brain hybrid cell line NCB-20.
Topics: Alprostadil; Animals; Apomorphine; Brain; Cell Line; Cell Membrane; Clonidine; Cricetinae; Cricetulu | 1984 |
Trapping of labelled ligands in intact cells: a pitfall in binding studies.
Topics: Animals; Binding, Competitive; Cell Line; Haloperidol; Humans; Kinetics; Lymphocytes; Mice; Neurobla | 1983 |
Inhibition of murine neuroblastoma growth by dopamine antagonists.
Topics: Animals; Cell Line; DNA; Domperidone; Dopamine; Dopamine Antagonists; Leucine; Male; Mice; Mice, Inb | 1984 |
[3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma.
Topics: Animals; Binding Sites; Binding, Competitive; Butyrophenones; Cell Line; Cerebral Cortex; Corpus Str | 1983 |
N-(p-azido-3-[125I]iodophenethyl)spiperone binds to specific regions of P-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transpo | 1994 |
Advantages of heterologous expression of human D2long dopamine receptors in human neuroblastoma SH-SY5Y over human embryonic kidney 293 cells.
Topics: Calcium Channels; Cells, Cultured; Cloning, Molecular; Dopamine Antagonists; Dopamine D2 Receptor An | 2000 |
Identification and characterization of D1 and D2 dopamine receptors in cultured neuroblastoma and retinoblastoma clonal cell lines.
Topics: Animals; Benzazepines; Binding, Competitive; Cell Line; Dopamine Antagonists; Humans; Mice; Neurobla | 1989 |
Inhibition of human neuroblastoma by dopamine antagonists.
Topics: Animals; Cell Division; Cell Line; Domperidone; Dopamine; Dopamine Antagonists; Female; Humans; Levo | 1985 |