spiperone has been researched along with Nerve Degeneration in 7 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agnati, LF | 1 |
| Fuxe, K | 1 |
| Calza, L | 1 |
| Benfenati, F | 1 |
| Cavicchioli, L | 1 |
| Toffano, G | 1 |
| Goldstein, M | 1 |
| Bardgett, ME | 1 |
| Jackson, JL | 1 |
| Taylor, GT | 1 |
| Csernansky, JG | 1 |
| Volkow, ND | 1 |
| Wang, GJ | 1 |
| Fowler, JS | 1 |
| Logan, J | 1 |
| Gatley, SJ | 1 |
| MacGregor, RR | 1 |
| Schlyer, DJ | 1 |
| Hitzemann, R | 1 |
| Wolf, AP | 1 |
| Gallagher, IM | 1 |
| Jenner, P | 1 |
| Glover, V | 1 |
| Clow, A | 1 |
| Araujo, DM | 1 |
| Cherry, SR | 1 |
| Tatsukawa, KJ | 1 |
| Toyokuni, T | 1 |
| Kornblum, HI | 1 |
| Ben-Shachar, D | 1 |
| Pinhassi, B | 1 |
| Youdim, MB | 1 |
| Ruberg, M | 1 |
| Javoy-Agid, F | 1 |
| Hirsch, E | 1 |
| Scatton, B | 1 |
| LHeureux, R | 1 |
| Hauw, JJ | 1 |
| Duyckaerts, C | 1 |
| Gray, F | 1 |
| Morel-Maroger, A | 1 |
| Rascol, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults[NCT03512171] | Phase 1 | 65 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for spiperone and Nerve Degeneration
| Article | Year |
|---|---|
Gangliosides increase the survival of lesioned nigral dopamine neurons and favour the recovery of dopaminergic synaptic function in striatum of rats by collateral sprouting.
Topics: Animals; Cell Survival; Dendrites; G(M1) Ganglioside; Gangliosides; Male; Nerve Degeneration; Nerve | 1983 |
Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: an animal model of schizophrenia.
Topics: Animals; Brain Mapping; Caudate Nucleus; Cell Count; Disease Models, Animal; Dose-Response Relations | 1995 |
Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol.
Topics: Adult; Age Factors; Aged; Aging; Cerebellum; Corpus Striatum; Dopamine Agonists; Female; Humans; Lig | 1996 |
CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months.
Topics: Animals; Binding Sites; Longevity; Male; Mazindol; Mice; Mice, Transgenic; Motor Activity; Neostriat | 2000 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Prevention of neuroleptic-induced dopamine D2 receptor supersensitivity by chronic iron salt treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Chlorpr | 1991 |
Dopaminergic and cholinergic lesions in progressive supranuclear palsy.
Topics: Aged; Brain; Bulbar Palsy, Progressive; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; Fema | 1985 |