spiperone has been researched along with Muscle Contraction in 30 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Long-term administration of lithium decreased the number of not only 5-HT2 receptors in the frontal cortex but also 5-HT1 and 5-HT2 receptors in the hippocampus in rats." | 1.27 | Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain. ( Hotta, I; Segawa, T; Yamawaki, S, 1986) |
| "Pimozide has no such effect." | 1.26 | The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat. ( Maj, J; Palider, W; Rawłów, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (43.33) | 18.7374 |
| 1990's | 13 (43.33) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wainscott, DB | 1 |
| Cohen, ML | 3 |
| Schenck, KW | 2 |
| Audia, JE | 1 |
| Nissen, JS | 1 |
| Baez, M | 1 |
| Kursar, JD | 1 |
| Lucaites, VL | 1 |
| Nelson, DL | 1 |
| Leopoldo, M | 1 |
| Lacivita, E | 1 |
| Contino, M | 1 |
| Colabufo, NA | 1 |
| Berardi, F | 1 |
| Perrone, R | 1 |
| Sung, DJ | 1 |
| Noh, HJ | 1 |
| Kim, JG | 1 |
| Park, SW | 1 |
| Kim, B | 1 |
| Cho, H | 1 |
| Bae, YM | 1 |
| Hernández, M | 1 |
| Barahona, MV | 1 |
| Simonsen, U | 1 |
| Recio, P | 1 |
| Rivera, L | 1 |
| Martínez, AC | 1 |
| García-Sacristán, A | 1 |
| Orensanz, LM | 1 |
| Prieto, D | 1 |
| Jurkiewicz, NH | 1 |
| Caricati-Neto, A | 1 |
| Verde, LF | 1 |
| Avellar, MC | 1 |
| Reuter, HR | 1 |
| Jurkiewicz, A | 1 |
| Millar, JA | 1 |
| Facoory, BD | 1 |
| Laverty, R | 1 |
| Janicki, PK | 1 |
| Członkowski, A | 1 |
| Libich, J | 1 |
| Gumułka, SW | 1 |
| Pax, RA | 1 |
| Siefker, C | 1 |
| Bennett, JL | 1 |
| Fuller, RW | 1 |
| Wiley, KS | 1 |
| Testa, R | 1 |
| Guarneri, L | 1 |
| Poggesi, E | 1 |
| Simonazzi, I | 1 |
| Taddei, C | 1 |
| Leonardi, A | 1 |
| Craig, DA | 1 |
| Martin, GR | 2 |
| Glusa, E | 1 |
| Müller-Schweinitzer, E | 2 |
| O'Rourke, M | 1 |
| Kearns, S | 1 |
| Docherty, JR | 1 |
| Nishimura, Y | 1 |
| Furukawa, T | 1 |
| Morishita, H | 2 |
| Chairungsrilerd, N | 1 |
| Furukawa, KI | 1 |
| Ohta, T | 1 |
| Nozoe, S | 1 |
| Ohizumi, Y | 1 |
| Yousif, M | 1 |
| Kadavil, EA | 1 |
| Oriowo, MA | 1 |
| Katsuragi, T | 1 |
| Amobi, N | 1 |
| Guillebaud, J | 1 |
| Coker, C | 1 |
| Mulvin, D | 1 |
| Smith, IC | 1 |
| Maj, J | 1 |
| Palider, W | 1 |
| Rawłów, A | 1 |
| MacLennan, SJ | 1 |
| Parsons, AA | 1 |
| Motevalian, M | 1 |
| Whalley, ET | 1 |
| Kurz, KD | 1 |
| Frenken, M | 1 |
| Kalkman, HO | 1 |
| Neumann, V | 1 |
| Brauner, V | 1 |
| Skarsfeldt, T | 1 |
| Hyttel, J | 1 |
| Murakami, H | 1 |
| Sano, M | 1 |
| Tsukimura, T | 1 |
| Yamazaki, A | 1 |
| Feniuk, W | 1 |
| Humphrey, PP | 1 |
| Perren, MJ | 1 |
| Watts, AD | 1 |
| Hotta, I | 1 |
| Yamawaki, S | 1 |
| Segawa, T | 1 |
| Victorzon, M | 1 |
| Tapparelli, C | 1 |
30 other studies available for spiperone and Muscle Contraction
| Article | Year |
|---|---|
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; | 1993 |
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Topics: Amides; Animals; Cell Line; Guinea Pigs; Humans; Ileum; Male; Muscle Contraction; Muscle, Smooth; Pi | 2007 |
Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cult | 2013 |
Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter.
Topics: Animals; Dose-Response Relationship, Drug; Female; Guanethidine; In Vitro Techniques; Male; Muscle C | 2003 |
Sympathetic neurotransmission in the rat testicular capsule: functional characterization and identification of mRNA encoding alpha1-adrenoceptor subtypes.
Topics: Acetyl-CoA C-Acyltransferase; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptak | 2006 |
Mechanism of action of ketanserin.
Topics: Animals; Antihypertensive Agents; Humans; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; | 1982 |
Lack of postulated opiate-receptor antagonistic properties of compound 48/80.
Topics: Analgesics; Animals; Binding, Competitive; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Cont | 1981 |
Schistosoma mansoni: differences in acetylcholine, dopamine, and serotonin control of circular and longitudinal parasite muscles.
Topics: Acetylcholine; Animals; Atropine; Carbachol; Dopamine; Magnesium; Male; Metergoline; Muscle Contract | 1984 |
Evidence for 5-HT2 receptors mediating contraction in vascular smooth muscle.
Topics: Animals; Aorta; In Vitro Techniques; Jugular Veins; Male; Muscle Contraction; Muscle, Smooth, Vascul | 1981 |
Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Clonidine; Computer Si | 1995 |
5-HT1B receptors mediate potent contractile responses to 5-HT in rat caudal artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Ergolines; In | 1993 |
Heterogeneity of 5-HT receptor subtypes in isolated human femoral and saphenous veins.
Topics: Adult; Aged; Femoral Vein; Humans; In Vitro Techniques; Kinetics; Middle Aged; Muscle Contraction; M | 1993 |
Investigation of the actions of chloroethylclonidine in rat aorta.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aorta; Clonidine; Cystamine; Dioxanes; | 1995 |
Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Basilar Artery; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Male; Me | 1996 |
Existence of dopamine D1 receptor on the sympathetic nerve endings in the guinea-pig vas deferens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine Triphosphate; Adrenergic alpha | 1997 |
Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Guinea Pigs; HIV Protease Inhibitor | 1998 |
Heterogeneity of alpha 1-adrenoceptor subtypes mediating noradrenaline-induced contractions of the rat superior mesenteric artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine Antagonists; Do | 1998 |
Existence of postsynaptic dopamine D2 receptor as an enhancer of contractile response in vas deferens.
Topics: Adenosine Triphosphate; Animals; Dopamine; Dopamine Agonists; Guinea Pigs; In Vitro Techniques; Male | 1998 |
Functional characterization of alpha1-adrenoceptor subtypes in longitudinal and circular muscle of human vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Alkylating Agents; Binding, Competit | 1999 |
The effect of haloperidol, spiperone and pimozide on the flexor reflex of the hind limb of the spinal rat.
Topics: Animals; Butyrophenones; Clonidine; Denervation; Fenfluramine; Haloperidol; Hindlimb; Lysergic Acid | 1978 |
Effect of the thromboxane A2-mimetic U46619 on 5-HT1-like and 5-HT2 receptor-mediated contraction of the rabbit isolated femoral artery.
Topics: Animals; Biphenyl Compounds; Femoral Artery; Heptanoic Acids; In Vitro Techniques; Ketanserin; Male; | 1992 |
Contractile effects of 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan in human isolated basilar artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antihypertensive Agents; Basilar Artery; Humans; In Vitro Te | 1991 |
5-HT2-receptor antagonists: alpha 1- vs. 5-HT2-receptor blocking properties in blood vessels.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Ergolines; Ketanserin; Male; Muscle Contracti | 1988 |
Evidence for two populations of 5-hydroxytryptamine receptors in dog basilar artery.
Topics: Animals; Basilar Artery; Cocaine; Dogs; In Vitro Techniques; Indomethacin; Ketanserin; Muscle Contra | 1989 |
Supersensitivity of atherosclerotic rabbit aorta to ergometrine is mediated by 5-HT2 receptors.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Body Weight; Cyproheptadine; Ergonovine; In Vitro Techni | 1989 |
The St 587-induced flexor reflex in pithed rats: a model to evaluate central alpha 1-receptor blocking properties.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Binding, Competitive; Clonidine; Decere | 1986 |
The relaxation induced by indole and nonindole 5-HT agonists in the molluscan smooth muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bivalvia; Cyclic AMP; In Vitro Techniques; Indoles; | 1988 |
A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists.
Topics: Animals; Aorta; Dogs; In Vitro Techniques; Ketanserin; Methoxamine; Muscle Contraction; Muscle, Smoo | 1985 |
Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Frontal Lobe; Head; Hippocampus; In Vitro Techniques; Ketanseri | 1986 |
Comparison of the actions of serotoninergic agents on human saphenous veins and platelets.
Topics: Blood Platelets; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Receptor | 1986 |