spiperone has been researched along with Huntington Disease in 11 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we report that the putamen in Huntington's disease (HD) lacks GI-D2 receptors." | 1.28 | Lack of GTP-insensitive D2 dopamine receptors in Huntington's disease. ( De Keyser, J; Ebinger, G; Roos, RA; Vauquelin, G, 1989) |
| "A 48-year-old man with typical Huntington's disease was investigated with computed tomography (CT) and positron emission tomography." | 1.27 | Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography. ( Frackowiak, RS; Leenders, KL; Marsden, CD; Quinn, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cross, A | 1 |
| Rossor, M | 1 |
| Araujo, DM | 1 |
| Cherry, SR | 1 |
| Tatsukawa, KJ | 1 |
| Toyokuni, T | 1 |
| Kornblum, HI | 1 |
| Reisine, TD | 2 |
| Fields, JZ | 2 |
| Stern, LZ | 1 |
| Johnson, PC | 1 |
| Bird, ED | 2 |
| Yamamura, HI | 2 |
| Spokes, E | 1 |
| Brandt, J | 1 |
| Folstein, SE | 1 |
| Wong, DF | 1 |
| Links, J | 1 |
| Dannals, RF | 1 |
| McDonnell-Sill, A | 1 |
| Starkstein, S | 1 |
| Anders, P | 1 |
| Strauss, ME | 1 |
| Tune, LE | 1 |
| De Keyser, J | 1 |
| Roos, RA | 1 |
| Ebinger, G | 1 |
| Vauquelin, G | 1 |
| Hägglund, J | 2 |
| Aquilonius, SM | 2 |
| Bergström, K | 1 |
| Eckernäs, SA | 2 |
| Hartvig, P | 2 |
| Lundqvist, H | 1 |
| Långström, B | 2 |
| Malmborg, P | 1 |
| Någren, K | 1 |
| Lundquist, H | 1 |
| Gullberg, P | 1 |
| Joyce, JN | 1 |
| Lexow, N | 1 |
| Bird, E | 1 |
| Winokur, A | 1 |
| Leenders, KL | 1 |
| Frackowiak, RS | 1 |
| Quinn, N | 1 |
| Marsden, CD | 1 |
| de Yebenes, JG | 1 |
| Bazán, E | 1 |
| Muradas, V | 1 |
| Reiriz, J | 1 |
| Mena, MA | 1 |
11 other studies available for spiperone and Huntington Disease
| Article | Year |
|---|---|
Dopamine D-1 and D-2 receptors in Huntington's disease.
Topics: Aged; Brain; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Kinetics; Male; Middle Age | 1983 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Alterations in dopaminergic receptors in Huntington's disease.
Topics: Adult; Brain; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Choline O-Acetyltransferase; Humans; | 1977 |
Characterization of brain dopaminergic receptors in Huntington's disease.
Topics: Aged; Brain; Butaclamol; Butyrophenones; Humans; Huntington Disease; Kinetics; Middle Aged; Receptor | 1978 |
D2 receptors in Huntington's disease: positron emission tomography findings and clinical correlates.
Topics: Adult; Brain; Brain Mapping; Caudate Nucleus; Cerebellum; Dopamine Agents; Female; Humans; Huntingto | 1990 |
Lack of GTP-insensitive D2 dopamine receptors in Huntington's disease.
Topics: Aged; Binding, Competitive; Female; Globus Pallidus; Guanosine Triphosphate; Humans; Huntington Dise | 1989 |
Regional kinetics of [11C]methylspiperone in the brain studied by positron emission tomography in patients with Parkinson's disease.
Topics: Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Humans; Huntington Disease; Kinetics; Parkinson | 1987 |
Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using 11C-N-methyl-spiperone.
Topics: Aged; Caudate Nucleus; Corpus Striatum; Female; Frontal Lobe; Humans; Huntington Disease; Kinetics; | 1987 |
Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophrenia.
Topics: Aged; Autoradiography; Benzazepines; Corpus Striatum; Female; Humans; Huntington Disease; Male; Midd | 1988 |
Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography.
Topics: Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenyl | 1986 |
3H-spiroperidol binding sites in lymphocytes of patients and individuals at risk of Huntington's disease.
Topics: Binding Sites; Butyrophenones; Humans; Huntington Disease; Lymphocytes; Spiperone | 1985 |