spiperone has been researched along with Hepatolenticular Degeneration in 5 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Hepatolenticular Degeneration: A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied." | 5.27 | [3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987) |
| "All the patients with Parkinson's disease also demonstrated symmetrical basal ganglia uptake in the late SPECT images, but it was diminished in parkinsonism and Wilson's disease." | 1.29 | Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography. ( Fukuyama, H; Iida, Y; Iwasaki, Y; Konishi, J; Magata, Y; Saji, H; Shimatsu, A; Tsuchida, T; Yokoyama, A; Yonekura, Y, 1995) |
| "[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied." | 1.27 | [3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Członkowski, A | 2 |
| Członkowska, A | 2 |
| Schlaug, G | 2 |
| Hefter, H | 2 |
| Nebeling, B | 1 |
| Engelbrecht, V | 2 |
| Weiss, P | 1 |
| Stöcklin, G | 2 |
| Seitz, RJ | 2 |
| Yonekura, Y | 1 |
| Saji, H | 1 |
| Iwasaki, Y | 1 |
| Tsuchida, T | 1 |
| Fukuyama, H | 1 |
| Shimatsu, A | 1 |
| Iida, Y | 1 |
| Magata, Y | 1 |
| Konishi, J | 1 |
| Yokoyama, A | 1 |
| Kuwert, T | 1 |
| Arnold, S | 1 |
| Jachowicz-Jeszka, J | 1 |
1 trial available for spiperone and Hepatolenticular Degeneration
| Article | Year |
|---|---|
Neurological impairment and recovery in Wilson's disease: evidence from PET and MRI.
Topics: Adult; Brain Chemistry; Chelating Agents; Deoxyglucose; Female; Fluorodeoxyglucose F18; Glucose; Hep | 1996 |
4 other studies available for spiperone and Hepatolenticular Degeneration
| Article | Year |
|---|---|
Reduced binding of 3H-spiroperidol to lymphocyte in Wilson's disease.
Topics: Adolescent; Adult; Butyrophenones; Hepatolenticular Degeneration; Humans; Kinetics; Lymphocytes; Rec | 1984 |
Dopamine D2 receptor binding and cerebral glucose metabolism recover after D-penicillamine-therapy in Wilson's disease.
Topics: Adult; Basal Ganglia; Brain; Deoxyglucose; Dopamine Agents; Fluorine Radioisotopes; Glucose; Hepatol | 1994 |
Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography.
Topics: Adenoma; Basal Ganglia; Brain; Frontal Lobe; Hepatolenticular Degeneration; Humans; Iodine Radioisot | 1995 |
[3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging.
Topics: Adult; Aged; Aging; Antiparkinson Agents; Female; Hepatolenticular Degeneration; Humans; Lymphocytes | 1987 |