spiperone has been researched along with Hepatic Encephalopathy in 3 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The binding of a D2 receptor ligand, [3H]spiperone, was measured in striatal membranes derived from rats in which acute hepatic failure induced with thioacetamide (TAA) was associated with symptoms of hepatic encephalopathy (HE), and during recovery from HE." | 3.71 | Reversible decrease of dopamine D2 receptor density in the striatum of rats with acute hepatic failure. ( Albrecht, J; Freśko, I; Lenkiewicz, A; Waśkiewicz, J, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baraldi, M | 1 |
| Zeneroli, ML | 1 |
| Ricci, P | 1 |
| Caselgrandi, E | 1 |
| Ventura, E | 1 |
| Mousseau, DD | 1 |
| Perney, P | 1 |
| Layrargues, GP | 1 |
| Butterworth, RF | 1 |
| Waśkiewicz, J | 1 |
| Freśko, I | 1 |
| Lenkiewicz, A | 1 |
| Albrecht, J | 1 |
3 other studies available for spiperone and Hepatic Encephalopathy
| Article | Year |
|---|---|
Down regulation of striatal dopamine receptors in experimental hepatic encephalopathy.
Topics: Amino Acids; Animals; Catecholamines; Corpus Striatum; Hepatic Encephalopathy; Male; Octopamine; Rat | 1983 |
Selective loss of pallidal dopamine D2 receptor density in hepatic encephalopathy.
Topics: Benzazepines; Brain Chemistry; Globus Pallidus; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Mal | 1993 |
Reversible decrease of dopamine D2 receptor density in the striatum of rats with acute hepatic failure.
Topics: Acute Disease; Animals; Corpus Striatum; Dopamine Antagonists; Down-Regulation; Hepatic Encephalopat | 2001 |