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spiperone and Glioma

spiperone has been researched along with Glioma in 6 studies

Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells."7.66[3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983)
"5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1."3.67Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987)
"Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells."3.66[3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983)
" The dose-response curve for 5-HT was shifted 9-fold to the left compared to controls, and the Vmax value was also significantly enhanced."1.29Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells. ( Kagaya, A; Mikuni, M; Muraoka, S; Saitoh, K; Takahashi, K, 1993)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Severson, JA1
de Vellis, JS1
Finch, CE1
Kozell, LB1
Machida, CA1
Neve, RL1
Neve, KA2
Muraoka, S1
Mikuni, M1
Kagaya, A1
Saitoh, K1
Takahashi, K1
Kozlowski, MR1
Rosser, MP1
Donta, ST1
Shanley, JD1
Ananth, US1
Leli, U1
Hauser, G1

Other Studies

6 other studies available for spiperone and Glioma

ArticleYear
[3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma.
    Journal of neuroscience research, 1983, Volume: 9, Issue:1

    Topics: Animals; Binding Sites; Binding, Competitive; Butyrophenones; Cell Line; Cerebral Cortex; Corpus Str

1983
Chimeric D1/D2 dopamine receptors. Distinct determinants of selective efficacy, potency, and signal transduction.
    The Journal of biological chemistry, 1994, Dec-02, Volume: 269, Issue:48

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Benzazepines; Binding, C

1994
Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells.
    Neuroendocrinology, 1993, Volume: 57, Issue:2

    Topics: Amphetamines; Animals; Calcium; Dexamethasone; Glioma; Ketanserin; Rats; Receptors, Serotonin; Serot

1993
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
    The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36

    Topics: Amiloride; Animals; Carrier Proteins; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines;

1992
Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor.
    Journal of virology, 1990, Volume: 64, Issue:2

    Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Dihydroalprenolol; Glioma; Isoproterenol; Ki

1990
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
    Journal of neurochemistry, 1987, Volume: 48, Issue:1

    Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat

1987