spiperone and Glioma
spiperone has been researched along with Glioma in 6 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells." | 7.66 | [3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983) |
| "5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1." | 3.67 | Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987) |
| "Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells." | 3.66 | [3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983) |
| " The dose-response curve for 5-HT was shifted 9-fold to the left compared to controls, and the Vmax value was also significantly enhanced." | 1.29 | Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells. ( Kagaya, A; Mikuni, M; Muraoka, S; Saitoh, K; Takahashi, K, 1993) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Severson, JA | 1 |
| de Vellis, JS | 1 |
| Finch, CE | 1 |
| Kozell, LB | 1 |
| Machida, CA | 1 |
| Neve, RL | 1 |
| Neve, KA | 2 |
| Muraoka, S | 1 |
| Mikuni, M | 1 |
| Kagaya, A | 1 |
| Saitoh, K | 1 |
| Takahashi, K | 1 |
| Kozlowski, MR | 1 |
| Rosser, MP | 1 |
| Donta, ST | 1 |
| Shanley, JD | 1 |
| Ananth, US | 1 |
| Leli, U | 1 |
| Hauser, G | 1 |
Other Studies
6 other studies available for spiperone and Glioma
| Article | Year |
|---|---|
[3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma.
Topics: Animals; Binding Sites; Binding, Competitive; Butyrophenones; Cell Line; Cerebral Cortex; Corpus Str | 1983 |
Chimeric D1/D2 dopamine receptors. Distinct determinants of selective efficacy, potency, and signal transduction.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Benzazepines; Binding, C | 1994 |
Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells.
Topics: Amphetamines; Animals; Calcium; Dexamethasone; Glioma; Ketanserin; Rats; Receptors, Serotonin; Serot | 1993 |
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
Topics: Amiloride; Animals; Carrier Proteins; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; | 1992 |
Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor.
Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Dihydroalprenolol; Glioma; Isoproterenol; Ki | 1990 |
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat | 1987 |