spiperone has been researched along with Glial Cell Tumors in 6 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells." | 7.66 | [3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983) |
| "5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1." | 3.67 | Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987) |
| "Binding sites for [3H]spiperone were detected on membranes from primary glial cultures from neonatal rat cortex and striatum and from the C6 glioma cells." | 3.66 | [3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma. ( de Vellis, JS; Finch, CE; Severson, JA, 1983) |
| " The dose-response curve for 5-HT was shifted 9-fold to the left compared to controls, and the Vmax value was also significantly enhanced." | 1.29 | Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells. ( Kagaya, A; Mikuni, M; Muraoka, S; Saitoh, K; Takahashi, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Severson, JA | 1 |
| de Vellis, JS | 1 |
| Finch, CE | 1 |
| Kozell, LB | 1 |
| Machida, CA | 1 |
| Neve, RL | 1 |
| Neve, KA | 2 |
| Muraoka, S | 1 |
| Mikuni, M | 1 |
| Kagaya, A | 1 |
| Saitoh, K | 1 |
| Takahashi, K | 1 |
| Kozlowski, MR | 1 |
| Rosser, MP | 1 |
| Donta, ST | 1 |
| Shanley, JD | 1 |
| Ananth, US | 1 |
| Leli, U | 1 |
| Hauser, G | 1 |
6 other studies available for spiperone and Glial Cell Tumors
| Article | Year |
|---|---|
[3H]spiperone binding sites in rat primary glial cultures, C6 glioma, and B104 neuroblastoma.
Topics: Animals; Binding Sites; Binding, Competitive; Butyrophenones; Cell Line; Cerebral Cortex; Corpus Str | 1983 |
Chimeric D1/D2 dopamine receptors. Distinct determinants of selective efficacy, potency, and signal transduction.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Benzamides; Benzazepines; Binding, C | 1994 |
Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells.
Topics: Amphetamines; Animals; Calcium; Dexamethasone; Glioma; Ketanserin; Rats; Receptors, Serotonin; Serot | 1993 |
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
Topics: Amiloride; Animals; Carrier Proteins; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; | 1992 |
Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor.
Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Dihydroalprenolol; Glioma; Isoproterenol; Ki | 1990 |
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat | 1987 |