Compounds > spiperone
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spiperone and Dyskinesia, Drug-Induced

spiperone has been researched along with Dyskinesia, Drug-Induced in 32 studies

Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.

Dyskinesia, Drug-Induced: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)

Research Excerpts

ExcerptRelevanceReference
" Chronic administration of ceruletide (160 micrograms."1.29Effect of chronic ceruletide treatment on dopaminergic neurotransmitters, receptors and their mRNAs in the striatum of rats with dyskinesia induced by iminodipropionitrile. ( Asanuma, M; Hirata, H; Mori, A; Ogawa, N; Ota, Z, 1993)
"Treatment with molindone for 14 days at 3, 6, 20 and 40 mg/kg, enhanced the stereotyped behavioral response induced by apomorphine and increased the numbered of D-2 dopamine receptors in the striatum (Bmax) labelled by high affinity (Kd = 40 pmol) binding or [3H] spiroperidol in the guinea-pig."1.27Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia. ( Curtin, J; Fields, J; Koller, W, 1984)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199024 (75.00)18.7374
1990's7 (21.88)18.2507
2000's1 (3.13)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, H1
Ma, L1
Wang, F1
Chen, J1
Zhen, X1
Waddington, JL2
Cross, AJ3
Gamble, SJ1
Bourne, RC1
Wagner, HN1
Mishra, RK1
Rosengarten, H2
Schweitzer, JW3
Friedhoff, AJ3
Koller, W1
Curtin, J1
Fields, J1
Bédard, PJ2
Boucher, R2
Daigle, M1
Di Paolo, T3
Bhargava, HN1
Bannet, J1
Belmaker, RH1
Ebstein, RP1
Crow, TJ2
Johnstone, EC2
Owen, F2
Owens, DG2
Schwartz, R1
Clow, A1
Theodorou, A1
Jenner, P1
Marsden, CD1
Hirata, H1
Ogawa, N1
Asanuma, M1
Ota, Z1
Mori, A1
Bossé, R1
DiPaolo, T1
Jeanjean, AP1
Laterre, EC1
Maloteaux, JM1
Maj, J1
Rogóz, Z1
Skuza, G1
Kołodziejczyk, K1
List, SJ1
Seeman, P2
Eibergen, RD2
Carlson, KR2
Coppens, HJ1
Slooff, CJ1
Paans, AM1
Wiegman, T1
Vaalburg, W1
Korf, J1
Fields, JZ1
Drucker, GE1
Wichlinski, L1
Gordon, JH1
Andersson, U1
Eckernäs, SA1
Hartvig, P1
Ulin, J1
Långström, B1
Häggström, JE1
See, RE1
Aravagiri, M1
Ellison, GD1
Kornhuber, J1
Riederer, P1
Reynolds, GP1
Beckmann, H1
Jellinger, K1
Gabriel, E1
Blin, J1
Baron, JC1
Cambon, H1
Bonnet, AM2
Dubois, B1
Loc'h, C1
Mazière, B1
Agid, Y2
Ferrier, IN1
Johnson, JA1
Poulter, M1
Egawa, M1
Ruberg, M1
Javoy-Agid, F1
Falardeau, P2
Bouchard, S1
Twery, MJ1
Kirkpatrick, B1
Critcher, EC1
Lewis, MH1
Mailman, RB1
Cooper, CW1

Reviews

1 review available for spiperone and Dyskinesia, Drug-Induced

ArticleYear
CNS dopamine receptors: effect of prolyl-leucyl-glycinamide and solubilization.
    Nutrition and health, 1984, Volume: 3, Issue:3

    Topics: Adenylyl Cyclases; Animals; Binding Sites; Brain; Cattle; Dopamine; Dopamine Antagonists; Dyskinesia

1984

Other Studies

31 other studies available for spiperone and Dyskinesia, Drug-Induced

ArticleYear
Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Disease M

2007
Dopamine receptor function and spontaneous orofacial dyskinesia in rats during 6-month neuroleptic treatments.
    Advances in biochemical psychopharmacology, 1983, Volume: 37

    Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dyskinesia, Drug-Induced; Humans; Male

1983
Imaging CNS receptors: the dopaminergic system.
    Hospital practice (Office ed.), 1984, Volume: 19, Issue:6

    Topics: Animals; Antipsychotic Agents; Apomorphine; Binding Sites; Brain; Carbon Radioisotopes; Deoxyglucose

1984
Induction of oral dyskinesias in naive rats by D1 stimulation.
    Life sciences, 1983, Dec-19, Volume: 33, Issue:25

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Dysk

1983
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia.
    Neuropharmacology, 1984, Volume: 23, Issue:10

    Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Guinea Pigs

1984
Similar effect of estradiol and haloperidol on experimental tardive dyskinesia in monkeys.
    Psychoneuroendocrinology, 1984, Volume: 9, Issue:4

    Topics: Animals; Apomorphine; Drug Interactions; Dyskinesia, Drug-Induced; Estradiol; Female; Haloperidol; M

1984
Cyclo(Leu-Gly): a possible treatment for tardive dyskinesia?
    Modern problems of pharmacopsychiatry, 1983, Volume: 21

    Topics: Animals; Apomorphine; Corpus Striatum; Dipeptides; Drug Tolerance; Dyskinesia, Drug-Induced; Haloper

1983
The effect of drug holidays in an animal model of tardive dyskinesia.
    Psychopharmacology, 1980, Volume: 69, Issue:2

    Topics: Animals; Corpus Striatum; Dopamine; Drug Administration Schedule; Dyskinesia, Drug-Induced; Haloperi

1980
Abnormal involuntary movements in schizophrenia: are they related to the disease process or its treatment? Are they associated with changes in dopamine receptors?
    Journal of clinical psychopharmacology, 1982, Volume: 2, Issue:5

    Topics: Adult; Aged; Brain; Dyskinesia, Drug-Induced; Female; Flupenthixol; Humans; Male; Middle Aged; Mouth

1982
Factors contributing to the up regulation of dopaminergic receptors by chronic haloperidol.
    Research communications in chemical pathology and pharmacology, 1982, Volume: 38, Issue:1

    Topics: Animals; Corpus Striatum; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Rats; Rats, Inbred St

1982
Changes in cerebral dopamine function induced by a year's administration of trifluoperazine or thioridazine and their subsequent withdrawal.
    Advances in biochemical psychopharmacology, 1980, Volume: 24

    Topics: Adenylyl Cyclases; Animals; Apomorphine; Brain; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced;

1980
Effect of chronic ceruletide treatment on dopaminergic neurotransmitters, receptors and their mRNAs in the striatum of rats with dyskinesia induced by iminodipropionitrile.
    Brain research, 1993, Feb-26, Volume: 604, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Blotting, Northern; Ceruletide; Corpus Striat

1993
The modulation of brain dopamine and GABAA receptors by estradiol: a clue for CNS changes occurring at menopause.
    Cellular and molecular neurobiology, 1996, Volume: 16, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Autoradiography; Benzazepines; Binding Sites; Brain; Brain Chemistry;

1996
Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia.
    Biological psychiatry, 1997, May-15, Volume: 41, Issue:10

    Topics: Animals; Antipsychotic Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Male; Piperidines; Quinu

1997
The behavioural effects of pramipexole, a novel dopamine receptor agonist.
    European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1

    Topics: Animals; Antiparkinson Agents; Benzazepines; Benzothiazoles; Body Temperature; Catalepsy; Clozapine;

1997
Dopamine agonists reverse the elevated 3H-neuroleptic binding in neuroleptic-pretreated rats.
    Life sciences, 1979, Apr-16, Volume: 24, Issue:16

    Topics: Animals; Apomorphine; Bromocriptine; Carbidopa; Corpus Striatum; Dyskinesia, Drug-Induced; Haloperid

1979
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2

    Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Hum

1976
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperid

1976
High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients.
    Biological psychiatry, 1991, Apr-01, Volume: 29, Issue:7

    Topics: Adult; Antipsychotic Agents; Brain; Dyskinesia, Drug-Induced; Female; Humans; Male; Psychiatric Stat

1991
Neurochemical basis for the absence of overt "stereotyped" behaviors in rats with up-regulated striatal D2 dopamine receptors.
    Clinical neuropharmacology, 1991, Volume: 14, Issue:3

    Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Dyskinesia, Drug-Induced; Kinetics; Rat

1991
Striatal binding of 11C-NMSP studied with positron emission tomography in patients with persistent tardive dyskinesia: no evidence for altered dopamine D2 receptor binding.
    Journal of neural transmission. General section, 1990, Volume: 79, Issue:3

    Topics: Aged; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, D

1990
Chronic neuroleptic treatment in rats produces persisting changes in GABAA and dopamine D-2, but not dopamine D-1 receptors.
    Life sciences, 1989, Volume: 44, Issue:3

    Topics: Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain; Disease Models, Animal; Dyskinesia,

1989
3H-spiperone binding sites in post-mortem brains from schizophrenic patients: relationship to neuroleptic drug treatment, abnormal movements, and positive symptoms.
    Journal of neural transmission, 1989, Volume: 75, Issue:1

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Dyskinesia, Drug-Induced; Female; Humans; Male; Middl

1989
Striatal dopamine D2 receptors in tardive dyskinesia: PET study.
    Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:11

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Brain; Cerebellum; Corpus Striatum; Delirium; Dementi

1989
Chemical and structural changes in the brain in patients with movement disorder.
    Psychopharmacology. Supplementum, 1985, Volume: 2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Antipsychotic Agents; Brain; Choline O-Acetyltransfer

1985
Diminished D2 dopamine receptor function and the emergence of repetitive jaw movements.
    Advances in experimental medicine and biology, 1988, Volume: 235

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Disease Models, A

1988
Pathophysiology of L-dopa-induced abnormal involuntary movements.
    Psychopharmacology. Supplementum, 1985, Volume: 2

    Topics: Brain; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Humans; Levodopa; Neural Pathways; Parki

1985
Brain dopamine receptors in schizophrenia and tardive dyskinesia.
    Psychopharmacology. Supplementum, 1985, Volume: 2

    Topics: Acetylcholine; Animals; Brain; Caudate Nucleus; Dopamine; Dyskinesia, Drug-Induced; Humans; Kinetics

1985
Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys.
    European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzaze

1988
Motor effects of calcitonin administered intracerebroventricularly in the rat.
    European journal of pharmacology, 1986, Feb-18, Volume: 121, Issue:2

    Topics: Animals; Behavior, Animal; Calcitonin; Cerebral Ventricles; Corpus Striatum; Dopamine; Dyskinesia, D

1986
Modulation of brain and pituitary dopamine receptors by estrogens and prolactin.
    Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:5-6

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Estradiol; Estrogens; Fe

1985