spiperone has been researched along with Disease Models, Animal in 27 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spiperone was shown to inhibit the damaging action of picrylsulfonic acid during the first ten days of the beginning of modeling, and to accelerate reparative processes." | 1.34 | [The role of the serotoninergic system in the pathogenesis of experimental ulcerous colitis]. ( Lazebnik, LB; Lychkova, AE; Potapova, VB, 2007) |
| "Treatment with molindone for 14 days at 3, 6, 20 and 40 mg/kg, enhanced the stereotyped behavioral response induced by apomorphine and increased the numbered of D-2 dopamine receptors in the striatum (Bmax) labelled by high affinity (Kd = 40 pmol) binding or [3H] spiroperidol in the guinea-pig." | 1.27 | Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia. ( Curtin, J; Fields, J; Koller, W, 1984) |
| " These results indicate that chronic administration of either bromocriptine or L-Dopa will reverse the DA receptor denervation supersensitivity in striatum seen following 6-OHDA lesion." | 1.27 | Dopamine receptors: effects of chronic L-dopa and bromocriptine treatment in an animal model of Parkinson's disease. ( Deupree, JD; Murrin, LC; Pfeiffer, RF; Schneider, MB, 1984) |
| " An experimental study of the long-term administrations of haloperidol revealed the formation of adaptation to the drug which can be overcome by a zigzag-like sharp elevation of the dosage followed by rapid reduction to the baseline level." | 1.27 | [Various methods of overcoming secondary resistance to treatment developing in relation to adaptation to psychotropic drugs during long-term treatment (clinico-experimental study)]. ( Allikmets, LKh; Avrutskiĭ, GIa; Beliakov, AV; Neduva, AA; Zharkovskiĭ, AM, 1984) |
| " Enhanced ambulatory activity by MAP reduced during the long-term administration of MAP." | 1.27 | [Chronological change in abnormal behavior produced by long-term methamphetamine administration in the rat]. ( Fujiwara, Y; Fukuda, K; Harada, T; Kashihara, K; Otsuki, S; Sato, M; Yasuda, J, 1985) |
| "A model of minimal brain dysfunction (MBD) in rats based on injection of 6-OH-dopamine (DA) intracisternally on the 5th day of life has been described previously." | 1.26 | Dopamine receptors in a rat model of minimal brain dysfunction. ( Belmaker, RH; Brecher-Fride, E; Ebstein, RP; Eisenberg, J; Weizman, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Rahman, SMK | 1 |
| Hussain, Z | 1 |
| Morito, K | 1 |
| Takahashi, N | 1 |
| Sikder, MM | 1 |
| Tanaka, T | 1 |
| Ohta, KI | 1 |
| Ueno, M | 1 |
| Takahashi, H | 1 |
| Yamamoto, T | 1 |
| Murakami, M | 1 |
| Uyama, T | 1 |
| Ueda, N | 1 |
| Thomson, K | 1 |
| Morgan, I | 1 |
| Karouta, C | 1 |
| Ashby, R | 1 |
| Zhang, H | 2 |
| Zheng, X | 1 |
| Yang, X | 1 |
| Fang, S | 1 |
| Shen, G | 1 |
| Zhao, C | 1 |
| Tian, M | 1 |
| Liang, L | 1 |
| MacDonald, K | 1 |
| Schwiebert, EM | 1 |
| Zeitlin, PL | 1 |
| Guggino, WB | 1 |
| Ashby, RS | 1 |
| Schaeffel, F | 1 |
| Birioukova, LM | 1 |
| Midzyanovskaya, IS | 1 |
| Lensu, S | 1 |
| Tuomisto, L | 1 |
| van Luijtelaar, G | 1 |
| Kellendonk, C | 1 |
| Simpson, EH | 1 |
| Polan, HJ | 1 |
| Malleret, G | 1 |
| Vronskaya, S | 1 |
| Winiger, V | 1 |
| Moore, H | 1 |
| Kandel, ER | 1 |
| Ma, L | 1 |
| Wang, F | 1 |
| Chen, J | 1 |
| Zhen, X | 1 |
| Lazebnik, LB | 1 |
| Lychkova, AE | 1 |
| Potapova, VB | 1 |
| Thanos, PK | 1 |
| Michaelides, M | 1 |
| Piyis, YK | 1 |
| Wang, GJ | 1 |
| Volkow, ND | 1 |
| Koller, W | 1 |
| Curtin, J | 1 |
| Fields, J | 1 |
| Schneider, MB | 1 |
| Murrin, LC | 1 |
| Pfeiffer, RF | 1 |
| Deupree, JD | 1 |
| Avrutskiĭ, GIa | 1 |
| Allikmets, LKh | 1 |
| Neduva, AA | 1 |
| Zharkovskiĭ, AM | 1 |
| Beliakov, AV | 1 |
| Eisenberg, J | 1 |
| Brecher-Fride, E | 1 |
| Weizman, R | 1 |
| Ebstein, RP | 1 |
| Belmaker, RH | 1 |
| Ng, GY | 1 |
| O'Dowd, BF | 1 |
| George, SR | 1 |
| Kanazawa, I | 1 |
| Murata, M | 1 |
| Kimura, M | 1 |
| Bardgett, ME | 1 |
| Jackson, JL | 1 |
| Taylor, GT | 1 |
| Csernansky, JG | 1 |
| Flores, G | 1 |
| Barbeau, D | 1 |
| Quirion, R | 1 |
| Srivastava, LK | 1 |
| Efange, SM | 1 |
| Langason, RB | 1 |
| Khare, AB | 1 |
| Low, WC | 1 |
| Araujo, DM | 1 |
| Cherry, SR | 1 |
| Tatsukawa, KJ | 1 |
| Toyokuni, T | 1 |
| Kornblum, HI | 1 |
| See, RE | 1 |
| Aravagiri, M | 1 |
| Ellison, GD | 1 |
| Joyce, JN | 1 |
| Marshall, JF | 1 |
| Bankiewicz, KS | 1 |
| Kopin, IJ | 1 |
| Jacobowitz, DM | 1 |
| Rosengarten, H | 1 |
| Schweitzer, JW | 1 |
| Egawa, M | 1 |
| Friedhoff, AJ | 1 |
| Hantraye, P | 1 |
| Loc'h, C | 1 |
| Tacke, U | 1 |
| Riche, D | 1 |
| Stulzaft, O | 1 |
| Doudet, D | 1 |
| Guibert, B | 1 |
| Naquet, R | 1 |
| Mazière, B | 1 |
| Mazière, M | 1 |
| Kashihara, K | 1 |
| Sato, M | 1 |
| Fujiwara, Y | 1 |
| Yasuda, J | 1 |
| Fukuda, K | 1 |
| Harada, T | 1 |
| Otsuki, S | 1 |
27 other studies available for spiperone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A
Topics: Acyltransferases; Animals; Brain Ischemia; Disease Models, Animal; Glycerophospholipids; Mice; Phosp | 2022 |
Levodopa inhibits the development of lens-induced myopia in chicks.
Topics: Animals; Benzazepines; Chickens; Disease Models, Animal; Dose-Response Relationship, Drug; Intravitr | 2020 |
11C-NMSP/ 18F-FDG microPET to monitor neural stem cell transplantation in a rat model of traumatic brain injury.
Topics: Animals; Brain Injuries; Carbon Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Gene | 2008 |
Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway.
Topics: Animals; Biological Assay; Bronchi; Calcium; Cell Line; Cell Polarity; Chloride Channels; Chlorides; | 2009 |
The effect of bright light on lens compensation in chicks.
Topics: Animals; Animals, Newborn; Biometry; Chickens; Disease Models, Animal; Dopamine; Dopamine Antagonist | 2010 |
Distribution of D1-like and D2-like dopamine receptors in the brain of genetic epileptic WAG/Rij rats.
Topics: Animals; Benzazepines; Brain; Disease Models, Animal; Dopamine Antagonists; Epilepsy, Absence; Image | 2005 |
Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Behavior, Animal; Carbon Isotopes; Cognition Disor | 2006 |
Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Disease M | 2007 |
[The role of the serotoninergic system in the pathogenesis of experimental ulcerous colitis].
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Dopamine Antagonists; Rats; Rats, Wistar; Sero | 2007 |
Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.
Topics: Age Factors; Animals; Apomorphine; Appetite Regulation; Autoradiography; Brain; Disease Models, Anim | 2008 |
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Guinea Pigs | 1984 |
Dopamine receptors: effects of chronic L-dopa and bromocriptine treatment in an animal model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bromocriptine; Corpus Striatum; Disease Models, Animal; Dop | 1984 |
[Various methods of overcoming secondary resistance to treatment developing in relation to adaptation to psychotropic drugs during long-term treatment (clinico-experimental study)].
Topics: Adult; Animals; Catalepsy; Corpus Striatum; Disease Models, Animal; Drug Therapy, Combination; Drug | 1984 |
Dopamine receptors in a rat model of minimal brain dysfunction.
Topics: Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Caudate Nucleus; Di | 1982 |
Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Base Sequence; Benzazepines; Blotting, Northern; Brain; Dise | 1994 |
Roles of dopamine and its receptors in generation of choreic movements.
Topics: Afferent Pathways; Animals; Brain Mapping; Cerebral Cortex; Choline O-Acetyltransferase; Chorea; Cor | 1993 |
Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: an animal model of schizophrenia.
Topics: Animals; Brain Mapping; Caudate Nucleus; Cell Count; Disease Models, Animal; Dose-Response Relations | 1995 |
Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus.
Topics: Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Benzazepines; Disease Models, Animal; | 1996 |
The vesamicol receptor ligand (+)-meta-[125I]iodobenzyltrozamicol [(+)-[125I]-MIBT] reveals blunting of the striatal cholinergic response to dopamine D2 receptor blockade in the 6-hydroxydopamine (6-OHDA)-lesioned rat: possible implications for Parkinson'
Topics: Animals; Brain Diseases; Cholinergic Fibers; Corpus Striatum; Disease Models, Animal; Dopamine Antag | 1996 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Chronic neuroleptic treatment in rats produces persisting changes in GABAA and dopamine D-2, but not dopamine D-1 receptors.
Topics: Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain; Disease Models, Animal; Dyskinesia, | 1989 |
Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is associated with regional ipsilateral changes in striatal dopamine D-2 receptor density.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Carotid Arteries; Corpus Str | 1986 |
Diminished D2 dopamine receptor function and the emergence of repetitive jaw movements.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Disease Models, A | 1988 |
"In vivo" visualization by positron emission tomography of the progressive striatal dopamine receptor damage occurring in MPTP-intoxicated non-human primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bromine; Corpus Striatum; Disease Models, Ani | 1986 |
[Chronological change in abnormal behavior produced by long-term methamphetamine administration in the rat].
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Injections, Intraperitoneal; Mal | 1985 |