spiperone has been researched along with Cancer of Pituitary in 31 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to define whether assessment of the uptake of [18F]fluoro-ethyl-spiperone (FESP) with positron emission tomography (PET) could be helpful for the differential diagnosis of pituitary adenomas and other parasellar lesions, and for establishing the appropriate therapeutic approach." | 7.69 | Differentiation of clinically non-functioning pituitary adenomas from meningiomas and craniopharyngiomas by positron emission tomography with [18F]fluoro-ethyl-spiperone. ( Bettinardi, V; Del Sole, A; Fazio, F; Giovanelli, M; Losa, M; Lucignani, G; Matarrese, M; Moresco, RM; Mortini, P, 1997) |
| "D2-dopamine (3,4-dihydroxyphenylethylamine) receptors were successfully solubilized with 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate from an estrone-induced rat pituitary adenoma." | 7.67 | Solubilization and characterization of D2-dopamine receptors in an estrone-induced, prolactin-secreting rat pituitary adenoma. ( Amlaiky, N; Beauregard, G; Bouvier, C; Caron, MG; Collu, R; Lafond, J; Potier, M, 1986) |
| " Because D2(High) receptors have not yet been detected in intact cells, we used [(3)H]domperidone to detect D2(High) sites in intact rat anterior pituitary adenoma culture cells." | 3.74 | Dopamine D2(High) receptors on intact cells. ( Seeman, P, 2008) |
| " The aim of this study was to define whether assessment of the uptake of [18F]fluoro-ethyl-spiperone (FESP) with positron emission tomography (PET) could be helpful for the differential diagnosis of pituitary adenomas and other parasellar lesions, and for establishing the appropriate therapeutic approach." | 3.69 | Differentiation of clinically non-functioning pituitary adenomas from meningiomas and craniopharyngiomas by positron emission tomography with [18F]fluoro-ethyl-spiperone. ( Bettinardi, V; Del Sole, A; Fazio, F; Giovanelli, M; Losa, M; Lucignani, G; Matarrese, M; Moresco, RM; Mortini, P, 1997) |
| "Dopamine receptors on human pituitary adenoma membranes were characterized using [3H] spiperone as the radioligand." | 3.67 | Demonstration of specific dopamine receptors on human pituitary adenomas. ( Arao, M; Kishimoto, S; Koga, M; Mori, S; Morimoto, Y; Nakao, H; Noma, K; Sato, B; Uozumi, T, 1987) |
| "D2-dopamine (3,4-dihydroxyphenylethylamine) receptors were successfully solubilized with 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate from an estrone-induced rat pituitary adenoma." | 3.67 | Solubilization and characterization of D2-dopamine receptors in an estrone-induced, prolactin-secreting rat pituitary adenoma. ( Amlaiky, N; Beauregard, G; Bouvier, C; Caron, MG; Collu, R; Lafond, J; Potier, M, 1986) |
| "Eight patients with pituitary adenoma including four non-functioning adenomas, two growth hormone (GH) secreting adenomas, one ACTH secreting adenoma and one TSH secreting adenoma and ten normal healthy volunteers were examined." | 1.29 | [Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. ( Inoue, Y; Momose, T; Nishikawa, J; Sasaki, Y; Teramoto, A; Watanabe, T, 1993) |
| "All the patients with Parkinson's disease also demonstrated symmetrical basal ganglia uptake in the late SPECT images, but it was diminished in parkinsonism and Wilson's disease." | 1.29 | Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography. ( Fukuyama, H; Iida, Y; Iwasaki, Y; Konishi, J; Magata, Y; Saji, H; Shimatsu, A; Tsuchida, T; Yokoyama, A; Yonekura, Y, 1995) |
| "In cultures of prolactinoma cells from patients normally responsive to bromocriptine therapy (n = 10), considered as controls, 10(-9) mol/L bromocriptine inhibited PRL release by 71 +/- 6% (+/- SE), and the half-inhibitory dose was 7 x 10(-11) mol/L." | 1.28 | Resistance to bromocriptine in prolactinomas. ( Bertrand, P; Delivet, S; Enjalbert, A; Gunz, G; Jaquet, P; Jedynak, CP; Kordon, C; Peillon, F; Pellegrini, I; Rasolonjanahary, R, 1989) |
| "Bromocriptine (2." | 1.27 | Dopamine receptors in rat pituitary and estradiol-induced pituitary tumor: effect of chronic treatment with bromocriptine. ( Di Paolo, T; Falardeau, P, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (61.29) | 18.7374 |
| 1990's | 11 (35.48) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mach, RH | 1 |
| Luedtke, RR | 1 |
| Unsworth, CD | 1 |
| Boundy, VA | 1 |
| Nowak, PA | 1 |
| Scripko, JG | 1 |
| Elder, ST | 1 |
| Jackson, JR | 1 |
| Hoffman, PL | 1 |
| Evora, PH | 1 |
| Seeman, P | 1 |
| Albaladejo, V | 1 |
| Collu, R | 6 |
| Andre, J | 2 |
| Cronin, MJ | 4 |
| Cheung, CY | 1 |
| Wilson, CB | 1 |
| Jaffe, RB | 1 |
| Weiner, RI | 1 |
| Di Paolo, T | 5 |
| Falardeau, P | 3 |
| Reches, A | 1 |
| MacLeod, RM | 3 |
| Login, IS | 2 |
| Serri, O | 1 |
| Marchisio, AM | 2 |
| Hardy, J | 1 |
| Somma, M | 1 |
| Morel, Y | 1 |
| Valdenegro, CA | 1 |
| Perkins, SN | 1 |
| Senogles, SE | 1 |
| Momose, T | 1 |
| Teramoto, A | 1 |
| Nishikawa, J | 1 |
| Inoue, Y | 1 |
| Watanabe, T | 1 |
| Sasaki, Y | 1 |
| Allard, S | 1 |
| Lapointe, S | 1 |
| Yonekura, Y | 1 |
| Saji, H | 1 |
| Iwasaki, Y | 1 |
| Tsuchida, T | 1 |
| Fukuyama, H | 1 |
| Shimatsu, A | 1 |
| Iida, Y | 1 |
| Magata, Y | 1 |
| Konishi, J | 1 |
| Yokoyama, A | 1 |
| Lucignani, G | 1 |
| Losa, M | 1 |
| Moresco, RM | 1 |
| Del Sole, A | 1 |
| Matarrese, M | 1 |
| Bettinardi, V | 1 |
| Mortini, P | 1 |
| Giovanelli, M | 1 |
| Fazio, F | 1 |
| Missale, C | 1 |
| Castelletti, L | 1 |
| Boroni, F | 1 |
| Memo, M | 1 |
| Spano, P | 1 |
| Lew, JY | 1 |
| Zawadzka, H | 1 |
| Feigenblum, D | 1 |
| Tang, D | 1 |
| Filer, D | 1 |
| Benedetto, P | 1 |
| Goldstein, M | 1 |
| McChesney, R | 1 |
| Sealfon, SC | 1 |
| Tsutsumi, M | 1 |
| Dong, KW | 1 |
| Roberts, JL | 1 |
| Bancroft, C | 1 |
| Bouvier, C | 3 |
| Lagacé, G | 2 |
| Potier, M | 3 |
| Coenen, K | 1 |
| Pellegrini, I | 1 |
| Rasolonjanahary, R | 1 |
| Gunz, G | 1 |
| Bertrand, P | 1 |
| Delivet, S | 1 |
| Jedynak, CP | 1 |
| Kordon, C | 1 |
| Peillon, F | 1 |
| Jaquet, P | 2 |
| Enjalbert, A | 1 |
| Lin, C | 1 |
| McGonigle, P | 1 |
| Molinoff, PB | 1 |
| Lafond, J | 2 |
| Beauregard, G | 2 |
| Day, RN | 1 |
| Hinkle, PM | 1 |
| Lévesque, D | 1 |
| Bernier, MA | 1 |
| Koga, M | 1 |
| Nakao, H | 1 |
| Arao, M | 1 |
| Sato, B | 1 |
| Noma, K | 1 |
| Morimoto, Y | 1 |
| Kishimoto, S | 1 |
| Mori, S | 1 |
| Uozumi, T | 1 |
| Amlaiky, N | 1 |
| Caron, MG | 1 |
| Lloyd, RV | 1 |
| Fields, KL | 1 |
| Israel, JM | 1 |
| Vincent, JD | 1 |
31 other studies available for spiperone and Cancer of Pituitary
| Article | Year |
|---|---|
18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.
Topics: Animals; Baculoviridae; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocycl | 1993 |
Dopamine D2(High) receptors on intact cells.
Topics: Adenoma; Animals; Binding, Competitive; Corpus Striatum; Domperidone; Dopamine Antagonists; Pituitar | 2008 |
Down-regulation by 17 beta-estradiol of D2 dopamine receptors in the MtTF4 pituitary tumor.
Topics: Animals; Cell Line; Cell Membrane; Dexamethasone; Dopamine; Epinephrine; Estradiol; Male; Norepineph | 1984 |
[3H]Spiperone binding to human anterior pituitaries and pituitary adenomas secreting prolactin, growth hormone, and adrenocorticotropic hormone.
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Breast Neoplasms; Butyrophenones; Female; Growth H | 1980 |
Effects of a luteinizing hormone-releasing hormone analog on the growth of estrogen-induced prolactin-secreting rat pituitary tumors and its influence on their dopamine receptors.
Topics: Animals; Estrogens; Female; Gonadotropin-Releasing Hormone; Kinetics; Pituitary Neoplasms; Prolactin | 1984 |
Dopamine receptors in rat pituitary and estradiol-induced pituitary tumor: effect of chronic treatment with bromocriptine.
Topics: Adenoma; Animals; Bromocriptine; Estradiol; Female; Kinetics; Organ Size; Pituitary Gland, Anterior; | 1984 |
Tumors producing chronic hyperprolactinemia do not alter [3H]spiperone binding and dopamine turnover in the corpus striatum of the female rat.
Topics: Animals; Butyrophenones; Corpus Striatum; Dopamine; Female; Pituitary Neoplasms; Prolactin; Rats; Re | 1983 |
Dopaminergic binding sites in human pituitary adenomas other than prolactinomas.
Topics: Adenoma; Adult; Aged; Dopamine; Female; Growth Hormone; Humans; Male; Middle Aged; Pituitary Neoplas | 1984 |
Dopamine receptors in the rat pituitary and the transplantable, pituitary tumor MtTF4: effect of chronic treatment with oestradiol.
Topics: Animals; Cell Membrane; Estradiol; Hypertrophy; Kinetics; Male; Neoplasms, Experimental; Pituitary G | 1982 |
Tetrabenazine has properties of a dopamine receptor antagonist.
Topics: Animals; Binding, Competitive; Corpus Striatum; Female; In Vitro Techniques; Neoplasms, Experimental | 1982 |
The 7315a pituitary tumor is refractory to dopaminergic inhibition of prolactin release but contains dopamine receptors.
Topics: Animals; Binding, Competitive; Dopamine; Female; In Vitro Techniques; Kinetics; Neoplasms, Experimen | 1981 |
The D2 dopamine receptor mediates inhibition of growth in GH4ZR7 cells: involvement of protein kinase-C epsilon.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Alprenolol; Animals; Apomorphine; Benzaz | 1994 |
[Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma].
Topics: Adenoma; Adult; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Pituitary Neoplasms; Prolac | 1993 |
Specific induction of a functional endogenous D2 short dopamine receptor in GH4C1 cells.
Topics: Animals; Apomorphine; Base Sequence; Colforsin; Cyclic AMP; Dopamine; Dose-Response Relationship, Dr | 1993 |
Initial clinical experiences with dopamine D2 receptor imaging by means of 2'-iodospiperone and single-photon emission computed tomography.
Topics: Adenoma; Basal Ganglia; Brain; Frontal Lobe; Hepatolenticular Degeneration; Humans; Iodine Radioisot | 1995 |
Differentiation of clinically non-functioning pituitary adenomas from meningiomas and craniopharyngiomas by positron emission tomography with [18F]fluoro-ethyl-spiperone.
Topics: Adenoma; Adolescent; Aged; Craniopharyngioma; Diagnosis, Differential; Female; Fluorine Radioisotope | 1997 |
Epidermal growth factor induces the functional expression of dopamine receptors in the GH3 cell line.
Topics: Animals; Binding, Competitive; Cell Line; Cells, Cultured; Dopamine Agents; Epidermal Growth Factor; | 1991 |
Regulation and molecular characterization of dopamine D2 receptors in a prolactin-secreting 7315a anterior pituitary tumor.
Topics: Animals; Azides; Blotting, Northern; Butaclamol; Corpus Striatum; Female; Haloperidol; In Vitro Tech | 1990 |
Either isoform of the dopamine D2 receptor can mediate dopaminergic repression of the rat prolactin promoter.
Topics: Animals; Cell Line; Ergolines; Female; Hysterectomy; Ovariectomy; Pituitary Neoplasms; Plasmids; Pro | 1991 |
Structural differences between dopamine D2 receptors present in a rat pituitary adenoma and in transplantable rat pituitary tumors 7315a and MtTW15.
Topics: Adenoma; Animals; Apomorphine; Binding, Competitive; Carrier Proteins; Chemical Phenomena; Chemistry | 1990 |
Modulation of dopamine receptors by cations in 7315a, MtTW15 and estradiol-induced pituitary tumors.
Topics: Animals; Cations; Estradiol; Female; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Rats | 1990 |
Resistance to bromocriptine in prolactinomas.
Topics: 17-Hydroxycorticosteroids; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adolescent; Adult; Bromoc | 1989 |
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Colforsin; Dopamine; Female; Guanosine Triphospha | 1987 |
Characterization of D2 dopamine receptors in dopamine-resistant prolactin-secreting rat pituitary tumors 7315a and MtTW15.
Topics: Affinity Labels; Animals; Apomorphine; Cell Membrane; Dopamine; Drug Resistance; Electrophoresis, Po | 1987 |
Transient dopaminergic inhibition of prolactin release from hybrid cells derived by fusion of normal rat pituitary and GH4C1 tumor cells.
Topics: Animals; Bromocriptine; Cell Fusion; Cell Line; Cells, Cultured; Dopamine; Female; Growth Hormone; H | 1988 |
Sodium and guanine nucleotide regulation of dopamine receptor agonist and antagonist binding sites in MtTW15 pituitary tumors.
Topics: Animals; Binding, Competitive; Female; Guanine Nucleotides; Neoplasm Transplantation; Pituitary Neop | 1988 |
Estradiol and guanine nucleotide modulation of dopamine receptor agonist and antagonist binding sites in 7315a pituitary tumors.
Topics: Animals; Binding Sites; Estradiol; Female; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pituit | 1988 |
Demonstration of specific dopamine receptors on human pituitary adenomas.
Topics: Adenoma; Adult; Bromocriptine; Female; Growth Hormone; Humans; Male; Middle Aged; Pituitary Neoplasm | 1987 |
Solubilization and characterization of D2-dopamine receptors in an estrone-induced, prolactin-secreting rat pituitary adenoma.
Topics: Adenoma; Affinity Labels; Animals; Cholic Acids; Electrophoresis, Polyacrylamide Gel; Estrone; Femal | 1986 |
Regulation of dopamine receptors in the MtT/W15 transplantable pituitary tumor by estrogen.
Topics: Animals; Binding, Competitive; Cell Line; Diethylstilbestrol; Estradiol; Female; Kinetics; Ovariecto | 1986 |
The electrical properties of isolated human prolactin-secreting adenoma cells and their modification by dopamine.
Topics: Adenoma; Bromocriptine; Domperidone; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; | 1985 |