Page last updated: 2024-11-04

spiperone and Atherosclerotic Parkinsonism

spiperone has been researched along with Atherosclerotic Parkinsonism in 17 studies

Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"Treatment with bromocriptine was very effective and five months after the poisoning, MR and (11)C-NMSP/PET images showed improvement, concomitantly with the disappearance of the neuropsychiatric symptoms."5.30Magnetic resonance imaging and 11C-N-methylspiperone/positron emission tomography studies in a patient with the interval form of carbon monoxide poisoning. ( Haida, M; Kozuma, R; Shinohara, Y; Takagi, S; Takahashi, W; Yoshii, F, 1998)
"Treatment with bromocriptine was very effective and five months after the poisoning, MR and (11)C-NMSP/PET images showed improvement, concomitantly with the disappearance of the neuropsychiatric symptoms."1.30Magnetic resonance imaging and 11C-N-methylspiperone/positron emission tomography studies in a patient with the interval form of carbon monoxide poisoning. ( Haida, M; Kozuma, R; Shinohara, Y; Takagi, S; Takahashi, W; Yoshii, F, 1998)
"Treatment with bromocriptine (5 mg/kg) relieved the parkinsonian symptoms, but the efficacy of this treatment appeared to decrease slightly with time."1.28Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393. ( Bédard, PJ; Di Paolo, T; Rouillard, C, 1990)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19908 (47.06)18.7374
1990's9 (52.94)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gnanalingham, KK2
Erol, DD1
Hunter, AJ2
Smith, LA2
Jenner, P2
Marsden, CD2
Curran, EJ1
Albin, RL1
Becker, JB1
Alexander, GM1
Schwartzman, RJ1
Grothusen, JR1
Brainard, L1
Gordon, SW1
Yoshii, F1
Kozuma, R1
Takahashi, W1
Haida, M1
Takagi, S1
Shinohara, Y1
Borbely, K1
Brooks, RA1
Wong, DF1
Burns, RS1
Cumming, P1
Gjedde, A1
Di Chiro, G1
Cadet, JL1
Zhu, SM1
Lisovoski, F1
Haby, C1
Borrelli, E1
Schleef, C1
Revel, MO1
Hindelang, C1
Zwiller, J1
Rouillard, C1
Bédard, PJ3
Di Paolo, T3
Camps, M1
Ambrosio, S1
Ballarin, M1
Reiriz, J1
Blesa, R1
Mahy, N1
Joyce, JN1
Marshall, JF1
Bankiewicz, KS1
Kopin, IJ1
Jacobowitz, DM1
Ruberg, M1
Javoy-Agid, F1
Hirsch, E1
Scatton, B1
LHeureux, R1
Hauw, JJ1
Duyckaerts, C1
Gray, F1
Morel-Maroger, A1
Rascol, A1
Crossman, AR1
Clarke, CE1
Boyce, S1
Robertson, RG1
Sambrook, MA1
Falardeau, P2
Bouchard, S1
Boucher, R2
Beresford, IJ1
Davenport, AP1
Sirinathsinghji, DJ1
Hall, MD1
Hill, RG1
Hughes, J1
Hantraye, P1
Loc'h, C1
Tacke, U1
Riche, D1
Stulzaft, O1
Doudet, D1
Guibert, B1
Naquet, R1
Mazière, B1
Mazière, M1

Reviews

1 review available for spiperone and Atherosclerotic Parkinsonism

ArticleYear
MPTP-induced parkinsonism in the monkey: neurochemical pathology, complications of treatment and pathophysiological mechanisms.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1987, Volume: 14, Issue:3 Suppl

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Deoxyglucose; Haplorhini; Humans; Levo

1987

Other Studies

16 other studies available for spiperone and Atherosclerotic Parkinsonism

ArticleYear
Differential anti-parkinsonian effects of benzazepine D1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset.
    Psychopharmacology, 1995, Volume: 117, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Benza

1995
Adrenal medulla grafts in the hemiparkinsonian rat: profile of behavioral recovery predicts restoration of the symmetry between the two striata in measures of pre- and postsynaptic dopamine function.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:9

    Topics: Adrenal Medulla; Amphetamine; Animals; Apomorphine; Benzazepines; Cerebral Ventricles; Corpus Striat

1993
Changes in brain dopamine receptors in MPTP parkinsonian monkeys following L-dopa treatment.
    Brain research, 1993, Oct-22, Volume: 625, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Benzazepines; Brain; Levodop

1993
Alterations in striatal and extrastriatal D-1 and D-2 dopamine receptors in the MPTP-treated common marmoset: an autoradiographic study.
    Synapse (New York, N.Y.), 1993, Volume: 14, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Benzazepines; Brain; Callith

1993
Magnetic resonance imaging and 11C-N-methylspiperone/positron emission tomography studies in a patient with the interval form of carbon monoxide poisoning.
    Journal of the neurological sciences, 1998, Sep-18, Volume: 160, Issue:1

    Topics: Basal Ganglia; Bromocriptine; Carbon Monoxide Poisoning; Carbon Radioisotopes; Caudate Nucleus; Cere

1998
NMSP binding to dopamine and serotonin receptors in MPTP-induced parkinsonism: relation to dopa therapy.
    Acta neurologica Scandinavica, 1999, Volume: 100, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adult; Antiparkinson Agents; Binding Sites; Cerebellum

1999
The intrastriatal 6-hydroxydopamine model of hemiparkinsonism: quantitative receptor autoradiographic evidence of correlation between circling behavior and presynaptic as well as postsynaptic nigrostriatal markers in the rat.
    Brain research, 1992, Nov-13, Volume: 595, Issue:2

    Topics: Amphetamine; Animals; Apomorphine; Autoradiography; Biomarkers; Corpus Striatum; Immunohistochemistr

1992
Induction of D2 dopamine receptor mRNA synthesis in a 6-hydroxydopamine parkinsonian rat model.
    Brain research bulletin, 1992, Volume: 28, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Blotting, Northern; Corpus Striatum; Dopamine;

1992
Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393.
    European journal of pharmacology, 1990, Aug-28, Volume: 185, Issue:2-3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzaze

1990
Dopamine D1 and D2 receptors visualized in MPTP treated C57 mice by in vitro autoradiography: lack of evidence of receptor modifications in parkinsonian mice.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Benzazepines; Brain; Dopamine; Homovanilli

1989
Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is associated with regional ipsilateral changes in striatal dopamine D-2 receptor density.
    Brain research, 1986, Sep-24, Volume: 382, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Carotid Arteries; Corpus Str

1986
Dopaminergic and cholinergic lesions in progressive supranuclear palsy.
    Annals of neurology, 1985, Volume: 18, Issue:5

    Topics: Aged; Brain; Bulbar Palsy, Progressive; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; Fema

1985
Behavioral and biochemical effect of chronic treatment with D-1 and/or D-2 dopamine agonists in MPTP monkeys.
    European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzaze

1988
Experimental hemiparkinsonism in the rat following chronic unilateral infusion of MPP+ into the nigrostriatal dopamine pathway--II. Differential localization of dopamine and cholecystokinin receptors.
    Neuroscience, 1988, Volume: 27, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Autoradiography; Benzazepines; Corpus Striatum; Functional Lat

1988
Chronic treatment with L-DOPA, but not bromocriptine induces dyskinesia in MPTP-parkinsonian monkeys. Correlation with [3H]spiperone binding.
    Brain research, 1986, Aug-06, Volume: 379, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Bromocriptine; Butyrophenones;

1986
"In vivo" visualization by positron emission tomography of the progressive striatal dopamine receptor damage occurring in MPTP-intoxicated non-human primates.
    Life sciences, 1986, Oct-13, Volume: 39, Issue:15

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bromine; Corpus Striatum; Disease Models, Ani

1986