spiperone has been researched along with Alcoholism in 9 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both lisuride-treated (AL) and untreated ethanol-addicted rats (A) displayed a significant (P < ." | 1.29 | Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment. ( May, T; Wolf, U; Wolffgramm, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbaccia, ML | 1 |
| Bosio, A | 1 |
| Lucchi, L | 1 |
| Spano, PF | 1 |
| Trabucchi, M | 1 |
| Ng, GY | 1 |
| O'Dowd, BF | 1 |
| George, SR | 1 |
| May, T | 1 |
| Wolf, U | 1 |
| Wolffgramm, J | 1 |
| Tajuddin, NF | 1 |
| Druse, MJ | 2 |
| Tabakoff, B | 1 |
| Hoffman, PL | 1 |
| Pellegrino, SM | 1 |
| Noble, EP | 1 |
| Blum, K | 1 |
| Ritchie, T | 1 |
| Montgomery, A | 1 |
| Sheridan, PJ | 1 |
| Syvälahti, EK | 1 |
| Hietala, J | 1 |
| Röyttä, M | 1 |
| Grönroos, J | 1 |
| Korpi, ER | 1 |
| Sinclair, JD | 1 |
| Malminen, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Gut-brain Axis: a Novel Target for Treating Behavioral Alterations in Obesity[NCT01976156] | 100 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for spiperone and Alcoholism
| Article | Year |
|---|---|
Neuronal mechanisms regulating ethanol effects on the dopaminergic system.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcoholism; Animals; Dopamine; Ethanol; Haloperidol; Humans; Male; M | 1982 |
Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Base Sequence; Benzazepines; Blotting, Northern; Brain; Dise | 1994 |
Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Benzazepines; Corpus Striatum; Dopamine Agonists; Dopamine A | 1995 |
Effects of chronic alcohol consumption and aging on dopamine D2 receptors in Fischer 344 rats.
Topics: Age Factors; Alcoholism; Animals; Brain; Brain Mapping; Cerebral Cortex; Corpus Striatum; Ethanol; F | 1996 |
Development of functional dependence on ethanol in dopaminergic systems.
Topics: Adenylyl Cyclases; Alcoholism; Animals; Corpus Striatum; Dopamine; Drug Tolerance; Ethanol; Humans; | 1979 |
The effects of chronic ethanol consumption on the mesolimbic and nigrostriatal dopamine systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcoholism; Animals; Benzazepines; Brain Mapping; Corpus Striatum; D | 1992 |
Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.
Topics: Alcoholism; Alleles; Caudate Nucleus; DNA Probes; Female; Humans; Male; Middle Aged; Protein Binding | 1991 |
Decrease in the number of rat brain dopamine and muscarinic receptors after chronic alcohol intake.
Topics: Alcoholism; Animals; Corpus Striatum; Ethanol; Male; Quinuclidinyl Benzilate; Rats; Rats, Inbred Str | 1988 |
Dopamine D2 receptor binding in striatal membranes of rat lines selected for differences in alcohol-related behaviours.
Topics: Alcoholism; Animals; Corpus Striatum; Kinetics; Male; Radioligand Assay; Receptors, Dopamine; Spiper | 1987 |