spiperone has been researched along with Akinetic-Rigid Variant of Huntington Disease in 11 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we report that the putamen in Huntington's disease (HD) lacks GI-D2 receptors." | 1.28 | Lack of GTP-insensitive D2 dopamine receptors in Huntington's disease. ( De Keyser, J; Ebinger, G; Roos, RA; Vauquelin, G, 1989) |
| "A 48-year-old man with typical Huntington's disease was investigated with computed tomography (CT) and positron emission tomography." | 1.27 | Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography. ( Frackowiak, RS; Leenders, KL; Marsden, CD; Quinn, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cross, A | 1 |
| Rossor, M | 1 |
| Araujo, DM | 1 |
| Cherry, SR | 1 |
| Tatsukawa, KJ | 1 |
| Toyokuni, T | 1 |
| Kornblum, HI | 1 |
| Reisine, TD | 2 |
| Fields, JZ | 2 |
| Stern, LZ | 1 |
| Johnson, PC | 1 |
| Bird, ED | 2 |
| Yamamura, HI | 2 |
| Spokes, E | 1 |
| Brandt, J | 1 |
| Folstein, SE | 1 |
| Wong, DF | 1 |
| Links, J | 1 |
| Dannals, RF | 1 |
| McDonnell-Sill, A | 1 |
| Starkstein, S | 1 |
| Anders, P | 1 |
| Strauss, ME | 1 |
| Tune, LE | 1 |
| De Keyser, J | 1 |
| Roos, RA | 1 |
| Ebinger, G | 1 |
| Vauquelin, G | 1 |
| Hägglund, J | 2 |
| Aquilonius, SM | 2 |
| Bergström, K | 1 |
| Eckernäs, SA | 2 |
| Hartvig, P | 2 |
| Lundqvist, H | 1 |
| Långström, B | 2 |
| Malmborg, P | 1 |
| Någren, K | 1 |
| Lundquist, H | 1 |
| Gullberg, P | 1 |
| Joyce, JN | 1 |
| Lexow, N | 1 |
| Bird, E | 1 |
| Winokur, A | 1 |
| Leenders, KL | 1 |
| Frackowiak, RS | 1 |
| Quinn, N | 1 |
| Marsden, CD | 1 |
| de Yebenes, JG | 1 |
| Bazán, E | 1 |
| Muradas, V | 1 |
| Reiriz, J | 1 |
| Mena, MA | 1 |
11 other studies available for spiperone and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Dopamine D-1 and D-2 receptors in Huntington's disease.
Topics: Aged; Brain; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Kinetics; Male; Middle Age | 1983 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Alterations in dopaminergic receptors in Huntington's disease.
Topics: Adult; Brain; Butyrophenones; Caudate Nucleus; Cerebral Cortex; Choline O-Acetyltransferase; Humans; | 1977 |
Characterization of brain dopaminergic receptors in Huntington's disease.
Topics: Aged; Brain; Butaclamol; Butyrophenones; Humans; Huntington Disease; Kinetics; Middle Aged; Receptor | 1978 |
D2 receptors in Huntington's disease: positron emission tomography findings and clinical correlates.
Topics: Adult; Brain; Brain Mapping; Caudate Nucleus; Cerebellum; Dopamine Agents; Female; Humans; Huntingto | 1990 |
Lack of GTP-insensitive D2 dopamine receptors in Huntington's disease.
Topics: Aged; Binding, Competitive; Female; Globus Pallidus; Guanosine Triphosphate; Humans; Huntington Dise | 1989 |
Regional kinetics of [11C]methylspiperone in the brain studied by positron emission tomography in patients with Parkinson's disease.
Topics: Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Humans; Huntington Disease; Kinetics; Parkinson | 1987 |
Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using 11C-N-methyl-spiperone.
Topics: Aged; Caudate Nucleus; Corpus Striatum; Female; Frontal Lobe; Humans; Huntington Disease; Kinetics; | 1987 |
Organization of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntington's disease and schizophrenia.
Topics: Aged; Autoradiography; Benzazepines; Corpus Striatum; Female; Humans; Huntington Disease; Male; Midd | 1988 |
Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography.
Topics: Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenyl | 1986 |
3H-spiroperidol binding sites in lymphocytes of patients and individuals at risk of Huntington's disease.
Topics: Binding Sites; Butyrophenones; Humans; Huntington Disease; Lymphocytes; Spiperone | 1985 |