spiperone and Aging
spiperone has been researched along with Aging in 83 studies
Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied." | 5.27 | [3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987) |
| "Dopamine D2 receptor binding potential (BP) was measured by C-11 N-methylspiperone (NMSP) and PET in normal healthy volunteers and patients with various neurodegenerative diseases including Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Huntington disease (HD) and so on." | 4.79 | [Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET]. ( Momose, T; Sasaki, Y, 1997) |
| "We assessed the relation between serotonin 5-HT2 receptor availability and aging and compared it with that for dopamine D2 receptors on 19 healthy male volunteers (age range, 21-49 years) using positron emission tomography (PET) and F-18 N-methylspiperone (NMS)." | 3.69 | Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. ( Fowler, JS; Gur, RC; Hitzemann, RJ; Logan, J; MacGregor, RR; Schlyer, D; Volkow, ND; Wang, GJ; Wolf, AP, 1995) |
| " Using positron emission tomography and constrained analysis of the brain uptake of the radioligand N-[11C]methyl-spiperone ([11C]NMSP), we tested four questions: Were the assumptions underlying the quantitation valid? Is there an age decline of the density of D2-like dopamine receptors in drug-naive schizophrenia and bipolar illness? If so, is it different from that observed in normal aging? Are D2-like dopamine receptors elevated at any age in either drug-naive schizophrenic or psychotic bipolar illness patients? NMSP and haloperidol partition volumes and plasma protein fractions were not significantly different among patient groups and normal volunteers." | 3.69 | Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. ( Dannals, RF; Gjedde, A; Kuhar, MJ; Meltzer, CC; Pearlson, GD; Ravert, HT; Reith, J; Tune, LE; Wong, DF; Young, LT, 1997) |
| "The effect of aging on 11C-N-methylspiperone binding to living human striatum was demonstrated using positron emission tomography." | 3.67 | [Age-related decrease of 11C-N-methylspiperone in vivo binding to human striatum detected by PET]. ( Fukuda, H; Inoue, O; Ito, T; Iyo, M; Koseki, A; Nishio, M; Shinotoh, H; Suzuki, K; Yamasaki, T; Yonezawa, H, 1989) |
| "The primary etiology of Parkinson's disease is still unknown, although the aging process may be an important predisposing factor." | 2.36 | Parkinson's disease as a model for changes in dopamine receptor dynamics with aging. ( Rinne, UK, 1982) |
| " Spiroperidol binding (dopamine D2 receptors) and quinuclidinyl benzilate binding (muscarinic receptors) in striata of 19-month old mice was analyzed for animals that had received chronic administration of cytidine 5'-diphosphocholine (CDP-choline) incorporated into the chow consumed (100 or 500 mg kg-1 added per day) for the 7 months before they were killed." | 1.28 | Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice. ( Aguilar, J; Giménez, R; Raïch, J, 1991) |
| "[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied." | 1.27 | [3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987) |
| "A model of minimal brain dysfunction (MBD) in rats based on injection of 6-OH-dopamine (DA) intracisternally on the 5th day of life has been described previously." | 1.26 | Dopamine receptors in a rat model of minimal brain dysfunction. ( Belmaker, RH; Brecher-Fride, E; Ebstein, RP; Eisenberg, J; Weizman, R, 1982) |
| "Atropine alone was shown paradoxically to elicit mild to moderate cataleptic responses in 10- and 15-day-olds, but not at day 20." | 1.26 | Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy. ( Baez, LA; Burt, DK; Crowner, ML; Hungerford, SM, 1982) |
| "It is proposed that the decrement in catalepsy occurring between 10 and 15 days of age is related to increased dopaminergic activity in the neostriatum." | 1.26 | Dopaminergic antagonism and catalepsy in the developing rat. ( Baez, LA; Burt, DK; Granneman, J; Shanklin, C, 1979) |
| "Spiperone produced catalepsy in rats 1, 5 and 10 days old, and also in adults." | 1.26 | Postnatal development of dopaminergic and cholinergic catalepsy in the rat. ( Baez, LA; Eskridge, NK; Schein, R, 1976) |
Research
Studies (83)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (71.08) | 18.7374 |
| 1990's | 23 (27.71) | 18.2507 |
| 2000's | 1 (1.20) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mastroeni, D | 1 |
| Grover, A | 1 |
| Leonard, B | 1 |
| Joyce, JN | 2 |
| Coleman, PD | 1 |
| Kozik, B | 1 |
| Bellinger, DL | 1 |
| Rogers, J | 1 |
| Burchinsky, SG | 1 |
| Collier, WL | 1 |
| Iacopino, L | 1 |
| Amenta, F | 1 |
| Joseph, JA | 4 |
| Filburn, CR | 1 |
| Roth, GS | 5 |
| Seth, PK | 1 |
| Chandra, SV | 1 |
| Powell, DA | 1 |
| Buchanan, SL | 1 |
| Hernandez, LL | 1 |
| O'Boyle, KM | 1 |
| Waddington, JL | 1 |
| Severson, JA | 4 |
| Finch, CE | 4 |
| Nomura, Y | 2 |
| Oki, K | 2 |
| Segawa, T | 1 |
| Govoni, S | 2 |
| Memo, M | 2 |
| Saiani, L | 1 |
| Spano, PF | 3 |
| Trabucchi, M | 3 |
| Marshall, JF | 1 |
| Drew, MC | 1 |
| Neve, KA | 1 |
| Bruinink, A | 2 |
| Lichtensteiger, W | 2 |
| Schlumpf, M | 2 |
| Cimino, M | 2 |
| Vantini, G | 2 |
| Algeri, S | 2 |
| Curatola, G | 1 |
| Pezzoli, C | 1 |
| Stramentinoli, G | 1 |
| Agnati, LF | 1 |
| Fuxe, K | 1 |
| Battistini, N | 1 |
| Benfenati, F | 1 |
| Henry, JM | 2 |
| Marcusson, JO | 1 |
| Morgan, DG | 1 |
| Winblad, B | 2 |
| Bartus, RT | 1 |
| Clody, D | 1 |
| Morgan, D | 1 |
| Finch, C | 1 |
| Beer, B | 1 |
| Sesack, S | 1 |
| Arita, J | 1 |
| Reymond, MJ | 1 |
| Porter, JC | 1 |
| Eisenberg, J | 1 |
| Brecher-Fride, E | 1 |
| Weizman, R | 1 |
| Ebstein, RP | 1 |
| Belmaker, RH | 1 |
| Roy, EJ | 1 |
| Sheinkop, S | 1 |
| Wilson, MA | 1 |
| Rinne, UK | 1 |
| Burt, DK | 2 |
| Hungerford, SM | 1 |
| Crowner, ML | 1 |
| Baez, LA | 3 |
| De Blasi, A | 1 |
| Mennini, T | 1 |
| Murrin, LC | 1 |
| Marcusson, J | 1 |
| Achilli, G | 1 |
| Perego, C | 1 |
| Ponzio, F | 1 |
| Riederer, P | 1 |
| Jellinger, K | 1 |
| Randall, PK | 2 |
| Papavasiliou, PS | 1 |
| Miller, ST | 1 |
| Thal, LJ | 4 |
| Nerder, LJ | 1 |
| Houlihan, G | 1 |
| Rao, SN | 1 |
| Stevens, JM | 1 |
| Misra, CH | 1 |
| Smith, RC | 1 |
| Horowitz, SG | 3 |
| Dvorkin, B | 3 |
| Makman, MH | 3 |
| Mackay, AV | 1 |
| Bird, ED | 1 |
| Iversen, LL | 1 |
| Spokes, EG | 1 |
| Creese, I | 3 |
| Snyder, SH | 1 |
| Lucchi, L | 1 |
| Wang, GJ | 2 |
| Volkow, ND | 2 |
| Logan, J | 2 |
| Fowler, JS | 2 |
| Schlyer, D | 1 |
| MacGregor, RR | 2 |
| Hitzemann, RJ | 1 |
| Gur, RC | 1 |
| Wolf, AP | 2 |
| Beas-Zárate, C | 1 |
| Ortuño-Sahagún, D | 1 |
| Del Angel Meza, AR | 1 |
| Feria-Velasco, A | 1 |
| Kostrzewa, RM | 2 |
| Guo, J | 1 |
| Kostrzewa, FP | 1 |
| Crawford, CA | 1 |
| Rowlett, JK | 1 |
| McDougall, SA | 2 |
| Bardo, MT | 2 |
| May, T | 1 |
| Sugawa, M | 1 |
| Iyo, M | 3 |
| Yamasaki, T | 3 |
| Gatley, SJ | 1 |
| Schlyer, DJ | 1 |
| Hitzemann, R | 1 |
| Momose, T | 1 |
| Sasaki, Y | 1 |
| Wong, DF | 2 |
| Young, D | 1 |
| Wilson, PD | 1 |
| Meltzer, CC | 2 |
| Gjedde, A | 2 |
| Pearlson, GD | 1 |
| Tune, LE | 1 |
| Young, LT | 1 |
| Dannals, RF | 1 |
| Ravert, HT | 1 |
| Reith, J | 1 |
| Kuhar, MJ | 1 |
| Araki, T | 1 |
| Kato, H | 1 |
| Shuto, K | 1 |
| Fujiwara, T | 1 |
| Itoyama, Y | 1 |
| Thomas, WS | 1 |
| Neal-Beliveau, BS | 1 |
| Rudner, XL | 1 |
| Berkowitz, DE | 1 |
| Booth, JV | 1 |
| Funk, BL | 1 |
| Cozart, KL | 1 |
| D'Amico, EB | 1 |
| El-Moalem, H | 1 |
| Page, SO | 1 |
| Richardson, CD | 1 |
| Winters, B | 1 |
| Marucci, L | 1 |
| Schwinn, DA | 1 |
| Ahn, HS | 2 |
| Sharpless, NS | 2 |
| Rosenfeld, M | 2 |
| Granneman, J | 1 |
| Shanklin, C | 1 |
| Eskridge, NK | 1 |
| Schein, R | 1 |
| Ferretti, C | 2 |
| Blengio, M | 2 |
| Vigna, I | 1 |
| Ghi, P | 2 |
| Genazzani, E | 1 |
| Yonezawa, H | 2 |
| Itoh, T | 1 |
| Fukuda, H | 2 |
| Inoue, O | 2 |
| Suhara, T | 1 |
| Shinotoh, H | 2 |
| Nishio, M | 2 |
| Tohgi, H | 1 |
| Brus, R | 1 |
| Kalbfleisch, J | 1 |
| De Keyser, J | 2 |
| De Backer, JP | 1 |
| Vauquelin, G | 2 |
| Ebinger, G | 2 |
| Greenwood, CE | 1 |
| Cinader, B | 2 |
| Giménez, R | 1 |
| Raïch, J | 1 |
| Aguilar, J | 1 |
| Kaseda, Y | 1 |
| Ghetti, B | 1 |
| Low, WC | 1 |
| Norton, J | 1 |
| Brittain, H | 1 |
| Triarhou, LC | 1 |
| Richter, JA | 1 |
| Simon, JR | 1 |
| Lange, KW | 1 |
| Rinne, JO | 2 |
| Lönnberg, P | 1 |
| Marjamäki, P | 1 |
| Camps, M | 1 |
| Cortés, R | 1 |
| Gueye, B | 1 |
| Probst, A | 1 |
| Palacios, JM | 1 |
| Suzuki, K | 1 |
| Ito, T | 1 |
| Koseki, A | 1 |
| Han, Z | 1 |
| Kuyatt, BL | 1 |
| Kochman, KA | 1 |
| DeSouza, EB | 1 |
| Kochman, K | 2 |
| Neisewander, JL | 1 |
| Zolman, JF | 1 |
| Ben-Shachar, D | 1 |
| Ashkenazi, R | 1 |
| Youdim, MB | 1 |
| Sparks, DL | 1 |
| Hess, EJ | 1 |
| Bracha, HS | 1 |
| Kleinman, JE | 1 |
| Norman, AB | 1 |
| Battaglia, G | 1 |
| Leprohon-Greenwood, CE | 1 |
| Członkowska, A | 1 |
| Jachowicz-Jeszka, J | 1 |
| Członkowski, A | 1 |
| Wagner, HN | 1 |
| Burchill, SA | 1 |
| Thody, AJ | 1 |
| Noisin, EL | 1 |
| Thomas, WE | 1 |
| Bonetti, AC | 1 |
| Bellini, F | 1 |
| Calderini, G | 1 |
| Galbiati, E | 1 |
| Toffano, G | 1 |
| Peters, DA | 1 |
| Eva, C | 1 |
| Bosco, MC | 1 |
| Portaleone, P | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults[NCT03512171] | Phase 1 | 65 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
3 reviews available for spiperone and Aging
| Article | Year |
|---|---|
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph | 1984 |
Parkinson's disease as a model for changes in dopamine receptor dynamics with aging.
Topics: Aged; Aging; Brain; Corpus Striatum; Humans; Models, Biological; Parkinson Disease; Receptors, Dopam | 1982 |
[Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET].
Topics: Aging; Biomarkers; Carbon Radioisotopes; Corpus Striatum; Diagnosis, Differential; Dopamine Agonists | 1997 |
Other Studies
80 other studies available for spiperone and Aging
| Article | Year |
|---|---|
Microglial responses to dopamine in a cell culture model of Parkinson's disease.
Topics: Aged; Aging; Antineoplastic Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Coculture Te | 2009 |
Changes of [3H]spiroperidol binding in the renal artery of aged rabbits.
Topics: Aging; Animals; Butyrophenones; Cyclic AMP; Dopamine; Male; Rabbits; Receptors, Dopamine; Renal Arte | 1984 |
Development of dopamine receptor denervation supersensitivity in the neostriatum of the senescent rat.
Topics: Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Dextroamphetamine; Ergolines; Female; Male; Moto | 1981 |
Neurotransmitters and neurotransmitter receptors in developing and adult rats during manganese poisoning.
Topics: Aging; Animals; Animals, Newborn; Biogenic Amines; Cerebellum; Haplorhini; Manganese Poisoning; Musc | 1984 |
Age-related changes in Pavlovian conditioning: central nervous system correlates.
Topics: Aging; Animals; Arousal; Brain; Conditioning, Eyelid; Dopamine; Electromyography; Female; Heart Rate | 1984 |
Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: association with increased non-specific binding of the D-1 ligand [3H]piflutixol.
Topics: Adenylyl Cyclases; Aging; Animals; Antipsychotic Agents; Corpus Striatum; In Vitro Techniques; Kinet | 1984 |
Reduced dopaminergic binding during aging in the rodent striatum.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Butaclamol; Corpus Striatum; Hypothalamus; Male; | 1980 |
Ontogenetic development of the striatal [3H]spiperone binding: regulation by sodium and guanine nucleotide in rats.
Topics: Aging; Animals; Animals, Newborn; Butaclamol; Butyrophenones; Corpus Striatum; Female; Guanosine Tri | 1982 |
Impairment of brain neurotransmitter receptors in aged rats.
Topics: Aging; Animals; Brain; Corpus Striatum; gamma-Aminobutyric Acid; Male; Olfactory Bulb; Pituitary Gla | 1980 |
Recovery of function after mesotelencephalic dopaminergic injury in senescence.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Dominance, Cerebral; Dopamine; Male; Mesencephalon; Ne | 1983 |
Ontogeny of diurnal rhythms of central dopamine, serotonin and spirodecanone binding sites and of motor activity in the rat.
Topics: Aging; Animals; Brain; Circadian Rhythm; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors | 1983 |
Age-related modification of dopaminergic and beta-Adrenergic receptor system: restoration to normal activity by modifying membrane fluidity with S-adenosylmethionine.
Topics: Aging; Animals; Cell Membrane; Cerebral Cortex; Corpus Striatum; Dihydroalprenolol; Kinetics; Membra | 1984 |
Aging brain and dopamine receptors: abnormal regulation by CCK-8 of 3H-spiperone labeled dopamine receptors in striatal membranes.
Topics: Age Factors; Aging; Animals; Butyrophenones; Corpus Striatum; Male; Rats; Rats, Inbred Strains; Rece | 1984 |
Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade.
Topics: Aging; Animals; Corpus Striatum; Kinetics; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, | 1984 |
Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.
Topics: Adolescent; Adult; Aged; Aging; Cerebral Cortex; Hippocampus; Humans; Ketanserin; Kinetics; Methyser | 1984 |
Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Motor Skills; Rats; Rats, Inbred | 1983 |
Evidence for alteration in the processing of dopamine in the anterior pituitary gland of aged rats: receptors and intracellular compartmentalization of dopamine.
Topics: Aging; Animals; Cell Membrane; Dopamine; Female; Kinetics; Luteinizing Hormone; Organ Size; Pituitar | 1984 |
Dopamine receptors in a rat model of minimal brain dysfunction.
Topics: Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Caudate Nucleus; Di | 1982 |
Pre- and postnatal ontogeny and characterization of dopaminergic D2, serotonergic S2, and spirodecanone binding sites in rat forebrain.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Brain; Butyrophenones; Female; Fetus; Kinetics; | 1983 |
Age alters dopaminergic responses to estradiol.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Castration; Corpus Striatum; Estradiol; Female; H | 1982 |
Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy.
Topics: Aging; Animals; Atropine; Brain; Butyrophenones; Clozapine; Dibenzazepines; Dose-Response Relationsh | 1982 |
Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats.
Topics: Aging; Animals; Binding, Competitive; Brain; Cell Membrane; Corpus Striatum; Fluorescent Dyes; Kinet | 1982 |
In vivo studies of dopamine receptor ontogeny.
Topics: Aging; Animals; Binding, Competitive; Brain; Cerebellum; Corpus Striatum; Kinetics; Rats; Rats, Inbr | 1982 |
Development of inhibitory activity of sulpiride for synaptic [3H]-spiperone binding in the rat striatum.
Topics: Aging; Animals; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Guanosine Triphosphat | 1982 |
Age-correlated loss of dopaminergic binding sites in human basal ganglia.
Topics: Adolescent; Adult; Aged; Aging; Basal Ganglia; Caudate Nucleus; Child; Child, Preschool; Female; Hum | 1982 |
Study on some compensatory responses of dopaminergic system in aging rats.
Topics: Aging; Animals; Apomorphine; Butyrophenones; Corpus Striatum; Feedback; Haloperidol; Homovanillic Ac | 1982 |
Morphological and biochemical changes in the aging brain: pathophysiological and possible therapeutic consequences.
Topics: Aged; Aging; Animals; Brain; Female; Frontal Lobe; Humans; Isoenzymes; Male; Monoamine Oxidase; Orga | 1982 |
Aging and the regulation of striatal dopaminergic mechanisms in mice.
Topics: Aging; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Haloperidol; Humans; Male; Mice; Mice, | 1981 |
Age-related motor and catecholamine alterations in mice on levodopa supplemented diet.
Topics: Aging; Animals; Brain Chemistry; Catecholamines; Diet; Levodopa; Male; Mice; Motor Activity; Quinucl | 1981 |
Effects of age on dopaminergic supersensitivity induced by chronic fluphenazine.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Fluphenazine; Kinetics; Rats; Rats, Inbred F344; Spiperon | 1980 |
Evidence for loss of brain [3H]spiroperidil and [3H]ADTN binding sites in rabbit brain with aging.
Topics: Aging; Animals; Binding, Competitive; Brain; Butyrophenones; Corpus Striatum; Frontal Lobe; Limbic S | 1980 |
Dopaminergic abnormalities in postmortem schizophrenic brain.
Topics: Aging; Brain Chemistry; Caudate Nucleus; Dopamine; Humans; Kinetics; Nucleus Accumbens; Schizophreni | 1980 |
Aging process affects a single class of dopamine receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Haloperidol; Hum | 1980 |
Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects.
Topics: Adult; Aging; Brain; Corpus Striatum; Fluorine Radioisotopes; Frontal Lobe; Humans; Male; Middle Age | 1995 |
Effect of a corn diet during development on [3H]-spiperone binding in the brain of rats at the perinatal stage.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Diet; Embryonic and Fetal Development; Female; | 1995 |
Ontogenetic quinpirole treatment induces vertical jumping activity in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz | 1993 |
Age-dependent differences in the rate of recovery of striatal dopamine D1 and D2 receptors after inactivation with EEDQ.
Topics: Aging; Animals; Behavior, Animal; Benzazepines; Dopamine D2 Receptor Antagonists; Female; Injections | 1994 |
Altered dopamine receptor mediated signal transmission in the striatum of aged rats.
Topics: Adenylyl Cyclases; Aging; Animals; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine; Fe | 1993 |
The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain.
Topics: Adult; Aged; Aging; Benzazepines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Female; Humans; | 1993 |
Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol.
Topics: Adult; Age Factors; Aged; Aging; Cerebellum; Corpus Striatum; Dopamine Agonists; Female; Humans; Lig | 1996 |
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine A | 1997 |
Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
Topics: Adult; Aged; Aging; Basal Ganglia; Bipolar Disorder; Brain Chemistry; Caudate Nucleus; Chromatograph | 1997 |
Effect of aging on dopaminergic receptors and uptake sites in the rat brain studied by receptor autoradiography.
Topics: Aging; Animals; Autoradiography; Benzamides; Benzazepines; Brain Chemistry; Dopamine Antagonists; Do | 1997 |
There is a limited critical period for dopamine's effects on D1 receptor expression in the developing rat neostriatum.
Topics: Aging; Animals; Animals, Newborn; Benzazepines; Carrier Proteins; Corpus Striatum; Dopamine; Dopamin | 1998 |
Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Aorta; Arteries; Celiac | 1999 |
[3H]Haloperidol and [3H]spiroperidol binding in rat striatum during ageing.
Topics: Adenylyl Cyclases; Aging; Animals; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Haloper | 1978 |
Aging and monoamine receptors in brain.
Topics: Adenylyl Cyclases; Aging; Animals; Biogenic Amines; Brain; Choline O-Acetyltransferase; Dopamine; En | 1979 |
Dopaminergic antagonism and catalepsy in the developing rat.
Topics: Aging; Animals; Catalepsy; Dopamine; Dopamine Antagonists; Female; Haloperidol; Humans; Male; Rats; | 1979 |
Biogenic amine-stimulated adenylate cyclase and spiroperidol-binding sites in rabbit brain: evidence for selective loss of receptors with aging.
Topics: Adenylyl Cyclases; Aging; Animals; Biogenic Amines; Brain; Butyrophenones; Dopamine; Histamine; Kine | 1978 |
Postnatal development of dopaminergic and cholinergic catalepsy in the rat.
Topics: Aging; Animals; Butyrophenones; Catalepsy; Catecholamines; Female; Humans; Male; Neurons; Pilocarpin | 1976 |
Effects of estradiol on the ontogenesis of striatal dopamine D1 and D2 receptor sites in male and female rats.
Topics: Aging; Animals; Benzazepines; Corpus Striatum; Estradiol; Estrus; Female; Male; Rats; Rats, Inbred S | 1992 |
[Effect of aging on in vivo binding of 11C-N-methylspiperone in living human frontal cortex].
Topics: Adult; Aged; Aging; Carbon Radioisotopes; Dopamine Agents; Frontal Lobe; Humans; Male; Middle Aged; | 1991 |
Ontogenetic homologous sensitization to the antinociceptive action of quinpirole in rats.
Topics: Aging; Analgesics; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Erg | 1991 |
D1 and D2 dopamine receptors in human substantia nigra: localization and the effect of aging.
Topics: Aged; Aging; Benzazepines; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopami | 1991 |
Age-related decline in striatal D2-dopamine receptors is subject to 'economic correction'.
Topics: Aging; Animals; Corpus Striatum; Dietary Fats; Female; Mice; Mice, Inbred Strains; Receptors, Dopami | 1991 |
Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice.
Topics: Aging; Animals; Corpus Striatum; Cytidine Diphosphate Choline; Female; In Vitro Techniques; Membrane | 1991 |
Age-related changes in the human nigrostriatal dopaminergic system.
Topics: Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Corpus Striatum; Dopamine; Female; GTP-Binding | 1990 |
Age-related changes in striatal dopamine D2 receptor binding in weaver mice and effects of ventral mesencephalic grafts.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; F | 1990 |
Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Behavior, Animal; Injections; Male; MP | 1990 |
Age-dependent decline in human brain dopamine D1 and D2 receptors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Brain; Child; Child, Preschool; Fem | 1990 |
Dopamine receptors in human brain: autoradiographic distribution of D2 sites.
Topics: Aging; Autoradiography; Binding Sites; Brain; Female; Humans; Male; Postmortem Changes; Receptors, D | 1989 |
[Age-related decrease of 11C-N-methylspiperone in vivo binding to human striatum detected by PET].
Topics: Adult; Aged; Aging; Cerebellum; Corpus Striatum; Female; Humans; Male; Middle Aged; Receptors, Dopam | 1989 |
Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum.
Topics: Aging; Animals; Autoradiography; Cell Count; Corpus Striatum; Diagnosis, Computer-Assisted; Male; Ne | 1989 |
Reduction of motor behavioural deficits in senescence via chronic prolactin or estrogen administration: time course and putative mechanisms of action.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Estrogens; Female; Male; Motor Activity; Oxotremorine; Pr | 1989 |
Ontogenetic changes in [3H]-spiroperidol binding sites in posthatch chick brain.
Topics: Aging; Brain; Cerebellum; Diencephalon; Receptors, Dopamine; Spiperone; Superior Colliculi; Telencep | 1989 |
Long-term consequence of early iron-deficiency on dopaminergic neurotransmission in rats.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Brain; Dopamine; Iron; Iron Deficiencies; Motor Activ | 1986 |
Aging and Alzheimer's disease. Altered cortical serotonergic binding.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cerebral Cortex; Frontal Lobe; Humans; Middle Age | 1989 |
Dopamine receptor subtype imbalance in schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Brain; Female; Humans; Male; Middle Aged; Recep | 1987 |
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techn | 1987 |
Variations in age-related decline in striatal D2-dopamine receptors in a variety of mouse strains.
Topics: Aging; Animals; Corpus Striatum; Female; Kinetics; Mice; Mice, Inbred Strains; Receptors, Dopamine; | 1987 |
Effect of aging on striatal dopamine receptor subtype recovery following N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline blockade and relation to motor function in Wistar rats.
Topics: Aging; Animals; Corpus Striatum; Male; Motor Activity; Quinolines; Rats; Rats, Inbred Strains; Recep | 1987 |
[3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging.
Topics: Adult; Aged; Aging; Antiparkinson Agents; Female; Hepatolenticular Degeneration; Humans; Lymphocytes | 1987 |
Radiolabeled drugs as probes of central nervous system neurons.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Female; Fentanyl; Forecasting; Humans; Isotope Labeling; | 1985 |
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocript | 1986 |
D-2 dopamine receptors in aging mouse striatum: determination of high- and low-affinity agonist binding sites.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Corpus Striatum; Dopamine; GTP-Binding Proteins | 1985 |
Ontogeny of dopaminergic function in the rat midbrain tegmentum, corpus striatum and frontal cortex.
Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Cell Membrane; Cerebral Cortex; Corpus Stria | 1988 |
Muscarinic and dopaminergic receptors in the aging human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Brain; Child; Child, Preschool; Flupenthixol; Hum | 1987 |
Age-dependent changes in the mechanisms controlling prolactin secretion and phosphatidylinositol turnover in male rats: effect of phosphatidylserine.
Topics: Aging; Animals; Dopamine; In Vitro Techniques; Kinetics; Liposomes; Male; Phosphatidylcholines; Phos | 1987 |
Prenatal stress: effect on development of rat brain serotonergic neurons.
Topics: Aging; Animals; Circadian Rhythm; Female; Kinetics; Motor Activity; Neurons; Pregnancy; Prenatal Exp | 1986 |
The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related.
Topics: Aging; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dihydroergotoxine; Dose-Response | 1986 |