Page last updated: 2024-11-04

spiperone and Aging

spiperone has been researched along with Aging in 83 studies

Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied."5.27[3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987)
"Dopamine D2 receptor binding potential (BP) was measured by C-11 N-methylspiperone (NMSP) and PET in normal healthy volunteers and patients with various neurodegenerative diseases including Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Huntington disease (HD) and so on."4.79[Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET]. ( Momose, T; Sasaki, Y, 1997)
"We assessed the relation between serotonin 5-HT2 receptor availability and aging and compared it with that for dopamine D2 receptors on 19 healthy male volunteers (age range, 21-49 years) using positron emission tomography (PET) and F-18 N-methylspiperone (NMS)."3.69Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. ( Fowler, JS; Gur, RC; Hitzemann, RJ; Logan, J; MacGregor, RR; Schlyer, D; Volkow, ND; Wang, GJ; Wolf, AP, 1995)
" Using positron emission tomography and constrained analysis of the brain uptake of the radioligand N-[11C]methyl-spiperone ([11C]NMSP), we tested four questions: Were the assumptions underlying the quantitation valid? Is there an age decline of the density of D2-like dopamine receptors in drug-naive schizophrenia and bipolar illness? If so, is it different from that observed in normal aging? Are D2-like dopamine receptors elevated at any age in either drug-naive schizophrenic or psychotic bipolar illness patients? NMSP and haloperidol partition volumes and plasma protein fractions were not significantly different among patient groups and normal volunteers."3.69Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. ( Dannals, RF; Gjedde, A; Kuhar, MJ; Meltzer, CC; Pearlson, GD; Ravert, HT; Reith, J; Tune, LE; Wong, DF; Young, LT, 1997)
"The effect of aging on 11C-N-methylspiperone binding to living human striatum was demonstrated using positron emission tomography."3.67[Age-related decrease of 11C-N-methylspiperone in vivo binding to human striatum detected by PET]. ( Fukuda, H; Inoue, O; Ito, T; Iyo, M; Koseki, A; Nishio, M; Shinotoh, H; Suzuki, K; Yamasaki, T; Yonezawa, H, 1989)
"The primary etiology of Parkinson's disease is still unknown, although the aging process may be an important predisposing factor."2.36Parkinson's disease as a model for changes in dopamine receptor dynamics with aging. ( Rinne, UK, 1982)
" Spiroperidol binding (dopamine D2 receptors) and quinuclidinyl benzilate binding (muscarinic receptors) in striata of 19-month old mice was analyzed for animals that had received chronic administration of cytidine 5'-diphosphocholine (CDP-choline) incorporated into the chow consumed (100 or 500 mg kg-1 added per day) for the 7 months before they were killed."1.28Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice. ( Aguilar, J; Giménez, R; Raïch, J, 1991)
"[3H]Spiperone binding to lymphocytes in Parkinson's disease (PD), Wilson's disease (WD), and age-matched control groups was studied."1.27[3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging. ( Członkowska, A; Członkowski, A; Jachowicz-Jeszka, J, 1987)
"A model of minimal brain dysfunction (MBD) in rats based on injection of 6-OH-dopamine (DA) intracisternally on the 5th day of life has been described previously."1.26Dopamine receptors in a rat model of minimal brain dysfunction. ( Belmaker, RH; Brecher-Fride, E; Ebstein, RP; Eisenberg, J; Weizman, R, 1982)
"Atropine alone was shown paradoxically to elicit mild to moderate cataleptic responses in 10- and 15-day-olds, but not at day 20."1.26Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy. ( Baez, LA; Burt, DK; Crowner, ML; Hungerford, SM, 1982)
"It is proposed that the decrement in catalepsy occurring between 10 and 15 days of age is related to increased dopaminergic activity in the neostriatum."1.26Dopaminergic antagonism and catalepsy in the developing rat. ( Baez, LA; Burt, DK; Granneman, J; Shanklin, C, 1979)
"Spiperone produced catalepsy in rats 1, 5 and 10 days old, and also in adults."1.26Postnatal development of dopaminergic and cholinergic catalepsy in the rat. ( Baez, LA; Eskridge, NK; Schein, R, 1976)

Research

Studies (83)

TimeframeStudies, this research(%)All Research%
pre-199059 (71.08)18.7374
1990's23 (27.71)18.2507
2000's1 (1.20)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mastroeni, D1
Grover, A1
Leonard, B1
Joyce, JN2
Coleman, PD1
Kozik, B1
Bellinger, DL1
Rogers, J1
Burchinsky, SG1
Collier, WL1
Iacopino, L1
Amenta, F1
Joseph, JA4
Filburn, CR1
Roth, GS5
Seth, PK1
Chandra, SV1
Powell, DA1
Buchanan, SL1
Hernandez, LL1
O'Boyle, KM1
Waddington, JL1
Severson, JA4
Finch, CE4
Nomura, Y2
Oki, K2
Segawa, T1
Govoni, S2
Memo, M2
Saiani, L1
Spano, PF3
Trabucchi, M3
Marshall, JF1
Drew, MC1
Neve, KA1
Bruinink, A2
Lichtensteiger, W2
Schlumpf, M2
Cimino, M2
Vantini, G2
Algeri, S2
Curatola, G1
Pezzoli, C1
Stramentinoli, G1
Agnati, LF1
Fuxe, K1
Battistini, N1
Benfenati, F1
Henry, JM2
Marcusson, JO1
Morgan, DG1
Winblad, B2
Bartus, RT1
Clody, D1
Morgan, D1
Finch, C1
Beer, B1
Sesack, S1
Arita, J1
Reymond, MJ1
Porter, JC1
Eisenberg, J1
Brecher-Fride, E1
Weizman, R1
Ebstein, RP1
Belmaker, RH1
Roy, EJ1
Sheinkop, S1
Wilson, MA1
Rinne, UK1
Burt, DK2
Hungerford, SM1
Crowner, ML1
Baez, LA3
De Blasi, A1
Mennini, T1
Murrin, LC1
Marcusson, J1
Achilli, G1
Perego, C1
Ponzio, F1
Riederer, P1
Jellinger, K1
Randall, PK2
Papavasiliou, PS1
Miller, ST1
Thal, LJ4
Nerder, LJ1
Houlihan, G1
Rao, SN1
Stevens, JM1
Misra, CH1
Smith, RC1
Horowitz, SG3
Dvorkin, B3
Makman, MH3
Mackay, AV1
Bird, ED1
Iversen, LL1
Spokes, EG1
Creese, I3
Snyder, SH1
Lucchi, L1
Wang, GJ2
Volkow, ND2
Logan, J2
Fowler, JS2
Schlyer, D1
MacGregor, RR2
Hitzemann, RJ1
Gur, RC1
Wolf, AP2
Beas-Zárate, C1
Ortuño-Sahagún, D1
Del Angel Meza, AR1
Feria-Velasco, A1
Kostrzewa, RM2
Guo, J1
Kostrzewa, FP1
Crawford, CA1
Rowlett, JK1
McDougall, SA2
Bardo, MT2
May, T1
Sugawa, M1
Iyo, M3
Yamasaki, T3
Gatley, SJ1
Schlyer, DJ1
Hitzemann, R1
Momose, T1
Sasaki, Y1
Wong, DF2
Young, D1
Wilson, PD1
Meltzer, CC2
Gjedde, A2
Pearlson, GD1
Tune, LE1
Young, LT1
Dannals, RF1
Ravert, HT1
Reith, J1
Kuhar, MJ1
Araki, T1
Kato, H1
Shuto, K1
Fujiwara, T1
Itoyama, Y1
Thomas, WS1
Neal-Beliveau, BS1
Rudner, XL1
Berkowitz, DE1
Booth, JV1
Funk, BL1
Cozart, KL1
D'Amico, EB1
El-Moalem, H1
Page, SO1
Richardson, CD1
Winters, B1
Marucci, L1
Schwinn, DA1
Ahn, HS2
Sharpless, NS2
Rosenfeld, M2
Granneman, J1
Shanklin, C1
Eskridge, NK1
Schein, R1
Ferretti, C2
Blengio, M2
Vigna, I1
Ghi, P2
Genazzani, E1
Yonezawa, H2
Itoh, T1
Fukuda, H2
Inoue, O2
Suhara, T1
Shinotoh, H2
Nishio, M2
Tohgi, H1
Brus, R1
Kalbfleisch, J1
De Keyser, J2
De Backer, JP1
Vauquelin, G2
Ebinger, G2
Greenwood, CE1
Cinader, B2
Giménez, R1
Raïch, J1
Aguilar, J1
Kaseda, Y1
Ghetti, B1
Low, WC1
Norton, J1
Brittain, H1
Triarhou, LC1
Richter, JA1
Simon, JR1
Lange, KW1
Rinne, JO2
Lönnberg, P1
Marjamäki, P1
Camps, M1
Cortés, R1
Gueye, B1
Probst, A1
Palacios, JM1
Suzuki, K1
Ito, T1
Koseki, A1
Han, Z1
Kuyatt, BL1
Kochman, KA1
DeSouza, EB1
Kochman, K2
Neisewander, JL1
Zolman, JF1
Ben-Shachar, D1
Ashkenazi, R1
Youdim, MB1
Sparks, DL1
Hess, EJ1
Bracha, HS1
Kleinman, JE1
Norman, AB1
Battaglia, G1
Leprohon-Greenwood, CE1
Członkowska, A1
Jachowicz-Jeszka, J1
Członkowski, A1
Wagner, HN1
Burchill, SA1
Thody, AJ1
Noisin, EL1
Thomas, WE1
Bonetti, AC1
Bellini, F1
Calderini, G1
Galbiati, E1
Toffano, G1
Peters, DA1
Eva, C1
Bosco, MC1
Portaleone, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults[NCT03512171]Phase 165 participants (Actual)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for spiperone and Aging

ArticleYear
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
    Experimental gerontology, 1984, Volume: 19, Issue:4

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph

1984
Parkinson's disease as a model for changes in dopamine receptor dynamics with aging.
    Gerontology, 1982, Volume: 28 Suppl 1

    Topics: Aged; Aging; Brain; Corpus Striatum; Humans; Models, Biological; Parkinson Disease; Receptors, Dopam

1982
[Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:1

    Topics: Aging; Biomarkers; Carbon Radioisotopes; Corpus Striatum; Diagnosis, Differential; Dopamine Agonists

1997

Other Studies

80 other studies available for spiperone and Aging

ArticleYear
Microglial responses to dopamine in a cell culture model of Parkinson's disease.
    Neurobiology of aging, 2009, Volume: 30, Issue:11

    Topics: Aged; Aging; Antineoplastic Agents; Brain-Derived Neurotrophic Factor; Cells, Cultured; Coculture Te

2009
Changes of [3H]spiroperidol binding in the renal artery of aged rabbits.
    Mechanisms of ageing and development, 1984, Volume: 28, Issue:1

    Topics: Aging; Animals; Butyrophenones; Cyclic AMP; Dopamine; Male; Rabbits; Receptors, Dopamine; Renal Arte

1984
Development of dopamine receptor denervation supersensitivity in the neostriatum of the senescent rat.
    Life sciences, 1981, Aug-10, Volume: 29, Issue:6

    Topics: Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Dextroamphetamine; Ergolines; Female; Male; Moto

1981
Neurotransmitters and neurotransmitter receptors in developing and adult rats during manganese poisoning.
    Neurotoxicology, 1984,Spring, Volume: 5, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Biogenic Amines; Cerebellum; Haplorhini; Manganese Poisoning; Musc

1984
Age-related changes in Pavlovian conditioning: central nervous system correlates.
    Physiology & behavior, 1984, Volume: 32, Issue:4

    Topics: Aging; Animals; Arousal; Brain; Conditioning, Eyelid; Dopamine; Electromyography; Female; Heart Rate

1984
Loss of rat striatal dopamine receptors with ageing is selective for D-2 but not D-1 sites: association with increased non-specific binding of the D-1 ligand [3H]piflutixol.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: Adenylyl Cyclases; Aging; Animals; Antipsychotic Agents; Corpus Striatum; In Vitro Techniques; Kinet

1984
Reduced dopaminergic binding during aging in the rodent striatum.
    Brain research, 1980, Jun-16, Volume: 192, Issue:1

    Topics: Aging; Animals; Apomorphine; Binding, Competitive; Butaclamol; Corpus Striatum; Hypothalamus; Male;

1980
Ontogenetic development of the striatal [3H]spiperone binding: regulation by sodium and guanine nucleotide in rats.
    Journal of neurochemistry, 1982, Volume: 38, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Butaclamol; Butyrophenones; Corpus Striatum; Female; Guanosine Tri

1982
Impairment of brain neurotransmitter receptors in aged rats.
    Mechanisms of ageing and development, 1980, Volume: 12, Issue:1

    Topics: Aging; Animals; Brain; Corpus Striatum; gamma-Aminobutyric Acid; Male; Olfactory Bulb; Pituitary Gla

1980
Recovery of function after mesotelencephalic dopaminergic injury in senescence.
    Brain research, 1983, Jan-24, Volume: 259, Issue:2

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Dominance, Cerebral; Dopamine; Male; Mesencephalon; Ne

1983
Ontogeny of diurnal rhythms of central dopamine, serotonin and spirodecanone binding sites and of motor activity in the rat.
    Life sciences, 1983, Jul-04, Volume: 33, Issue:1

    Topics: Aging; Animals; Brain; Circadian Rhythm; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors

1983
Age-related modification of dopaminergic and beta-Adrenergic receptor system: restoration to normal activity by modifying membrane fluidity with S-adenosylmethionine.
    Life sciences, 1984, May-21, Volume: 34, Issue:21

    Topics: Aging; Animals; Cell Membrane; Cerebral Cortex; Corpus Striatum; Dihydroalprenolol; Kinetics; Membra

1984
Aging brain and dopamine receptors: abnormal regulation by CCK-8 of 3H-spiperone labeled dopamine receptors in striatal membranes.
    Acta physiologica Scandinavica, 1984, Volume: 120, Issue:3

    Topics: Age Factors; Aging; Animals; Butyrophenones; Corpus Striatum; Male; Rats; Rats, Inbred Strains; Rece

1984
Effect of aging on recovery of striatal dopamine receptors following N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) blockade.
    Life sciences, 1984, Aug-20, Volume: 35, Issue:8

    Topics: Aging; Animals; Corpus Striatum; Kinetics; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors,

1984
Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.
    Brain research, 1984, Oct-08, Volume: 311, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Cerebral Cortex; Hippocampus; Humans; Ketanserin; Kinetics; Methyser

1984
Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation.
    Neurobiology of aging, 1983,Winter, Volume: 4, Issue:4

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Haloperidol; Humans; Motor Skills; Rats; Rats, Inbred

1983
Evidence for alteration in the processing of dopamine in the anterior pituitary gland of aged rats: receptors and intracellular compartmentalization of dopamine.
    Endocrinology, 1984, Volume: 114, Issue:3

    Topics: Aging; Animals; Cell Membrane; Dopamine; Female; Kinetics; Luteinizing Hormone; Organ Size; Pituitar

1984
Dopamine receptors in a rat model of minimal brain dysfunction.
    Neuropsychobiology, 1982, Volume: 8, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Caudate Nucleus; Di

1982
Pre- and postnatal ontogeny and characterization of dopaminergic D2, serotonergic S2, and spirodecanone binding sites in rat forebrain.
    Journal of neurochemistry, 1983, Volume: 40, Issue:5

    Topics: Aging; Animals; Binding Sites; Binding, Competitive; Brain; Butyrophenones; Female; Fetus; Kinetics;

1983
Age alters dopaminergic responses to estradiol.
    European journal of pharmacology, 1982, Aug-13, Volume: 82, Issue:1-2

    Topics: Aging; Animals; Apomorphine; Binding, Competitive; Castration; Corpus Striatum; Estradiol; Female; H

1982
Postnatal development of a cholinergic influence on neuroleptic-induced catalepsy.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:4

    Topics: Aging; Animals; Atropine; Brain; Butyrophenones; Clozapine; Dibenzazepines; Dose-Response Relationsh

1982
Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats.
    Brain research, 1982, Jun-24, Volume: 242, Issue:2

    Topics: Aging; Animals; Binding, Competitive; Brain; Cell Membrane; Corpus Striatum; Fluorescent Dyes; Kinet

1982
In vivo studies of dopamine receptor ontogeny.
    Life sciences, 1982, Sep-06, Volume: 31, Issue:10

    Topics: Aging; Animals; Binding, Competitive; Brain; Cerebellum; Corpus Striatum; Kinetics; Rats; Rats, Inbr

1982
Development of inhibitory activity of sulpiride for synaptic [3H]-spiperone binding in the rat striatum.
    Developmental neuroscience, 1982, Volume: 5, Issue:4

    Topics: Aging; Animals; Binding, Competitive; Butyrophenones; Corpus Striatum; Female; Guanosine Triphosphat

1982
Age-correlated loss of dopaminergic binding sites in human basal ganglia.
    Journal of neurochemistry, 1982, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Basal Ganglia; Caudate Nucleus; Child; Child, Preschool; Female; Hum

1982
Study on some compensatory responses of dopaminergic system in aging rats.
    Experimental brain research, 1982, Volume: Suppl 5

    Topics: Aging; Animals; Apomorphine; Butyrophenones; Corpus Striatum; Feedback; Haloperidol; Homovanillic Ac

1982
Morphological and biochemical changes in the aging brain: pathophysiological and possible therapeutic consequences.
    Experimental brain research, 1982, Volume: Suppl 5

    Topics: Aged; Aging; Animals; Brain; Female; Frontal Lobe; Humans; Isoenzymes; Male; Monoamine Oxidase; Orga

1982
Aging and the regulation of striatal dopaminergic mechanisms in mice.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3

    Topics: Aging; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Haloperidol; Humans; Male; Mice; Mice,

1981
Age-related motor and catecholamine alterations in mice on levodopa supplemented diet.
    Life sciences, 1981, Jun-29, Volume: 28, Issue:26

    Topics: Aging; Animals; Brain Chemistry; Catecholamines; Diet; Levodopa; Male; Mice; Motor Activity; Quinucl

1981
Effects of age on dopaminergic supersensitivity induced by chronic fluphenazine.
    Communications in psychopharmacology, 1980, Volume: 4, Issue:5

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Fluphenazine; Kinetics; Rats; Rats, Inbred F344; Spiperon

1980
Evidence for loss of brain [3H]spiroperidil and [3H]ADTN binding sites in rabbit brain with aging.
    Brain research, 1980, Jun-16, Volume: 192, Issue:1

    Topics: Aging; Animals; Binding, Competitive; Brain; Butyrophenones; Corpus Striatum; Frontal Lobe; Limbic S

1980
Dopaminergic abnormalities in postmortem schizophrenic brain.
    Advances in biochemical psychopharmacology, 1980, Volume: 24

    Topics: Aging; Brain Chemistry; Caudate Nucleus; Dopamine; Humans; Kinetics; Nucleus Accumbens; Schizophreni

1980
Aging process affects a single class of dopamine receptors.
    Brain research, 1980, Dec-08, Volume: 202, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aging; Animals; Corpus Striatum; Haloperidol; Hum

1980
Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects.
    Life sciences, 1995, Volume: 56, Issue:14

    Topics: Adult; Aging; Brain; Corpus Striatum; Fluorine Radioisotopes; Frontal Lobe; Humans; Male; Middle Age

1995
Effect of a corn diet during development on [3H]-spiperone binding in the brain of rats at the perinatal stage.
    Comparative biochemistry and physiology. Part A, Physiology, 1995, Volume: 112, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Diet; Embryonic and Fetal Development; Female;

1995
Ontogenetic quinpirole treatment induces vertical jumping activity in rats.
    European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz

1993
Age-dependent differences in the rate of recovery of striatal dopamine D1 and D2 receptors after inactivation with EEDQ.
    European journal of pharmacology, 1994, Feb-03, Volume: 252, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Benzazepines; Dopamine D2 Receptor Antagonists; Female; Injections

1994
Altered dopamine receptor mediated signal transmission in the striatum of aged rats.
    Brain research, 1993, Feb-26, Volume: 604, Issue:1-2

    Topics: Adenylyl Cyclases; Aging; Animals; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine; Fe

1993
The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain.
    Progress in neuro-psychopharmacology & biological psychiatry, 1993, Volume: 17, Issue:3

    Topics: Adult; Aged; Aging; Benzazepines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Female; Humans;

1993
Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol.
    Psychiatry research, 1996, May-31, Volume: 67, Issue:1

    Topics: Adult; Age Factors; Aged; Aging; Cerebellum; Corpus Striatum; Dopamine Agonists; Female; Humans; Lig

1996
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine A

1997
Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Adult; Aged; Aging; Basal Ganglia; Bipolar Disorder; Brain Chemistry; Caudate Nucleus; Chromatograph

1997
Effect of aging on dopaminergic receptors and uptake sites in the rat brain studied by receptor autoradiography.
    Journal of the neurological sciences, 1997, May-29, Volume: 148, Issue:2

    Topics: Aging; Animals; Autoradiography; Benzamides; Benzazepines; Brain Chemistry; Dopamine Antagonists; Do

1997
There is a limited critical period for dopamine's effects on D1 receptor expression in the developing rat neostriatum.
    Brain research. Developmental brain research, 1998, Nov-01, Volume: 111, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Benzazepines; Carrier Proteins; Corpus Striatum; Dopamine; Dopamin

1998
Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.
    Circulation, 1999, Dec-07, Volume: 100, Issue:23

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Aorta; Arteries; Celiac

1999
[3H]Haloperidol and [3H]spiroperidol binding in rat striatum during ageing.
    The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:7

    Topics: Adenylyl Cyclases; Aging; Animals; Binding Sites; Butyrophenones; Corpus Striatum; Dopamine; Haloper

1978
Aging and monoamine receptors in brain.
    Federation proceedings, 1979, Volume: 38, Issue:5

    Topics: Adenylyl Cyclases; Aging; Animals; Biogenic Amines; Brain; Choline O-Acetyltransferase; Dopamine; En

1979
Dopaminergic antagonism and catalepsy in the developing rat.
    European journal of pharmacology, 1979, Feb-15, Volume: 54, Issue:1-2

    Topics: Aging; Animals; Catalepsy; Dopamine; Dopamine Antagonists; Female; Haloperidol; Humans; Male; Rats;

1979
Biogenic amine-stimulated adenylate cyclase and spiroperidol-binding sites in rabbit brain: evidence for selective loss of receptors with aging.
    Advances in experimental medicine and biology, 1978, Volume: 113

    Topics: Adenylyl Cyclases; Aging; Animals; Biogenic Amines; Brain; Butyrophenones; Dopamine; Histamine; Kine

1978
Postnatal development of dopaminergic and cholinergic catalepsy in the rat.
    European journal of pharmacology, 1976, Volume: 36, Issue:1

    Topics: Aging; Animals; Butyrophenones; Catalepsy; Catecholamines; Female; Humans; Male; Neurons; Pilocarpin

1976
Effects of estradiol on the ontogenesis of striatal dopamine D1 and D2 receptor sites in male and female rats.
    Brain research, 1992, Feb-07, Volume: 571, Issue:2

    Topics: Aging; Animals; Benzazepines; Corpus Striatum; Estradiol; Estrus; Female; Male; Rats; Rats, Inbred S

1992
[Effect of aging on in vivo binding of 11C-N-methylspiperone in living human frontal cortex].
    Kaku igaku. The Japanese journal of nuclear medicine, 1991, Volume: 28, Issue:1

    Topics: Adult; Aged; Aging; Carbon Radioisotopes; Dopamine Agents; Frontal Lobe; Humans; Male; Middle Aged;

1991
Ontogenetic homologous sensitization to the antinociceptive action of quinpirole in rats.
    European journal of pharmacology, 1991, Dec-17, Volume: 209, Issue:3

    Topics: Aging; Analgesics; Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Erg

1991
D1 and D2 dopamine receptors in human substantia nigra: localization and the effect of aging.
    Journal of neurochemistry, 1991, Volume: 56, Issue:4

    Topics: Aged; Aging; Benzazepines; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopami

1991
Age-related decline in striatal D2-dopamine receptors is subject to 'economic correction'.
    Gerontology, 1991, Volume: 37, Issue:5

    Topics: Aging; Animals; Corpus Striatum; Dietary Fats; Female; Mice; Mice, Inbred Strains; Receptors, Dopami

1991
Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice.
    British journal of pharmacology, 1991, Volume: 104, Issue:3

    Topics: Aging; Animals; Corpus Striatum; Cytidine Diphosphate Choline; Female; In Vitro Techniques; Membrane

1991
Age-related changes in the human nigrostriatal dopaminergic system.
    Annals of neurology, 1990, Volume: 27, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Corpus Striatum; Dopamine; Female; GTP-Binding

1990
Age-related changes in striatal dopamine D2 receptor binding in weaver mice and effects of ventral mesencephalic grafts.
    Experimental brain research, 1990, Volume: 83, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain Tissue Transplantation; Corpus Striatum; F

1990
Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration.
    European journal of pharmacology, 1990, Jan-03, Volume: 175, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Behavior, Animal; Injections; Male; MP

1990
Age-dependent decline in human brain dopamine D1 and D2 receptors.
    Brain research, 1990, Feb-05, Volume: 508, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Brain; Child; Child, Preschool; Fem

1990
Dopamine receptors in human brain: autoradiographic distribution of D2 sites.
    Neuroscience, 1989, Volume: 28, Issue:2

    Topics: Aging; Autoradiography; Binding Sites; Brain; Female; Humans; Male; Postmortem Changes; Receptors, D

1989
[Age-related decrease of 11C-N-methylspiperone in vivo binding to human striatum detected by PET].
    Kaku igaku. The Japanese journal of nuclear medicine, 1989, Volume: 26, Issue:2

    Topics: Adult; Aged; Aging; Cerebellum; Corpus Striatum; Female; Humans; Male; Middle Aged; Receptors, Dopam

1989
Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum.
    Brain research, 1989, Oct-02, Volume: 498, Issue:2

    Topics: Aging; Animals; Autoradiography; Cell Count; Corpus Striatum; Diagnosis, Computer-Assisted; Male; Ne

1989
Reduction of motor behavioural deficits in senescence via chronic prolactin or estrogen administration: time course and putative mechanisms of action.
    Brain research, 1989, Dec-29, Volume: 505, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Estrogens; Female; Male; Motor Activity; Oxotremorine; Pr

1989
Ontogenetic changes in [3H]-spiroperidol binding sites in posthatch chick brain.
    Life sciences, 1989, Volume: 44, Issue:20

    Topics: Aging; Brain; Cerebellum; Diencephalon; Receptors, Dopamine; Spiperone; Superior Colliculi; Telencep

1989
Long-term consequence of early iron-deficiency on dopaminergic neurotransmission in rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1986, Volume: 4, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Apomorphine; Brain; Dopamine; Iron; Iron Deficiencies; Motor Activ

1986
Aging and Alzheimer's disease. Altered cortical serotonergic binding.
    Archives of neurology, 1989, Volume: 46, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cerebral Cortex; Frontal Lobe; Humans; Middle Age

1989
Dopamine receptor subtype imbalance in schizophrenia.
    Life sciences, 1987, Apr-13, Volume: 40, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Aging; Benzazepines; Brain; Female; Humans; Male; Middle Aged; Recep

1987
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:5

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techn

1987
Variations in age-related decline in striatal D2-dopamine receptors in a variety of mouse strains.
    Mechanisms of ageing and development, 1987, Volume: 38, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Female; Kinetics; Mice; Mice, Inbred Strains; Receptors, Dopamine;

1987
Effect of aging on striatal dopamine receptor subtype recovery following N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline blockade and relation to motor function in Wistar rats.
    Brain research, 1987, Aug-25, Volume: 418, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Male; Motor Activity; Quinolines; Rats; Rats, Inbred Strains; Recep

1987
[3H]spiperone binding to lymphocyte in extrapyramidal disease and in aging.
    Brain, behavior, and immunity, 1987, Volume: 1, Issue:3

    Topics: Adult; Aged; Aging; Antiparkinson Agents; Female; Hepatolenticular Degeneration; Humans; Lymphocytes

1987
Radiolabeled drugs as probes of central nervous system neurons.
    Clinical chemistry, 1985, Volume: 31, Issue:9

    Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Female; Fentanyl; Forecasting; Humans; Isotope Labeling;

1985
Dopaminergic inhibition of tyrosinase activity in hair follicular melanocytes of the mouse.
    The Journal of endocrinology, 1986, Volume: 111, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Benzazepines; Bromocript

1986
D-2 dopamine receptors in aging mouse striatum: determination of high- and low-affinity agonist binding sites.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:2

    Topics: Aging; Animals; Binding Sites; Binding, Competitive; Corpus Striatum; Dopamine; GTP-Binding Proteins

1985
Ontogeny of dopaminergic function in the rat midbrain tegmentum, corpus striatum and frontal cortex.
    Brain research, 1988, Jun-01, Volume: 469, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Cell Membrane; Cerebral Cortex; Corpus Stria

1988
Muscarinic and dopaminergic receptors in the aging human brain.
    Brain research, 1987, Feb-24, Volume: 404, Issue:1-2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Brain; Child; Child, Preschool; Flupenthixol; Hum

1987
Age-dependent changes in the mechanisms controlling prolactin secretion and phosphatidylinositol turnover in male rats: effect of phosphatidylserine.
    Neuroendocrinology, 1987, Volume: 45, Issue:2

    Topics: Aging; Animals; Dopamine; In Vitro Techniques; Kinetics; Liposomes; Male; Phosphatidylcholines; Phos

1987
Prenatal stress: effect on development of rat brain serotonergic neurons.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5

    Topics: Aging; Animals; Circadian Rhythm; Female; Kinetics; Motor Activity; Neurons; Pregnancy; Prenatal Exp

1986
The effects of a long term dihydroergotoxine treatment on agonist and antagonist striatal dopamine binding sites are dose and age related.
    Pharmacological research communications, 1986, Volume: 18, Issue:10

    Topics: Aging; Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dihydroergotoxine; Dose-Response

1986