sphingosine-kinase has been researched along with Tongue-Neoplasms* in 1 studies
1 other study(ies) available for sphingosine-kinase and Tongue-Neoplasms
| Article | Year |
|---|---|
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.
We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of SphK1 and SGPP1 genes was up-regulated significantly in 70% and 75% OSCC tumors respectively. Importantly, expression of SphK2 and PPAP2B was down-regulated in the tumor tissues of 70% OSCC patients. Expression of SphK2 and PPAP2B negatively correlated with tumor-node-metastasis (TNM) staging and tumor volume respectively. Furthermore, LPP1 is an independent predictor of TNM staging and lymph node ratio. Topics: Adult; Aged; Female; Humans; Lip Neoplasms; Lysophospholipids; Male; Membrane Proteins; Middle Aged; Mouth Neoplasms; Neoplasm Staging; Phosphatidate Phosphatase; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Real-Time Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Tongue Neoplasms; Young Adult | 2017 |