sphingosine-kinase has been researched along with Renal-Insufficiency--Chronic* in 2 studies
1 review(s) available for sphingosine-kinase and Renal-Insufficiency--Chronic
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Sphingolipid signaling in renal fibrosis.
Over the last decade, various sphingolipid subspecies have gained increasing attention as important signaling molecules that regulate a multitude of physiological and pathophysiological processes including inflammation and tissue remodeling. These mediators include ceramide, sphingosine 1-phosphate (S1P), the cerebroside glucosylceramide, lactosylceramide, and the gangliosides GM3 and Gb3. These lipids have been shown to accumulate in various chronic kidney diseases that typically end in renal fibrosis and ultimately renal failure. This review will summarize the effects and contributions of those enzymes that regulate the generation and interconversion of these lipids, notably the acid sphingomyelinase, the acid sphingomyelinase-like protein SMPDL3B, the sphingosine kinases, the S1P lyase, the glucosylceramide synthase, the GM3 synthase, and the α-galactosidase A, to renal fibrotic diseases. Strategies of manipulating these enzymes for therapeutic purposes and the impact of existing drugs on renal pathologies will be discussed. Topics: alpha-Galactosidase; Animals; Fibrosis; Humans; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Renal Insufficiency, Chronic; Serine Endopeptidases; Sialyltransferases; Signal Transduction; Sphingolipids; Sphingomyelin Phosphodiesterase | 2018 |
1 other study(ies) available for sphingosine-kinase and Renal-Insufficiency--Chronic
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Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?
Undernutrition during childhood leads to chronic diseases in adult life including hypertension, diabetes and chronic kidney disease. Here we explore the hypothesis that physiological alterations in the bioactive lipids pattern within kidney tissue might be involved in the progression of chronic kidney disease.. Membrane fractions from kidney homogenates of undernourished rats (RBD) were submitted to lipid extraction and analysis by thin layer chromatography and cholesterol determination.. Kidneys from RBD rats had 25% lower cholesterol content, which disturb membrane microdomains, affecting Ca. Results point to an imbalance in the bioactive lipid generation with further consequences to key events related to kidney function, thus contributing to the establishment of chronic kidney disease. Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Animals, Newborn; Ceramides; Cholesterol; Diacylglycerol Kinase; Gene Expression Regulation; Hypertension; Kidney; Lipid Metabolism; Male; Malnutrition; Membrane Microdomains; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phospholipases A2; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Renal Insufficiency, Chronic | 2017 |