sphingosine-kinase has been researched along with Lymphoma--Mantle-Cell* in 1 studies
1 other study(ies) available for sphingosine-kinase and Lymphoma--Mantle-Cell
Article | Year |
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Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma.
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin's lymphoma. Despite being responsive to combination chemotherapy, median survival remains around 5 years due to high rates of relapse. Sphingolipid metabolism regulates MCL survival and proliferation and we found that sphingosine-1-phosphate (S1P) is upregulated in MCL cells. Therapeutic targeting of the S1P Topics: Animals; Antigens, CD1d; Cardiolipins; Cell Line, Tumor; Humans; Lymphocyte Activation; Lymphoma, Mantle-Cell; Lysophospholipids; Mice, Inbred C57BL; Natural Killer T-Cells; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine | 2020 |