Thorax, 2019, Volume: 74, Issue:6
Dysregulated sphingolipid metabolism has been implicated in the pathogenesis of various pulmonary disorders. Nuclear sphingosine-1-phosphate (S1P) has been shown to regulate histone acetylation, and therefore could mediate pro-inflammatory genes expression.. Profile of sphingolipid species in bronchoalveolar lavage fluids and lung tissue of mice challenged with. Genetic deletion of. Our studies define a critical role for nuclear SPHK2/S1P signalling in epigenetic regulation of bacterial-mediated inflammatory lung injury. Targeting SPHK2 may represent a potential strategy to reduce lung inflammatory pulmonary disorders such as pneumonia and CF. Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Epigenesis, Genetic; Inflammation; Lung Injury; Lysophospholipids; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Signal Transduction; Sphingosine | 2019 |