sphingosine-1-phosphate has been researched along with Cystitis* in 3 studies
3 other study(ies) available for sphingosine-1-phosphate and Cystitis
| Article | Year |
|---|---|
Modulations of urinary lipid mediators in acute bladder cystitis.
Bioactive lipids, such as lysophospholipids, ceramides, and eicosanoids and related mediators, have been demonstrated to be involved in inflammation. We aimed to investigate the possible orchestral modulations of these bioactive lipids in human inflammation. We simultaneously measured the urinary levels of lysophospholipids, ceramides, and eicosanoids and related mediators by a liquid chromatography-mass spectrometry method in patients with cystitis and control subjects. The urinary levels of lysophosphatidylcholine, lysophosphatidylethanolamine, sphingosine 1-phosphate, ceramides, prostaglandin (PG)E Topics: Ceramides; Cystitis; Dinoprostone; Eicosanoids; Humans; Inflammation; Lysophosphatidylcholines; Lysophospholipids; Urinary Bladder | 2023 |
Determination of the roles of cADPR and NAADP as intracellular calcium mobilizing messengers in S1P-induced contractions in rat bladders having IC/PBS.
Interstitial cystitis/painful bladder syndrome (IC/PBS) is characterized by lower abdominal pain and increased frequency and urgency of urine. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that plays role in calcium homeostasis in smooth muscle. The intracellular calcium mobilizing secondary messengers are also involved in smooth muscle contraction. The role of intracellular calcium storing depots in S1P-induced contraction was investigated in permeabilized detrusor smooth muscle having cystitis.. IC/PBS was induced by cyclophosphamide injection. The detrusor smooth muscle strips isolated from rats were permeabilized with β-escin.. S1P-induced contraction was increased in cystitis. S1P-induced enhanced contraction was inhibited by cyclopiazonic acid, ryanodine and heparin showing involvement of sarcoplasmic reticulum (SR) calcium stores. Inhibition of S1P-induced contraction by bafilomycin and NAADP suggested the participation of lysosome-related organelles.. IC/PBS triggers S1P-induced increase in intracellular calcium from SR and lysosome-related organelles in permeabilized detrusor smooth muscle. Topics: Animals; Calcium; Calcium, Dietary; Cyclic ADP-Ribose; Cystitis; Cystitis, Interstitial; Muscle Contraction; NADP; Rats | 2023 |
Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis.
Interstitial cystitis is a chronic disease characterized by lower abdominal pain and some nonspecific symptoms including an increase in urinary frequency and urgency. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that controls smooth muscle tone via G-protein coupled receptors (S1P Topics: Amides; Animals; Calcium; Cystitis; Female; Gene Expression Regulation; Indoles; Lysophospholipids; Maleimides; Muscle Contraction; Muscle, Smooth; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Urinary Bladder | 2017 |