sphingosine-1-phosphate and Adenomyosis

Is sphingosine 1-phosphate (S1P) pathway involved in the process of fibrosis in adenomyosis?. RNA was extracted from paraffin-embedded slices collected from the ectopic endometrium of patients with nodular adenomyosis (n = 27) and eutopic endometrium of healthy controls women (n = 29). Expression of genes involved in the metabolism and signalling of S1P, and actin-alpha-2 smooth muscle, encoded by ACTA2 gene, a gene involved in fibrogenesis, was evaluated by real-time polymerase chain reaction analysis.. Present data show a profound dysregulation of the S1P signalling axis in adenomyosis. This study also highlights that the bioactive sphingolipid might be involved in the fibrotic tract of the disease, correlated with the expression of ACTA2, suggesting its role as novel potential biomarker of adenomyosis.

Topics: Adenomyosis; Female; Fibrosis; Humans; Lysophospholipids; RNA, Messenger; Sphingosine