sphingosine-1-phosphate and Adenomatous-Polyposis-Coli

To remove dying or unwanted cells from an epithelium while preserving the barrier function of the layer, epithelia use a unique process called cell extrusion. To extrude, the cell fated to die emits the lipid Sphingosine 1 Phosphate (S1P), which binds the G-protein-coupled receptor Sphingosine 1 Phosphate receptor 2 (S1P

Topics: Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Cell Movement; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Humans; Listeria monocytogenes; Lysophospholipids; Neuronal Apoptosis-Inhibitory Protein; Proto-Oncogene Proteins p21(ras); Receptors, Lysosphingolipid; Salmonella typhimurium; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Transcription Factors