spermine has been researched along with Weight Loss in 7 studies
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear." | 7.91 | Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. ( Andrews, ZB; Cowley, MA; Dodd, GT; Eramo, M; Henry, BA; Mitchell, CA; Tiganis, T; Xirouchaki, CE, 2019) |
| "The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear." | 3.91 | Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. ( Andrews, ZB; Cowley, MA; Dodd, GT; Eramo, M; Henry, BA; Mitchell, CA; Tiganis, T; Xirouchaki, CE, 2019) |
| "We describe the pharmacological properties of a novel spermine-cholesterol adduct, MSI 1436 (3beta-N-1(spermine)-7alpha, 24R-dihydroxy-5alpha-cholestane 24-sulfate), which causes reversible suppression of food and fluid intake in mammals resulting in profound weight loss, not associated with other signs or symptoms of illness, and which exhibits antidiabetic properties in genetically obese mice." | 3.71 | A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. ( Anderson, M; Chen, Q; Cheshire, K; Holroyd, K; Jones, S; Kinney, W; Maeder, T; McLane, M; Williams, JI; Zasloff, M, 2001) |
| " We show that a spermine metabolite of cholesterol (MSI-1436) decreases body weight, specifically fat, by suppressing feeding and preventing the reduction in energy expenditure, hormonal changes, and patterns of neuropeptide expression normally associated with weight loss." | 3.71 | Appetite suppression and weight reduction by a centrally active aminosterol. ( Ahima, RS; Hileman, SM; Patel, HR; Qi, Y; Takahashi, N; Zasloff, MA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dodd, GT | 1 |
| Xirouchaki, CE | 1 |
| Eramo, M | 1 |
| Mitchell, CA | 1 |
| Andrews, ZB | 1 |
| Henry, BA | 1 |
| Cowley, MA | 1 |
| Tiganis, T | 1 |
| Thompson, D | 1 |
| Morrice, N | 1 |
| Grant, L | 1 |
| Le Sommer, S | 1 |
| Lees, EK | 1 |
| Mody, N | 1 |
| Wilson, HM | 1 |
| Delibegovic, M | 1 |
| Qin, Z | 1 |
| Pandey, NR | 1 |
| Zhou, X | 1 |
| Stewart, CA | 1 |
| Hari, A | 1 |
| Huang, H | 1 |
| Stewart, AF | 1 |
| Brunel, JM | 1 |
| Chen, HH | 1 |
| Lantz, KA | 1 |
| Hart, SG | 1 |
| Planey, SL | 1 |
| Roitman, MF | 1 |
| Ruiz-White, IA | 1 |
| Wolfe, HR | 1 |
| McLane, MP | 1 |
| Kobayashi, M | 1 |
| Watanabe, T | 1 |
| Xu, YJ | 1 |
| Tatemori, M | 1 |
| Goda, H | 1 |
| Niitsu, M | 1 |
| Shirahata, A | 1 |
| Samejima, K | 1 |
| Zasloff, M | 1 |
| Williams, JI | 1 |
| Chen, Q | 1 |
| Anderson, M | 1 |
| Maeder, T | 1 |
| Holroyd, K | 1 |
| Jones, S | 1 |
| Kinney, W | 1 |
| Cheshire, K | 1 |
| McLane, M | 1 |
| Ahima, RS | 1 |
| Patel, HR | 1 |
| Takahashi, N | 1 |
| Qi, Y | 1 |
| Hileman, SM | 1 |
| Zasloff, MA | 1 |
7 other studies available for spermine and Weight Loss
| Article | Year |
|---|---|
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.
Topics: Adipose Tissue, White; Administration, Intranasal; Animals; Blood-Brain Barrier; Cholestanes; Diet, | 2019 |
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Blood G | 2017 |
Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound.
Topics: Animals; Cells, Cultured; Cholestanes; Diabetes Mellitus, Experimental; Eating; Enzyme Inhibitors; G | 2015 |
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Topics: Animals; Appetite; Body Composition; Cholestanes; Diet; Disease Models, Animal; Hep G2 Cells; Humans | 2010 |
Control of spermidine and spermine levels in rat tissues by trans-4-methylcyclohexylamine, a spermidine-synthase inhibitor.
Topics: Alkenes; Animals; Cyclohexylamines; Dose-Response Relationship, Drug; Down-Regulation; Drug Administ | 2005 |
A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.
Topics: Animals; Appetite Depressants; Cholestanes; Diabetes Mellitus; Disease Models, Animal; Dogfish; Drin | 2001 |
Appetite suppression and weight reduction by a centrally active aminosterol.
Topics: Animals; Anticarcinogenic Agents; Appetite Depressants; Brain; Cerebral Ventricles; Cholestanes; Cho | 2002 |