spermine has been researched along with Trypanosomiasis, African in 3 studies
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishimura, K | 1 |
| Yanase, T | 1 |
| Araki, N | 1 |
| Ohnishi, Y | 1 |
| Kozaki, S | 1 |
| Shima, K | 1 |
| Asakura, M | 1 |
| Samosomsuk, W | 1 |
| Yamasaki, S | 1 |
| Clarkson, AB | 1 |
| Bacchi, CJ | 2 |
| Mellow, GH | 1 |
| Nathan, HC | 2 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Hutner, SH | 1 |
| Duch, DS | 1 |
| Nichol, CA | 1 |
3 other studies available for spermine and Trypanosomiasis, African
| Article | Year |
|---|---|
Effects of polyamines on two strains of Trypanosoma brucei in infected rats and in vitro culture.
Topics: Amide Synthases; Animals; Culture Media; Eflornithine; Enzyme Inhibitors; Gene Expression Regulation | 2006 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.
Topics: Amidines; Animals; Carbanilides; Female; Imidocarb; Male; Mice; Polyamines; Spermidine; Spermine; Tr | 1981 |