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spermine and Pulmonary Hypertension

spermine has been researched along with Pulmonary Hypertension in 11 studies

Research Excerpts

ExcerptRelevanceReference
" In support of this contention, we have shown in rat models of monocrotaline (MCT)- and chronic hypoxia-induced pulmonary hypertension that whole-lung polyamine contents are elevated and that blockade of polyamine synthesis forestalls development of hypertensive pulmonary vascular remodeling and sustained pulmonary hypertension."7.67Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension. ( Gillespie, MN; Olson, JW; Orlinska, U, 1988)
"Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration."5.27Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984)
" Using animal models of pulmonary hypertension, our data showed that CaSR expression and function were both enhanced in PASMC, whereas intraperitoneal injection of the calcilytic NPS 2143 prevented the development of pulmonary hypertension and right ventricular hypertrophy in rats injected with monocrotaline and mice exposed to hypoxia."3.78Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. ( Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM, 2012)
" In support of this contention, we have shown in rat models of monocrotaline (MCT)- and chronic hypoxia-induced pulmonary hypertension that whole-lung polyamine contents are elevated and that blockade of polyamine synthesis forestalls development of hypertensive pulmonary vascular remodeling and sustained pulmonary hypertension."3.67Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension. ( Gillespie, MN; Olson, JW; Orlinska, U, 1988)
"Spermine treatment significantly promoted PASMC proliferation, which was significantly inhibited by U50,488H, p38 inhibitor SB203580, JNK inhibitor SP600125, Erk inhibitor SCH772984, and MEK inhibitor U0126, especially Erk inhibitor (P < 0."1.56The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development. ( Cao, Z; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Liu, M; Pei, J; Wang, X; Wang, Y; Zhang, S, 2020)
"In the treatment of pulmonary hypertension, this pathway is exogenously activated using inhaled NO or other pharmacological agents."1.37Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. ( Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C, 2011)
"Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60."1.28Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990)
"Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration."1.27Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19902 (18.18)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Li, J1
Jia, M1
Liu, M2
Cao, Z1
Wang, X1
Feng, N1
Gu, X1
Zhang, S1
Fan, R1
Guo, H1
Wang, Y1
Pei, J1
Zhu, L1
Xiao, R1
Zhang, X1
Lang, Y1
Liu, F1
Yu, Z1
Zhang, J1
Su, Y1
Lu, Y1
Wang, T1
Luo, S1
Wang, J1
Liu, ML1
Dupuis, J1
Jing, ZC1
Li, T1
Xiong, W1
Hu, Q1
Wei, C1
Li, HZ1
Wang, YH1
Peng, X1
Shao, HJ1
Li, HX1
Bai, SZ1
Lu, XX1
Wu, LY1
Wang, R1
Xu, CQ1
Aggarwal, S1
Gross, CM1
Kumar, S1
Datar, S1
Oishi, P1
Kalkan, G1
Schreiber, C1
Fratz, S1
Fineman, JR1
Black, SM1
Yamamura, A1
Guo, Q1
Yamamura, H1
Zimnicka, AM1
Pohl, NM1
Smith, KA1
Fernandez, RA1
Zeifman, A1
Makino, A1
Dong, H1
Yuan, JX1
Jernigan, NL1
Broughton, BR1
Walker, BR2
Resta, TC2
Olson, JW4
Hacker, AD1
Altiere, RJ1
Gillespie, MN4
Kanagy, NL1
Babal, P1
Ruchko, M1
Ault-Ziel, K1
Cronenberg, L1
Shiao, RT1
Kostenbauder, HB1
Orlinska, U1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369]Phase 10 participants (Actual)Interventional2014-12-31Withdrawn (stopped due to Changes to cardiac surgery program)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

11 other studies available for spermine and Pulmonary Hypertension

ArticleYear
The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; C

2020
Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.
    Arteriosclerosis, thrombosis, and vascular biology, 2019, Volume: 39, Issue:3

    Topics: Animals; Benzamides; Biological Transport; Calcium; Calcium Signaling; Cyclohexylamines; Endothelial

2019
Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways.
    International journal of molecular medicine, 2016, Volume: 37, Issue:1

    Topics: Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypoxia; MAP

2016
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
    Journal of cellular physiology, 2011, Volume: 226, Issue:12

    Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Depen

2011
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
    Circulation research, 2012, Aug-03, Volume: 111, Issue:4

    Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultu

2012
Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:3

    Topics: Animals; Bronchodilator Agents; Calcium; Calcium Channels; Calcium-Transporting ATPases; Chronic Dis

2006
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
    The American journal of physiology, 1984, Volume: 247, Issue:4 Pt 2

    Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertens

1984
Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Chronic Disease; Endoth

2001
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:4

    Topics: Animals; Blotting, Western; Carbon Radioisotopes; Cattle; Cells, Cultured; Endothelium, Vascular; En

2002
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
    The American journal of physiology, 1990, Volume: 259, Issue:6 Pt 1

    Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv

1990
Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 62, Issue:2

    Topics: Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Polyamines; Pulmonary Artery; Putrescin

1988