spermine has been researched along with Prostatic Neoplasms in 59 studies
Prostatic Neoplasms: Tumors or cancer of the PROSTATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the in vitro and in vivo antitumor potential of the polyamine analog N(1), N(11)-diethylnorspermine (DENSpm) in human prostate carcinoma cells was examined." | 7.70 | Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. ( Deli, G; Deloyer, P; Lange, WP; Schalken, JA; Schipper, RG; Verhofstad, AA, 2000) |
| " In this study, the in vitro and in vivo antitumor potential of the polyamine analog N(1), N(11)-diethylnorspermine (DENSpm) in human prostate carcinoma cells was examined." | 3.70 | Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. ( Deli, G; Deloyer, P; Lange, WP; Schalken, JA; Schipper, RG; Verhofstad, AA, 2000) |
| "Urinary excretion of the basic polyamine, spermidine, was significantly elevated in patients with prostatic carcinoma as compared to a control group of patients, Of 44 urine specimens from patients with prostatic malignancy 31 had spermidine levels more than 2 mg." | 3.65 | Urinary polyamine levels in the diagnosis of carcinoma of the prostate. ( Brorsson, U; Fair, WR; Wehner, N, 1975) |
| "Beyond the specific implications for prostate cancer, this work establishes a much-needed model for the evaluation, cross-validation, and comparison of multiple cancer profiling studies." | 2.41 | Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. ( Barrette, TR; Chinnaiyan, AM; Ghosh, D; Rhodes, DR; Rubin, MA, 2002) |
| "Spermine has been considered as an endogenous inhibitor for prostate-confined cancer growth and its expression has shown correlation with prostate cancer growth rates." | 1.91 | ( Chen, S; Cheng, LL; Grant, A; Habbel, P; Li, B; Malloy, C; Mason, RP; Nowak, J; Vandergrift, LA; Wang, N; Wang, Y; Zhu, M, 2023) |
| "Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care." | 1.46 | Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy. ( Bathen, TF; Berge, V; Bertilsson, H; Braadland, PR; Eri, LM; Euceda, LR; Giskeødegård, G; Grytli, HH; Guldvik, IJ; Hansen, AF; Katz, B; Nygård, S; Sandsmark, E; Selnæs, KM; Svindland, A; Taskén, KA; Tessem, MB, 2017) |
| "Forty-six prostate cancer patients were scanned at 3T." | 1.46 | Quantification of metabolite concentrations in benign and malignant prostate tissues using 3D proton MR spectroscopic imaging. ( Ahlström, H; Häggman, M; Ladjevardi, S; Ortiz-Nieto, F; Tolf, A; von Below, C; Wassberg, C; Weis, J, 2017) |
| "Fifty-seven prostate cancer patients underwent an MR examination followed by prostatectomy." | 1.43 | Contribution of Histopathologic Tissue Composition to Quantitative MR Spectroscopy and Diffusion-weighted Imaging of the Prostate. ( Bruggink, CC; Hambrock, T; Heerschap, A; Hulsbergen-van de Kaa, CA; Kobus, T; Maas, MC; Scheenen, TW; van der Laak, JA, 2016) |
| "PCa, benign prostatic hyperplasia (BPH) patients and healthy controls (HC) showing PSA>4." | 1.43 | Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers. ( Chan, CF; Chan, WL; Chiu, KF; Ng, CF; Tsoi, TH; Wong, KL; Wong, WT, 2016) |
| "Separating indolent from aggressive prostate cancer is an important clinical challenge for identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment." | 1.39 | Spermine and citrate as metabolic biomarkers for assessing prostate cancer aggressiveness. ( Angelsen, A; Bathen, TF; Bertilsson, H; Giskeødegård, GF; Gribbestad, IS; Halgunset, J; Selnæs, KM; Tessem, MB; Viset, T; Wright, AJ, 2013) |
| "In 14 prostate cancer patients who had a final pathologic Gleason scores of i) (3 + 4 = 7, n = 7) and ii) (4 + 3 = 7, n = 7), the metabolite ratios (mean +/- SD) of (Cho + Cr)/Cit and (Cho + Cr)/Spm were calculated using the 2D JPRESS spectra as follows: i) (1." | 1.36 | Correlation of endorectal 2D JPRESS findings with pathological Gleason scores in prostate cancer patients. ( Gomez, AM; Margolis, DJ; McClure, T; Nagarajan, R; Raman, SS; Thomas, MA, 2010) |
| "Statistical data from prostate cancer (PCa) clinics indicates that a large patient population discovered by annual prostate specific antigen (PSA) screening may have a latent form of the disease." | 1.36 | Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. ( Adkins, CB; Cheng, LL; Defeo, EM; Habbel, P; Jordan, KW; Kaul, D; McDougal, WS; Peterson, RT; Pohl, U; Wu, CL, 2010) |
| "Spermine levels were reduced in tumor tissue, especially in prostatic carcinoma with metastases, and in xenografts of human prostatic carcinoma cells." | 1.31 | Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer. ( Heerschap, A; Oosterhof, GO; Schalken, JA; Schipper, RG; van der Graaf, M; Verhofstad, AA, 2000) |
| "Four cultured human prostate cancer cell lines (LnCap, DU145, DuPro, and PC-3) were treated with the new tetramines to examine their effects on cell growth with a MTT assay." | 1.31 | Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cells. ( Basu, HS; Frydman, B; Marton, LJ; Reddy, VK; Sarkar, A; Valasinas, A, 2001) |
| "Exposure of BIS-treated PC-3 prostate cancer cells to gamma-irradiation resulted in a significant increase in the number of cells undergoing apoptosis and a subsequent decrease in the IC50." | 1.30 | Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer. ( Callery, PS; Eiseman, JL; Guo, Y; Kauffman, J; Klinger, MF; Kyprianou, N; Rogers, FA; Sentz, DL, 1998) |
| "Spermine uptake was similar in both the sensitive and resistant cell lines." | 1.30 | Sensitivity to polyamine-induced growth arrest correlates with antizyme induction in prostate carcinoma cells. ( Chao, DT; Koike, C; Zetter, BR, 1999) |
| "There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients." | 1.26 | Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982) |
| "Only 17% of the patients with breast carcinoma had elevated levels of spermine, although there was a significant difference in the concentrations of the breast cancer group of patients compared to normals." | 1.26 | Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate. ( Chaisiri, P; Griffiths, K; Harper, ME, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (22.03) | 18.7374 |
| 1990's | 11 (18.64) | 18.2507 |
| 2000's | 13 (22.03) | 29.6817 |
| 2010's | 15 (25.42) | 24.3611 |
| 2020's | 7 (11.86) | 2.80 |
| Authors | Studies |
|---|---|
| Jupin, M | 1 |
| van Heijster, FHA | 1 |
| Heerschap, A | 4 |
| Zaletok, SP | 1 |
| Klenov, OO | 1 |
| Bentrad, VV | 1 |
| Prylutskyi, MP | 1 |
| Vitruk, YV | 1 |
| Stakhovsky, EO | 1 |
| Timoshenko, AV | 1 |
| Laginha, RC | 1 |
| Martins, CB | 1 |
| Brandão, ALC | 1 |
| Marques, J | 1 |
| Marques, MPM | 1 |
| Batista de Carvalho, LAE | 1 |
| Santos, IP | 1 |
| Batista de Carvalho, ALM | 1 |
| Vandergrift, LA | 1 |
| Wang, N | 1 |
| Zhu, M | 1 |
| Li, B | 1 |
| Chen, S | 1 |
| Habbel, P | 2 |
| Nowak, J | 1 |
| Mason, RP | 1 |
| Grant, A | 1 |
| Wang, Y | 1 |
| Malloy, C | 1 |
| Cheng, LL | 2 |
| Affronti, HC | 1 |
| Rowsam, AM | 1 |
| Pellerite, AJ | 1 |
| Rosario, SR | 1 |
| Long, MD | 1 |
| Jacobi, JJ | 1 |
| Bianchi-Smiraglia, A | 1 |
| Boerlin, CS | 1 |
| Gillard, BM | 1 |
| Karasik, E | 1 |
| Foster, BA | 1 |
| Moser, M | 1 |
| Wilton, JH | 1 |
| Attwood, K | 1 |
| Nikiforov, MA | 1 |
| Azabdaftari, G | 1 |
| Pili, R | 1 |
| Phillips, JG | 1 |
| Casero, RA | 2 |
| Smiraglia, DJ | 1 |
| Chiu, PK | 2 |
| Fung, YH | 1 |
| Teoh, JY | 2 |
| Chan, CH | 1 |
| Lo, KL | 1 |
| Li, KM | 1 |
| Tse, RT | 1 |
| Leung, CH | 1 |
| Wong, YP | 1 |
| Roobol, MJ | 1 |
| Wong, KL | 2 |
| Ng, CF | 3 |
| Peng, Q | 1 |
| Wong, CY | 1 |
| Cheuk, IW | 1 |
| Braadland, PR | 1 |
| Giskeødegård, G | 1 |
| Sandsmark, E | 2 |
| Bertilsson, H | 4 |
| Euceda, LR | 1 |
| Hansen, AF | 2 |
| Guldvik, IJ | 1 |
| Selnæs, KM | 3 |
| Grytli, HH | 1 |
| Katz, B | 1 |
| Svindland, A | 1 |
| Bathen, TF | 3 |
| Eri, LM | 1 |
| Nygård, S | 1 |
| Berge, V | 1 |
| Taskén, KA | 1 |
| Tessem, MB | 4 |
| Giskeødegård, GF | 1 |
| Wright, AJ | 2 |
| Viset, T | 2 |
| Halgunset, J | 1 |
| Angelsen, A | 3 |
| Gribbestad, IS | 2 |
| Kolhatkar, V | 1 |
| Khambati, H | 1 |
| Lote, A | 1 |
| Shanine, P | 1 |
| Insley, T | 1 |
| Sen, S | 1 |
| Munirathinam, G | 1 |
| Král, P | 1 |
| Kolhatkar, R | 1 |
| Basharat, M | 1 |
| Payne, GS | 1 |
| Morgan, VA | 1 |
| Parker, C | 1 |
| Dearnaley, D | 1 |
| deSouza, NM | 1 |
| Kobus, T | 1 |
| van der Laak, JA | 1 |
| Maas, MC | 1 |
| Hambrock, T | 1 |
| Bruggink, CC | 1 |
| Hulsbergen-van de Kaa, CA | 1 |
| Scheenen, TW | 1 |
| Rye, MB | 1 |
| Richardsen, E | 1 |
| Bofin, AM | 1 |
| Dezortova, M | 1 |
| Jiru, F | 1 |
| Skoch, A | 1 |
| Capek, V | 1 |
| Ryznarova, Z | 1 |
| Vik, V | 1 |
| Hajek, M | 1 |
| Weis, J | 1 |
| von Below, C | 1 |
| Tolf, A | 1 |
| Ortiz-Nieto, F | 1 |
| Wassberg, C | 1 |
| Häggman, M | 1 |
| Ladjevardi, S | 1 |
| Ahlström, H | 1 |
| Tsoi, TH | 1 |
| Chan, CF | 1 |
| Chan, WL | 1 |
| Chiu, KF | 1 |
| Wong, WT | 1 |
| Nagarajan, R | 1 |
| Gomez, AM | 1 |
| Raman, SS | 1 |
| Margolis, DJ | 1 |
| McClure, T | 1 |
| Thomas, MA | 2 |
| Nayvelt, I | 1 |
| Hyvönen, MT | 1 |
| Alhonen, L | 1 |
| Pandya, I | 1 |
| Thomas, T | 1 |
| Khomutov, AR | 1 |
| Vepsäläinen, J | 1 |
| Patel, R | 1 |
| Keinänen, TA | 1 |
| Thomas, TJ | 1 |
| Kaul, D | 1 |
| Wu, CL | 1 |
| Adkins, CB | 1 |
| Jordan, KW | 1 |
| Defeo, EM | 1 |
| Peterson, RT | 1 |
| McDougal, WS | 1 |
| Pohl, U | 1 |
| García-Martín, ML | 1 |
| Adrados, M | 1 |
| Ortega, MP | 1 |
| Fernández González, I | 1 |
| López-Larrubia, P | 1 |
| Viaño, J | 1 |
| García-Segura, JM | 1 |
| Vourtsis, D | 1 |
| Lamprou, M | 1 |
| Sadikoglou, E | 1 |
| Giannou, A | 1 |
| Theodorakopoulou, O | 1 |
| Sarrou, E | 1 |
| Magoulas, GE | 1 |
| Bariamis, SE | 1 |
| Athanassopoulos, CM | 1 |
| Drainas, D | 1 |
| Papaioannou, D | 1 |
| Papadimitriou, E | 1 |
| Selnaes, KM | 1 |
| Wright, A | 1 |
| Yue, K | 1 |
| Marumoto, A | 1 |
| Binesh, N | 1 |
| Rhodes, DR | 1 |
| Barrette, TR | 1 |
| Rubin, MA | 1 |
| Ghosh, D | 1 |
| Chinnaiyan, AM | 1 |
| Kawakita, M | 1 |
| Hiramatsu, K | 1 |
| Sugimoto, M | 1 |
| Takahashi, K | 1 |
| Toi, M | 1 |
| Harper, ME | 2 |
| Chaisiri, P | 2 |
| Slade, J | 1 |
| Peeling, WB | 1 |
| Griffiths, K | 2 |
| Dunzendorfer, U | 2 |
| Fujita, K | 1 |
| Shinpo, K | 1 |
| Nagatsu, T | 1 |
| Horn, Y | 1 |
| Beal, SL | 1 |
| Walach, N | 1 |
| Lubich, WP | 1 |
| Spigel, L | 1 |
| Marton, LJ | 4 |
| Smith, RC | 1 |
| Litwin, MS | 1 |
| Lu, Y | 1 |
| Zetter, BR | 2 |
| Cipolla, B | 4 |
| Guille, F | 5 |
| Moulinoux, JP | 5 |
| Bansard, JY | 2 |
| Roth, S | 1 |
| Staerman, F | 3 |
| Corbel, L | 2 |
| Quemener, V | 5 |
| Lobel, B | 5 |
| Cipolla, BG | 1 |
| Ziade, J | 1 |
| Jeffers, L | 1 |
| Church, D | 1 |
| Basu, H | 1 |
| Marton, L | 1 |
| Wilding, G | 1 |
| Mi, Z | 1 |
| Kramer, DL | 1 |
| Miller, JT | 1 |
| Bergeron, RJ | 1 |
| Bernacki, R | 1 |
| Porter, CW | 1 |
| Zagaja, GP | 1 |
| Shrivastav, M | 1 |
| Fleig, MJ | 1 |
| Rinker-Schaeffer, CW | 1 |
| Dolan, ME | 1 |
| Eiseman, JL | 1 |
| Rogers, FA | 1 |
| Guo, Y | 1 |
| Kauffman, J | 1 |
| Sentz, DL | 1 |
| Klinger, MF | 1 |
| Callery, PS | 1 |
| Kyprianou, N | 1 |
| Koike, C | 1 |
| Chao, DT | 1 |
| McCloskey, DE | 1 |
| Woster, PM | 1 |
| Davidson, NE | 1 |
| van der Graaf, M | 1 |
| Schipper, RG | 2 |
| Oosterhof, GO | 1 |
| Schalken, JA | 2 |
| Verhofstad, AA | 2 |
| Deli, G | 1 |
| Deloyer, P | 1 |
| Lange, WP | 1 |
| Weeks, RS | 1 |
| Vanderwerf, SM | 1 |
| Carlson, CL | 1 |
| Burns, MR | 1 |
| O'Day, CL | 1 |
| Cai, F | 1 |
| Devens, BH | 1 |
| Webb, HK | 1 |
| Simoneau, AR | 1 |
| Gerner, EW | 1 |
| Phung, M | 1 |
| McLaren, CE | 1 |
| Meyskens, FL | 1 |
| Valasinas, A | 2 |
| Sarkar, A | 2 |
| Reddy, VK | 2 |
| Basu, HS | 2 |
| Frydman, B | 2 |
| Cohen, RJ | 1 |
| Fujiwara, K | 1 |
| Holland, JW | 1 |
| McNeal, JE | 1 |
| Porciani, S | 1 |
| Lanini, A | 1 |
| Balzi, M | 1 |
| Faraoni, P | 1 |
| Becciolini, A | 1 |
| Srinath, P | 1 |
| McQuarrie, SA | 1 |
| Suresh, MR | 1 |
| Welch, MJ | 1 |
| Coleman, RE | 1 |
| Straatmann, MG | 1 |
| Asberry, BE | 1 |
| Primeau, JL | 1 |
| Fair, WR | 2 |
| Ter-Pogossian, MM | 1 |
| Sanford, EJ | 1 |
| Drago, JR | 1 |
| Rohner, TJ | 1 |
| Kessler, GF | 1 |
| Sheehan, L | 1 |
| Lipton, A | 1 |
| Wehner, N | 1 |
| Brorsson, U | 1 |
| Lévêque, JM | 1 |
| Havouis, R | 1 |
| Martin, LA | 1 |
| Knöner, M | 1 |
| Sakai, S | 1 |
| Ito, Y | 1 |
| Koide, T | 1 |
| Tei, K | 1 |
| Hara, A | 1 |
| Sawada, H | 1 |
| Levasseur, S | 1 |
| Poleck, T | 1 |
| Shaw, M | 1 |
| Guinan, P | 1 |
| Burke, G | 1 |
| Shukla, GS | 1 |
| Singhal, RL | 1 |
| Mann, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Artificial Intelligence (AI)-Assisted Risk-based Prostate Cancer Detection: A Synergy of Novel Biomarkers, Advanced Imaging, and Robotic-assisted Diagnosis[NCT05443412] | 510 participants (Anticipated) | Observational | 2022-08-01 | Not yet recruiting | |||
| To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920] | 0 participants (Actual) | Observational | 2021-09-01 | Withdrawn (stopped due to No funding) | |||
| To Investigate the Diagnostic Accuracy of Exosomal microRNA in Predicting the Aggressiveness of Prostate Cancer in Chinese Patients[NCT03911999] | 180 participants (Actual) | Observational | 2018-05-03 | Completed | |||
| To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802] | 2,500 participants (Anticipated) | Observational | 2021-01-20 | Recruiting | |||
| To Investigate the Role of Gut Microbiome in Androgen Deprivation Therapy Related Metabolic Changes in Prostate Cancer Patients[NCT04687709] | 50 participants (Anticipated) | Observational | 2021-01-14 | Recruiting | |||
| The Investigation of New Biological Markers for Prostate Cancer Diagnosis and Management in Chinese Population[NCT03893929] | 5,000 participants (Anticipated) | Observational | 2015-10-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for spermine and Prostatic Neoplasms
| Article | Year |
|---|---|
The Emerging Clinical Role of Spermine in Prostate Cancer.
Topics: Animals; Antineoplastic Agents; Humans; Male; Prostatic Neoplasms; Spermine | 2021 |
Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer.
Topics: Adenosine Monophosphate; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, | 2002 |
[Clinical usefulness of urinary diacetylpolyamines as novel tumor markers].
Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; H | 2004 |
Prostate cancer. Hormonal relationships, receptors, and tumour markers.
Topics: Acid Phosphatase; Aged; Androgens; Humans; Male; Polyamines; Prostatic Hyperplasia; Prostatic Neopla | 1981 |
[Polyamines and cancers (author's transl)].
Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas | 1981 |
Secretory function of the prostate, seminal vesicle and other male accessory organs of reproduction.
Topics: Acid Phosphatase; Animals; Body Fluids; Bulbourethral Glands; Cattle; Citrates; Dihydrotestosterone; | 1974 |
1 trial available for spermine and Prostatic Neoplasms
| Article | Year |
|---|---|
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Eflornithine; Enzyme Inhibitors; Humans | 2001 |
52 other studies available for spermine and Prostatic Neoplasms
| Article | Year |
|---|---|
Metabolite interactions in prostatic fluid mimics assessed by
Topics: Citrates; Citric Acid; Humans; Inositol; Magnetic Resonance Imaging; Male; Prostatic Neoplasms; Prot | 2022 |
POLYAMINES AS NEW POTENTIAL BIOMARKERS FOR DIFFERENTIAL DIAGNOSIS OF PROSTATE CANCER AND ESTIMATION OF ITS AGGRESSIVENESS.
Topics: Aged; Biomarkers; Diagnosis, Differential; Humans; Male; Polyamines; Prostatic Hyperplasia; Prostati | 2022 |
Evaluation of the Cytotoxic Effect of Pd
Topics: Antineoplastic Agents; Cisplatin; Humans; Lipids; Male; Prostatic Neoplasms; Spectroscopy, Fourier T | 2023 |
Topics: Animals; Humans; Male; Ornithine; Polyamines; Prostate; Prostatic Neoplasms; Rats; Spermine | 2023 |
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy.
Topics: Acetyltransferases; Adenine; Animals; Apoptosis; Cell Line, Tumor; Drug Therapy, Combination; Humans | 2020 |
Urine spermine and multivariable Spermine Risk Score predict high-grade prostate cancer.
Topics: Aged; Biomarkers, Tumor; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Grading; Prospective | 2021 |
Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy.
Topics: Aged; Biomarkers, Tumor; Citric Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Ne | 2017 |
Spermine and citrate as metabolic biomarkers for assessing prostate cancer aggressiveness.
Topics: Aged; Biomarkers, Tumor; Citric Acid; Disease Progression; Electron Spin Resonance Spectroscopy; Hum | 2013 |
Star-shaped tetraspermine enhances cellular uptake and cytotoxicity of T-oligo in prostate cancer cells.
Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Drug Carriers; Edet | 2015 |
TE = 32 ms vs TE = 100 ms echo-time (1)H-magnetic resonance spectroscopy in prostate cancer: Tumor metabolite depiction and absolute concentrations in tumors and adjacent tissues.
Topics: Aged; Algorithms; Biomarkers, Tumor; Citric Acid; Humans; Magnetic Resonance Imaging; Male; Prostati | 2015 |
Contribution of Histopathologic Tissue Composition to Quantitative MR Spectroscopy and Diffusion-weighted Imaging of the Prostate.
Topics: Biomarkers, Tumor; Choline; Citric Acid; Creatine; Diffusion Magnetic Resonance Imaging; Humans; Ima | 2016 |
Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer.
Topics: Biomarkers, Tumor; Citrates; Cohort Studies; Fatty Acids; Follow-Up Studies; Humans; Kaplan-Meier Es | 2016 |
The aging effect on prostate metabolite concentrations measured by
Topics: Adult; Aged; Choline; Citrates; Creatinine; Decision Making; Humans; Magnetic Fields; Magnetic Reson | 2017 |
Quantification of metabolite concentrations in benign and malignant prostate tissues using 3D proton MR spectroscopic imaging.
Topics: Aged; Biomarkers, Tumor; Choline; Citric Acid; Humans; Imaging, Three-Dimensional; Male; Middle Aged | 2017 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Urinary Polyamines: A Pilot Study on Their Roles as Prostate Cancer Detection Biomarkers.
Topics: Aged; Aged, 80 and over; Area Under Curve; Biomarkers, Tumor; Biopsy; Case-Control Studies; Chromato | 2016 |
Correlation of endorectal 2D JPRESS findings with pathological Gleason scores in prostate cancer patients.
Topics: Aged; Choline; Citric Acid; Creatine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pr | 2010 |
DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage.
Topics: DNA; DNA Damage; Humans; Indicators and Reagents; Male; Methylation; Oxidation-Reduction; Prostatic | 2010 |
Assessing prostate cancer growth with mRNA of spermine metabolic enzymes.
Topics: Acetyltransferases; Adult; Aged; Cell Proliferation; Humans; Lasers; Magnetic Resonance Spectroscopy | 2010 |
Quantitative (1) H MR spectroscopic imaging of the prostate gland using LCModel and a dedicated basis-set: correlation with histologic findings.
Topics: Adenocarcinoma; Choline; Citric Acid; Creatine; Humans; In Vitro Techniques; Magnetic Resonance Spec | 2011 |
Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Count; Cell Line, Tumor; Ce | 2013 |
Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer -- investigation of a correlation with Gleason score.
Topics: Aged; Aged, 80 and over; Choline; Citric Acid; Creatine; Humans; Magnetic Resonance Spectroscopy; Ma | 2013 |
2D JPRESS of human prostates using an endorectal receiver coil.
Topics: Adult; Biomarkers, Tumor; Choline; Citric Acid; Creatine; Humans; Magnetic Resonance Spectroscopy; M | 2002 |
[Therapy of prostate carcinoma with polyamine synthesis inhibitors. I. Physiological and pathophysiological principles].
Topics: Antineoplastic Agents; Humans; Male; Polyamines; Prostatic Hyperplasia; Prostatic Neoplasms; Putresc | 1982 |
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N | 1982 |
Identification of an endogenous inhibitor of prostatic carcinoma cell growth.
Topics: Adenocarcinoma; Animals; Enzyme Inhibitors; Growth Inhibitors; Guanidines; Humans; Male; Neoplasm In | 1995 |
Erythrocyte polyamines and prognosis in stage D2 prostatic carcinoma patients.
Topics: Aged; Aged, 80 and over; Erythrocytes; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate An | 1994 |
Polyamines and prostatic carcinoma: clinical and therapeutic implications.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Eflornithin | 1993 |
Pretherapeutic erythrocyte polyamine spermine levels discriminate high risk relapsing patients with M1 prostate carcinoma.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Bone Neoplasms; Erythrocytes; Follow-Up Studies; Gona | 1996 |
Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines.
Topics: Animals; Antineoplastic Agents; Cell Division; Growth Inhibitors; Male; Mice; Mice, Nude; Polyamines | 1997 |
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors.
Topics: Adenosylmethionine Decarboxylase; Amidines; Biological Transport; Growth Inhibitors; Humans; Indans; | 1998 |
Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Dose-Response Relationship | 1998 |
Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aziridines; Humans; Male; Mice; Mice, SCID; Prostatic Neo | 1998 |
Sensitivity to polyamine-induced growth arrest correlates with antizyme induction in prostate carcinoma cells.
Topics: Animals; Apoptosis; Cell Division; Gene Expression Regulation; Male; Prostatic Neoplasms; Protein Bi | 1999 |
Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; DNA Fragmentation; Humans; Kinetics; Male; Polyamin | 2000 |
Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer.
Topics: Biomarkers, Tumor; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Ma | 2000 |
Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells.
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Biogenic Polyamines; Carcinoma; Cell Division; D | 2000 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; | 2000 |
Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cells.
Topics: Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance S | 2001 |
cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cell lines.
Topics: Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance S | 2001 |
Polyamines in prostatic epithelial cells and adenocarcinoma; the effects of androgen blockade.
Topics: Adenocarcinoma; Androgen Antagonists; Eosinophils; Epithelial Cells; Humans; Immunohistochemistry; M | 2001 |
Polyamines as biochemical indicators of radiation injury.
Topics: Animals; Biomarkers; Bone Marrow Transplantation; Erythrocytes; Female; Gamma Rays; Humans; Male; Pr | 2001 |
Comparative uptake of polyamines by prostate and non-prostate cancer cell lines.
Topics: Animals; Breast Neoplasms; Carbon Radioisotopes; Humans; Male; Ornithine; Polyamines; Prostatic Neop | 2002 |
Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Cross Reactions; Female; Humans; Male; Middle Aged; Neopl | 1979 |
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne | 1977 |
Preliminary evaluation of urinary polyamines in the diagnosis of genitourinary tract malignancy.
Topics: Adenocarcinoma; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Male; Polyamines; Pr | 1975 |
Urinary polyamine levels in the diagnosis of carcinoma of the prostate.
Topics: Aged; Carcinoma; Diagnosis, Differential; Electrophoresis, Paper; Humans; Male; Middle Aged; Polyami | 1975 |
[The diagnostic value of erythrocyte polyamines (EPA) in prostatic adenocarcinoma (PA): apropos of 100 patients].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Erythrocytes; Humans; Male; Middl | 1992 |
Erythrocyte polyamine levels in human prostatic carcinoma.
Topics: Adenocarcinoma; Aged; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Male; Prostatic Hy | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
[Detection of urinary polyamine by a new enzymatic differential assay. (III). Studies on urinary polyamines in patients with malignant genitourinary diseases].
Topics: Diamines; Humans; Kidney Neoplasms; Male; Polyamines; Prostatic Hyperplasia; Prostatic Neoplasms; Sp | 1986 |
The effects of polyamine antimetabolites on polyamine-responsive casein kinase activity.
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Alkynes; Animals; Antineoplastic Agents; Casein Ki | 1987 |
Hormone-independent polyamine metabolism of squamous cell carcinoma of the prostate.
Topics: Adenosylmethionine Decarboxylase; Androgens; Animals; Carcinoma, Squamous Cell; Castration; Cyproter | 1985 |