Page last updated: 2024-10-20

spermine and Pancreatic Neoplasms

spermine has been researched along with Pancreatic Neoplasms in 15 studies

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
"This 52-year-old male without a significant medical history was receiving chemotherapy with diethylnorspermine (DENSPM), a polyamine analogue, for a partially resected pancreatic adenocarcinoma."3.70Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation. ( Rojiani, AM; Valenstein, EJ; Williams, LS, 1999)
"As many cancer cell types including pancreatic cancer cells express high levels of polyamines, the possibility to develop anti-tumor strategies to deplete polyamine pools has drawn considerable attention in recent years."1.37Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity. ( Guerra, B; Issinger, OG; Kreutzer, JN; Lech, K; Olsen, BB, 2011)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (46.67)18.2507
2000's4 (26.67)29.6817
2010's3 (20.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Sekhar, V1
Andl, T1
Phanstiel, O2
Tang, B1
Chow, JY1
Dong, TX1
Yang, SM1
Lu, DS1
Carethers, JM1
Dong, H1
Kreutzer, JN1
Olsen, BB1
Lech, K1
Issinger, OG1
Guerra, B1
Yamaguchi, K3
Nagano, M1
Torada, N1
Hamasaki, N3
Kawakita, M3
Tanaka, M3
Kaku, T1
Enjoji, M1
Kato, M1
Anai, M1
Nakamura, M1
Shirahane, K1
Konomi, H1
Torata, N1
Sjöholm, A2
Arkhammar, P1
Welsh, N1
Bokvist, K1
Rorsman, P1
Hallberg, A1
Nilsson, T1
Welsh, M1
Berggren, PO1
Aoki, Y1
Kawa, S1
Karasawa, Y1
Horiuchi, A1
Kiyosawa, K1
Rojiani, AM1
Williams, LS1
Valenstein, EJ1
Honkanen, RE1
Chang, BK2
Bergeron, RJ2
Porter, CW2
Liang, Y2
Vinson, JR1
Libby, PR1
Nicolet, T1
Scemama, JL1
Pradayrol, L1
Berthélémy, P1
Seva, C1
Vaysse, N1
Löser, C1
Fölsch, UR1
Paprotny, C1
Creutzfeldt, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for spermine and Pancreatic Neoplasms

ArticleYear
An overview of polyamine metabolism in pancreatic ductal adenocarcinoma.
    International journal of cancer, 2018, 05-15, Volume: 142, Issue:10

    Topics: Animals; Biogenic Polyamines; Carcinoma, Pancreatic Ductal; Humans; Pancreatic Neoplasms; Spermine

2018
[Urine diacetylspermine as a novel tumor marker].
    Rinsho byori. The Japanese journal of clinical pathology, 2005, Volume: 53, Issue:2

    Topics: Biliary Tract Neoplasms; Biomarkers, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Genital Neopl

2005

Other Studies

13 other studies available for spermine and Pancreatic Neoplasms

ArticleYear
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells.
    Scientific reports, 2022, 03-08, Volume: 12, Issue:1

    Topics: Adenosine Triphosphatases; Animals; Biological Transport; Humans; Mammals; Membrane Transport Protei

2022
Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/β-catenin signaling pathway.
    Cancer letters, 2016, 07-10, Volume: 377, Issue:1

    Topics: Animals; Antineoplastic Agents; beta Catenin; Calcium Signaling; Carcinoma, Pancreatic Ductal; Cell

2016
Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity.
    Molecular and cellular biochemistry, 2011, Volume: 356, Issue:1-2

    Topics: Acetyltransferases; Antineoplastic Agents; Casein Kinase II; Cell Death; Cell Line, Tumor; Cell Prol

2011
[Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas].
    Rinsho byori. The Japanese journal of clinical pathology, 2004, Volume: 52, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino

2004
Urine diacetylspermine as a novel tumour maker for pancreatobiliary carcinomas.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2005, Volume: 37, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino

2005
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne

1993
Anti-proliferative effects of unmodified antisense oligodeoxynucleotides targeted against c-raf mRNA: use of poly (lysine/serine) copolymers or cationic lipopolyamines.
    Clinical and experimental pharmacology & physiology, 1998, Volume: 25, Issue:9

    Topics: Cations; Cell Division; Drug Carriers; Glycine; Humans; Oligonucleotides, Antisense; Pancreatic Neop

1998
Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 1999, Volume: 9, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Brain; Brain Neoplasms; Demyelinating Diseases; Diagnosis, Di

1999
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
    Pancreas, 2000, Volume: 20, Issue:1

    Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec

2000
Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Humans; Male; Mice; Mice, Nude; Neoplasm Transplanta

1992
Regulatory and antiproliferative effects of N-alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Humans; Mesocricetus; Pancreatic Neoplas

1992
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
    International journal of cancer, 1991, Oct-21, Volume: 49, Issue:4

    Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithin

1991
Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer.
    Pancreas, 1990, Volume: 5, Issue:2

    Topics: Antigens, Tumor-Associated, Carbohydrate; Biogenic Polyamines; Cadaverine; Carcinoembryonic Antigen;

1990