spermine has been researched along with Pancreatic Neoplasms in 15 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This 52-year-old male without a significant medical history was receiving chemotherapy with diethylnorspermine (DENSPM), a polyamine analogue, for a partially resected pancreatic adenocarcinoma." | 3.70 | Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation. ( Rojiani, AM; Valenstein, EJ; Williams, LS, 1999) |
| "As many cancer cell types including pancreatic cancer cells express high levels of polyamines, the possibility to develop anti-tumor strategies to deplete polyamine pools has drawn considerable attention in recent years." | 1.37 | Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity. ( Guerra, B; Issinger, OG; Kreutzer, JN; Lech, K; Olsen, BB, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sekhar, V | 1 |
| Andl, T | 1 |
| Phanstiel, O | 2 |
| Tang, B | 1 |
| Chow, JY | 1 |
| Dong, TX | 1 |
| Yang, SM | 1 |
| Lu, DS | 1 |
| Carethers, JM | 1 |
| Dong, H | 1 |
| Kreutzer, JN | 1 |
| Olsen, BB | 1 |
| Lech, K | 1 |
| Issinger, OG | 1 |
| Guerra, B | 1 |
| Yamaguchi, K | 3 |
| Nagano, M | 1 |
| Torada, N | 1 |
| Hamasaki, N | 3 |
| Kawakita, M | 3 |
| Tanaka, M | 3 |
| Kaku, T | 1 |
| Enjoji, M | 1 |
| Kato, M | 1 |
| Anai, M | 1 |
| Nakamura, M | 1 |
| Shirahane, K | 1 |
| Konomi, H | 1 |
| Torata, N | 1 |
| Sjöholm, A | 2 |
| Arkhammar, P | 1 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 1 |
| Aoki, Y | 1 |
| Kawa, S | 1 |
| Karasawa, Y | 1 |
| Horiuchi, A | 1 |
| Kiyosawa, K | 1 |
| Rojiani, AM | 1 |
| Williams, LS | 1 |
| Valenstein, EJ | 1 |
| Honkanen, RE | 1 |
| Chang, BK | 2 |
| Bergeron, RJ | 2 |
| Porter, CW | 2 |
| Liang, Y | 2 |
| Vinson, JR | 1 |
| Libby, PR | 1 |
| Nicolet, T | 1 |
| Scemama, JL | 1 |
| Pradayrol, L | 1 |
| Berthélémy, P | 1 |
| Seva, C | 1 |
| Vaysse, N | 1 |
| Löser, C | 1 |
| Fölsch, UR | 1 |
| Paprotny, C | 1 |
| Creutzfeldt, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for spermine and Pancreatic Neoplasms
| Article | Year |
|---|---|
An overview of polyamine metabolism in pancreatic ductal adenocarcinoma.
Topics: Animals; Biogenic Polyamines; Carcinoma, Pancreatic Ductal; Humans; Pancreatic Neoplasms; Spermine | 2018 |
[Urine diacetylspermine as a novel tumor marker].
Topics: Biliary Tract Neoplasms; Biomarkers, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Genital Neopl | 2005 |
13 other studies available for spermine and Pancreatic Neoplasms
| Article | Year |
|---|---|
ATP13A3 facilitates polyamine transport in human pancreatic cancer cells.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Humans; Mammals; Membrane Transport Protei | 2022 |
Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca(2+)/β-catenin signaling pathway.
Topics: Animals; Antineoplastic Agents; beta Catenin; Calcium Signaling; Carcinoma, Pancreatic Ductal; Cell | 2016 |
Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity.
Topics: Acetyltransferases; Antineoplastic Agents; Casein Kinase II; Cell Death; Cell Line, Tumor; Cell Prol | 2011 |
[Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas].
Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino | 2004 |
Urine diacetylspermine as a novel tumour maker for pancreatobiliary carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino | 2005 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Anti-proliferative effects of unmodified antisense oligodeoxynucleotides targeted against c-raf mRNA: use of poly (lysine/serine) copolymers or cationic lipopolyamines.
Topics: Cations; Cell Division; Drug Carriers; Glycine; Humans; Oligonucleotides, Antisense; Pancreatic Neop | 1998 |
Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation.
Topics: Adenocarcinoma; Antineoplastic Agents; Brain; Brain Neoplasms; Demyelinating Diseases; Diagnosis, Di | 1999 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec | 2000 |
Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Humans; Male; Mice; Mice, Nude; Neoplasm Transplanta | 1992 |
Regulatory and antiproliferative effects of N-alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Humans; Mesocricetus; Pancreatic Neoplas | 1992 |
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithin | 1991 |
Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Biogenic Polyamines; Cadaverine; Carcinoembryonic Antigen; | 1990 |