spermine has been researched along with Obesity in 13 studies
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear." | 7.91 | Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. ( Andrews, ZB; Cowley, MA; Dodd, GT; Eramo, M; Henry, BA; Mitchell, CA; Tiganis, T; Xirouchaki, CE, 2019) |
| "The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear." | 3.91 | Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. ( Andrews, ZB; Cowley, MA; Dodd, GT; Eramo, M; Henry, BA; Mitchell, CA; Tiganis, T; Xirouchaki, CE, 2019) |
| "The mechanisms of leptin resistance observed in most cases of human obesity are poorly understood." | 3.74 | Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation. ( Jang, EH; Kang, JH; Lee, SK; Park, CS; Pie, JE, 2007) |
| "We describe the pharmacological properties of a novel spermine-cholesterol adduct, MSI 1436 (3beta-N-1(spermine)-7alpha, 24R-dihydroxy-5alpha-cholestane 24-sulfate), which causes reversible suppression of food and fluid intake in mammals resulting in profound weight loss, not associated with other signs or symptoms of illness, and which exhibits antidiabetic properties in genetically obese mice." | 3.71 | A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. ( Anderson, M; Chen, Q; Cheshire, K; Holroyd, K; Jones, S; Kinney, W; Maeder, T; McLane, M; Williams, JI; Zasloff, M, 2001) |
| "In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes." | 1.40 | Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. ( Alhonen, L; Asara, JM; Banks, AS; Bhanot, S; Cen, Y; Gong, F; Kahn, BB; Kong, D; Kraus, D; Monia, BP; Peroni, OD; Pirinen, E; Puigserver, P; Pulinilkunnil, TC; Rodgers, JT; Sauve, AA; Wang, YC; Yang, Q; Zhang, L, 2014) |
| "Obesity is associated with risks for mother and infant, and the mothers' dietary habits influence breast milk composition." | 1.39 | Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight. ( Ali, MA; Palme-Kilander, C; Strandvik, B; Yngve, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Nakatani, S | 1 |
| Horimoto, Y | 1 |
| Nakabayashi, N | 1 |
| Karasawa, M | 1 |
| Wada, M | 1 |
| Kobata, K | 1 |
| Dodd, GT | 1 |
| Xirouchaki, CE | 1 |
| Eramo, M | 1 |
| Mitchell, CA | 1 |
| Andrews, ZB | 1 |
| Henry, BA | 1 |
| Cowley, MA | 1 |
| Tiganis, T | 1 |
| Samarra, I | 1 |
| Ramos-Molina, B | 1 |
| Queipo-Ortuño, MI | 1 |
| Tinahones, FJ | 1 |
| Arola, L | 1 |
| Delpino-Rius, A | 1 |
| Herrero, P | 1 |
| Canela, N | 1 |
| Ali, MA | 1 |
| Strandvik, B | 1 |
| Palme-Kilander, C | 1 |
| Yngve, A | 1 |
| Kraus, D | 1 |
| Yang, Q | 1 |
| Kong, D | 1 |
| Banks, AS | 1 |
| Zhang, L | 1 |
| Rodgers, JT | 1 |
| Pirinen, E | 1 |
| Pulinilkunnil, TC | 1 |
| Gong, F | 1 |
| Wang, YC | 1 |
| Cen, Y | 1 |
| Sauve, AA | 1 |
| Asara, JM | 1 |
| Peroni, OD | 1 |
| Monia, BP | 1 |
| Bhanot, S | 1 |
| Alhonen, L | 1 |
| Puigserver, P | 1 |
| Kahn, BB | 1 |
| Lantz, KA | 1 |
| Hart, SG | 1 |
| Planey, SL | 1 |
| Roitman, MF | 1 |
| Ruiz-White, IA | 1 |
| Wolfe, HR | 1 |
| McLane, MP | 1 |
| Soda, K | 1 |
| Kano, Y | 1 |
| Chiba, F | 1 |
| Jang, EH | 1 |
| Park, CS | 1 |
| Lee, SK | 1 |
| Pie, JE | 1 |
| Kang, JH | 1 |
| Olefsky, JM | 1 |
| Jamdar, SC | 1 |
| Cao, WF | 1 |
| Samaniego, E | 1 |
| Sjöholm , A | 1 |
| Arkhammar, P | 1 |
| Berggren, PO | 1 |
| Andersson, A | 1 |
| Zasloff, M | 1 |
| Williams, JI | 1 |
| Chen, Q | 1 |
| Anderson, M | 1 |
| Maeder, T | 1 |
| Holroyd, K | 1 |
| Jones, S | 1 |
| Kinney, W | 1 |
| Cheshire, K | 1 |
| McLane, M | 1 |
| Lockwood, DH | 1 |
| Livingston, JN | 1 |
| Amatruda, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of an Immediate-postpartum Support by IBCLC to Women With Obesity, on Breastfeeding Performance: A Randomized Trial.[NCT02756169] | 261 participants (Actual) | Interventional | 2016-07-14 | Completed | |||
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spermine and Obesity
| Article | Year |
|---|---|
LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective.
Topics: Adipose Tissue; Adult; Animals; Blood Glucose; Child, Preschool; Deoxyglucose; Diabetes Mellitus; Do | 1981 |
12 other studies available for spermine and Obesity
| Article | Year |
|---|---|
Spermine Suppresses Adipocyte Differentiation and Exerts Anti-Obesity Effects In Vitro and In Vivo.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; Cell Differentiation; Lipids; Mice; Obesity; | 2022 |
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.
Topics: Adipose Tissue, White; Administration, Intranasal; Animals; Blood-Brain Barrier; Cholestanes; Diet, | 2019 |
Gender-Related Differences on Polyamine Metabolome in Liquid Biopsies by a Simple and Sensitive Two-Step Liquid-Liquid Extraction and LC-MS/MS.
Topics: Acetylation; Cadaverine; Chromatography, Liquid; Dansyl Compounds; Diamines; Female; gamma-Aminobuty | 2019 |
Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight.
Topics: Adult; Body Mass Index; Breast Feeding; Feeding Behavior; Female; Guidelines as Topic; Humans; Lacta | 2013 |
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Topics: Acetyltransferases; Adipocytes; Adipose Tissue; Adipose Tissue, White; Animals; Diabetes Mellitus, T | 2014 |
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Topics: Animals; Appetite; Body Composition; Cholestanes; Diet; Disease Models, Animal; Hep G2 Cells; Humans | 2010 |
Food polyamine and cardiovascular disease--an epidemiological study.
Topics: Cardiovascular Diseases; Diet; Fruit; Global Health; Gross Domestic Product; Humans; Linear Models; | 2012 |
Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation.
Topics: Animals; Ascorbic Acid; Caveolin 1; Cell Line, Tumor; Dietary Fats; Down-Regulation; Drug Antagonism | 2007 |
Relationship between adipose polyamine concentrations and triacylglycerol synthetic enzymes in lean and obese Zucker rats.
Topics: Acyltransferases; Adipose Tissue; Animals; Chromatography, High Pressure Liquid; Diacylglycerol O-Ac | 1996 |
Polyamines in pancreatic islets of obese-hyperglycemic (ob/ob) mice of different ages.
Topics: Age Factors; Animals; Cells, Cultured; DNA; Enzyme Inhibitors; Female; Insulin; Islets of Langerhans | 2001 |
A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.
Topics: Animals; Appetite Depressants; Cholestanes; Diabetes Mellitus; Disease Models, Animal; Dogfish; Drin | 2001 |
Relation of insulin receptors to insulin resistance.
Topics: Adipose Tissue; Animals; Biological Transport, Active; Glucose; Humans; Insulin; Insulin Resistance; | 1975 |