Page last updated: 2024-10-20

spermine and Neoplasms

spermine has been researched along with Neoplasms in 112 studies

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" This report describes a Phase Ib clinical trial investigating PG-11047 in combination with cytotoxic and anti-angiogenic chemotherapeutic agents in patients with advanced refractory metastatic solid tumors or lymphoma."7.01A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. ( Becerra, CHR; Boyd, TE; Casero, RA; Conkling, PR; Fitzgerald, M; Garbo, LE; Jotte, RM; Marton, LJ; Murray Stewart, T; Richards, DA; Smith, DA; Stephenson, JJ; Vogelzang, NJ; Von Hoff, D; Wu, HH, 2021)
"Inflammation has been implicated in the development of many human epithelial cancers, including those of the stomach, lung, colon, and prostate."5.33Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ( Babbar, N; Casero, RA, 2006)
"The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice."3.66Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980)
" This report describes a Phase Ib clinical trial investigating PG-11047 in combination with cytotoxic and anti-angiogenic chemotherapeutic agents in patients with advanced refractory metastatic solid tumors or lymphoma."3.01A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. ( Becerra, CHR; Boyd, TE; Casero, RA; Conkling, PR; Fitzgerald, M; Garbo, LE; Jotte, RM; Marton, LJ; Murray Stewart, T; Richards, DA; Smith, DA; Stephenson, JJ; Vogelzang, NJ; Von Hoff, D; Wu, HH, 2021)
"Forty-six patients were treated with 60-min intravenous infusions of PG-11047 using a 28-day dosing cycle with treatments on days 1, 8, and 15."2.94A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors. ( Casero, RA; Desai, AA; Fitzgerald, ML; Marton, LJ; Murray Stewart, T, 2020)
"The roles of polyamines in cancer development have been widely discussed in recent years."2.82The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies. ( Chiu, PK; Ng, CF; Tse, RT; Wong, CY, 2022)
"Adult patients with refractory solid tumors were treated with DENSPM administered by intravenous infusion in 100 ml of normal saline over 30 minutes."2.70Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies. ( Bender, JF; Streiff, RR, 2001)
"Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i."2.68Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997)
"Since both wild-type and MDR cancer cells after pre-treatment with MDL 72527, a lysosomotropic compound, are sensitized to subsequent exposure to BSAO/spermine, it is conceivable that combined treatment with a lysosomotropic compound and BSAO/spermine would be effective against tumor cells."2.46Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach. ( Agostinelli, E; Battaglia, V; Grancara, S; Saccoccio, S; Stevanato, R; Tempera, G; Toninello, A; Viceconte, N, 2010)
"In these primary brain tumors changes in urinary DiAcSpm were well correlated with the efficacy of treatments, recurrence of disease and increased malignancy of a tumor."2.43[Urinary diacetylspermine: its analysis and performance as a novel tumor marker]. ( Hiramatsu, K; Kariyone, K; Kawaguchi, M; Kawakita, M; Mori, T; Sasaki, Y; Shinoura, N; Takahashi, K; Tamamori, Y; Tanaka, T; Yamada, R, 2005)
"Two third of cancers generally show elevated urinary excretion of polyamines."2.36[Polyamines and malignant diseases (author's transl)]. ( Boublil, JL; Cambon, P; Cassuto, JP; Krebs, BP; Lalanne, CM; Lesbats, G; Milano, G; Namer, M; Schneider, M; Viguier, E, 1980)
"Cancers are a broad spectrum of diseases in which there are altered growth fractions and cell-turnover fractions, and therefore cancer chemotherapeutic agents have been developed to take tumor kinetics into account."2.36Clinical relevance of polyamines as biochemical markers of tumor kinetics. ( Russell, DH, 1977)
"A major challenge in cancer research is the lack of characterization of antibodies used for identification of target proteins."1.72Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues. ( Chu, G; Impagliazzo, A; Kalin, JH; Klaren, VNA; Molina-Ortiz, P; Tepper, AWJW, 2022)
"A total of 32 patients with cancer and 405 controls were enrolled in the study."1.62Urinary N ( Amano, H; Hinoki, A; Hiramatsu, K; Kawakita, M; Kawamura, M; Kuwatsuka, Y; Makita, S; Nakagawa, Y; Okamoto, M; Shirota, C; Sumida, W; Tainaka, T; Takimoto, A; Uchida, H; Yasui, A; Yokota, K, 2021)
"The Prickly NPs exhibit very effective cancer cell antiproliferative capability."1.46Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy. ( Baranauskiene, L; Cui, W; Janoniene, A; Liu, D; Liu, Z; Ma, M; Matulis, D; Pan, G; Pan, J; Petrikaite, V; Santos, HA; Wang, L; Wu, R; Zhang, H; Zhang, L; Zhao, H, 2017)
"RNA has been recently validated as a cancer target by the use of different specific ligands and/or by different agents able to destroy its diverse forms."1.39Exploiting RNA as a new biomolecular target for synthetic polyamines. ( Calcabrini, C; Ferruzzi, L; Fimognari, C; Hrelia, P; Lenzi, M; Milelli, A; Minarini, A; Rosini, M; Sestili, P; Tumiatti, V; Turrini, E, 2013)
"The anticancer activity of DNA intercalators is related to their ability to intercalate into the DNA duplex with high affinity, thereby interfering with DNA replication and transcription."1.38Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication. ( Chen, JJ; Chuang, SM; Hou, MH; Lai, YH; Lee, AY; Lee, YL; Su, WL; Wang, SY; Wu, WL; Yuann, JM, 2012)
"Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood."1.35Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. ( Belting, M; Bengtson, P; Bjurberg, M; Kucharzewska, P; Påhlman, S; Persson, L; Svensson, KJ; Ten Dam, GB; Welch, JE, 2008)
"In a group of 25 cancer patients, changes in blood spermine levels after surgery were negatively correlated with changes in LAK cytotoxicity after surgery (r = -0."1.34Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion. ( Kano, Y; Kawakami, M; Konishi, F; Nakamura, T; Saitoh, M; Soda, K, 2007)
"Inflammation has been implicated in the development of many human epithelial cancers, including those of the stomach, lung, colon, and prostate."1.33Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ( Babbar, N; Casero, RA, 2006)
"The recurrence of a cancer as well as the complication of a second one during the period of follow-up examination was accompanied by elevation of urinary diacetylpolyamines."1.30Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy. ( Hiramatsu, K; Hoshino, M; Iwasaki, K; Kamei, S; Kawakita, M; Kinoshita, K; Sugimoto, M, 1997)
"6 mumol after dosing with 1500 mg/day for 4 weeks, the levels after each treatment schedule being sufficient to inhibit ODC as demonstrated by increases in the urinary excretion of decarboxylated S-adenosylmethionine (dc-SAM)."1.28Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis. ( Cornbleet, MA; Haegele, KD; Joder-Ohlenbusch, AM; Kingsnorth, A; Smyth, JF; Tell, GP, 1989)
"This method is applied to cancer patients treated by cytotoxic chemotherapy with or without difluoromethylornithine (DFMO)."1.27Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn ( Belleville, F; Brossat, B; Metz, R; Nabet, P; Straczek, J, 1983)
"There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients."1.26Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982)
"Serial studies in seven patients with cancer indicated that both polyamines in RBC were reduced after successful surgery."1.26Elevated contents of spermidine and spermine in the erythrocytes of cancer patients. ( Saeki, Y; Shirakawa, S; Uchino, H; Uehara, N, 1980)
"All 6 patients with localized malignant tumors had elevated urinary polyamine levels."1.25Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975)
"In 37 (88%) of 42 cancer patients and in 24 (44%) of 54 patients with various nonmalignant diseases, increased amounts of polyamines were found in the urine."1.25Polyamine excretion in the urine of cancer patients. ( Chayen, R; Dreyfuss, F; Dreyfuss, G; Dvir, R; Ratan, J, 1975)

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-199053 (47.32)18.7374
1990's5 (4.46)18.2507
2000's22 (19.64)29.6817
2010's16 (14.29)24.3611
2020's16 (14.29)2.80

Authors

AuthorsStudies
de Medina, P1
Paillasse, MR1
Payré, B1
Silvente-Poirot, S1
Poirot, M1
Tian, HW1
Chang, YX1
Hu, XY1
Shah, MR1
Li, HB1
Guo, DS1
Tse, RT2
Wong, CY2
Chiu, PK2
Ng, CF2
Tepper, AWJW1
Chu, G1
Klaren, VNA1
Kalin, JH1
Molina-Ortiz, P1
Impagliazzo, A1
Holbert, CE2
Cullen, MT1
Casero, RA5
Stewart, TM1
Ding, X1
Cheng, CK1
Foley, JR1
Murray Stewart, T3
Lu, B1
Wang, L2
Ran, X1
Tang, H1
Cao, D1
Bhosle, AA1
Banerjee, M1
Hiremath, SD1
Sisodiya, DS1
Naik, VG1
Barooah, N1
Bhasikuttan, AC1
Chattopadhyay, A1
Chatterjee, A1
Afrouz, M1
Amani, A1
Eftekhari, A1
Coudret, C1
Elias, SG1
Ahmadian, Z1
Alebrahim, MT1
Zhang, S1
Chen, L1
Zhou, C1
Gao, C2
Yang, J1
Liao, X1
Yang, B1
Xie, B1
Zhao, H2
Ding, YF1
Wang, Z1
Wang, Y1
Wang, R1
Desai, AA1
Fitzgerald, ML1
Marton, LJ4
Rhodes, CJ1
Von Hoff, D1
Fitzgerald, M1
Becerra, CHR1
Boyd, TE1
Conkling, PR1
Garbo, LE1
Jotte, RM1
Richards, DA1
Smith, DA1
Stephenson, JJ1
Vogelzang, NJ1
Wu, HH1
Amin, M1
Tang, S1
Shalamanova, L1
Taylor, RL1
Wylie, S1
Abdullah, BM1
Whitehead, KA1
Yokota, K1
Hinoki, A1
Hiramatsu, K7
Amano, H1
Kawamura, M1
Kuwatsuka, Y1
Tainaka, T1
Shirota, C1
Sumida, W1
Makita, S1
Okamoto, M1
Takimoto, A1
Yasui, A1
Nakagawa, Y1
Uchida, H1
Kawakita, M8
Xie, L1
Yang, Y1
Meng, J1
Wen, T1
Liu, J1
Xu, H1
Minarini, A1
Milelli, A1
Tumiatti, V1
Rosini, M1
Lenzi, M1
Ferruzzi, L1
Turrini, E1
Hrelia, P1
Sestili, P1
Calcabrini, C1
Fimognari, C1
Amendola, R2
Cervelli, M2
Tempera, G2
Fratini, E2
Varesio, L1
Mariottini, P2
Agostinelli, E3
Ramani, D1
De Bandt, JP1
Cynober, L1
Hu, YL1
Miao, PH1
Huang, B1
Zhang, TY1
Hu, ZJ1
Tabata, Y3
Gao, JQ1
Ou, Y1
Wang, SJ1
Li, D1
Chu, B1
Gu, W1
Scozzafava, A1
Supuran, CT1
Carta, F1
Zhang, H1
Liu, D1
Liu, Z1
Wu, R1
Janoniene, A1
Ma, M1
Pan, G1
Baranauskiene, L1
Zhang, L1
Cui, W1
Petrikaite, V1
Matulis, D1
Pan, J1
Santos, HA1
Svensson, KJ1
Welch, JE1
Kucharzewska, P1
Bengtson, P1
Bjurberg, M1
Påhlman, S1
Ten Dam, GB1
Persson, L1
Belting, M1
Polticelli, F1
Sallustio, DE1
Viceconte, N1
Saccoccio, S1
Battaglia, V1
Grancara, S1
Toninello, A1
Stevanato, R1
Dong, Y1
Li, J1
Wu, C1
Oupický, D1
Smith, MA1
Maris, JM1
Lock, R1
Kolb, EA1
Gorlick, R1
Keir, ST1
Carol, H1
Morton, CL1
Reynolds, CP1
Kang, MH1
Houghton, PJ1
Shen, Y1
Wang, B1
Lu, Y1
Ouahab, A1
Li, Q1
Tu, J1
Pesnel, S1
Guminski, Y1
Pillon, A1
Lerondel, S1
Imbert, T1
Guilbaud, N1
Kruczynski, A1
Bailly, C1
Le Pape, A1
Matsumoto, M1
Kurihara, S1
Kibe, R1
Ashida, H1
Benno, Y1
Alarcon, RA2
Wang, SY1
Lee, AY1
Lee, YL1
Lai, YH1
Chen, JJ1
Wu, WL1
Yuann, JM1
Su, WL1
Chuang, SM1
Hou, MH1
Hosseinkhani, H1
Aoyama, T1
Ogawa, O1
ARDIZZONE, G1
RICCI, P1
TOKUOKA, S1
FONTANILI, E1
DELPIANO, E1
LISI, B1
PASQUALUCCI, E1
DESANTIS, U1
BACHRACH, U1
ROBINSON, E1
Wilding, G1
King, D1
Tutsch, K1
Pomplun, M1
Feierabend, C1
Alberti, D1
Arzoomanian, R1
Yamaguchi, K1
Nagano, M1
Torada, N1
Hamasaki, N1
Tanaka, M1
ZEITLER, E1
Takahashi, K1
Yamada, R1
Kawaguchi, M1
Shinoura, N1
Tanaka, T1
Kariyone, K1
Tamamori, Y1
Sasaki, Y1
Mori, T1
Enjoji, M1
Kotoh, K1
Nakamuta, M1
Samejima, K2
Kano, Y1
Soda, K1
Nakamura, T1
Saitoh, M1
Kawakami, M1
Konishi, F1
Babbar, N1
Mitchell, JL1
Thane, TK1
Sequeira, JM1
Thokala, R1
Zoumas-Morse, C1
Rock, CL1
Quintana, EL1
Neuhouser, ML1
Gerner, EW2
Meyskens, FL1
Seiler, N1
Jiang, R1
Choi, W1
Hu, L1
Hamilton, SR1
Zhang, W1
Buchanan, MS1
Carroll, AR1
Fechner, GA1
Boyle, A1
Simpson, MM1
Addepalli, R1
Avery, VM1
Hooper, JN1
Su, N1
Chen, H1
Quinn, RJ1
Okasora, T1
Jo, JI1
Petty, AP1
Dick, CL1
Lindsey, JS1
Petering, HG1
Van Giessen, GJ1
Buskirk, HH1
Crim, JA1
Evans, JS1
Musser, EA1
Tabor, CW1
Tabor, H1
Fujita, K3
Shinpo, K2
Nagatsu, T3
Russell, DH8
Fujiwara, K1
Asada, H1
Kitagawa, T1
Yamamoto, K1
Ito, T1
Tsuchiya, R1
Sohda, M1
Nakamura, N1
Hara, K1
Tomonaga, Y1
Ichimaru, M1
Takahashi, S1
Scalabrino, G1
Ferioli, ME1
Matsuzaki, S1
Takenoshita, S1
Filipović, N1
Borcić, N1
Hotić, A1
Kecman, G1
Hadziabdić, E1
Jusufović, D1
Brossat, B1
Straczek, J1
Belleville, F1
Nabet, P1
Metz, R1
Williams-Ashman, HG2
Seidenfeld, J2
Galletti, P1
Szeszko, A1
Lutz, W1
Milano, G1
Viguier, E1
Cassuto, JP1
Schneider, M1
Namer, M1
Boublil, JL1
Lesbats, G1
Cambon, P1
Krebs, BP1
Lalanne, CM1
Horn, Y1
Beal, SL1
Walach, N1
Lubich, WP1
Spigel, L1
Sadananda, B1
Natarajan, RS1
Vittal, C1
Kalyankar, GD1
Uehara, N2
Shirakawa, S2
Uchino, H1
Saeki, Y2
Maruta, K2
Teradaira, R1
Nakamura, M1
Takami, H2
Nishioka, K3
Bardocz, S1
Sugimoto, M2
Kamei, S3
Kinoshita, K2
Hoshino, M2
Iwasaki, K2
Creaven, PJ1
Perez, R1
Pendyala, L1
Meropol, NJ1
Loewen, G1
Levine, E1
Berghorn, E1
Raghavan, D1
Streiff, RR1
Bender, JF1
Kobayashi, M1
Lipton, A2
Sheehan, LM1
Kessler, GF1
Romsdahl, MM2
Savory, J1
Shipe, JR1
Wills, MR1
Roch, AM1
Quash, GA1
Ripoll, JP1
Saez, S1
Canellakis, ZN1
Durie, BG1
Salmon, SE1
Rosenblum, MG1
Woo, KB1
Enagonio, RD1
Sheehan, L1
Mortel, R1
Harvey, HA1
Tsuji, M1
Nakajima, T1
Sano, I1
Dreyfuss, F1
Chayen, R1
Dreyfuss, G1
Dvir, R1
Ratan, J1
Bartos, D1
Campbell, RA1
Bartos, F1
Grettie, DP1
Ito, M1
Senba, H1
Jiang, XC1
Cornbleet, MA1
Kingsnorth, A1
Tell, GP1
Haegele, KD1
Joder-Ohlenbusch, AM1
Smyth, JF1
Mashige, F1
Tanaka, N1
Murakami, T1
Shimosaka, H1
Ohkubo, A1
Otsuji, S3
Soejima, Y2
Isobe, K1
Yamada, H1
Takao, S1
Nishi, M1
Levy, CC2
Schimpff, SC1
Hawk, IA1
Fukushima, Y1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Study of CGC-11047 in Subjects With Advanced Refractory Solid Tumors[NCT00705653]Phase 146 participants (Actual)Interventional2005-03-31Completed
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920]0 participants (Actual)Observational2021-09-01Withdrawn (stopped due to No funding)
Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938]120 participants (Anticipated)Observational2013-08-31Recruiting
To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802]2,500 participants (Anticipated)Observational2021-01-20Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maximum Tolerated Dose (MTD)

"The MTD was defined as the dose below one-third of at least 6 subjects (e.g., 2/6, 3/9, 4/12) experienced a Dose-limiting toxicity (DLT).~Dose-limiting toxicities (DLTs) used to determine the MTD had to occur during cycle 1 of treatment and had to be considered related to PG-11047." (NCT00705653)
Timeframe: The MTD had to occur during cycle 1 of treatment

Interventionmg (Number)
PG-11047610

Preliminary Efficacy

As per RECIST Criteria (V 1.0) by radiologic evaluations: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR) >= 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum LD; Progressive Disease (PD), >= 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions; Stable Disease (SD), neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD. (NCT00705653)
Timeframe: For the purposes of this study, patients were reevaluated radiologically every 8 weeks. In addition to a baseline scan, confirmatory scans were obtained 6-8 weeks following initial documentation of an objective response, when appropriate.

Interventionpercentage (of participants) (Number)
PG-1104730

Reviews

28 reviews available for spermine and Neoplasms

ArticleYear
The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies.
    International journal of molecular sciences, 2022, Jan-23, Volume: 23, Issue:3

    Topics: Acetylation; Biomarkers, Tumor; Humans; Neoplasms; Polyamines; Prognosis; Spermidine; Spermine

2022
Polyamines in cancer: integrating organismal metabolism and antitumour immunity.
    Nature reviews. Cancer, 2022, Volume: 22, Issue:8

    Topics: Animals; Humans; Mammals; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tumor Microenviro

2022
The Association between Spermidine/Spermine N
    International journal of molecular sciences, 2022, May-25, Volume: 23, Issue:11

    Topics: Acetyltransferases; Animals; Humans; Mammals; Neoplasms; Polyamines; Spermidine; Spermine

2022
Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment.
    Biosensors, 2022, Aug-12, Volume: 12, Issue:8

    Topics: Humans; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine

2022
Polyamine biomarkers as indicators of human disease.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021, Volume: 26, Issue:2

    Topics: Acrolein; Alzheimer Disease; Apoptosis; Biomarkers; Biotransformation; Cadaverine; Cell Movement; Hu

2021
Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response.
    Amino acids, 2014, Volume: 46, Issue:3

    Topics: Animals; DNA Repair; Humans; Neoplasms; Reactive Oxygen Species; Spermine; X-Rays

2014
Aliphatic polyamines in physiology and diseases.
    Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:1

    Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spe

2014
Polyamines and α-Carbonic Anhydrases.
    Molecules (Basel, Switzerland), 2016, Dec-15, Volume: 21, Issue:12

    Topics: Antineoplastic Agents; Biological Products; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Coum

2016
Spermine metabolism and anticancer therapy.
    Current cancer drug targets, 2009, Volume: 9, Issue:2

    Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Enzyme Inhibitors; Homeostasis; Humans; Inflamm

2009
Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach.
    Amino acids, 2010, Volume: 38, Issue:2

    Topics: Amine Oxidase (Copper-Containing); Animals; Cattle; Cell Line, Tumor; Drug Resistance, Neoplasm; Hum

2010
Anticancer system created by acrolein and hydroxyl radical generated in enzymatic oxidation of spermine and other biochemical reactions.
    Medical hypotheses, 2012, Volume: 79, Issue:4

    Topics: Acrolein; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Humans; Hydroxyl Radical; Models,

2012
[Urinary diacetylspermine: its analysis and performance as a novel tumor marker].
    Rinsho byori. The Japanese journal of clinical pathology, 2005, Volume: 53, Issue:2

    Topics: Biomarkers, Tumor; Brain Neoplasms; Chromatography, High Pressure Liquid; Colonic Neoplasms; Enzyme-

2005
[Urinary diacetylspermine].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8

    Topics: Biomarkers, Tumor; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans;

2005
[Factors affecting the increase of urinary diacetylspermine levels : a study in patients with liver diseases].
    Rinsho byori. The Japanese journal of clinical pathology, 2006, Volume: 54, Issue:2

    Topics: Biomarkers, Tumor; Diagnosis, Differential; False Positive Reactions; Fatty Liver; Glucocorticoids;

2006
Diacetylated derivatives of spermine and spermidine as novel promising tumor markers.
    Journal of biochemistry, 2006, Volume: 139, Issue:3

    Topics: Animals; Biomarkers, Tumor; Humans; Neoplasms; Spermidine; Spermine

2006
[Regulation of polyamine and cancer].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2006, Volume: 126, Issue:8

    Topics: Animals; Biogenic Polyamines; Cell Division; Cyclohexylamines; Humans; Liver Regeneration; Male; Mas

2006
Unusual aspects of the polyamine transport system affect the design of strategies for use of polyamine analogues in chemotherapy.
    Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2

    Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Survival; Drug Design; Enzyme Inhibitors;

2007
Lysosomotropic compounds and spermine enzymatic oxidation products in cancer therapy (review).
    International journal of oncology, 2007, Volume: 31, Issue:3

    Topics: Adenosine Triphosphatases; Animals; Apoptosis; Drug Evaluation, Preclinical; Drug Resistance, Neopla

2007
Polyamines.
    Annual review of biochemistry, 1984, Volume: 53

    Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning,

1984
[Polyamines and cancers (author's transl)].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1981, Volume: 26, Issue:11

    Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas

1981
Clinical relevance of polyamines.
    Critical reviews in clinical laboratory sciences, 1983, Volume: 18, Issue:3

    Topics: Animals; Cadaverine; Cystic Fibrosis; Diamines; Female; Growth Disorders; Humans; Kidney Failure, Ch

1983
Polyamines in mammalian ageing: an oncological problem, too? A review.
    Mechanisms of ageing and development, 1984, Volume: 26, Issue:2-3

    Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Humans; Male; Neoplasms; Ornithine Decarboxylase;

1984
[Polyamine analysis of blood, tissue and gastric juice and its clinical significance. II. Analysis of tissue polyamines and their derivatives and their significance].
    Rinsho byori. The Japanese journal of clinical pathology, 1984, Volume: Spec No 59

    Topics: Humans; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tissue Distribution

1984
Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.
    Biochemical pharmacology, 1982, Feb-01, Volume: 31, Issue:3

    Topics: Adenosine; Animals; Deoxyadenosines; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylas

1982
[Polyamines and malignant diseases (author's transl)].
    Pathologie-biologie, 1980, Volume: 28, Issue:5

    Topics: Cell Division; Humans; Kinetics; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine

1980
The role of dietary polyamines.
    European journal of clinical nutrition, 1993, Volume: 47, Issue:10

    Topics: Cadaverine; Cell Division; Diet; Digestive System; DNA; Eflornithine; Humans; Neoplasms; Protein Bio

1993
Clinical relevance of polyamines as biochemical markers of tumor kinetics.
    Clinical chemistry, 1977, Volume: 23, Issue:1

    Topics: Animals; Humans; Kinetics; Neoplasms; Neoplasms, Experimental; Polyamines; Putrescine; Rats; Spermid

1977
The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues.
    Life sciences, 1973, Dec-16, Volume: 13, Issue:12

    Topics: Animals; Carboxy-Lyases; DNA-Directed RNA Polymerases; Drug Synergism; Humans; Neoplasms; Ornithine;

1973

Trials

5 trials available for spermine and Neoplasms

ArticleYear
A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors.
    Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans;

2020
A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma.
    Cancer chemotherapy and pharmacology, 2021, Volume: 87, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cisplat

2021
Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors.
    Investigational new drugs, 2004, Volume: 22, Issue:2

    Topics: Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Disea

2004
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
    Investigational new drugs, 1997, Volume: 15, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr

1997
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.
    Investigational new drugs, 2001, Volume: 19, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Biological Availability; Female; Humans; Infusions, Intravenous;

2001

Other Studies

79 other studies available for spermine and Neoplasms

ArticleYear
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Amines; Animals; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cholestanols; Dendrites; Dru

2009
Supramolecular imaging of spermine in cancer cells.
    Nanoscale, 2021, Sep-23, Volume: 13, Issue:36

    Topics: Neoplasms; Spermine

2021
Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues.
    PloS one, 2022, Volume: 17, Issue:4

    Topics: Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Humans; Immunohistochemistry; Male; Ne

2022
Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic.
    International journal of molecular sciences, 2022, Jun-18, Volume: 23, Issue:12

    Topics: Animals; Antineoplastic Agents; Mice; Neoplasms; Ornithine Decarboxylase; Polyamines; Spermine

2022
A combination of a graphene quantum dots-cationic red dye donor-acceptor pair and cucurbit[7]uril as a supramolecular sensor for ultrasensitive detection of cancer biomarkers spermine and spermidine.
    Journal of materials chemistry. B, 2022, 10-19, Volume: 10, Issue:40

    Topics: Amino Acids; Biomarkers, Tumor; Cations; Graphite; Humans; Neoplasms; Quantum Dots; Spermidine; Sper

2022
Design and synthesis of multi-targeted nanoparticles for gene delivery to breast cancer tissues.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:1

    Topics: Animals; DNA; Female; Folic Acid; Gene Transfer Techniques; Glucose; Heparan Sulfate Proteoglycans;

2023
Supramolecular fluorescent probe based on acyclic cucurbituril for detection of cancer Labels in human urine.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023, Jun-05, Volume: 294

    Topics: Copper; Fluorescent Dyes; Humans; Neoplasms; Spectrometry, Fluorescence; Spermidine; Spermine

2023
Drug-free tumor therapy via spermine-responsive intracellular biomineralization.
    Journal of controlled release : official journal of the Controlled Release Society, 2023, Volume: 357

    Topics: Biomineralization; Calcium Carbonate; Drug Carriers; Humans; Nanoparticles; Neoplasms; Spermine

2023
The cancer hypothesis of pulmonary arterial hypertension: are polyamines the new Warburg?
    The European respiratory journal, 2020, Volume: 56, Issue:5

    Topics: Glycogen Synthase; Humans; Neoplasms; Polyamines; Pulmonary Arterial Hypertension; Spermine; Vascula

2020
Urinary N
    Pediatric surgery international, 2021, Volume: 37, Issue:12

    Topics: Adult; Aged; Biomarkers, Tumor; Case-Control Studies; Child; Humans; Neoplasms; Spermine

2021
Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression.
    International journal of biological macromolecules, 2019, Feb-15, Volume: 123

    Topics: Animals; Cations; Cell Line, Tumor; Cell Polarity; Disease Progression; Female; Glucans; Lectins, C-

2019
Exploiting RNA as a new biomolecular target for synthetic polyamines.
    Gene, 2013, Jul-25, Volume: 524, Issue:2

    Topics: Antineoplastic Agents; Cell Survival; Diamines; DNA, Neoplasm; Dose-Response Relationship, Drug; Ele

2013
Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles.
    Journal of biomedical nanotechnology, 2014, Volume: 10, Issue:2

    Topics: Animals; Cell Death; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA; Female; Glucans

2014
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 11-01, Volume: 113, Issue:44

    Topics: Acetyltransferases; Animals; Apoptosis; Arachidonate 15-Lipoxygenase; Carcinogenesis; Cell Cycle Che

2016
Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy.
    Advanced healthcare materials, 2017, Volume: 6, Issue:11

    Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Copper; Dextrans; Female;

2017
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.
    Cancer research, 2008, Nov-15, Volume: 68, Issue:22

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz

2008
Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.
    Pharmaceutical research, 2010, Volume: 27, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; DNA; Drug Carrier

2010
Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.
    Pediatric blood & cancer, 2011, Volume: 57, Issue:2

    Topics: Animals; Cell Line, Tumor; Child; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fe

2011
A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery.
    International journal of pharmaceutics, 2011, Jul-29, Volume: 414, Issue:1-2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Culture Techniques; Cell Line, Tumor; Drug Carr

2011
99mTc-HYNIC-spermine for imaging polyamine transport system-positive tumours: preclinical evaluation.
    European journal of nuclear medicine and molecular imaging, 2011, Volume: 38, Issue:10

    Topics: Animals; Biological Transport; Carrier Proteins; Cell Line, Tumor; Drug Stability; Female; Humans; H

2011
Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Animals; Bacteria; Bifidobacterium; Cellular Senescence; Colon; Feces; Female; Gene Expression Profi

2011
Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Antineoplastic Agents; Bacteriophage T7; Cell Line, Tumor; Dactinomycin; DNA; DNA Polymerase I; DNA

2012
Tumor targeting of gene expression through metal-coordinated conjugation with dextran.
    Journal of controlled release : official journal of the Controlled Release Society, 2003, Mar-07, Volume: 88, Issue:2

    Topics: Animals; Chelating Agents; Dextrans; DNA; Electrophoresis; Gene Expression Regulation, Neoplastic; G

2003
[Seroreaction to spermine for diagnosis of genital carcinoma].
    Quaderni di clinica ostetrica e ginecologica, 1955, Volume: 10, Issue:10

    Topics: Carcinoma; Genitalia; Genitalia, Female; Neoplasms; Spermine; Urogenital System

1955
[Pathophysiological significance of spermine in cancer patients].
    Gan, 1956, Volume: 47, Issue:3-4

    Topics: Humans; Neoplasms; Spermine

1956
[Considerations on the use of the Tokuoka reaction in the serodiagnosis of cancer].
    Rivista di patologia e clinica, 1958, Volume: 13, Issue:10

    Topics: Humans; Neoplasms; Serologic Tests; Spermine

1958
[THE DIAMINOPROPYL-PUTRESCIN REACTION (TOKUOKA'S SPERMINE REACTION) IN NEOPLASMS AND IN VARIOUS BLOOD DISEASES].
    La Riforma medica, 1963, Jul-20, Volume: 77

    Topics: Blood Chemical Analysis; Hematologic Diseases; Hematology; Humans; Neoplasms; Putrescine; Spermine

1963
[CLINICO-SEMEIOLOGICAL CONSIDERATIONS ON THE TOKUOKA TEST IN THE DIAGNOSIS OF CANCER].
    Gazzetta internazionale di medicina e chirurgia, 1963, Dec-31, Volume: 67

    Topics: Colorimetry; Humans; Neoplasms; Serologic Tests; Spermine

1963
ISOLATION OF ACROLEIN FROM INCUBATED MIXTURES OF SPERMINE WITH CALF SERUM AND ITS EFFECTS ON MAMMALIAN CELLS.
    Archives of biochemistry and biophysics, 1964, Jul-20, Volume: 106

    Topics: Acrolein; Aldehydes; Amines; Animals; Blood; Cattle; Neoplasms; Neoplasms, Experimental; Pharmacolog

1964
OCCURRENCE OF SPERMINE IN SERA OF CANCER BEARING INDIVIDUALS.
    Israel journal of medical sciences, 1965, Volume: 1

    Topics: Blood; Humans; Neoplasms; Spermine

1965
[Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas].
    Rinsho byori. The Japanese journal of clinical pathology, 2004, Volume: 52, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino

2004
[Clinical verification of the Tokuoka spermine test].
    Medizinische Klinik, 1961, Aug-18, Volume: 56

    Topics: Humans; Neoplasms; Spermine

1961
Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion.
    Cancer immunology, immunotherapy : CII, 2007, Volume: 56, Issue:6

    Topics: Cell Adhesion; Humans; Killer Cells, Lymphokine-Activated; Lymphocyte Subsets; Neoplasms; Spermidine

2007
Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis.
    Cancer research, 2006, Dec-01, Volume: 66, Issue:23

    Topics: Acetyltransferases; Aged; Amino Acid Sequence; Blotting, Western; Cell Line; Cell Line, Transformed;

2006
Development of a polyamine database for assessing dietary intake.
    Journal of the American Dietetic Association, 2007, Volume: 107, Issue:6

    Topics: Beverages; Databases, Factual; Food Analysis; Fruit; Humans; Meat; Neoplasms; Pisum sativum; Polyami

2007
Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells.
    Cancer biology & therapy, 2007, Volume: 6, Issue:10

    Topics: Antineoplastic Agents; Cell Adhesion Molecules; Cell Line, Tumor; Down-Regulation; Glioblastoma; Hum

2007
Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.
    Bioorganic & medicinal chemistry letters, 2007, Dec-15, Volume: 17, Issue:24

    Topics: Antineoplastic Agents; Biological Products; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Mole

2007
Augmented anti-tumor therapy through natural targetability of macrophages genetically engineered by NK4 plasmid DNA.
    Gene therapy, 2008, Volume: 15, Issue:7

    Topics: Animals; Cells, Cultured; Dextrans; DNA; Fibronectins; Fibrosarcoma; Gene Targeting; Genetic Enginee

2008
Translation of an atypical human cDNA requires fidelity of apurine-pyrimidine repeat region and recoding.
    Gene, 2008, May-15, Volume: 414, Issue:1-2

    Topics: Amino Acid Sequence; Apurinic Acid; Base Sequence; Cloning, Molecular; DNA, Complementary; DNA, Z-Fo

2008
The isolation, characterization, and antigenicity of malignolipin-like material from normal and tumor tissue.
    Cancer research, 1967, Volume: 27, Issue:1

    Topics: Animals; Antigen-Antibody Reactions; Antigens; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chro

1967
Preparation of polyamine antibody and its use in enzyme immunoassay of spermine and spermidine with beta-D-galactosidase as a label.
    Journal of immunological methods, 1983, Jul-15, Volume: 61, Issue:2

    Topics: Animals; Antibody Formation; Antibody Specificity; Galactosidases; Humans; Immunoenzyme Techniques;

1983
[Polyamines as biochemical markers of malignant tumors and the efficacy of chemotherapy].
    Medicinski arhiv, 1983, Volume: 37, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Humans; Middle Aged; Neoplasms; Polyamines; P

1983
Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn
    Journal of chromatography, 1983, Oct-14, Volume: 277

    Topics: Aged; Cadaverine; Chromatography, High Pressure Liquid; Eflornithine; Female; Fluorescence; Humans;

1983
[Analytical and clinical aspects of polyamines].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1983, Feb-01, Volume: 36, Issue:3

    Topics: Humans; Kidney Diseases; Neoplasms; Putrescine; Spermidine; Spermine

1983
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
    Cancer research, 1982, Volume: 42, Issue:8

    Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N

1982
Urinary polyamines in cancer.
    Indian journal of cancer, 1980, Volume: 17, Issue:4

    Topics: Humans; Neoplasms; Putrescine; Spermidine; Spermine

1980
Elevated contents of spermidine and spermine in the erythrocytes of cancer patients.
    Cancer, 1980, Jan-01, Volume: 45, Issue:1

    Topics: Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Male; Neoplasms; Spermidine; Spe

1980
Improved analysis for urinary polyamines by use of high-voltage electrophoresis on paper.
    Clinical chemistry, 1980, Volume: 26, Issue:11

    Topics: Autoanalysis; Cadaverine; Electrophoresis, Paper; Histamine; Humans; Neoplasms; Polyamines; Putresci

1980
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
    British journal of cancer, 1980, Volume: 41, Issue:5

    Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm

1980
Significance of urinary N1,N8-diacetylspermidine and N1,N12-diacetylspermine as indicators of neoplastic diseases.
    Journal of cancer research and clinical oncology, 1995, Volume: 121, Issue:5

    Topics: Adult; Female; Humans; Male; Middle Aged; Neoplasms; Spermidine; Spermine

1995
Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy.
    Journal of cancer research and clinical oncology, 1997, Volume: 123, Issue:10

    Topics: Adult; Biomarkers, Tumor; Female; Humans; Male; Middle Aged; Neoplasms; Prognosis; Spermidine; Sperm

1997
Mass spectrometric separation and determination of N1,N12-diacetylspermine in the urine of cancer patients.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:3

    Topics: Enzyme-Linked Immunosorbent Assay; Humans; Neoplasms; Reference Standards; Spermine

2002
Urinary polyamine levels in human cancer.
    Cancer, 1975, Volume: 35, Issue:2

    Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous

1975
Polyamines in blood-cells as a cancer marker.
    Lancet (London, England), 1979, Oct-27, Volume: 2, Issue:8148

    Topics: Female; Humans; Leukocytes; Male; Neoplasms; Plasma; Putrescine; Spermidine; Spermine

1979
Polyamines in blood-cells as cancer markers.
    Lancet (London, England), 1979, Nov-24, Volume: 2, Issue:8152

    Topics: Adult; Aged; Erythrocytes; Evaluation Studies as Topic; False Positive Reactions; Female; Humans; Ma

1979
Evidence for natural antibodies (IgG) to polyamines in human sera.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1979, Volume: 67

    Topics: Antibody Specificity; Hemagglutination Inhibition Tests; Humans; Immunity, Innate; Immunoglobulin G;

1979
Polyamines in mammalian biology and medicine.
    Perspectives in biology and medicine, 1979,Spring, Volume: 22, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Animals; Isoelectric Point; Molecular Conformation; Neoplasms; Orn

1979
Sensitive fluorimetric method for the determination of putrescine, spermidine and spermine by high-performance liquid chromatography and its application to human blood.
    Journal of chromatography, 1978, Mar-01, Volume: 145, Issue:2

    Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Erythrocytes; Humans; Neoplasms; Putrescine;

1978
Polyamines as markers of response and disease activity in cancer chemotherapy.
    Cancer research, 1977, Volume: 37, Issue:1

    Topics: Antineoplastic Agents; Female; Humans; Male; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine

1977
Conjugation of radiolabeled polyamines in the rat.
    Cancer research, 1977, Volume: 37, Issue:1

    Topics: Animals; Hepatectomy; Kidney; Liver; Male; Metabolic Clearance Rate; Neoplasms; Nephrectomy; Putresc

1977
Polyamines as markers of response to chemotherapy of cancer.
    British medical journal, 1977, Jun-25, Volume: 1, Issue:6077

    Topics: Humans; Neoplasms; Putrescine; Spermidine; Spermine

1977
Quantitative analysis of biological marker synthesis in tumor cell cycle.
    Clinical chemistry, 1977, Volume: 23, Issue:8

    Topics: Cell Division; Cells, Cultured; DNA; Kinetics; Models, Biological; Neoplasms; Spermidine; Spermine;

1977
Urinary polyamine levels in patients with localized malignancy.
    Cancer, 1976, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Humans; Lung Neopl

1976
Putrescine, spermidine, N-acetylspermidine and spermine in the urine of patients with leukaemias and tumors.
    Clinica chimica acta; international journal of clinical chemistry, 1975, Mar-10, Volume: 59, Issue:2

    Topics: Age Factors; Chromatography, Ion Exchange; Female; Humans; Leukemia; Male; Neoplasms; Putrescine; Se

1975
Polyamine excretion in the urine of cancer patients.
    Israel journal of medical sciences, 1975, Volume: 11, Issue:8

    Topics: Adult; Aged; Cadaverine; Female; Humans; Male; Middle Aged; Neoplasms; Polyamines; Putrescine; Sperm

1975
Direct determination of polyamines in human serum by radioimmunoassay.
    Cancer research, 1975, Volume: 35, Issue:8

    Topics: Animals; Cadaverine; Cross Reactions; Horses; Humans; Neoplasms; Polyamines; Putrescine; Rabbits; Ra

1975
Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats.
    Cancer research, 1976, Volume: 36, Issue:4

    Topics: Animals; Female; Humans; Leukemia; Lymphoma; Methylnitronitrosoguanidine; Neoplasms; Neoplasms, Expe

1976
Determination of polyamines in urine of normal human and cancer patients by capillary gas chromatography.
    Biomedical chromatography : BMC, 1990, Volume: 4, Issue:2

    Topics: Adolescent; Adult; Aged; Chromatography, Gas; Female; Humans; Male; Middle Aged; Neoplasms; Polyamin

1990
Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis.
    Cancer chemotherapy and pharmacology, 1989, Volume: 23, Issue:6

    Topics: Adult; Aged; Alkynes; Antineoplastic Agents; Diamines; Drug Evaluation; Female; Humans; Male; Middle

1989
Clinical usefulness of an enzymatic determination of total urinary polyamines, excluding cadaverine.
    Clinical chemistry, 1988, Volume: 34, Issue:11

    Topics: Adult; Cadaverine; Circadian Rhythm; Diamines; Female; Humans; Liver Diseases; Male; Methods; Neopla

1988
Effects of difluoromethylornithine on proliferation, polyamine content and plating efficiency of cultured human carcinoma cells.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:3

    Topics: Cell Division; Cell Line; Clone Cells; Eflornithine; Female; Humans; Kinetics; Neoplasms; Ornithine;

1985
An enzymatic differential assay for urinary diamines, spermidine, and spermine.
    Journal of cancer research and clinical oncology, 1985, Volume: 109, Issue:2

    Topics: Diamines; Humans; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Spermi

1985
Polyamines.
    Lancet (London, England), 1973, Volume: 2, Issue:7822

    Topics: Animals; Cell Differentiation; DNA-Directed RNA Polymerases; Humans; Mammals; Methylation; Neoplasms

1973
Elevation of putrescine and spermidine in sera of patients with solid tumors.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Dec-02, Volume: 57, Issue:2

    Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc

1974
Measurement of putrescine, spermidine, and spermine in physiological fluids by use of an amino acid analyzer.
    Clinical chemistry, 1973, Volume: 19, Issue:8

    Topics: Autoanalysis; Carbon Isotopes; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Humans; Lung

1973
[Glycolytic rate limiting enzymes and polyamines in blood cell. II. Polyamines (spermine and spermidine) in blood of cancer patients (author's transl)].
    Rinsho byori. The Japanese journal of clinical pathology, 1973, Volume: 21, Issue:8

    Topics: Blood Cells; Humans; Neoplasms; Spermidine; Spermine

1973
Urinary polyamines in cancer patients.
    Cancer research, 1971, Volume: 31, Issue:11

    Topics: Brain Neoplasms; Chemistry, Clinical; Daunorubicin; Female; Hodgkin Disease; Humans; Leukemia, Lymph

1971
[Clinical biochemical study of amines (spermine and spermidine). 1. Micro-quantitative analysis (3). 2. Blood levels in cancer patients (1)].
    Rinsho byori. The Japanese journal of clinical pathology, 1971, Volume: 19

    Topics: Humans; Microchemistry; Neoplasms; Polyamines; Spermidine; Spermine

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971
Increased polyamine concentrations in the urine of human cancer patients.
    Nature: New biology, 1971, Sep-29, Volume: 233, Issue:39

    Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N

1971