spermine has been researched along with Neoplasms in 112 studies
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This report describes a Phase Ib clinical trial investigating PG-11047 in combination with cytotoxic and anti-angiogenic chemotherapeutic agents in patients with advanced refractory metastatic solid tumors or lymphoma." | 7.01 | A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. ( Becerra, CHR; Boyd, TE; Casero, RA; Conkling, PR; Fitzgerald, M; Garbo, LE; Jotte, RM; Marton, LJ; Murray Stewart, T; Richards, DA; Smith, DA; Stephenson, JJ; Vogelzang, NJ; Von Hoff, D; Wu, HH, 2021) |
| "Inflammation has been implicated in the development of many human epithelial cancers, including those of the stomach, lung, colon, and prostate." | 5.33 | Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ( Babbar, N; Casero, RA, 2006) |
| "The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
| " This report describes a Phase Ib clinical trial investigating PG-11047 in combination with cytotoxic and anti-angiogenic chemotherapeutic agents in patients with advanced refractory metastatic solid tumors or lymphoma." | 3.01 | A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. ( Becerra, CHR; Boyd, TE; Casero, RA; Conkling, PR; Fitzgerald, M; Garbo, LE; Jotte, RM; Marton, LJ; Murray Stewart, T; Richards, DA; Smith, DA; Stephenson, JJ; Vogelzang, NJ; Von Hoff, D; Wu, HH, 2021) |
| "Forty-six patients were treated with 60-min intravenous infusions of PG-11047 using a 28-day dosing cycle with treatments on days 1, 8, and 15." | 2.94 | A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors. ( Casero, RA; Desai, AA; Fitzgerald, ML; Marton, LJ; Murray Stewart, T, 2020) |
| "The roles of polyamines in cancer development have been widely discussed in recent years." | 2.82 | The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies. ( Chiu, PK; Ng, CF; Tse, RT; Wong, CY, 2022) |
| "Adult patients with refractory solid tumors were treated with DENSPM administered by intravenous infusion in 100 ml of normal saline over 30 minutes." | 2.70 | Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies. ( Bender, JF; Streiff, RR, 2001) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| "Since both wild-type and MDR cancer cells after pre-treatment with MDL 72527, a lysosomotropic compound, are sensitized to subsequent exposure to BSAO/spermine, it is conceivable that combined treatment with a lysosomotropic compound and BSAO/spermine would be effective against tumor cells." | 2.46 | Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach. ( Agostinelli, E; Battaglia, V; Grancara, S; Saccoccio, S; Stevanato, R; Tempera, G; Toninello, A; Viceconte, N, 2010) |
| "In these primary brain tumors changes in urinary DiAcSpm were well correlated with the efficacy of treatments, recurrence of disease and increased malignancy of a tumor." | 2.43 | [Urinary diacetylspermine: its analysis and performance as a novel tumor marker]. ( Hiramatsu, K; Kariyone, K; Kawaguchi, M; Kawakita, M; Mori, T; Sasaki, Y; Shinoura, N; Takahashi, K; Tamamori, Y; Tanaka, T; Yamada, R, 2005) |
| "Two third of cancers generally show elevated urinary excretion of polyamines." | 2.36 | [Polyamines and malignant diseases (author's transl)]. ( Boublil, JL; Cambon, P; Cassuto, JP; Krebs, BP; Lalanne, CM; Lesbats, G; Milano, G; Namer, M; Schneider, M; Viguier, E, 1980) |
| "Cancers are a broad spectrum of diseases in which there are altered growth fractions and cell-turnover fractions, and therefore cancer chemotherapeutic agents have been developed to take tumor kinetics into account." | 2.36 | Clinical relevance of polyamines as biochemical markers of tumor kinetics. ( Russell, DH, 1977) |
| "A major challenge in cancer research is the lack of characterization of antibodies used for identification of target proteins." | 1.72 | Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues. ( Chu, G; Impagliazzo, A; Kalin, JH; Klaren, VNA; Molina-Ortiz, P; Tepper, AWJW, 2022) |
| "A total of 32 patients with cancer and 405 controls were enrolled in the study." | 1.62 | Urinary N ( Amano, H; Hinoki, A; Hiramatsu, K; Kawakita, M; Kawamura, M; Kuwatsuka, Y; Makita, S; Nakagawa, Y; Okamoto, M; Shirota, C; Sumida, W; Tainaka, T; Takimoto, A; Uchida, H; Yasui, A; Yokota, K, 2021) |
| "The Prickly NPs exhibit very effective cancer cell antiproliferative capability." | 1.46 | Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy. ( Baranauskiene, L; Cui, W; Janoniene, A; Liu, D; Liu, Z; Ma, M; Matulis, D; Pan, G; Pan, J; Petrikaite, V; Santos, HA; Wang, L; Wu, R; Zhang, H; Zhang, L; Zhao, H, 2017) |
| "RNA has been recently validated as a cancer target by the use of different specific ligands and/or by different agents able to destroy its diverse forms." | 1.39 | Exploiting RNA as a new biomolecular target for synthetic polyamines. ( Calcabrini, C; Ferruzzi, L; Fimognari, C; Hrelia, P; Lenzi, M; Milelli, A; Minarini, A; Rosini, M; Sestili, P; Tumiatti, V; Turrini, E, 2013) |
| "The anticancer activity of DNA intercalators is related to their ability to intercalate into the DNA duplex with high affinity, thereby interfering with DNA replication and transcription." | 1.38 | Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication. ( Chen, JJ; Chuang, SM; Hou, MH; Lai, YH; Lee, AY; Lee, YL; Su, WL; Wang, SY; Wu, WL; Yuann, JM, 2012) |
| "Hypoxia is a hallmark of solid tumors, which may offer opportunities for targeted therapies of cancer; however, the mechanisms that link hypoxia to malignant transformation and tumor progression are not fully understood." | 1.35 | Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. ( Belting, M; Bengtson, P; Bjurberg, M; Kucharzewska, P; Påhlman, S; Persson, L; Svensson, KJ; Ten Dam, GB; Welch, JE, 2008) |
| "In a group of 25 cancer patients, changes in blood spermine levels after surgery were negatively correlated with changes in LAK cytotoxicity after surgery (r = -0." | 1.34 | Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion. ( Kano, Y; Kawakami, M; Konishi, F; Nakamura, T; Saitoh, M; Soda, K, 2007) |
| "Inflammation has been implicated in the development of many human epithelial cancers, including those of the stomach, lung, colon, and prostate." | 1.33 | Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ( Babbar, N; Casero, RA, 2006) |
| "The recurrence of a cancer as well as the complication of a second one during the period of follow-up examination was accompanied by elevation of urinary diacetylpolyamines." | 1.30 | Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy. ( Hiramatsu, K; Hoshino, M; Iwasaki, K; Kamei, S; Kawakita, M; Kinoshita, K; Sugimoto, M, 1997) |
| "6 mumol after dosing with 1500 mg/day for 4 weeks, the levels after each treatment schedule being sufficient to inhibit ODC as demonstrated by increases in the urinary excretion of decarboxylated S-adenosylmethionine (dc-SAM)." | 1.28 | Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis. ( Cornbleet, MA; Haegele, KD; Joder-Ohlenbusch, AM; Kingsnorth, A; Smyth, JF; Tell, GP, 1989) |
| "This method is applied to cancer patients treated by cytotoxic chemotherapy with or without difluoromethylornithine (DFMO)." | 1.27 | Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn ( Belleville, F; Brossat, B; Metz, R; Nabet, P; Straczek, J, 1983) |
| "There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients." | 1.26 | Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982) |
| "Serial studies in seven patients with cancer indicated that both polyamines in RBC were reduced after successful surgery." | 1.26 | Elevated contents of spermidine and spermine in the erythrocytes of cancer patients. ( Saeki, Y; Shirakawa, S; Uchino, H; Uehara, N, 1980) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| "In 37 (88%) of 42 cancer patients and in 24 (44%) of 54 patients with various nonmalignant diseases, increased amounts of polyamines were found in the urine." | 1.25 | Polyamine excretion in the urine of cancer patients. ( Chayen, R; Dreyfuss, F; Dreyfuss, G; Dvir, R; Ratan, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (47.32) | 18.7374 |
| 1990's | 5 (4.46) | 18.2507 |
| 2000's | 22 (19.64) | 29.6817 |
| 2010's | 16 (14.29) | 24.3611 |
| 2020's | 16 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| de Medina, P | 1 |
| Paillasse, MR | 1 |
| Payré, B | 1 |
| Silvente-Poirot, S | 1 |
| Poirot, M | 1 |
| Tian, HW | 1 |
| Chang, YX | 1 |
| Hu, XY | 1 |
| Shah, MR | 1 |
| Li, HB | 1 |
| Guo, DS | 1 |
| Tse, RT | 2 |
| Wong, CY | 2 |
| Chiu, PK | 2 |
| Ng, CF | 2 |
| Tepper, AWJW | 1 |
| Chu, G | 1 |
| Klaren, VNA | 1 |
| Kalin, JH | 1 |
| Molina-Ortiz, P | 1 |
| Impagliazzo, A | 1 |
| Holbert, CE | 2 |
| Cullen, MT | 1 |
| Casero, RA | 5 |
| Stewart, TM | 1 |
| Ding, X | 1 |
| Cheng, CK | 1 |
| Foley, JR | 1 |
| Murray Stewart, T | 3 |
| Lu, B | 1 |
| Wang, L | 2 |
| Ran, X | 1 |
| Tang, H | 1 |
| Cao, D | 1 |
| Bhosle, AA | 1 |
| Banerjee, M | 1 |
| Hiremath, SD | 1 |
| Sisodiya, DS | 1 |
| Naik, VG | 1 |
| Barooah, N | 1 |
| Bhasikuttan, AC | 1 |
| Chattopadhyay, A | 1 |
| Chatterjee, A | 1 |
| Afrouz, M | 1 |
| Amani, A | 1 |
| Eftekhari, A | 1 |
| Coudret, C | 1 |
| Elias, SG | 1 |
| Ahmadian, Z | 1 |
| Alebrahim, MT | 1 |
| Zhang, S | 1 |
| Chen, L | 1 |
| Zhou, C | 1 |
| Gao, C | 2 |
| Yang, J | 1 |
| Liao, X | 1 |
| Yang, B | 1 |
| Xie, B | 1 |
| Zhao, H | 2 |
| Ding, YF | 1 |
| Wang, Z | 1 |
| Wang, Y | 1 |
| Wang, R | 1 |
| Desai, AA | 1 |
| Fitzgerald, ML | 1 |
| Marton, LJ | 4 |
| Rhodes, CJ | 1 |
| Von Hoff, D | 1 |
| Fitzgerald, M | 1 |
| Becerra, CHR | 1 |
| Boyd, TE | 1 |
| Conkling, PR | 1 |
| Garbo, LE | 1 |
| Jotte, RM | 1 |
| Richards, DA | 1 |
| Smith, DA | 1 |
| Stephenson, JJ | 1 |
| Vogelzang, NJ | 1 |
| Wu, HH | 1 |
| Amin, M | 1 |
| Tang, S | 1 |
| Shalamanova, L | 1 |
| Taylor, RL | 1 |
| Wylie, S | 1 |
| Abdullah, BM | 1 |
| Whitehead, KA | 1 |
| Yokota, K | 1 |
| Hinoki, A | 1 |
| Hiramatsu, K | 7 |
| Amano, H | 1 |
| Kawamura, M | 1 |
| Kuwatsuka, Y | 1 |
| Tainaka, T | 1 |
| Shirota, C | 1 |
| Sumida, W | 1 |
| Makita, S | 1 |
| Okamoto, M | 1 |
| Takimoto, A | 1 |
| Yasui, A | 1 |
| Nakagawa, Y | 1 |
| Uchida, H | 1 |
| Kawakita, M | 8 |
| Xie, L | 1 |
| Yang, Y | 1 |
| Meng, J | 1 |
| Wen, T | 1 |
| Liu, J | 1 |
| Xu, H | 1 |
| Minarini, A | 1 |
| Milelli, A | 1 |
| Tumiatti, V | 1 |
| Rosini, M | 1 |
| Lenzi, M | 1 |
| Ferruzzi, L | 1 |
| Turrini, E | 1 |
| Hrelia, P | 1 |
| Sestili, P | 1 |
| Calcabrini, C | 1 |
| Fimognari, C | 1 |
| Amendola, R | 2 |
| Cervelli, M | 2 |
| Tempera, G | 2 |
| Fratini, E | 2 |
| Varesio, L | 1 |
| Mariottini, P | 2 |
| Agostinelli, E | 3 |
| Ramani, D | 1 |
| De Bandt, JP | 1 |
| Cynober, L | 1 |
| Hu, YL | 1 |
| Miao, PH | 1 |
| Huang, B | 1 |
| Zhang, TY | 1 |
| Hu, ZJ | 1 |
| Tabata, Y | 3 |
| Gao, JQ | 1 |
| Ou, Y | 1 |
| Wang, SJ | 1 |
| Li, D | 1 |
| Chu, B | 1 |
| Gu, W | 1 |
| Scozzafava, A | 1 |
| Supuran, CT | 1 |
| Carta, F | 1 |
| Zhang, H | 1 |
| Liu, D | 1 |
| Liu, Z | 1 |
| Wu, R | 1 |
| Janoniene, A | 1 |
| Ma, M | 1 |
| Pan, G | 1 |
| Baranauskiene, L | 1 |
| Zhang, L | 1 |
| Cui, W | 1 |
| Petrikaite, V | 1 |
| Matulis, D | 1 |
| Pan, J | 1 |
| Santos, HA | 1 |
| Svensson, KJ | 1 |
| Welch, JE | 1 |
| Kucharzewska, P | 1 |
| Bengtson, P | 1 |
| Bjurberg, M | 1 |
| Påhlman, S | 1 |
| Ten Dam, GB | 1 |
| Persson, L | 1 |
| Belting, M | 1 |
| Polticelli, F | 1 |
| Sallustio, DE | 1 |
| Viceconte, N | 1 |
| Saccoccio, S | 1 |
| Battaglia, V | 1 |
| Grancara, S | 1 |
| Toninello, A | 1 |
| Stevanato, R | 1 |
| Dong, Y | 1 |
| Li, J | 1 |
| Wu, C | 1 |
| Oupický, D | 1 |
| Smith, MA | 1 |
| Maris, JM | 1 |
| Lock, R | 1 |
| Kolb, EA | 1 |
| Gorlick, R | 1 |
| Keir, ST | 1 |
| Carol, H | 1 |
| Morton, CL | 1 |
| Reynolds, CP | 1 |
| Kang, MH | 1 |
| Houghton, PJ | 1 |
| Shen, Y | 1 |
| Wang, B | 1 |
| Lu, Y | 1 |
| Ouahab, A | 1 |
| Li, Q | 1 |
| Tu, J | 1 |
| Pesnel, S | 1 |
| Guminski, Y | 1 |
| Pillon, A | 1 |
| Lerondel, S | 1 |
| Imbert, T | 1 |
| Guilbaud, N | 1 |
| Kruczynski, A | 1 |
| Bailly, C | 1 |
| Le Pape, A | 1 |
| Matsumoto, M | 1 |
| Kurihara, S | 1 |
| Kibe, R | 1 |
| Ashida, H | 1 |
| Benno, Y | 1 |
| Alarcon, RA | 2 |
| Wang, SY | 1 |
| Lee, AY | 1 |
| Lee, YL | 1 |
| Lai, YH | 1 |
| Chen, JJ | 1 |
| Wu, WL | 1 |
| Yuann, JM | 1 |
| Su, WL | 1 |
| Chuang, SM | 1 |
| Hou, MH | 1 |
| Hosseinkhani, H | 1 |
| Aoyama, T | 1 |
| Ogawa, O | 1 |
| ARDIZZONE, G | 1 |
| RICCI, P | 1 |
| TOKUOKA, S | 1 |
| FONTANILI, E | 1 |
| DELPIANO, E | 1 |
| LISI, B | 1 |
| PASQUALUCCI, E | 1 |
| DESANTIS, U | 1 |
| BACHRACH, U | 1 |
| ROBINSON, E | 1 |
| Wilding, G | 1 |
| King, D | 1 |
| Tutsch, K | 1 |
| Pomplun, M | 1 |
| Feierabend, C | 1 |
| Alberti, D | 1 |
| Arzoomanian, R | 1 |
| Yamaguchi, K | 1 |
| Nagano, M | 1 |
| Torada, N | 1 |
| Hamasaki, N | 1 |
| Tanaka, M | 1 |
| ZEITLER, E | 1 |
| Takahashi, K | 1 |
| Yamada, R | 1 |
| Kawaguchi, M | 1 |
| Shinoura, N | 1 |
| Tanaka, T | 1 |
| Kariyone, K | 1 |
| Tamamori, Y | 1 |
| Sasaki, Y | 1 |
| Mori, T | 1 |
| Enjoji, M | 1 |
| Kotoh, K | 1 |
| Nakamuta, M | 1 |
| Samejima, K | 2 |
| Kano, Y | 1 |
| Soda, K | 1 |
| Nakamura, T | 1 |
| Saitoh, M | 1 |
| Kawakami, M | 1 |
| Konishi, F | 1 |
| Babbar, N | 1 |
| Mitchell, JL | 1 |
| Thane, TK | 1 |
| Sequeira, JM | 1 |
| Thokala, R | 1 |
| Zoumas-Morse, C | 1 |
| Rock, CL | 1 |
| Quintana, EL | 1 |
| Neuhouser, ML | 1 |
| Gerner, EW | 2 |
| Meyskens, FL | 1 |
| Seiler, N | 1 |
| Jiang, R | 1 |
| Choi, W | 1 |
| Hu, L | 1 |
| Hamilton, SR | 1 |
| Zhang, W | 1 |
| Buchanan, MS | 1 |
| Carroll, AR | 1 |
| Fechner, GA | 1 |
| Boyle, A | 1 |
| Simpson, MM | 1 |
| Addepalli, R | 1 |
| Avery, VM | 1 |
| Hooper, JN | 1 |
| Su, N | 1 |
| Chen, H | 1 |
| Quinn, RJ | 1 |
| Okasora, T | 1 |
| Jo, JI | 1 |
| Petty, AP | 1 |
| Dick, CL | 1 |
| Lindsey, JS | 1 |
| Petering, HG | 1 |
| Van Giessen, GJ | 1 |
| Buskirk, HH | 1 |
| Crim, JA | 1 |
| Evans, JS | 1 |
| Musser, EA | 1 |
| Tabor, CW | 1 |
| Tabor, H | 1 |
| Fujita, K | 3 |
| Shinpo, K | 2 |
| Nagatsu, T | 3 |
| Russell, DH | 8 |
| Fujiwara, K | 1 |
| Asada, H | 1 |
| Kitagawa, T | 1 |
| Yamamoto, K | 1 |
| Ito, T | 1 |
| Tsuchiya, R | 1 |
| Sohda, M | 1 |
| Nakamura, N | 1 |
| Hara, K | 1 |
| Tomonaga, Y | 1 |
| Ichimaru, M | 1 |
| Takahashi, S | 1 |
| Scalabrino, G | 1 |
| Ferioli, ME | 1 |
| Matsuzaki, S | 1 |
| Takenoshita, S | 1 |
| Filipović, N | 1 |
| Borcić, N | 1 |
| Hotić, A | 1 |
| Kecman, G | 1 |
| Hadziabdić, E | 1 |
| Jusufović, D | 1 |
| Brossat, B | 1 |
| Straczek, J | 1 |
| Belleville, F | 1 |
| Nabet, P | 1 |
| Metz, R | 1 |
| Williams-Ashman, HG | 2 |
| Seidenfeld, J | 2 |
| Galletti, P | 1 |
| Szeszko, A | 1 |
| Lutz, W | 1 |
| Milano, G | 1 |
| Viguier, E | 1 |
| Cassuto, JP | 1 |
| Schneider, M | 1 |
| Namer, M | 1 |
| Boublil, JL | 1 |
| Lesbats, G | 1 |
| Cambon, P | 1 |
| Krebs, BP | 1 |
| Lalanne, CM | 1 |
| Horn, Y | 1 |
| Beal, SL | 1 |
| Walach, N | 1 |
| Lubich, WP | 1 |
| Spigel, L | 1 |
| Sadananda, B | 1 |
| Natarajan, RS | 1 |
| Vittal, C | 1 |
| Kalyankar, GD | 1 |
| Uehara, N | 2 |
| Shirakawa, S | 2 |
| Uchino, H | 1 |
| Saeki, Y | 2 |
| Maruta, K | 2 |
| Teradaira, R | 1 |
| Nakamura, M | 1 |
| Takami, H | 2 |
| Nishioka, K | 3 |
| Bardocz, S | 1 |
| Sugimoto, M | 2 |
| Kamei, S | 3 |
| Kinoshita, K | 2 |
| Hoshino, M | 2 |
| Iwasaki, K | 2 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Streiff, RR | 1 |
| Bender, JF | 1 |
| Kobayashi, M | 1 |
| Lipton, A | 2 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Romsdahl, MM | 2 |
| Savory, J | 1 |
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| Wills, MR | 1 |
| Roch, AM | 1 |
| Quash, GA | 1 |
| Ripoll, JP | 1 |
| Saez, S | 1 |
| Canellakis, ZN | 1 |
| Durie, BG | 1 |
| Salmon, SE | 1 |
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| Dreyfuss, F | 1 |
| Chayen, R | 1 |
| Dreyfuss, G | 1 |
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| Tanaka, N | 1 |
| Murakami, T | 1 |
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| Yamada, H | 1 |
| Takao, S | 1 |
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| Schimpff, SC | 1 |
| Hawk, IA | 1 |
| Fukushima, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study of CGC-11047 in Subjects With Advanced Refractory Solid Tumors[NCT00705653] | Phase 1 | 46 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920] | 0 participants (Actual) | Observational | 2021-09-01 | Withdrawn (stopped due to No funding) | |||
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802] | 2,500 participants (Anticipated) | Observational | 2021-01-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The MTD was defined as the dose below one-third of at least 6 subjects (e.g., 2/6, 3/9, 4/12) experienced a Dose-limiting toxicity (DLT).~Dose-limiting toxicities (DLTs) used to determine the MTD had to occur during cycle 1 of treatment and had to be considered related to PG-11047." (NCT00705653)
Timeframe: The MTD had to occur during cycle 1 of treatment
| Intervention | mg (Number) |
|---|---|
| PG-11047 | 610 |
As per RECIST Criteria (V 1.0) by radiologic evaluations: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR) >= 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum LD; Progressive Disease (PD), >= 20% increase in the sum of the LD of target lesions, taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions; Stable Disease (SD), neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD. (NCT00705653)
Timeframe: For the purposes of this study, patients were reevaluated radiologically every 8 weeks. In addition to a baseline scan, confirmatory scans were obtained 6-8 weeks following initial documentation of an objective response, when appropriate.
| Intervention | percentage (of participants) (Number) |
|---|---|
| PG-11047 | 30 |
28 reviews available for spermine and Neoplasms
| Article | Year |
|---|---|
The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies.
Topics: Acetylation; Biomarkers, Tumor; Humans; Neoplasms; Polyamines; Prognosis; Spermidine; Spermine | 2022 |
Polyamines in cancer: integrating organismal metabolism and antitumour immunity.
Topics: Animals; Humans; Mammals; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tumor Microenviro | 2022 |
The Association between Spermidine/Spermine N
Topics: Acetyltransferases; Animals; Humans; Mammals; Neoplasms; Polyamines; Spermidine; Spermine | 2022 |
Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment.
Topics: Humans; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine | 2022 |
Polyamine biomarkers as indicators of human disease.
Topics: Acrolein; Alzheimer Disease; Apoptosis; Biomarkers; Biotransformation; Cadaverine; Cell Movement; Hu | 2021 |
Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response.
Topics: Animals; DNA Repair; Humans; Neoplasms; Reactive Oxygen Species; Spermine; X-Rays | 2014 |
Aliphatic polyamines in physiology and diseases.
Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spe | 2014 |
Polyamines and α-Carbonic Anhydrases.
Topics: Antineoplastic Agents; Biological Products; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Coum | 2016 |
Spermine metabolism and anticancer therapy.
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Enzyme Inhibitors; Homeostasis; Humans; Inflamm | 2009 |
Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach.
Topics: Amine Oxidase (Copper-Containing); Animals; Cattle; Cell Line, Tumor; Drug Resistance, Neoplasm; Hum | 2010 |
Anticancer system created by acrolein and hydroxyl radical generated in enzymatic oxidation of spermine and other biochemical reactions.
Topics: Acrolein; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Humans; Hydroxyl Radical; Models, | 2012 |
[Urinary diacetylspermine: its analysis and performance as a novel tumor marker].
Topics: Biomarkers, Tumor; Brain Neoplasms; Chromatography, High Pressure Liquid; Colonic Neoplasms; Enzyme- | 2005 |
[Urinary diacetylspermine].
Topics: Biomarkers, Tumor; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Humans; | 2005 |
[Factors affecting the increase of urinary diacetylspermine levels : a study in patients with liver diseases].
Topics: Biomarkers, Tumor; Diagnosis, Differential; False Positive Reactions; Fatty Liver; Glucocorticoids; | 2006 |
Diacetylated derivatives of spermine and spermidine as novel promising tumor markers.
Topics: Animals; Biomarkers, Tumor; Humans; Neoplasms; Spermidine; Spermine | 2006 |
[Regulation of polyamine and cancer].
Topics: Animals; Biogenic Polyamines; Cell Division; Cyclohexylamines; Humans; Liver Regeneration; Male; Mas | 2006 |
Unusual aspects of the polyamine transport system affect the design of strategies for use of polyamine analogues in chemotherapy.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Survival; Drug Design; Enzyme Inhibitors; | 2007 |
Lysosomotropic compounds and spermine enzymatic oxidation products in cancer therapy (review).
Topics: Adenosine Triphosphatases; Animals; Apoptosis; Drug Evaluation, Preclinical; Drug Resistance, Neopla | 2007 |
Polyamines.
Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, | 1984 |
[Polyamines and cancers (author's transl)].
Topics: Adult; Animals; Brain Neoplasms; Child; Erythrocytes; Female; Humans; Male; Mice; Neoplasms; Neoplas | 1981 |
Clinical relevance of polyamines.
Topics: Animals; Cadaverine; Cystic Fibrosis; Diamines; Female; Growth Disorders; Humans; Kidney Failure, Ch | 1983 |
Polyamines in mammalian ageing: an oncological problem, too? A review.
Topics: Adenosylmethionine Decarboxylase; Aging; Animals; Humans; Male; Neoplasms; Ornithine Decarboxylase; | 1984 |
[Polyamine analysis of blood, tissue and gastric juice and its clinical significance. II. Analysis of tissue polyamines and their derivatives and their significance].
Topics: Humans; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine; Tissue Distribution | 1984 |
Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.
Topics: Adenosine; Animals; Deoxyadenosines; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylas | 1982 |
[Polyamines and malignant diseases (author's transl)].
Topics: Cell Division; Humans; Kinetics; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine | 1980 |
The role of dietary polyamines.
Topics: Cadaverine; Cell Division; Diet; Digestive System; DNA; Eflornithine; Humans; Neoplasms; Protein Bio | 1993 |
Clinical relevance of polyamines as biochemical markers of tumor kinetics.
Topics: Animals; Humans; Kinetics; Neoplasms; Neoplasms, Experimental; Polyamines; Putrescine; Rats; Spermid | 1977 |
The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues.
Topics: Animals; Carboxy-Lyases; DNA-Directed RNA Polymerases; Drug Synergism; Humans; Neoplasms; Ornithine; | 1973 |
5 trials available for spermine and Neoplasms
| Article | Year |
|---|---|
A phase I dose-escalation study of the polyamine analog PG-11047 in patients with advanced solid tumors.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; | 2020 |
A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cisplat | 2021 |
Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors.
Topics: Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Disea | 2004 |
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.
Topics: Adult; Aged; Antineoplastic Agents; Biological Availability; Female; Humans; Infusions, Intravenous; | 2001 |
79 other studies available for spermine and Neoplasms
| Article | Year |
|---|---|
Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.
Topics: Amines; Animals; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cholestanols; Dendrites; Dru | 2009 |
Supramolecular imaging of spermine in cancer cells.
Topics: Neoplasms; Spermine | 2021 |
Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues.
Topics: Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Humans; Immunohistochemistry; Male; Ne | 2022 |
Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic.
Topics: Animals; Antineoplastic Agents; Mice; Neoplasms; Ornithine Decarboxylase; Polyamines; Spermine | 2022 |
A combination of a graphene quantum dots-cationic red dye donor-acceptor pair and cucurbit[7]uril as a supramolecular sensor for ultrasensitive detection of cancer biomarkers spermine and spermidine.
Topics: Amino Acids; Biomarkers, Tumor; Cations; Graphite; Humans; Neoplasms; Quantum Dots; Spermidine; Sper | 2022 |
Design and synthesis of multi-targeted nanoparticles for gene delivery to breast cancer tissues.
Topics: Animals; DNA; Female; Folic Acid; Gene Transfer Techniques; Glucose; Heparan Sulfate Proteoglycans; | 2023 |
Supramolecular fluorescent probe based on acyclic cucurbituril for detection of cancer Labels in human urine.
Topics: Copper; Fluorescent Dyes; Humans; Neoplasms; Spectrometry, Fluorescence; Spermidine; Spermine | 2023 |
Drug-free tumor therapy via spermine-responsive intracellular biomineralization.
Topics: Biomineralization; Calcium Carbonate; Drug Carriers; Humans; Nanoparticles; Neoplasms; Spermine | 2023 |
The cancer hypothesis of pulmonary arterial hypertension: are polyamines the new Warburg?
Topics: Glycogen Synthase; Humans; Neoplasms; Polyamines; Pulmonary Arterial Hypertension; Spermine; Vascula | 2020 |
Urinary N
Topics: Adult; Aged; Biomarkers, Tumor; Case-Control Studies; Child; Humans; Neoplasms; Spermine | 2021 |
Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression.
Topics: Animals; Cations; Cell Line, Tumor; Cell Polarity; Disease Progression; Female; Glucans; Lectins, C- | 2019 |
Exploiting RNA as a new biomolecular target for synthetic polyamines.
Topics: Antineoplastic Agents; Cell Survival; Diamines; DNA, Neoplasm; Dose-Response Relationship, Drug; Ele | 2013 |
Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles.
Topics: Animals; Cell Death; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA; Female; Glucans | 2014 |
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses.
Topics: Acetyltransferases; Animals; Apoptosis; Arachidonate 15-Lipoxygenase; Carcinogenesis; Cell Cycle Che | 2016 |
Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy.
Topics: Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Copper; Dextrans; Female; | 2017 |
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz | 2008 |
Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; DNA; Drug Carrier | 2010 |
Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.
Topics: Animals; Cell Line, Tumor; Child; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fe | 2011 |
A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Culture Techniques; Cell Line, Tumor; Drug Carr | 2011 |
99mTc-HYNIC-spermine for imaging polyamine transport system-positive tumours: preclinical evaluation.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Line, Tumor; Drug Stability; Female; Humans; H | 2011 |
Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production.
Topics: Animals; Bacteria; Bifidobacterium; Cellular Senescence; Colon; Feces; Female; Gene Expression Profi | 2011 |
Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication.
Topics: Antineoplastic Agents; Bacteriophage T7; Cell Line, Tumor; Dactinomycin; DNA; DNA Polymerase I; DNA | 2012 |
Tumor targeting of gene expression through metal-coordinated conjugation with dextran.
Topics: Animals; Chelating Agents; Dextrans; DNA; Electrophoresis; Gene Expression Regulation, Neoplastic; G | 2003 |
[Seroreaction to spermine for diagnosis of genital carcinoma].
Topics: Carcinoma; Genitalia; Genitalia, Female; Neoplasms; Spermine; Urogenital System | 1955 |
[Pathophysiological significance of spermine in cancer patients].
Topics: Humans; Neoplasms; Spermine | 1956 |
[Considerations on the use of the Tokuoka reaction in the serodiagnosis of cancer].
Topics: Humans; Neoplasms; Serologic Tests; Spermine | 1958 |
[THE DIAMINOPROPYL-PUTRESCIN REACTION (TOKUOKA'S SPERMINE REACTION) IN NEOPLASMS AND IN VARIOUS BLOOD DISEASES].
Topics: Blood Chemical Analysis; Hematologic Diseases; Hematology; Humans; Neoplasms; Putrescine; Spermine | 1963 |
[CLINICO-SEMEIOLOGICAL CONSIDERATIONS ON THE TOKUOKA TEST IN THE DIAGNOSIS OF CANCER].
Topics: Colorimetry; Humans; Neoplasms; Serologic Tests; Spermine | 1963 |
ISOLATION OF ACROLEIN FROM INCUBATED MIXTURES OF SPERMINE WITH CALF SERUM AND ITS EFFECTS ON MAMMALIAN CELLS.
Topics: Acrolein; Aldehydes; Amines; Animals; Blood; Cattle; Neoplasms; Neoplasms, Experimental; Pharmacolog | 1964 |
OCCURRENCE OF SPERMINE IN SERA OF CANCER BEARING INDIVIDUALS.
Topics: Blood; Humans; Neoplasms; Spermine | 1965 |
[Urine diacetylspermine as a novel tumor marker for pancreatobiliary carcinomas].
Topics: Adult; Aged; Aged, 80 and over; Biliary Tract Neoplasms; Biomarkers, Tumor; CA-19-9 Antigen; Carcino | 2004 |
[Clinical verification of the Tokuoka spermine test].
Topics: Humans; Neoplasms; Spermine | 1961 |
Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion.
Topics: Cell Adhesion; Humans; Killer Cells, Lymphokine-Activated; Lymphocyte Subsets; Neoplasms; Spermidine | 2007 |
Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis.
Topics: Acetyltransferases; Aged; Amino Acid Sequence; Blotting, Western; Cell Line; Cell Line, Transformed; | 2006 |
Development of a polyamine database for assessing dietary intake.
Topics: Beverages; Databases, Factual; Food Analysis; Fruit; Humans; Meat; Neoplasms; Pisum sativum; Polyami | 2007 |
Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells.
Topics: Antineoplastic Agents; Cell Adhesion Molecules; Cell Line, Tumor; Down-Regulation; Glioblastoma; Hum | 2007 |
Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target.
Topics: Antineoplastic Agents; Biological Products; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Mole | 2007 |
Augmented anti-tumor therapy through natural targetability of macrophages genetically engineered by NK4 plasmid DNA.
Topics: Animals; Cells, Cultured; Dextrans; DNA; Fibronectins; Fibrosarcoma; Gene Targeting; Genetic Enginee | 2008 |
Translation of an atypical human cDNA requires fidelity of apurine-pyrimidine repeat region and recoding.
Topics: Amino Acid Sequence; Apurinic Acid; Base Sequence; Cloning, Molecular; DNA, Complementary; DNA, Z-Fo | 2008 |
The isolation, characterization, and antigenicity of malignolipin-like material from normal and tumor tissue.
Topics: Animals; Antigen-Antibody Reactions; Antigens; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chro | 1967 |
Preparation of polyamine antibody and its use in enzyme immunoassay of spermine and spermidine with beta-D-galactosidase as a label.
Topics: Animals; Antibody Formation; Antibody Specificity; Galactosidases; Humans; Immunoenzyme Techniques; | 1983 |
[Polyamines as biochemical markers of malignant tumors and the efficacy of chemotherapy].
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers, Tumor; Humans; Middle Aged; Neoplasms; Polyamines; P | 1983 |
Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn
Topics: Aged; Cadaverine; Chromatography, High Pressure Liquid; Eflornithine; Female; Fluorescence; Humans; | 1983 |
[Analytical and clinical aspects of polyamines].
Topics: Humans; Kidney Diseases; Neoplasms; Putrescine; Spermidine; Spermine | 1983 |
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N | 1982 |
Urinary polyamines in cancer.
Topics: Humans; Neoplasms; Putrescine; Spermidine; Spermine | 1980 |
Elevated contents of spermidine and spermine in the erythrocytes of cancer patients.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Male; Neoplasms; Spermidine; Spe | 1980 |
Improved analysis for urinary polyamines by use of high-voltage electrophoresis on paper.
Topics: Autoanalysis; Cadaverine; Electrophoresis, Paper; Histamine; Humans; Neoplasms; Polyamines; Putresci | 1980 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Significance of urinary N1,N8-diacetylspermidine and N1,N12-diacetylspermine as indicators of neoplastic diseases.
Topics: Adult; Female; Humans; Male; Middle Aged; Neoplasms; Spermidine; Spermine | 1995 |
Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy.
Topics: Adult; Biomarkers, Tumor; Female; Humans; Male; Middle Aged; Neoplasms; Prognosis; Spermidine; Sperm | 1997 |
Mass spectrometric separation and determination of N1,N12-diacetylspermine in the urine of cancer patients.
Topics: Enzyme-Linked Immunosorbent Assay; Humans; Neoplasms; Reference Standards; Spermine | 2002 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
Polyamines in blood-cells as a cancer marker.
Topics: Female; Humans; Leukocytes; Male; Neoplasms; Plasma; Putrescine; Spermidine; Spermine | 1979 |
Polyamines in blood-cells as cancer markers.
Topics: Adult; Aged; Erythrocytes; Evaluation Studies as Topic; False Positive Reactions; Female; Humans; Ma | 1979 |
Evidence for natural antibodies (IgG) to polyamines in human sera.
Topics: Antibody Specificity; Hemagglutination Inhibition Tests; Humans; Immunity, Innate; Immunoglobulin G; | 1979 |
Polyamines in mammalian biology and medicine.
Topics: Adenosylmethionine Decarboxylase; Animals; Isoelectric Point; Molecular Conformation; Neoplasms; Orn | 1979 |
Sensitive fluorimetric method for the determination of putrescine, spermidine and spermine by high-performance liquid chromatography and its application to human blood.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Erythrocytes; Humans; Neoplasms; Putrescine; | 1978 |
Polyamines as markers of response and disease activity in cancer chemotherapy.
Topics: Antineoplastic Agents; Female; Humans; Male; Neoplasms; Polyamines; Putrescine; Spermidine; Spermine | 1977 |
Conjugation of radiolabeled polyamines in the rat.
Topics: Animals; Hepatectomy; Kidney; Liver; Male; Metabolic Clearance Rate; Neoplasms; Nephrectomy; Putresc | 1977 |
Polyamines as markers of response to chemotherapy of cancer.
Topics: Humans; Neoplasms; Putrescine; Spermidine; Spermine | 1977 |
Quantitative analysis of biological marker synthesis in tumor cell cycle.
Topics: Cell Division; Cells, Cultured; DNA; Kinetics; Models, Biological; Neoplasms; Spermidine; Spermine; | 1977 |
Urinary polyamine levels in patients with localized malignancy.
Topics: Adolescent; Adult; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Humans; Lung Neopl | 1976 |
Putrescine, spermidine, N-acetylspermidine and spermine in the urine of patients with leukaemias and tumors.
Topics: Age Factors; Chromatography, Ion Exchange; Female; Humans; Leukemia; Male; Neoplasms; Putrescine; Se | 1975 |
Polyamine excretion in the urine of cancer patients.
Topics: Adult; Aged; Cadaverine; Female; Humans; Male; Middle Aged; Neoplasms; Polyamines; Putrescine; Sperm | 1975 |
Direct determination of polyamines in human serum by radioimmunoassay.
Topics: Animals; Cadaverine; Cross Reactions; Horses; Humans; Neoplasms; Polyamines; Putrescine; Rabbits; Ra | 1975 |
Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats.
Topics: Animals; Female; Humans; Leukemia; Lymphoma; Methylnitronitrosoguanidine; Neoplasms; Neoplasms, Expe | 1976 |
Determination of polyamines in urine of normal human and cancer patients by capillary gas chromatography.
Topics: Adolescent; Adult; Aged; Chromatography, Gas; Female; Humans; Male; Middle Aged; Neoplasms; Polyamin | 1990 |
Phase I study of methylacetylenic putrescine, an inhibitor of polyamine biosynthesis.
Topics: Adult; Aged; Alkynes; Antineoplastic Agents; Diamines; Drug Evaluation; Female; Humans; Male; Middle | 1989 |
Clinical usefulness of an enzymatic determination of total urinary polyamines, excluding cadaverine.
Topics: Adult; Cadaverine; Circadian Rhythm; Diamines; Female; Humans; Liver Diseases; Male; Methods; Neopla | 1988 |
Effects of difluoromethylornithine on proliferation, polyamine content and plating efficiency of cultured human carcinoma cells.
Topics: Cell Division; Cell Line; Clone Cells; Eflornithine; Female; Humans; Kinetics; Neoplasms; Ornithine; | 1985 |
An enzymatic differential assay for urinary diamines, spermidine, and spermine.
Topics: Diamines; Humans; Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Spermi | 1985 |
Polyamines.
Topics: Animals; Cell Differentiation; DNA-Directed RNA Polymerases; Humans; Mammals; Methylation; Neoplasms | 1973 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |
Measurement of putrescine, spermidine, and spermine in physiological fluids by use of an amino acid analyzer.
Topics: Autoanalysis; Carbon Isotopes; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Humans; Lung | 1973 |
[Glycolytic rate limiting enzymes and polyamines in blood cell. II. Polyamines (spermine and spermidine) in blood of cancer patients (author's transl)].
Topics: Blood Cells; Humans; Neoplasms; Spermidine; Spermine | 1973 |
Urinary polyamines in cancer patients.
Topics: Brain Neoplasms; Chemistry, Clinical; Daunorubicin; Female; Hodgkin Disease; Humans; Leukemia, Lymph | 1971 |
[Clinical biochemical study of amines (spermine and spermidine). 1. Micro-quantitative analysis (3). 2. Blood levels in cancer patients (1)].
Topics: Humans; Microchemistry; Neoplasms; Polyamines; Spermidine; Spermine | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |