spermine has been researched along with Mucopolysaccharidosis I in 1 studies
Mucopolysaccharidosis I: Systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDURONIDASE) and characterized by progressive physical deterioration with urinary excretion of DERMATAN SULFATE and HEPARAN SULFATE. There are three recognized phenotypes representing a spectrum of clinical severity from severe to mild: Hurler syndrome, Hurler-Scheie syndrome and Scheie syndrome (formerly mucopolysaccharidosis V). Symptoms may include DWARFISM; hepatosplenomegaly; thick, coarse facial features with low nasal bridge; corneal clouding; cardiac complications; and noisy breathing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Identification of biomarkers for central nervous system disease in MPS patients would facilitate the evaluation of new agents in clinical trials." | 1.46 | Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis. ( Bell, P; Dalla Corte, A; de Souza, CFM; Giugliani, R; Hinderer, C; Katz, N; Louboutin, JP; Lund, TC; Mesaros, C; Nayal, M; Orchard, PJ; Tolar, J; Weng, L; Wilson, JM, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hinderer, C | 1 |
| Katz, N | 1 |
| Louboutin, JP | 1 |
| Bell, P | 1 |
| Tolar, J | 1 |
| Orchard, PJ | 1 |
| Lund, TC | 1 |
| Nayal, M | 1 |
| Weng, L | 1 |
| Mesaros, C | 1 |
| de Souza, CFM | 1 |
| Dalla Corte, A | 1 |
| Giugliani, R | 1 |
| Wilson, JM | 1 |
1 other study available for spermine and Mucopolysaccharidosis I
| Article | Year |
|---|---|
Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis.
Topics: Adolescent; Animals; Biomarkers; Central Nervous System Diseases; Child; Disease Models, Animal; Dog | 2017 |