spermine has been researched along with Metastase in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated." | 7.74 | Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007) |
| " Experiments were carried out on the trastuzumab-resistant human epidermal growth factor receptor 2-overexpressing breast cancer cell line JIMT-1 to unravel the chemotherapeutic effects of the polyamine analogue [1N,12N]bis(ethyl)-cis-6,7-dehydrospermine (PG11047) and of the polyamine biosynthetic inhibitor 2-difluoromethylornithine (DFMO) on the CD44+CD24- CSC population." | 3.76 | Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. ( Cirenajwis, H; Hegardt, C; Honeth, G; Marton, LJ; Oredsson, SM; Smiljanic, S, 2010) |
| "The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated." | 3.74 | Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007) |
| "The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection." | 3.66 | [Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982) |
| "DFMO did not affect pulmonary metastasis when primary tumors of control and DFMO-treated mice were matched for size." | 1.34 | Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. ( Bruggeman, R; Demers, LM; Griffith, JW; Jun, JY; Manni, A; Verderame, MF; Washington, S, 2007) |
| "In a mouse model of experimental metastasis, DFMO provided in the water supply also dramatically diminished seeding and growth of tumor foci in the lungs by heparan sulfate-deficient mutant cells compared with the controls." | 1.31 | Tumor attenuation by combined heparan sulfate and polyamine depletion. ( Belting, M; Borsig, L; Brown, JR; Esko, JD; Fransson, LA; Fuster, MM; Persson, L, 2002) |
| "With the P7 sarcoma no metastases were detected following implantation; similarly, no significant changes occurred in the levels of transglutaminase activity, putrescine, spermidine or spermine during tumour growth." | 1.27 | Correlation of changes in transglutaminase activity and polyamine content of neoplastic tissue during the metastatic process. ( Elliott, BM; Griffin, M; Hand, D, 1987) |
| "There were 105 patients with these tumors; 319 polyamine determinations were obtained from this subset of patients." | 1.26 | Further evidence for the use of polyamines as biochemical markers for malignant tumors. ( Beal, SL; Horn, Y; Lubich, WP; Marton, LJ; Spigel, L; Walach, N, 1982) |
| "Only 17% of the patients with breast carcinoma had elevated levels of spermine, although there was a significant difference in the concentrations of the breast cancer group of patients compared to normals." | 1.26 | Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate. ( Chaisiri, P; Griffiths, K; Harper, ME, 1979) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Fahrmann, JF | 1 |
| Vykoukal, J | 1 |
| Fleury, A | 1 |
| Tripathi, S | 1 |
| Dennison, JB | 1 |
| Murage, E | 1 |
| Wang, P | 1 |
| Yu, CY | 1 |
| Capello, M | 1 |
| Creighton, CJ | 1 |
| Do, KA | 1 |
| Long, JP | 1 |
| Irajizad, E | 1 |
| Peterson, C | 1 |
| Katayama, H | 1 |
| Disis, ML | 1 |
| Arun, B | 1 |
| Hanash, S | 1 |
| Cirenajwis, H | 1 |
| Smiljanic, S | 1 |
| Honeth, G | 1 |
| Hegardt, C | 1 |
| Marton, LJ | 2 |
| Oredsson, SM | 1 |
| Lentini, A | 1 |
| Forni, C | 1 |
| Provenzano, B | 1 |
| Beninati, S | 2 |
| Jun, JY | 1 |
| Griffith, JW | 1 |
| Bruggeman, R | 1 |
| Washington, S | 1 |
| Demers, LM | 1 |
| Verderame, MF | 1 |
| Manni, A | 1 |
| Woo, KB | 1 |
| Waalkes, TP | 2 |
| Abeloff, MD | 1 |
| Lenhard, RE | 1 |
| Gehrke, CW | 1 |
| Kuo, KC | 1 |
| Desser, H | 1 |
| Kläring, WJ | 1 |
| Luger, T | 1 |
| Gebhart, W | 1 |
| Horn, Y | 1 |
| Beal, SL | 1 |
| Walach, N | 1 |
| Lubich, WP | 1 |
| Spigel, L | 1 |
| Cipolla, B | 1 |
| Guille, F | 1 |
| Moulinoux, JP | 1 |
| Bansard, JY | 1 |
| Roth, S | 1 |
| Staerman, F | 1 |
| Corbel, L | 1 |
| Quemener, V | 1 |
| Lobel, B | 1 |
| Abbruzzese, A | 1 |
| Cardinali, M | 1 |
| Belting, M | 1 |
| Borsig, L | 1 |
| Fuster, MM | 1 |
| Brown, JR | 1 |
| Persson, L | 1 |
| Fransson, LA | 1 |
| Esko, JD | 1 |
| Lipton, A | 1 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Terabayashi, T | 1 |
| Chaisiri, P | 1 |
| Harper, ME | 1 |
| Griffiths, K | 1 |
| Tormey, DC | 1 |
| Dunzendorfer, U | 1 |
| Knöner, M | 1 |
| Hand, D | 1 |
| Elliott, BM | 1 |
| Griffin, M | 1 |
| Hibasami, H | 1 |
| Tsukada, T | 1 |
| Nakashima, K | 1 |
2 reviews available for spermine and Metastase
| Article | Year |
|---|---|
Biochemical markers in cancer of the breast.
Topics: Breast Neoplasms; Cadaverine; Carcinoembryonic Antigen; Chorionic Gonadotropin; Cyclophosphamide; Do | 1976 |
[Cancer metastasis and polyamines].
Topics: Adenosylmethionine Decarboxylase; Animals; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; | 1985 |
15 other studies available for spermine and Metastase
| Article | Year |
|---|---|
Association Between Plasma Diacetylspermine and Tumor Spermine Synthase With Outcome in Triple-Negative Breast Cancer.
Topics: Animals; Chromatography, Liquid; Female; Gene Expression; Humans; Mice; Mice, Transgenic; Neoplasm M | 2020 |
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; | 2010 |
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Activation; Estrogen Antagonists; Flavano | 2007 |
Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Drug Combinations; Eflornithi | 2007 |
Urinary polyamines for evaluating the course of disease for patients with small cell carcinoma of the lung.
Topics: Carcinoma, Small Cell; Creatinine; Humans; Lung Neoplasms; Neoplasm Metastasis; Polyamines; Putresci | 1983 |
[Polyamine levels in blood and plasma of patients with malignant melanoma].
Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged | 1982 |
Further evidence for the use of polyamines as biochemical markers for malignant tumors.
Topics: Breast Neoplasms; Clinical Laboratory Techniques; Female; Genital Neoplasms, Female; Humans; Male; N | 1982 |
Erythrocyte polyamines and prognosis in stage D2 prostatic carcinoma patients.
Topics: Aged; Aged, 80 and over; Erythrocytes; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate An | 1994 |
Differences in the post-translational modification of proteins by polyamines between weakly and highly metastatic B16 melanoma cells.
Topics: Animals; Melanins; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neoplasm Proteins; Putrescine; | 1993 |
Tumor attenuation by combined heparan sulfate and polyamine depletion.
Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; DNA, Complementary; Dose-Response Relationshi | 2002 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
[Measurement of blood polyamines in patients with brain tumor--special reference to relationship between the blood levels of spermidine and spermine, and histological malignancy in patients with glioma (author's transl)].
Topics: Adenoma; Adolescent; Adult; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangiosarcoma; Human | 1977 |
Plasma spermine concentrations of patients with benign and malignant tumours of the breast or prostate.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Cross Reactions; Female; Humans; Male; Middle Aged; Neopl | 1979 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
Correlation of changes in transglutaminase activity and polyamine content of neoplastic tissue during the metastatic process.
Topics: Animals; Cell Division; Kinetics; Neoplasm Metastasis; Putrescine; Rats; Sarcoma, Experimental; Sper | 1987 |