Page last updated: 2024-10-20

spermine and Melanoma

spermine has been researched along with Melanoma in 39 studies

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."7.80The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach. ( Agostinelli, E; Arancia, G; Bozzuto, G; Calcabrini, A; Condello, M; Macone, A; Molinari, A; Ohkubo, S; Tempera, G, 2014)
"It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."7.75Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009)
"The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated."7.74Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007)
" We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."7.73Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006)
"In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, and increases the polyamine catabolizing enzyme, spermidine/spermine N1-acetyl-transferase (SSAT) by more than 200-fold."7.68Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. ( Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW, 1993)
"Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme."7.68Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991)
" Although the three sublines were 2- to 10-fold less sensitive than the parent line to classical MDR-type agents, they were found in dose-response studies to be significantly more sensitive to DENSPM than the parent line."5.29Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. ( Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C, 1994)
" Similar antitumor activity was obtained with 120 mg/kg once daily for 6 days and 40 mg/kg once daily for 6 days, indicating that against this tumor model, the dosing schedule can be relaxed up to sixfold without compromising antitumor activity."5.29Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. ( Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW, 1993)
"It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."3.80The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach. ( Agostinelli, E; Arancia, G; Bozzuto, G; Calcabrini, A; Condello, M; Macone, A; Molinari, A; Ohkubo, S; Tempera, G, 2014)
"It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."3.75Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009)
"The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated."3.74Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007)
" We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."3.73Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006)
"We have previously shown that the clinically relevant polyamine analog N1,N11-diethylnorspermine (DENSPM) causes rapid apoptosis in human melanoma SK-MEL-28 cells via a series of events that include mitochondrial release of cytochrome c and activation of the caspase cascade."3.72Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. ( Chen, Y; Kramer, DL; Li, F; Porter, CW, 2003)
" We have found that treatment of MALME-3M human melanoma cells for 6 h with 10 micrograms/ml cycloheximide (CHX) increases ODC and SSAT mRNA 6-9-fold."3.69Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines. ( Fogel-Petrovic, M; Miller, J; Porter, CW; Vujcic, S, 1996)
"In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, and increases the polyamine catabolizing enzyme, spermidine/spermine N1-acetyl-transferase (SSAT) by more than 200-fold."3.68Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. ( Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW, 1993)
"Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme."3.68Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991)
"The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection."3.66[Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982)
"The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice."3.66Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980)
"Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i."2.68Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997)
" Although the three sublines were 2- to 10-fold less sensitive than the parent line to classical MDR-type agents, they were found in dose-response studies to be significantly more sensitive to DENSPM than the parent line."1.29Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. ( Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C, 1994)
" Similar antitumor activity was obtained with 120 mg/kg once daily for 6 days and 40 mg/kg once daily for 6 days, indicating that against this tumor model, the dosing schedule can be relaxed up to sixfold without compromising antitumor activity."1.29Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. ( Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW, 1993)
" In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0."1.29Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995)
"The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal-bis[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine."1.27Differential toxicity of methylglyoxal-bis [guanylhydrazone]. ( Dewey, DL; Gaugas, JM; Minchinton, AI; Stratford, MR, 1983)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199012 (30.77)18.7374
1990's17 (43.59)18.2507
2000's8 (20.51)29.6817
2010's2 (5.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agostinelli, E3
Condello, M3
Tempera, G2
Macone, A1
Bozzuto, G1
Ohkubo, S1
Calcabrini, A1
Arancia, G3
Molinari, A3
Tan, SY1
Ang, CY1
Luo, Z1
Li, P1
Nguyen, KT1
Zhao, Y1
Viceconte, N1
Chen, Y3
Alm, K1
Vujcic, S5
Kramer, DL7
Kee, K1
Diegelman, P6
Porter, CW16
Li, F1
Minchin, RF1
Knight, S1
Arulpragasam, A1
Fogel-Petrovic, M4
Lentini, A1
Forni, C1
Provenzano, B1
Beninati, S1
Belli, F1
Palmigiani, P1
Vedova, LD1
Marra, M1
Seiler, N1
Muskiet, FA1
van den Berg, GA1
Kingma, AW1
Fremouw-Ottevangers, DC1
Halie, MR1
Dewey, DL1
Gaugas, JM1
Stratford, MR1
Minchinton, AI1
Desser, H1
Kläring, WJ1
Luger, T1
Gebhart, W1
Prussak, CE1
Russell, DH2
Hazan, G1
Takami, H1
Nishioka, K2
Kramer, D1
Stanek, J1
Regenass, U1
Schneider, P1
Gutman, M1
Beltran, PJ1
Fan, D1
Delworth, MG1
Singh, RK1
Wilson, MR1
Fidler, IJ1
Fujiwara, K1
Furukawa, K1
Nakayama, E1
Shiku, H1
Ganis, B3
Rustum, Y1
Wrzosek, C1
Bergeron, RJ9
Shappell, NW2
Maragos, CM1
Wang, JM1
Hrabie, JA1
Oppenheim, JJ1
Keefer, LK1
Bernacki, RJ4
Miller, J2
Fogel-Petrovic, MF1
Creaven, PJ1
Perez, R1
Pendyala, L1
Meropol, NJ1
Loewen, G1
Levine, E1
Berghorn, E1
Raghavan, D1
Cooley, JM1
McManis, JS1
Oberman, EJ1
Seweryniak, KE1
Atwood, A1
White, C1
Black, JD2
Alderfer, J1
Miller, JT1
Weeks, RS1
Vanderwerf, SM1
Carlson, CL1
Burns, MR1
O'Day, CL1
Cai, F1
Devens, BH1
Webb, HK1
Pavel, P1
Schwippelová, Z1
Welch, MJ1
Coleman, RE1
Straatmann, MG1
Asberry, BE1
Primeau, JL1
Fair, WR1
Ter-Pogossian, MM1
Townsend, RM1
Banda, PW1
Marton, LJ1
Fleisher, JH1
Libby, PR2
Romsdahl, MM1
Glick, JL1
Majumdar, A1

Reviews

2 reviews available for spermine and Melanoma

ArticleYear
Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.
    Biochemical Society transactions, 1998, Volume: 26, Issue:4

    Topics: Acetyltransferases; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme In

1998
[Polyamines and malignant melanoma (author's transl)].
    Ceskoslovenska dermatologie, 1979, Volume: 54, Issue:2

    Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine

1979

Trials

1 trial available for spermine and Melanoma

ArticleYear
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
    Investigational new drugs, 1997, Volume: 15, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr

1997

Other Studies

36 other studies available for spermine and Melanoma

ArticleYear
The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach.
    International journal of oncology, 2014, Volume: 45, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cells, Cultured; Chloroquine;

2014
An iGlu receptor antagonist and its simultaneous use with an anticancer drug for cancer therapy.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Apr-13, Volume: 21, Issue:16

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Combinations; Drug Delivery Syst

2015
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
    International journal of oncology, 2009, Volume: 35, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line

2009
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.
    Cancer research, 2003, Jul-01, Volume: 63, Issue:13

    Topics: Antineoplastic Agents; Apoptosis; Enzyme Activation; Flavonoids; Humans; Kinetics; Melanoma; Mitogen

2003
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells.
    Oncogene, 2003, Aug-07, Volume: 22, Issue:32

    Topics: Antineoplastic Agents; Apoptosis; Humans; Inhibitor of Apoptosis Proteins; Melanoma; Polyamines; Pro

2003
Concentration-dependent effects of N1, N11-diethylnorspermine on melanoma cell proliferation.
    International journal of cancer, 2006, Jan-15, Volume: 118, Issue:2

    Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neopla

2006
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.
    Amino acids, 2007, Volume: 32, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Activation; Estrogen Antagonists; Flavano

2007
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.
    Biochimica et biophysica acta, 2006, Volume: 1763, Issue:10

    Topics: Animals; Annexin A5; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relations

2006
Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications.
    Clinical chemistry, 1984, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Aged; Amino Acids, Diamino; Cadaverine; Child; Child, Preschool; Chromatography,

1984
Differential toxicity of methylglyoxal-bis [guanylhydrazone].
    The Journal of pathology, 1983, Volume: 139, Issue:2

    Topics: Animals; Cell Count; Cell Line; DNA; Dose-Response Relationship, Drug; Fibroblasts; Guanidines; Mela

1983
[Polyamine levels in blood and plasma of patients with malignant melanoma].
    Onkologie, 1982, Volume: 5, Issue:1

    Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged

1982
Single-step high-performance liquid chromatographic method for the analysis of acetylated polyamines.
    Journal of chromatography, 1982, Apr-16, Volume: 229, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Leukemia; Male; Melanoma; Mesothelioma; Putrescine; Re

1982
Effect of heat combined with polyamines on tumor growth in mice.
    Israel journal of medical sciences, 1980, Volume: 16, Issue:3

    Topics: Animals; Cadaverine; Hot Temperature; Melanoma; Mice; Neoplasms, Experimental; Polyamines; Skin Neop

1980
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
    British journal of cancer, 1980, Volume: 41, Issue:5

    Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm

1980
Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.
    Biochemical pharmacology, 1995, Oct-26, Volume: 50, Issue:9

    Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; Cell Membrane Permeab

1995
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
    Melanoma research, 1995, Volume: 5, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Cell Division; Culture Media; Dose-Response Rel

1995
Production and characterization of monoclonal antibodies against the polyamine, spermine: immunocytochemical localization in rat tissues.
    Histochemistry, 1994, Volume: 102, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cross-Linking Reagents; Enzyme-Linked Immunos

1994
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
    Cancer research, 1994, Nov-15, Volume: 54, Issue:22

    Topics: Adenosylmethionine Decarboxylase; Amidines; ATP Binding Cassette Transporter, Subfamily B, Member 1;

1994
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
    The Journal of biological chemistry, 1993, Sep-05, Volume: 268, Issue:25

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Base Sequence; Blotting, Northern; Dactinomyci

1993
Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.
    Cancer research, 1993, Feb-01, Volume: 53, Issue:3

    Topics: Antineoplastic Agents; Cell Division; Diamines; Diethylamines; DNA, Neoplasm; Drug Carriers; Humans;

1993
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
    Cancer research, 1993, Feb-01, Volume: 53, Issue:3

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Dose-Response

1993
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
    FEBS letters, 1993, Apr-26, Volume: 321, Issue:2-3

    Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeo

1993
Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines.
    FEBS letters, 1996, Aug-05, Volume: 391, Issue:1-2

    Topics: Acetyltransferases; Blotting, Northern; Cell Line; Cycloheximide; Gene Expression Regulation, Enzymo

1996
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
    Cancer research, 1997, Dec-15, Volume: 57, Issue:24

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Cell Cycle; Cell Division

1997
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:8

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio

1995
Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells.
    Cancer research, 1999, Mar-15, Volume: 59, Issue:6

    Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; Cyclin-Dependent Kinase

1999
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
    Experimental cell research, 2000, Nov-25, Volume: 261, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine;

2000
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.
    Cancer research, 2001, Sep-01, Volume: 61, Issue:17

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Caspase 3; Caspases; Cyto

2001
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1977, Volume: 18, Issue:1

    Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne

1977
Polyamines in malignant melanoma. Urinary excretion and disease progress.
    Cancer, 1976, Volume: 38, Issue:5

    Topics: Female; Humans; Male; Melanoma; Polyamines; Putrescine; Spermidine; Spermine

1976
Estimation of urinary diamines and polyamines by thin-layer chromatography.
    Journal of chromatography, 1975, Jul-16, Volume: 110, Issue:2

    Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano

1975
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
    Cancer research, 1992, May-01, Volume: 52, Issue:9

    Topics: Acetyltransferases; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Administration Sc

1992
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
    Archives of biochemistry and biophysics, 1991, Feb-01, Volume: 284, Issue:2

    Topics: Acetyltransferases; Coenzyme A; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Stabil

1991
Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.
    Cancer research, 1991, Jul-15, Volume: 51, Issue:14

    Topics: Acetyltransferases; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Enzyme Induction; Hum

1991
Elevation of putrescine and spermidine in sera of patients with solid tumors.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Dec-02, Volume: 57, Issue:2

    Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc

1974
A "loop" model for integration of donor DNA into host DNA of eukaryote cells.
    Journal of theoretical biology, 1972, Volume: 36, Issue:3

    Topics: Alleles; Animals; Bromodeoxyuridine; Cell Differentiation; Cell Nucleus; Cell Transformation, Neopla

1972