spermine has been researched along with Melanoma in 39 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 7.80 | The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach. ( Agostinelli, E; Arancia, G; Bozzuto, G; Calcabrini, A; Condello, M; Macone, A; Molinari, A; Ohkubo, S; Tempera, G, 2014) |
| "It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 7.75 | Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009) |
| "The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated." | 7.74 | Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007) |
| " We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 7.73 | Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006) |
| "In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, and increases the polyamine catabolizing enzyme, spermidine/spermine N1-acetyl-transferase (SSAT) by more than 200-fold." | 7.68 | Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. ( Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW, 1993) |
| "Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme." | 7.68 | Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991) |
| " Although the three sublines were 2- to 10-fold less sensitive than the parent line to classical MDR-type agents, they were found in dose-response studies to be significantly more sensitive to DENSPM than the parent line." | 5.29 | Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. ( Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C, 1994) |
| " Similar antitumor activity was obtained with 120 mg/kg once daily for 6 days and 40 mg/kg once daily for 6 days, indicating that against this tumor model, the dosing schedule can be relaxed up to sixfold without compromising antitumor activity." | 5.29 | Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. ( Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW, 1993) |
| "It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.80 | The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach. ( Agostinelli, E; Arancia, G; Bozzuto, G; Calcabrini, A; Condello, M; Macone, A; Molinari, A; Ohkubo, S; Tempera, G, 2014) |
| "It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.75 | Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009) |
| "The in vitro and in vivo effects of two flavonons, naringenin (NG) and hesperitin (HP) on the proliferation rate of highly metastatic murine B16-F10 melanoma cell were investigated." | 3.74 | Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential. ( Beninati, S; Forni, C; Lentini, A; Provenzano, B, 2007) |
| " We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.73 | Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006) |
| "We have previously shown that the clinically relevant polyamine analog N1,N11-diethylnorspermine (DENSPM) causes rapid apoptosis in human melanoma SK-MEL-28 cells via a series of events that include mitochondrial release of cytochrome c and activation of the caspase cascade." | 3.72 | Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. ( Chen, Y; Kramer, DL; Li, F; Porter, CW, 2003) |
| " We have found that treatment of MALME-3M human melanoma cells for 6 h with 10 micrograms/ml cycloheximide (CHX) increases ODC and SSAT mRNA 6-9-fold." | 3.69 | Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines. ( Fogel-Petrovic, M; Miller, J; Porter, CW; Vujcic, S, 1996) |
| "In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, and increases the polyamine catabolizing enzyme, spermidine/spermine N1-acetyl-transferase (SSAT) by more than 200-fold." | 3.68 | Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells. ( Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW, 1993) |
| "Extreme inducibility of spermidine/spermine acetyltransferase (SSAT) by bis-ethyl derivatives of spermine in human large cell lung carcinoma and melanoma cells has prompted biochemical characterization of the purified enzyme." | 3.68 | Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. ( Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW, 1991) |
| "The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection." | 3.66 | [Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982) |
| "The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| " Although the three sublines were 2- to 10-fold less sensitive than the parent line to classical MDR-type agents, they were found in dose-response studies to be significantly more sensitive to DENSPM than the parent line." | 1.29 | Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. ( Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C, 1994) |
| " Similar antitumor activity was obtained with 120 mg/kg once daily for 6 days and 40 mg/kg once daily for 6 days, indicating that against this tumor model, the dosing schedule can be relaxed up to sixfold without compromising antitumor activity." | 1.29 | Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. ( Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW, 1993) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| "The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal-bis[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine." | 1.27 | Differential toxicity of methylglyoxal-bis [guanylhydrazone]. ( Dewey, DL; Gaugas, JM; Minchinton, AI; Stratford, MR, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (30.77) | 18.7374 |
| 1990's | 17 (43.59) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agostinelli, E | 3 |
| Condello, M | 3 |
| Tempera, G | 2 |
| Macone, A | 1 |
| Bozzuto, G | 1 |
| Ohkubo, S | 1 |
| Calcabrini, A | 1 |
| Arancia, G | 3 |
| Molinari, A | 3 |
| Tan, SY | 1 |
| Ang, CY | 1 |
| Luo, Z | 1 |
| Li, P | 1 |
| Nguyen, KT | 1 |
| Zhao, Y | 1 |
| Viceconte, N | 1 |
| Chen, Y | 3 |
| Alm, K | 1 |
| Vujcic, S | 5 |
| Kramer, DL | 7 |
| Kee, K | 1 |
| Diegelman, P | 6 |
| Porter, CW | 16 |
| Li, F | 1 |
| Minchin, RF | 1 |
| Knight, S | 1 |
| Arulpragasam, A | 1 |
| Fogel-Petrovic, M | 4 |
| Lentini, A | 1 |
| Forni, C | 1 |
| Provenzano, B | 1 |
| Beninati, S | 1 |
| Belli, F | 1 |
| Palmigiani, P | 1 |
| Vedova, LD | 1 |
| Marra, M | 1 |
| Seiler, N | 1 |
| Muskiet, FA | 1 |
| van den Berg, GA | 1 |
| Kingma, AW | 1 |
| Fremouw-Ottevangers, DC | 1 |
| Halie, MR | 1 |
| Dewey, DL | 1 |
| Gaugas, JM | 1 |
| Stratford, MR | 1 |
| Minchinton, AI | 1 |
| Desser, H | 1 |
| Kläring, WJ | 1 |
| Luger, T | 1 |
| Gebhart, W | 1 |
| Prussak, CE | 1 |
| Russell, DH | 2 |
| Hazan, G | 1 |
| Takami, H | 1 |
| Nishioka, K | 2 |
| Kramer, D | 1 |
| Stanek, J | 1 |
| Regenass, U | 1 |
| Schneider, P | 1 |
| Gutman, M | 1 |
| Beltran, PJ | 1 |
| Fan, D | 1 |
| Delworth, MG | 1 |
| Singh, RK | 1 |
| Wilson, MR | 1 |
| Fidler, IJ | 1 |
| Fujiwara, K | 1 |
| Furukawa, K | 1 |
| Nakayama, E | 1 |
| Shiku, H | 1 |
| Ganis, B | 3 |
| Rustum, Y | 1 |
| Wrzosek, C | 1 |
| Bergeron, RJ | 9 |
| Shappell, NW | 2 |
| Maragos, CM | 1 |
| Wang, JM | 1 |
| Hrabie, JA | 1 |
| Oppenheim, JJ | 1 |
| Keefer, LK | 1 |
| Bernacki, RJ | 4 |
| Miller, J | 2 |
| Fogel-Petrovic, MF | 1 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Cooley, JM | 1 |
| McManis, JS | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| White, C | 1 |
| Black, JD | 2 |
| Alderfer, J | 1 |
| Miller, JT | 1 |
| Weeks, RS | 1 |
| Vanderwerf, SM | 1 |
| Carlson, CL | 1 |
| Burns, MR | 1 |
| O'Day, CL | 1 |
| Cai, F | 1 |
| Devens, BH | 1 |
| Webb, HK | 1 |
| Pavel, P | 1 |
| Schwippelová, Z | 1 |
| Welch, MJ | 1 |
| Coleman, RE | 1 |
| Straatmann, MG | 1 |
| Asberry, BE | 1 |
| Primeau, JL | 1 |
| Fair, WR | 1 |
| Ter-Pogossian, MM | 1 |
| Townsend, RM | 1 |
| Banda, PW | 1 |
| Marton, LJ | 1 |
| Fleisher, JH | 1 |
| Libby, PR | 2 |
| Romsdahl, MM | 1 |
| Glick, JL | 1 |
| Majumdar, A | 1 |
2 reviews available for spermine and Melanoma
| Article | Year |
|---|---|
Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.
Topics: Acetyltransferases; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme In | 1998 |
[Polyamines and malignant melanoma (author's transl)].
Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine | 1979 |
1 trial available for spermine and Melanoma
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
36 other studies available for spermine and Melanoma
| Article | Year |
|---|---|
The combined treatment with chloroquine and the enzymatic oxidation products of spermine overcomes multidrug resistance of melanoma M14 ADR2 cells: a new therapeutic approach.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cells, Cultured; Chloroquine; | 2014 |
An iGlu receptor antagonist and its simultaneous use with an anticancer drug for cancer therapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Combinations; Drug Delivery Syst | 2015 |
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line | 2009 |
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Enzyme Activation; Flavonoids; Humans; Kinetics; Melanoma; Mitogen | 2003 |
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells.
Topics: Antineoplastic Agents; Apoptosis; Humans; Inhibitor of Apoptosis Proteins; Melanoma; Polyamines; Pro | 2003 |
Concentration-dependent effects of N1, N11-diethylnorspermine on melanoma cell proliferation.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neopla | 2006 |
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potential.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Activation; Estrogen Antagonists; Flavano | 2007 |
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.
Topics: Animals; Annexin A5; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relations | 2006 |
Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications.
Topics: Adolescent; Adult; Aged; Amino Acids, Diamino; Cadaverine; Child; Child, Preschool; Chromatography, | 1984 |
Differential toxicity of methylglyoxal-bis [guanylhydrazone].
Topics: Animals; Cell Count; Cell Line; DNA; Dose-Response Relationship, Drug; Fibroblasts; Guanidines; Mela | 1983 |
[Polyamine levels in blood and plasma of patients with malignant melanoma].
Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged | 1982 |
Single-step high-performance liquid chromatographic method for the analysis of acetylated polyamines.
Topics: Chromatography, High Pressure Liquid; Humans; Leukemia; Male; Melanoma; Mesothelioma; Putrescine; Re | 1982 |
Effect of heat combined with polyamines on tumor growth in mice.
Topics: Animals; Cadaverine; Hot Temperature; Melanoma; Mice; Neoplasms, Experimental; Polyamines; Skin Neop | 1980 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; Cell Membrane Permeab | 1995 |
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Cell Division; Culture Media; Dose-Response Rel | 1995 |
Production and characterization of monoclonal antibodies against the polyamine, spermine: immunocytochemical localization in rat tissues.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cross-Linking Reagents; Enzyme-Linked Immunos | 1994 |
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
Topics: Adenosylmethionine Decarboxylase; Amidines; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 1994 |
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Base Sequence; Blotting, Northern; Dactinomyci | 1993 |
Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.
Topics: Antineoplastic Agents; Cell Division; Diamines; Diethylamines; DNA, Neoplasm; Drug Carriers; Humans; | 1993 |
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Dose-Response | 1993 |
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeo | 1993 |
Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines.
Topics: Acetyltransferases; Blotting, Northern; Cell Line; Cycloheximide; Gene Expression Regulation, Enzymo | 1996 |
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Cell Cycle; Cell Division | 1997 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |
Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; Cyclin-Dependent Kinase | 1999 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; | 2000 |
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.
Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Caspase 3; Caspases; Cyto | 2001 |
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne | 1977 |
Polyamines in malignant melanoma. Urinary excretion and disease progress.
Topics: Female; Humans; Male; Melanoma; Polyamines; Putrescine; Spermidine; Spermine | 1976 |
Estimation of urinary diamines and polyamines by thin-layer chromatography.
Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano | 1975 |
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Topics: Acetyltransferases; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Administration Sc | 1992 |
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
Topics: Acetyltransferases; Coenzyme A; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme Stabil | 1991 |
Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.
Topics: Acetyltransferases; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Enzyme Induction; Hum | 1991 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |
A "loop" model for integration of donor DNA into host DNA of eukaryote cells.
Topics: Alleles; Animals; Bromodeoxyuridine; Cell Differentiation; Cell Nucleus; Cell Transformation, Neopla | 1972 |