spermine has been researched along with Leukemia L 1210 in 59 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spermidine was depleted in treated L1210 cells but was only partly reduced in treated R20 cells." | 1.29 | Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells. ( Byers, TL; Pegg, AE; Wechter, RS; Wiest, L, 1993) |
| " In the latter model, at a BE-3-3-3/cisplatin molar ratio of 250:1, an increased lifespan (ILS) of 56% is recorded during a 9-day dosing schedule, whereas BE-3-3-3 at the same dose caused a 21% ILS, and cisplatin only exhibited a 7% ILS." | 1.29 | Synergism of the polyamine analogue, N1,N11-bisethylnorspermine with cis-diaminedichloroplatinum (II) against murine neoplastic cell lines in vitro and in vivo. ( Austin, JK; Hawthorne, TR, 1996) |
| "Putrescine was similarly ineffective, supporting growth at 13% of control and viability at 7%." | 1.28 | Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells. ( Bukin, YV; Khomutov, AR; Khomutov, RM; Kramer, DL; Porter, CW, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (44.07) | 18.7374 |
| 1990's | 29 (49.15) | 18.2507 |
| 2000's | 3 (5.08) | 29.6817 |
| 2010's | 1 (1.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lakanen, JR | 2 |
| Coward, JK | 2 |
| Pegg, AE | 7 |
| Tomasi, S | 2 |
| Le Roch, M | 2 |
| Renault, J | 3 |
| Corbel, JC | 1 |
| Uriac, P | 3 |
| Carboni, B | 1 |
| Moncoq, D | 1 |
| Martin, B | 2 |
| Delcros, JG | 3 |
| Duhieu, S | 1 |
| Cerec, V | 1 |
| MISRA, DK | 1 |
| ADAMSON, RH | 1 |
| OCHOA, M | 1 |
| WEINSTEIN, IB | 1 |
| Bergeron, RJ | 13 |
| McManis, JS | 4 |
| Franklin, AM | 1 |
| Yao, H | 4 |
| Weimar, WR | 6 |
| Seppänen, P | 1 |
| Ruohola, H | 1 |
| Jänne, J | 2 |
| Cavanaugh, PF | 1 |
| Pavelic, ZP | 1 |
| Porter, CW | 12 |
| Casero, RA | 2 |
| Blair, DG | 1 |
| Byczkowski, JZ | 1 |
| Taylor, RF | 1 |
| Teague, LA | 1 |
| Yesair, DW | 1 |
| Kramer, D | 2 |
| Stanek, J | 2 |
| Diegelman, P | 1 |
| Regenass, U | 1 |
| Schneider, P | 1 |
| Grillo, MA | 1 |
| Colombatto, S | 1 |
| Liu, CZ | 1 |
| Feng, Y | 3 |
| Luchetta, GR | 1 |
| Wu, Q | 2 |
| Ortiz-Ocasio, J | 1 |
| Vinson, JR | 2 |
| Byers, TL | 2 |
| Stjernborg, L | 1 |
| Heby, O | 4 |
| Mamont, P | 1 |
| Persson, L | 3 |
| Wiest, L | 1 |
| Wechter, RS | 1 |
| Albanese, L | 1 |
| Ask, A | 2 |
| Seiler, N | 2 |
| Poulin, R | 1 |
| Hawthorne, TR | 2 |
| Austin, JK | 1 |
| Li, Y | 1 |
| Eiseman, JL | 1 |
| Sentz, DL | 1 |
| Rogers, FA | 1 |
| Pan, SS | 1 |
| Hu, LT | 1 |
| Egorin, MJ | 1 |
| Callery, PS | 1 |
| Yao, GW | 1 |
| Sninsky, CA | 1 |
| Raisler, B | 2 |
| Gao, F | 1 |
| Khomutov, AR | 2 |
| Shvetsov, AS | 1 |
| Vepsalainen, J | 1 |
| Dramer, DL | 1 |
| Hyvonen, T | 1 |
| Keinanen, T | 1 |
| Eloranta, TO | 1 |
| Khomutov, RM | 2 |
| Dorhout, B | 4 |
| Odink, MF | 1 |
| de Hoog, E | 4 |
| Kingma, AW | 4 |
| van der Veer, E | 1 |
| Muskiet, FA | 4 |
| Dimova, H | 1 |
| Porter, C | 1 |
| Phanstiel, O | 1 |
| Felschow, DM | 1 |
| Mi, Z | 1 |
| Frei, J | 1 |
| Douaud, F | 1 |
| Havouis, R | 1 |
| Moulinoux, JP | 1 |
| Ferwerda, H | 1 |
| Poortenga, PJ | 1 |
| Müller, R | 2 |
| Zimmerman, CO | 1 |
| McCosar, BH | 1 |
| Smith, RE | 1 |
| Stefanelli, C | 1 |
| Bonavita, F | 1 |
| Stanic', I | 1 |
| Mignani, M | 1 |
| Facchini, A | 1 |
| Pignatti, C | 1 |
| Flamigni, F | 1 |
| Caldarera, CM | 1 |
| Wang, Z | 1 |
| Fries, D | 1 |
| Blankenship, J | 1 |
| Huang, G | 1 |
| Algee, SE | 1 |
| Wiegand, J | 1 |
| Hegmans, A | 1 |
| Qu, Y | 1 |
| Kelland, LR | 1 |
| Roberts, JD | 1 |
| Farrell, N | 1 |
| Foa, P | 1 |
| Paile, W | 1 |
| Yuen, TL | 1 |
| Jones, WA | 1 |
| Rytömaa, T | 1 |
| Newton, NE | 2 |
| Abdel-Monem, MM | 2 |
| Ohno, K | 1 |
| Canellakis, ES | 1 |
| Bellantone, RA | 1 |
| Vertino, PM | 1 |
| Beerman, TA | 1 |
| Kelly, EJ | 1 |
| Ganis, B | 1 |
| Madhabala, R | 1 |
| Wotring, LL | 1 |
| Townsend, LB | 1 |
| Jones, LM | 1 |
| Borysko, KZ | 1 |
| Gildersleeve, DL | 1 |
| Parker, WB | 1 |
| Kramer, DL | 1 |
| Bukin, YV | 1 |
| Pommier, Y | 1 |
| Kerrigan, D | 1 |
| Kohn, K | 1 |
| Beck, DE | 1 |
| Ingeno, MJ | 1 |
| Libby, PR | 2 |
| Henderson, M | 1 |
| Madhubala, R | 1 |
| Secrist, JA | 1 |
| McManis, J | 1 |
| Hacker, B | 1 |
| McDermott, BJ | 1 |
| Israel, M | 1 |
| Zoll, EC | 1 |
| Muhammad, N | 1 |
| Modest, EJ | 1 |
| Russell, DH | 3 |
| Glick, JL | 2 |
| Majumdar, A | 1 |
| Levy, CC | 1 |
| Salim, AP | 1 |
| Crystal, HA | 1 |
1 review available for spermine and Leukemia L 1210
| Article | Year |
|---|---|
Polyamine transport in cells.
Topics: Animals; Biological Transport; Cells, Cultured; Escherichia coli; Humans; Kinetics; Leukemia L1210; | 1994 |
58 other studies available for spermine and Leukemia L 1210
| Article | Year |
|---|---|
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Topics: Animals; Cell Division; Cell Line, Transformed; Colonic Neoplasms; Eflornithine; Humans; Leukemia L1 | 1992 |
Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Calmodulin; Cattle; Cell Survival | 1998 |
Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates.
Topics: Animals; Antineoplastic Agents; Azepines; Benzazepines; Biological Transport; Cell Proliferation; CH | 2010 |
EFFECT OF AMINES ON DIHYDROFOLATE REDUCTASE.
Topics: Amines; Animals; Cadaver; Ethylenediamines; Folic Acid; Leukemia L1210; Liver; Mice; Oxidoreductases | 1963 |
POLYPEPTIDE SYNTHESIS IN A SUBCELLULAR SYSTEM DERIVED FROM THE L-1210 MOUSE ASCITES LEUKEMIA.
Topics: Animals; Ascites; Carbon Isotopes; Chloramphenicol; Deoxyribonucleases; DNA; Kinetics; Leukemia L121 | 1964 |
Polyamine-iron chelator conjugate.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Binding, Compe | 2003 |
Ethylglyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in L1210 leukemia cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Guanidines; Leukemia L1210; Microscopy, El | 1984 |
Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced cytotoxicity and DNA damage by alpha-difluoromethylornithine in L1210 leukemia cells.
Topics: Animals; Carmustine; Cell Survival; DNA, Neoplasm; Drug Synergism; Eflornithine; Kinetics; Leukemia | 1984 |
Treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Leukemia L1 | 1984 |
Stimulation of RNA polymerases I and II from mouse L1210 leukemia and Ehrlich ascites carcinoma cells by spermine and spermidine and its modification by ammonium sulfate.
Topics: Ammonium Sulfate; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Drug Interactions; Kinetics; Leuk | 1984 |
Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria.
Topics: Animals; Antineoplastic Agents; Carbanilides; Dinitrophenols; Drug Interactions; Guanidines; In Vitr | 1983 |
Drug-binding macromolecular lipids from L1210 leukemia tumors.
Topics: Anilides; Animals; Binding, Competitive; Carbanilides; Chromatography, Affinity; Electrophoresis, Po | 1981 |
Use of 4-fluoro-L-ornithine to monitor metabolic flux through the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; Cell Membrane Permeab | 1995 |
Antiproliferative properties of polyamine analogues: a structure-activity study.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Binding, Competitive; Cell Division; | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure L | 1994 |
Polyamine-mediated regulation of S-adenosylmethionine decarboxylase expression in mammalian cells. Studies using 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, a suicide inhibitor of the enzyme.
Topics: Adenosylmethionine Decarboxylase; Animals; Deoxyadenosines; Enzyme Precursors; Gene Expression Regul | 1993 |
Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Deoxyadenosines; Drug Resistance; Eukaryot | 1993 |
Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine.
Topics: Animals; Cell Division; Cell Line; DNA, Mitochondrial; Humans; Leukemia L1210; Mitoguazone; Oxygen C | 1993 |
Antileukemic effects of non-metabolizable derivatives of spermidine and spermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Drug Synergism; Eflornithine; Female; Leukemia L1210; Mic | 1993 |
Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells.
Topics: Animals; Antineoplastic Agents; Bicarbonates; Eflornithine; Hydrogen-Ion Concentration; Leukemia L12 | 1995 |
Synergism of the polyamine analogue, N1,N11-bisethylnorspermine with cis-diaminedichloroplatinum (II) against murine neoplastic cell lines in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Disease Susceptib | 1996 |
Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane.
Topics: Animals; Antineoplastic Agents; Aziridines; Cross-Linking Reagents; DNA; Electrophoresis, Agar Gel; | 1996 |
Metabolically programmed polyamine analogue antidiarrheals.
Topics: Animals; Antidiarrheals; Biological Transport; Castor Oil; Cell Division; Computer Simulation; Diarr | 1996 |
[New aminooxy analogs of biogenic polyamines].
Topics: Animals; Cell Division; Cell Line; Cricetinae; Leukemia L1210; Putrescine; Spermidine; Spermine; Tum | 1996 |
4-Amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) exerts in vitro growth inhibitory effects that are not only related to S-adenosylmethionine decarboxylase (SAMdc) inhibition.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Antineoplastic Agents; Cell Division; Deoxyaden | 1997 |
A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Cell Division; | 1997 |
Simultaneous determination of polyamines, N-acetylated polyamines and the polyamine analogues BE-3-3-3 and BE-4-4-4-4 by capillary gas chromatography with nitrogen-phosphorus detection.
Topics: Acetylation; Animals; Chromatography, Gas; Leukemia L1210; Polyamines; Propylamines; Sensitivity and | 1997 |
Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe.
Topics: Animals; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Cross-Linking | 1997 |
Polyamine sulfonamides with NMDA antagonist properties are potent calmodulin antagonists and cytotoxic agents.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agen | 1998 |
In vivo manipulation of L1210 cell cycle phase distribution with alpha-difluoromethylornithine, 4-amidinoindan-1-one 2'-amidinohydrazone and N1-acetylspermine.
Topics: Amidines; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Eflornithine; Female; | 1998 |
In vitro manipulation of L1210 cell cycle kinetics with 4-amidinoindan-1-one 2'-amidinohydrazone, alpha-difluoromethylornithine and N1-acetylspermine.
Topics: Amidines; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cell Cycle; DNA; Dose | 1998 |
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Divisio | 1998 |
Spermine causes caspase activation in leukaemia cells.
Topics: Animals; Caspase 3; Caspases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; H | 1998 |
Effect of N8-acetylspermidine deacetylase inhibition on the growth of L1210 cells.
Topics: Amidohydrolases; Animals; Cell Division; Chromatography, High Pressure Liquid; Diamines; Drug Intera | 1999 |
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Drug Screening | 2001 |
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.
Topics: Animals; Antineoplastic Agents; Carbamates; Catalysis; Chromatography, High Pressure Liquid; Female; | 2001 |
Granulocytic chalone is not a polyamine complex.
Topics: Animals; Bone Marrow; Granulocytes; Growth Inhibitors; Humans; Leukemia L1210; Leukemia, Experimenta | 1979 |
Inhibitors of polyamine biosynthesis. 4. Effects of alpha-methyl-(+/-)-ornithine and methylglyoxal bis(guanylhydrazone) on growth and polyamine content of L1210 leukemic cells of mice.
Topics: Animals; Cell Division; Cells, Cultured; DNA, Neoplasm; Guanidines; Leukemia L1210; Mice; Mitoguazon | 1977 |
Determination of diamines and polyamines in tissues by high-pressure liquid chromatography.
Topics: Animals; Brain Chemistry; Cells, Cultured; Chromatography, High Pressure Liquid; Dansyl Compounds; L | 1976 |
Diacridines: bifunctional intercalators. II. The biological effects of putrescine, sperimidine and spermine diacridines on HeLa cells and on the L-1210 and P-388 leukemia cells.
Topics: Acridines; Animals; Cell Division; HeLa Cells; Leukemia L1210; Leukemia, Experimental; Mice; Protein | 1976 |
Increased survival of L1210 leukemic mice by prevention of the utilization of extracellular polyamines. Studies using a polyamine-uptake mutant, antibiotics and a polyamine-deficient diet.
Topics: Animals; Anti-Bacterial Agents; Biological Transport; Carbon Radioisotopes; Drug Resistance; Eflorni | 1992 |
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
Topics: Animals; Antineoplastic Agents; Blotting, Southern; Cell Division; Cell Line, Transformed; DNA; DNA | 1991 |
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Kinetics; Leukemia | 1990 |
Dual mechanisms of inhibition of DNA synthesis by triciribine.
Topics: Animals; Antineoplastic Agents; DNA Polymerase I; DNA Primase; DNA Replication; DNA, Neoplasm; Kinet | 1990 |
Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Survival; Deoxyadenos | 1989 |
Topological complexes between DNA and topoisomerase II and effects of polyamines.
Topics: Amsacrine; Animals; DNA Topoisomerases, Type II; DNA, Viral; Kinetics; Leukemia L1210; Mice; Protein | 1989 |
Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Survival; DNA, Neoplasm; L | 1989 |
Major increases in spermidine/spermine-N1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells.
Topics: Acetyltransferases; Animals; Cell Division; Cell Line; Cell Survival; Dogs; Humans; Kinetics; Leukem | 1989 |
Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Deoxyadenosines; Leukemia L121 | 1988 |
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Cell Division; Leukemia L1210; Mice | 1987 |
Separation of two isozymes of polyamine oxidase from murine L1210 leukemia cells.
Topics: Animals; Isoenzymes; Kinetics; Leukemia L1210; Mice; Mice, Inbred DBA; Molecular Weight; Oxidoreduct | 1987 |
Polyamines and transfer RNA-methylation in mouse leukemic cells.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Chromatography, Gel; Chromatography, Paper; Chromatogr | 1972 |
Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N'-bis(3-aminopropyl)nonane-1,9-diamine.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Line; Dose-Response Relationship, Drug; Humans; Leuk | 1973 |
Effects of methylglyoxal-bis(guanylhydrazone) on polyamine metabolism in spleens of mice with disseminated L1210 lymphoid leukemia.
Topics: Amidines; Animals; Antineoplastic Agents; Carboxy-Lyases; Glyoxal; Hydrazones; Leukemia L1210; Male; | 1974 |
A "loop" model for integration of donor DNA into host DNA of eukaryote cells.
Topics: Alleles; Animals; Bromodeoxyuridine; Cell Differentiation; Cell Nucleus; Cell Transformation, Neopla | 1972 |
Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Cytarabine; Leukemia L1210; Methotrexate; Mice; Mice, Inbr | 1972 |
Polyamine accumulation and biosynthesis in a mouse L1210 leukemia.
Topics: Amines; Animals; Ascitic Fluid; Butylamines; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Leukem | 1971 |
The specific cytotoxic effect of DBA2 mouse DNA on L1210 leukemia.
Topics: Animals; Culture Techniques; DNA; Leukemia L1210; Mice; Spermine; Thymus Gland; Tritium | 1968 |