spermine has been researched along with Inflammation in 24 studies
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this report, we developed microparticles based on polymerization of alpha-ketoglutarate (a Krebs cycle metabolite), with or without encapsulation of spermine (a polyamine metabolite), to modulate cell phenotype that are critical for resolution of inflammation." | 8.31 | Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models. ( Acharya, AP; de Ávila, C; Esrafili, A; Fryer, JD; Halim, M; Inamdar, S; Jaggarapu, MMCS; Lintecum, K; Mantri, S; Ng, ND; Schmitzer, E; Spiller, KL; Suresh, AP; Thumsi, A; Tylek, T; Xu, Y, 2023) |
| " The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidant-antioxidant balance in liver." | 8.31 | Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion. ( Baltaci, AK; Cetin, N; Dasdelen, D; Menevse, E; Mogulkoc, R, 2023) |
| "Intervertebral disc degeneration (IDD) is the leading cause of back, neck, and radicular pain." | 5.72 | Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. ( Cai, X; Huang, W; Kang, H; Qu, H; Wang, D; Xu, F, 2022) |
| "Kukoamine A (KuA) was demonstrated to have neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats." | 5.46 | Kukoamine A Prevents Radiation-Induced Neuroinflammation and Preserves Hippocampal Neurogenesis in Rats by Inhibiting Activation of NF-κB and AP-1. ( Cai, J; Cheng, Z; Gao, L; Meng, W; Niu, Y; Zhang, Y; Zhao, Q, 2017) |
| "Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 5.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
| "Inflammation has been implicated in the development of many human epithelial cancers, including those of the stomach, lung, colon, and prostate." | 5.33 | Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ( Babbar, N; Casero, RA, 2006) |
| " In this report, we developed microparticles based on polymerization of alpha-ketoglutarate (a Krebs cycle metabolite), with or without encapsulation of spermine (a polyamine metabolite), to modulate cell phenotype that are critical for resolution of inflammation." | 4.31 | Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models. ( Acharya, AP; de Ávila, C; Esrafili, A; Fryer, JD; Halim, M; Inamdar, S; Jaggarapu, MMCS; Lintecum, K; Mantri, S; Ng, ND; Schmitzer, E; Spiller, KL; Suresh, AP; Thumsi, A; Tylek, T; Xu, Y, 2023) |
| " The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidant-antioxidant balance in liver." | 4.31 | Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion. ( Baltaci, AK; Cetin, N; Dasdelen, D; Menevse, E; Mogulkoc, R, 2023) |
| "The aim of this study was to elucidate the mechanism underlying the effects of Kukoamine A (KuA) treatment on endotoxin-induced lung injury/inflammation." | 4.12 | Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury. ( Jiang, Y; Jiang, Z; Li, W; Liu, X; Song, Y; Wang, M; Xu, B; Zhang, C, 2022) |
| "We formulated adenovirus (AdV) vectors with cationic steroid liposomes containing dexamethasone-spermine (DS)/dioleoylphosphatidylethanolamine (DOPE) in an effort to overcome the lack of apically expressed AdV vector receptors on airway epithelial cells and to reduce the inflammation associated with AdV vector exposure." | 3.73 | Targeting viral-mediated transduction to the lung airway epithelium with the anti-inflammatory cationic lipid dexamethasone-spermine. ( Diamond, SL; Gruneich, JA; Limberis, M; Price, A; Wilson, JM, 2005) |
| "Intervertebral disc degeneration (IDD) is the leading cause of back, neck, and radicular pain." | 1.72 | Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway. ( Cai, X; Huang, W; Kang, H; Qu, H; Wang, D; Xu, F, 2022) |
| "Kukoamine A (KuA) was demonstrated to have neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats." | 1.46 | Kukoamine A Prevents Radiation-Induced Neuroinflammation and Preserves Hippocampal Neurogenesis in Rats by Inhibiting Activation of NF-κB and AP-1. ( Cai, J; Cheng, Z; Gao, L; Meng, W; Niu, Y; Zhang, Y; Zhao, Q, 2017) |
| "Kukoamine B (KB) is a novel cationic alkaloid that interferes with LPS binding to TLR4." | 1.43 | Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes. ( Chen, Q; Fan, S; Liu, X; Lu, Y; Wang, N; Yang, D; Yang, Y; Zheng, J; Zheng, X, 2016) |
| "Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 1.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
| "Inflammation has been implicated in the development of many human epithelial cancers, including those of the stomach, lung, colon, and prostate." | 1.33 | Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. ( Babbar, N; Casero, RA, 2006) |
| "When spermine was added to cultures of human peripheral blood mononuclear cells stimulated with lipopolysaccharide (LPS), it effectively inhibited the synthesis of the proinflammatory cytokines tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, MIP-1alpha, and MIP-1beta." | 1.30 | Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. ( Bianchi, M; Botchkina, G; Caragine, T; Cerami, A; Cohen, PS; Sherry, B; Soda, K; Tracey, KJ; Ulrich, P; Wang, H; Zhang, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 7 (29.17) | 2.80 |
| Authors | Studies |
|---|---|
| McCubbrey, AL | 1 |
| McManus, SA | 1 |
| McClendon, JD | 1 |
| Thomas, SM | 1 |
| Chatwin, HB | 1 |
| Reisz, JA | 1 |
| D'Alessandro, A | 1 |
| Mould, KJ | 1 |
| Bratton, DL | 1 |
| Henson, PM | 1 |
| Janssen, WJ | 1 |
| Wang, D | 1 |
| Qu, H | 1 |
| Kang, H | 1 |
| Xu, F | 1 |
| Huang, W | 1 |
| Cai, X | 1 |
| Liu, X | 2 |
| Wang, M | 1 |
| Song, Y | 1 |
| Zhang, C | 1 |
| Jiang, Y | 1 |
| Li, W | 1 |
| Xu, B | 1 |
| Jiang, Z | 1 |
| Xu, H | 1 |
| Zhang, G | 1 |
| Deng, L | 1 |
| Inamdar, S | 1 |
| Tylek, T | 1 |
| Thumsi, A | 1 |
| Suresh, AP | 1 |
| Jaggarapu, MMCS | 1 |
| Halim, M | 1 |
| Mantri, S | 1 |
| Esrafili, A | 1 |
| Ng, ND | 1 |
| Schmitzer, E | 1 |
| Lintecum, K | 1 |
| de Ávila, C | 1 |
| Fryer, JD | 1 |
| Xu, Y | 1 |
| Spiller, KL | 1 |
| Acharya, AP | 1 |
| Dasdelen, D | 1 |
| Cetin, N | 1 |
| Menevse, E | 1 |
| Baltaci, AK | 1 |
| Mogulkoc, R | 1 |
| Ricke, KM | 1 |
| Cruz, SA | 1 |
| Qin, Z | 1 |
| Farrokhi, K | 1 |
| Sharmin, F | 1 |
| Zhang, L | 1 |
| Zasloff, MA | 1 |
| Stewart, AFR | 1 |
| Chen, HH | 1 |
| Cao, W | 1 |
| Wu, X | 1 |
| Jia, G | 1 |
| Zhao, H | 1 |
| Chen, X | 1 |
| Wu, C | 1 |
| Tang, J | 1 |
| Wang, J | 1 |
| Cai, J | 2 |
| Liu, G | 1 |
| North, ML | 1 |
| Grasemann, H | 1 |
| Khanna, N | 1 |
| Inman, MD | 1 |
| Gauvreau, GM | 1 |
| Scott, JA | 1 |
| Yang, D | 1 |
| Zheng, X | 1 |
| Wang, N | 1 |
| Fan, S | 1 |
| Yang, Y | 1 |
| Lu, Y | 1 |
| Chen, Q | 1 |
| Zheng, J | 1 |
| Zhang, Y | 1 |
| Gao, L | 1 |
| Cheng, Z | 1 |
| Niu, Y | 1 |
| Meng, W | 1 |
| Zhao, Q | 1 |
| Amendola, R | 1 |
| Cervelli, M | 1 |
| Fratini, E | 1 |
| Polticelli, F | 1 |
| Sallustio, DE | 1 |
| Mariottini, P | 1 |
| Gruneich, JA | 2 |
| Price, A | 2 |
| Zhu, J | 1 |
| Diamond, SL | 2 |
| Limberis, M | 1 |
| Wilson, JM | 1 |
| Staib, F | 1 |
| Robles, AI | 1 |
| Varticovski, L | 1 |
| Wang, XW | 1 |
| Zeeberg, BR | 1 |
| Sirotin, M | 1 |
| Zhurkin, VB | 1 |
| Hofseth, LJ | 1 |
| Hussain, SP | 1 |
| Weinstein, JN | 1 |
| Galle, PR | 1 |
| Harris, CC | 1 |
| Babbar, N | 1 |
| Casero, RA | 1 |
| Merentie, M | 1 |
| Uimari, A | 1 |
| Pietilä, M | 1 |
| Sinervirta, R | 1 |
| Keinänen, TA | 1 |
| Vepsäläinen, J | 1 |
| Khomutov, A | 1 |
| Grigorenko, N | 1 |
| Herzig, KH | 1 |
| Jänne, J | 1 |
| Alhonen, L | 1 |
| Zhang, M | 3 |
| Caragine, T | 1 |
| Wang, H | 3 |
| Cohen, PS | 1 |
| Botchkina, G | 1 |
| Soda, K | 1 |
| Bianchi, M | 1 |
| Ulrich, P | 1 |
| Cerami, A | 1 |
| Sherry, B | 1 |
| Tracey, KJ | 3 |
| ter Steege, JC | 1 |
| Forget, PP | 1 |
| Buurman, WA | 1 |
| Borovikova, LV | 1 |
| Metz, C | 1 |
| Kapoor, R | 1 |
| Davies, M | 1 |
| Smith, KJ | 1 |
| Haskó, G | 1 |
| Kuhel, DG | 1 |
| Marton, A | 1 |
| Nemeth, ZH | 1 |
| Deitch, EA | 1 |
| Szabó, C | 1 |
| Sandau, KB | 1 |
| Fandrey, J | 1 |
| Brüne, B | 1 |
2 reviews available for spermine and Inflammation
| Article | Year |
|---|---|
Spermine metabolism and anticancer therapy.
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Enzyme Inhibitors; Homeostasis; Humans; Inflamm | 2009 |
Regulation of macrophage activation and inflammation by spermine: a new chapter in an old story.
Topics: alpha-Fetoproteins; Humans; Inflammation; Macrophage Activation; Spermine | 2000 |
22 other studies available for spermine and Inflammation
| Article | Year |
|---|---|
Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells.
Topics: Animals; Apoptosis; Cytophagocytosis; Female; Healthy Volunteers; Humans; Immunomodulation; Inflamma | 2022 |
Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway.
Topics: Apoptosis; Cells, Cultured; Extracellular Matrix; Humans; Inflammation; Intervertebral Disc Degenera | 2022 |
Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Inflammation; Lipopolysaccharides; Lung; Mice; O | 2022 |
Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury.
Topics: Animals; Glutathione Peroxidase; Glycogen Synthase Kinase 3 beta; Inflammation; Interleukin-6; Male; | 2022 |
Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models.
Topics: Animals; Biocompatible Materials; Immunity, Innate; Inflammation; Ketoglutaric Acids; Mice; Phenotyp | 2023 |
Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion.
Topics: Acetyltransferases; Animals; Brain Ischemia; Inflammation; Liver; Male; Oxidative Stress; Putrescine | 2023 |
Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholestanes; Disease Models, Animal; Female; Glyc | 2020 |
New insights into the role of dietary spermine on inflammation, immune function and related-signalling molecules in the thymus and spleen of piglets.
Topics: Animal Feed; Animals; Diet; Dietary Supplements; Gene Expression Regulation; Immunity, Innate; Infla | 2017 |
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensi | 2013 |
Kukoamine B promotes TLR4-independent lipopolysaccharide uptake in murine hepatocytes.
Topics: Animals; Asialoglycoprotein Receptor; Biosensing Techniques; Caffeic Acids; Flow Cytometry; Hep G2 C | 2016 |
Kukoamine A Prevents Radiation-Induced Neuroinflammation and Preserves Hippocampal Neurogenesis in Rats by Inhibiting Activation of NF-κB and AP-1.
Topics: Animals; Brain; Cyclooxygenase 2; Cytokines; Dose-Response Relationship, Drug; Hippocampus; Inflamma | 2017 |
Cationic corticosteroid for nonviral gene delivery.
Topics: Animals; Cations; Dexamethasone; Endothelial Cells; Genetic Therapy; Glucocorticoids; Inflammation; | 2004 |
Targeting viral-mediated transduction to the lung airway epithelium with the anti-inflammatory cationic lipid dexamethasone-spermine.
Topics: Alkaline Phosphatase; Animals; beta-Galactosidase; Cations; CD8 Antigens; Cell Line; Cytokines; Depe | 2005 |
The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.
Topics: Cell Cycle; Cell Hypoxia; Flow Cytometry; Gene Expression Profiling; HCT116 Cells; Humans; Hydrogen | 2005 |
Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis.
Topics: Acetyltransferases; Aged; Amino Acid Sequence; Blotting, Western; Cell Line; Cell Line, Transformed; | 2006 |
Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis.
Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Inflammation; Interleukin | 2007 |
Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response.
Topics: Animals; Carrageenan; Cell Line; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Cytokines; Enzyme- | 1997 |
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistr | 1999 |
Spermine inhibition of monocyte activation and inflammation.
Topics: Animals; Carrageenan; Edema; Humans; Inflammation; Lipopolysaccharides; Macrophage Activation; Male; | 1999 |
Temporary axonal conduction block and axonal loss in inflammatory neurological disease. A potential role for nitric oxide?
Topics: Action Potentials; Animals; Axons; Electric Stimulation; Female; Ganglia, Spinal; Inflammation; Male | 1999 |
Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma.
Topics: Animals; Gene Expression Regulation; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-12; | 2000 |
Accumulation of HIF-1alpha under the influence of nitric oxide.
Topics: Animals; Benzoates; Cell Hypoxia; Cell Line; Cobalt; Coculture Techniques; Deferoxamine; DNA-Binding | 2001 |