spermine has been researched along with Hypoxia in 25 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Highly metastatic colon cancer cells (HT-29) were cultured under either normoxia (21% O2) or hypoxia (2% O2) for 48 h with 0, 100, or 500 µM spermine, one of the natural polyamines with the strongest biological activity." | 7.77 | Spermine accelerates hypoxia-initiated cancer cell migration. ( Kano, Y; Konishi, F; Soda, K; Tsujinaka, S, 2011) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| "This study tests the hypothesis that brain tissue hypoxia results in modification of spermine-dependent activation of the cerebral N-methyl-D-aspartate (NMDA) receptor ion-channel in newborn piglet brains and that pretreatment with N(omega)-nitro-L-arginine (NNLA), an inhibitor of nitric oxide synthase, will reduce the hypoxia-induced modification of the spermine-dependent activation of the receptor." | 7.70 | Spermine dependent activation of the N-methyl-D-aspartate receptor and the effect of nitric oxide synthase inhibition during hypoxia in the cerebral cortex of newborn piglets. ( Delivoria-Papadopoulos, M; Fritz, KI; Mishra, OP; Numagami, Y; Zubrow, AB, 2000) |
| " Using animal models of pulmonary hypertension, our data showed that CaSR expression and function were both enhanced in PASMC, whereas intraperitoneal injection of the calcilytic NPS 2143 prevented the development of pulmonary hypertension and right ventricular hypertrophy in rats injected with monocrotaline and mice exposed to hypoxia." | 3.78 | Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. ( Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM, 2012) |
| " Spermine inhibited the hypoxia-evoked catecholamine release from isolated carotid bodies and attenuated the depolarization- and hypoxia-evoked Ca²(+) influx into isolated glomus cells." | 3.77 | Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca²(+) channels. ( Cayzac, SH; Gonzalez, C; Kemp, PJ; Obeso, A; Riccardi, D; Rocher, A, 2011) |
| " Highly metastatic colon cancer cells (HT-29) were cultured under either normoxia (21% O2) or hypoxia (2% O2) for 48 h with 0, 100, or 500 µM spermine, one of the natural polyamines with the strongest biological activity." | 3.77 | Spermine accelerates hypoxia-initiated cancer cell migration. ( Kano, Y; Konishi, F; Soda, K; Tsujinaka, S, 2011) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| "This study tests the hypothesis that brain tissue hypoxia results in modification of spermine-dependent activation of the cerebral N-methyl-D-aspartate (NMDA) receptor ion-channel in newborn piglet brains and that pretreatment with N(omega)-nitro-L-arginine (NNLA), an inhibitor of nitric oxide synthase, will reduce the hypoxia-induced modification of the spermine-dependent activation of the receptor." | 3.70 | Spermine dependent activation of the N-methyl-D-aspartate receptor and the effect of nitric oxide synthase inhibition during hypoxia in the cerebral cortex of newborn piglets. ( Delivoria-Papadopoulos, M; Fritz, KI; Mishra, OP; Numagami, Y; Zubrow, AB, 2000) |
| "Acclimation to hypoxia and anoxia is important in various ecological systems, especially flooded soil." | 1.72 | Exogenous spermidine regulates the anaerobic enzyme system through hormone concentrations and related-gene expression in Phyllostachys praecox roots under flooding stress. ( Gao, J; Qian, Z; Zhang, Y; Zhuang, S, 2022) |
| "Spermine treatment significantly promoted PASMC proliferation, which was significantly inhibited by U50,488H, p38 inhibitor SB203580, JNK inhibitor SP600125, Erk inhibitor SCH772984, and MEK inhibitor U0126, especially Erk inhibitor (P < 0." | 1.56 | The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development. ( Cao, Z; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Liu, M; Pei, J; Wang, X; Wang, Y; Zhang, S, 2020) |
| "Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60." | 1.28 | Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, J | 1 |
| Qian, Z | 1 |
| Zhang, Y | 1 |
| Zhuang, S | 1 |
| Li, J | 1 |
| Jia, M | 1 |
| Liu, M | 2 |
| Cao, Z | 1 |
| Wang, X | 1 |
| Feng, N | 1 |
| Gu, X | 1 |
| Zhang, S | 1 |
| Fan, R | 1 |
| Guo, H | 1 |
| Wang, Y | 1 |
| Pei, J | 1 |
| Arif, S | 1 |
| Borgognone, A | 1 |
| Lin, EL | 1 |
| O'Sullivan, AG | 1 |
| Sharma, V | 1 |
| Drury, NE | 1 |
| Menon, A | 1 |
| Nightingale, P | 1 |
| Mascaro, J | 1 |
| Bonser, RS | 1 |
| Horowitz, JD | 1 |
| Feelisch, M | 1 |
| Frenneaux, MP | 1 |
| Madhani, M | 1 |
| Wei, C | 1 |
| Li, HZ | 1 |
| Wang, YH | 1 |
| Peng, X | 1 |
| Shao, HJ | 1 |
| Li, HX | 1 |
| Bai, SZ | 1 |
| Lu, XX | 1 |
| Wu, LY | 1 |
| Wang, R | 1 |
| Xu, CQ | 1 |
| Cayzac, SH | 1 |
| Rocher, A | 1 |
| Obeso, A | 1 |
| Gonzalez, C | 1 |
| Riccardi, D | 1 |
| Kemp, PJ | 1 |
| Tsujinaka, S | 1 |
| Soda, K | 1 |
| Kano, Y | 1 |
| Konishi, F | 1 |
| Duan, B | 1 |
| Wang, YZ | 1 |
| Yang, T | 1 |
| Chu, XP | 1 |
| Yu, Y | 1 |
| Huang, Y | 1 |
| Cao, H | 1 |
| Hansen, J | 1 |
| Simon, RP | 1 |
| Zhu, MX | 1 |
| Xiong, ZG | 1 |
| Xu, TL | 1 |
| Yamamura, A | 1 |
| Guo, Q | 1 |
| Yamamura, H | 1 |
| Zimnicka, AM | 1 |
| Pohl, NM | 1 |
| Smith, KA | 1 |
| Fernandez, RA | 1 |
| Zeifman, A | 1 |
| Makino, A | 1 |
| Dong, H | 1 |
| Yuan, JX | 1 |
| Steiner, DR | 1 |
| Gonzalez, NC | 2 |
| Wood, JG | 2 |
| Ruchko, M | 2 |
| Gillespie, MN | 3 |
| Weeks, RS | 1 |
| Olson, JW | 3 |
| Babal, P | 2 |
| Zhu, X | 3 |
| Heunks, LM | 3 |
| Machiels, HA | 3 |
| Ennen, L | 3 |
| Dekhuijzen, PN | 3 |
| Jernigan, NL | 2 |
| Walker, BR | 3 |
| Resta, TC | 3 |
| Broughton, BR | 1 |
| Van Der Heijden, HF | 1 |
| Nagao, Y | 1 |
| Takao, S | 1 |
| Fujita, E | 1 |
| Murayama, C | 1 |
| Mori, T | 1 |
| Asao, T | 1 |
| Suzue, T | 1 |
| Packianathan, S | 1 |
| Cain, CD | 1 |
| Longo, LD | 1 |
| Zubrow, AB | 1 |
| Numagami, Y | 1 |
| Fritz, KI | 1 |
| Mishra, OP | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Johnson, JS | 1 |
| Mattioli, LF | 1 |
| Kanagy, NL | 1 |
| Baker, JE | 1 |
| Contney, SJ | 1 |
| Singh, R | 1 |
| Kalyanaraman, B | 1 |
| Gross, GJ | 1 |
| Bosnjak, ZJ | 1 |
| Ault-Ziel, K | 1 |
| Cronenberg, L | 1 |
| Casti, A | 2 |
| Visioli, O | 1 |
| Reali, N | 1 |
| Caldarera, CM | 2 |
| Corti, A | 1 |
| Orlandini, G | 1 |
| Drusiani, F | 1 |
| Shiao, RT | 1 |
| Kostenbauder, HB | 1 |
25 other studies available for spermine and Hypoxia
| Article | Year |
|---|---|
Exogenous spermidine regulates the anaerobic enzyme system through hormone concentrations and related-gene expression in Phyllostachys praecox roots under flooding stress.
Topics: Abscisic Acid; Anaerobiosis; Ethylenes; Gene Expression; Hormones; Hydrogen Peroxide; Hypoxia; Indol | 2022 |
The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; C | 2020 |
Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans.
Topics: Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Arteries; C | 2015 |
Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways.
Topics: Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypoxia; MAP | 2016 |
Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca²(+) channels.
Topics: Animals; Calcium; Calcium Channels, L-Type; Calcium Channels, N-Type; Carotid Body; Catecholamines; | 2011 |
Spermine accelerates hypoxia-initiated cancer cell migration.
Topics: Blotting, Western; Cadherins; Cell Movement; Cell Proliferation; Collagen; Colonic Neoplasms; Dose-R | 2011 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultu | 2012 |
Interaction between reactive oxygen species and nitric oxide in the microvascular response to systemic hypoxia.
Topics: Animals; Arginine; Cell Adhesion; Endothelium, Vascular; Hypoxia; Leukocytes; Male; Nitric Oxide; Ni | 2002 |
Putrescine transport in hypoxic rat main PASMCs is required for p38 MAP kinase activation.
Topics: Animals; Binding, Competitive; Biological Transport; Cycloheximide; Dactinomycin; Enzyme Activation; | 2003 |
Effects of modulation of nitric oxide on rat diaphragm isotonic contractility during hypoxia.
Topics: Animals; Diaphragm; Enzyme Inhibitors; Hemoglobins; Hypoxia; In Vitro Techniques; Isotonic Contracti | 2003 |
Role of nitric oxide in isometric contraction properties of rat diaphragm during hypoxia.
Topics: Animals; Diaphragm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemoglobins; Hyperoxia; Hyp | 2003 |
Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia.
Topics: Animals; Diltiazem; Endothelin-1; Hypoxia; Kinetics; Male; Microcirculation; Muscle, Smooth, Vascula | 2004 |
Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.
Topics: Animals; Bronchodilator Agents; Calcium; Calcium Channels; Calcium-Transporting ATPases; Chronic Dis | 2006 |
Nitric oxide modulates neuromuscular transmission during hypoxia in rat diaphragm.
Topics: Animals; Diaphragm; Enzyme Inhibitors; Hypoxia; Male; Muscle Contraction; Muscle Fatigue; Neuromuscu | 2006 |
Development of new hypoxic cell sensitizers: amides of nitrobenzoic acid with spermidine and spermine.
Topics: Cell Survival; HeLa Cells; Humans; Hypoxia; Misonidazole; Radiation-Sensitizing Agents; Spermidine; | 1983 |
Ornithine decarboxylase activity and polyamine concentrations in fetal rat brain: response to chronic hypoxic-hypoxia and/or carbon monoxide-hypoxia.
Topics: Animals; Animals, Newborn; Brain; Carbon Monoxide; Embryonic and Fetal Development; Female; Gestatio | 1994 |
Spermine dependent activation of the N-methyl-D-aspartate receptor and the effect of nitric oxide synthase inhibition during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cerebral Cortex; Dizocilpine Maleate; Enzyme Inhi | 2000 |
Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats.
Topics: Animals; Antioxidants; Capillary Permeability; Catalase; Cell Adhesion; Consciousness; Endothelium, | 2000 |
Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Chronic Disease; Endoth | 2001 |
Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism.
Topics: Action Potentials; Animals; Animals, Newborn; Blood Pressure; Cyclic GMP; Electron Spin Resonance Sp | 2001 |
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.
Topics: Animals; Blotting, Western; Carbon Radioisotopes; Cattle; Cells, Cultured; Endothelium, Vascular; En | 2002 |
[Polyamines and RNA in myocardial hypoxia and anoxia (author's transl)].
Topics: Adenosylmethionine Decarboxylase; Animals; Hypoxia; Microsomes; Mitochondria, Heart; Myocardial Infa | 1978 |
Polyamine biosynthesis in rabbit perfused heart under various degrees of oxygen tension.
Topics: Adenosylmethionine Decarboxylase; Animals; Hypoxia; Myocardium; Ornithine Decarboxylase; Polyamines; | 1978 |
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv | 1990 |