spermine has been researched along with Hypertension, Pulmonary in 11 studies
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In support of this contention, we have shown in rat models of monocrotaline (MCT)- and chronic hypoxia-induced pulmonary hypertension that whole-lung polyamine contents are elevated and that blockade of polyamine synthesis forestalls development of hypertensive pulmonary vascular remodeling and sustained pulmonary hypertension." | 7.67 | Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension. ( Gillespie, MN; Olson, JW; Orlinska, U, 1988) |
| "Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration." | 5.27 | Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984) |
| " Using animal models of pulmonary hypertension, our data showed that CaSR expression and function were both enhanced in PASMC, whereas intraperitoneal injection of the calcilytic NPS 2143 prevented the development of pulmonary hypertension and right ventricular hypertrophy in rats injected with monocrotaline and mice exposed to hypoxia." | 3.78 | Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. ( Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM, 2012) |
| " In support of this contention, we have shown in rat models of monocrotaline (MCT)- and chronic hypoxia-induced pulmonary hypertension that whole-lung polyamine contents are elevated and that blockade of polyamine synthesis forestalls development of hypertensive pulmonary vascular remodeling and sustained pulmonary hypertension." | 3.67 | Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension. ( Gillespie, MN; Olson, JW; Orlinska, U, 1988) |
| "Spermine treatment significantly promoted PASMC proliferation, which was significantly inhibited by U50,488H, p38 inhibitor SB203580, JNK inhibitor SP600125, Erk inhibitor SCH772984, and MEK inhibitor U0126, especially Erk inhibitor (P < 0." | 1.56 | The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development. ( Cao, Z; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Liu, M; Pei, J; Wang, X; Wang, Y; Zhang, S, 2020) |
| "In the treatment of pulmonary hypertension, this pathway is exogenously activated using inhaled NO or other pharmacological agents." | 1.37 | Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. ( Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C, 2011) |
| "Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60." | 1.28 | Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990) |
| "Lung putrescine levels were increased from days 7 through 21, and both spermidine and spermine were first elevated at day 10 following MCT administration." | 1.27 | Polyamines and the development of monocrotaline-induced pulmonary hypertension. ( Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Jia, M | 1 |
| Liu, M | 2 |
| Cao, Z | 1 |
| Wang, X | 1 |
| Feng, N | 1 |
| Gu, X | 1 |
| Zhang, S | 1 |
| Fan, R | 1 |
| Guo, H | 1 |
| Wang, Y | 1 |
| Pei, J | 1 |
| Zhu, L | 1 |
| Xiao, R | 1 |
| Zhang, X | 1 |
| Lang, Y | 1 |
| Liu, F | 1 |
| Yu, Z | 1 |
| Zhang, J | 1 |
| Su, Y | 1 |
| Lu, Y | 1 |
| Wang, T | 1 |
| Luo, S | 1 |
| Wang, J | 1 |
| Liu, ML | 1 |
| Dupuis, J | 1 |
| Jing, ZC | 1 |
| Li, T | 1 |
| Xiong, W | 1 |
| Hu, Q | 1 |
| Wei, C | 1 |
| Li, HZ | 1 |
| Wang, YH | 1 |
| Peng, X | 1 |
| Shao, HJ | 1 |
| Li, HX | 1 |
| Bai, SZ | 1 |
| Lu, XX | 1 |
| Wu, LY | 1 |
| Wang, R | 1 |
| Xu, CQ | 1 |
| Aggarwal, S | 1 |
| Gross, CM | 1 |
| Kumar, S | 1 |
| Datar, S | 1 |
| Oishi, P | 1 |
| Kalkan, G | 1 |
| Schreiber, C | 1 |
| Fratz, S | 1 |
| Fineman, JR | 1 |
| Black, SM | 1 |
| Yamamura, A | 1 |
| Guo, Q | 1 |
| Yamamura, H | 1 |
| Zimnicka, AM | 1 |
| Pohl, NM | 1 |
| Smith, KA | 1 |
| Fernandez, RA | 1 |
| Zeifman, A | 1 |
| Makino, A | 1 |
| Dong, H | 1 |
| Yuan, JX | 1 |
| Jernigan, NL | 1 |
| Broughton, BR | 1 |
| Walker, BR | 2 |
| Resta, TC | 2 |
| Olson, JW | 4 |
| Hacker, AD | 1 |
| Altiere, RJ | 1 |
| Gillespie, MN | 4 |
| Kanagy, NL | 1 |
| Babal, P | 1 |
| Ruchko, M | 1 |
| Ault-Ziel, K | 1 |
| Cronenberg, L | 1 |
| Shiao, RT | 1 |
| Kostenbauder, HB | 1 |
| Orlinska, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for spermine and Hypertension, Pulmonary
| Article | Year |
|---|---|
The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; C | 2020 |
Spermine on Endothelial Extracellular Vesicles Mediates Smoking-Induced Pulmonary Hypertension Partially Through Calcium-Sensing Receptor.
Topics: Animals; Benzamides; Biological Transport; Calcium; Calcium Signaling; Cyclohexylamines; Endothelial | 2019 |
Exogenous spermine inhibits the proliferation of human pulmonary artery smooth muscle cells caused by chemically-induced hypoxia via the suppression of the ERK1/2- and PI3K/AKT-associated pathways.
Topics: Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Humans; Hypertension, Pulmonary; Hypoxia; MAP | 2016 |
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Depen | 2011 |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultu | 2012 |
Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.
Topics: Animals; Bronchodilator Agents; Calcium; Calcium Channels; Calcium-Transporting ATPases; Chronic Dis | 2006 |
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertens | 1984 |
Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Chronic Disease; Endoth | 2001 |
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.
Topics: Animals; Blotting, Western; Carbon Radioisotopes; Cattle; Cells, Cultured; Endothelium, Vascular; En | 2002 |
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv | 1990 |
Polyamine content in pulmonary arteries from rats with monocrotaline-induced pulmonary hypertension.
Topics: Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Polyamines; Pulmonary Artery; Putrescin | 1988 |