spermine has been researched along with Experimental Neoplasms in 38 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of polyamines (putrescine, spermidine and spermine) on endogenous protein phosphorylation in mouse neuroblastoma cells was investigated by using techniques of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography." | 3.67 | Spermine specifically inhibits the phosphorylation of an 11,000-dalton nuclear protein in various cultured mammalian cell lines. ( Chen, KY; Verma, R, 1984) |
| "The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
| "Cancers are a broad spectrum of diseases in which there are altered growth fractions and cell-turnover fractions, and therefore cancer chemotherapeutic agents have been developed to take tumor kinetics into account." | 2.36 | Clinical relevance of polyamines as biochemical markers of tumor kinetics. ( Russell, DH, 1977) |
| "The toxicity to cultured cells of the cancer chemotherapeutic agent methylglyoxal-bis[guanylhydrazone] (MGBG) varies considerably between different cell lines and is always more toxic in the absence of exogenous polyamine." | 1.27 | Differential toxicity of methylglyoxal-bis [guanylhydrazone]. ( Dewey, DL; Gaugas, JM; Minchinton, AI; Stratford, MR, 1983) |
| "RBC putrescine levels were significantly increased at a tumor weight of 12." | 1.27 | Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats. ( Grossie, VB; Martin, RG; Nishioka, K; Ota, DM, 1986) |
| "Spermine was more efficacious than spermidine as a stimulant of polymerase activity except for polymerase III from three tumors." | 1.27 | Comparison of the effects of polyamines on the activities of RNA polymerases from murine normal tissues and transplantable tumors. ( Blair, DG, 1986) |
| "(c) Spermine levels were significantly lowered, with 3 minima corresponding to the putrescine maxima." | 1.26 | Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide. ( Aussel, C; Lafaurie, M; Lalanne, CM; Milano, G; Soula, G; Stora, C, 1981) |
| "In the hepatomas, evidence was obtained for the preexistence of considerable amounts of the smaller, RNase-containing subunits in the cell." | 1.24 | Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas. ( Roth, JS; Utsunomiya, T, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (94.74) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ALARCON, RA | 2 |
| FOLEY, GE | 1 |
| MODEST, EJ | 1 |
| Hamaoki, M | 1 |
| Nagata, A | 1 |
| Russell, DH | 4 |
| Schindler, J | 1 |
| Kelly, M | 1 |
| McCann, PP | 1 |
| Barfod, NM | 1 |
| Chen, KY | 1 |
| Verma, R | 1 |
| Takigawa, M | 1 |
| Verma, AK | 1 |
| Simsiman, RC | 1 |
| Boutwell, RK | 1 |
| Ben-Hur, E | 1 |
| Shaw, JJ | 1 |
| Bleehen, NM | 1 |
| Dewey, DL | 1 |
| Gaugas, JM | 1 |
| Stratford, MR | 1 |
| Minchinton, AI | 1 |
| Milano, G | 1 |
| Aussel, C | 1 |
| Stora, C | 1 |
| Lafaurie, M | 1 |
| Soula, G | 1 |
| Lalanne, CM | 1 |
| Seidenfeld, J | 3 |
| Marton, LJ | 6 |
| Hazan, G | 1 |
| Takami, H | 1 |
| Nishioka, K | 2 |
| Lemaire, G | 1 |
| Alvarez-Pachon, FJ | 1 |
| Beuneu, C | 1 |
| Lepoivre, M | 1 |
| Petit, JF | 1 |
| Rose, KM | 1 |
| Ruch, PA | 1 |
| Morris, HP | 3 |
| Jacob, ST | 1 |
| Looney, WB | 2 |
| Kovacs, CJ | 2 |
| Hopkins, HA | 2 |
| Dattilo, JW | 1 |
| Canellakis, ZN | 1 |
| Theoharides, TC | 1 |
| Perin, A | 1 |
| Sessa, A | 1 |
| Farwell, DC | 1 |
| Nolan, CE | 1 |
| Herbst, EJ | 1 |
| Kallistratos, G | 1 |
| Welch, MJ | 1 |
| Coleman, RE | 1 |
| Straatmann, MG | 1 |
| Asberry, BE | 1 |
| Primeau, JL | 1 |
| Fair, WR | 1 |
| Ter-Pogossian, MM | 1 |
| Lee, PL | 2 |
| Fujita, K | 1 |
| Nagatsu, T | 1 |
| Maruta, K | 1 |
| Ito, M | 1 |
| Senba, H | 1 |
| Uchida, K | 1 |
| Rademaker, A | 1 |
| Oyasu, R | 1 |
| Hull, WE | 1 |
| Kunz, W | 1 |
| Port, RE | 1 |
| Seiler, N | 1 |
| Grossie, VB | 1 |
| Ota, DM | 1 |
| Martin, RG | 1 |
| Blair, DG | 1 |
| Hibasami, H | 1 |
| Tsukada, T | 1 |
| Nakashima, K | 1 |
| Berdinskikh, NK | 1 |
| Lialiushko, NM | 1 |
| Utsunomiya, T | 1 |
| Roth, JS | 1 |
| Williams-Ashman, HG | 1 |
| Coppoc, GL | 1 |
| Weber, G | 1 |
| LeGendre, SM | 1 |
| Crocker, J | 1 |
| Cater, DB | 1 |
| Heby, O | 2 |
| Wilson, CB | 1 |
3 reviews available for spermine and Experimental Neoplasms
| Article | Year |
|---|---|
Clinical relevance of polyamines.
Topics: Animals; Cadaverine; Cystic Fibrosis; Diamines; Female; Growth Disorders; Humans; Kidney Failure, Ch | 1983 |
Clinical relevance of polyamines as biochemical markers of tumor kinetics.
Topics: Animals; Humans; Kinetics; Neoplasms; Neoplasms, Experimental; Polyamines; Putrescine; Rats; Spermid | 1977 |
[Cancer metastasis and polyamines].
Topics: Adenosylmethionine Decarboxylase; Animals; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; | 1985 |
35 other studies available for spermine and Experimental Neoplasms
| Article | Year |
|---|---|
Effects of spermine on mammalian cells.
Topics: Animals; Neoplasms, Experimental; Spermine; Tissue Culture Techniques | 1961 |
ISOLATION OF ACROLEIN FROM INCUBATED MIXTURES OF SPERMINE WITH CALF SERUM AND ITS EFFECTS ON MAMMALIAN CELLS.
Topics: Acrolein; Aldehydes; Amines; Animals; Blood; Cattle; Neoplasms; Neoplasms, Experimental; Pharmacolog | 1964 |
Host macrophages produce diacetylspermine related with tumorigenesis.
Topics: Animals; Cell Line, Tumor; Coculture Techniques; Dose-Response Relationship, Drug; Female; Glucose; | 2006 |
Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Line; Eflornithine; Mice; Neoplasms, Experimenta | 1983 |
A flow cytometric in vivo chalone assay using retransplanted old murine JB-1 ascites tumour cells.
Topics: Animals; Biological Assay; Cytological Techniques; DNA, Neoplasm; Growth Inhibitors; Interphase; Mic | 1981 |
Spermine specifically inhibits the phosphorylation of an 11,000-dalton nuclear protein in various cultured mammalian cell lines.
Topics: Animals; Cell Line; Cell Nucleus; Mice; Molecular Weight; Neoplasms, Experimental; Neuroblastoma; Ph | 1984 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; | 1982 |
Enhancement of thermal killing by polyamines V. The response of EMT6 multicellular tumour spheroids versus monolayer cells.
Topics: Animals; Cell Line; Cell Survival; Hot Temperature; Neoplasms, Experimental; Spermine | 1983 |
Differential toxicity of methylglyoxal-bis [guanylhydrazone].
Topics: Animals; Cell Count; Cell Line; DNA; Dose-Response Relationship, Drug; Fibroblasts; Guanidines; Mela | 1983 |
Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Female; Liver Neoplasms; Neoplasms, Experimental; Organ | 1981 |
Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Cells, Cultured; Neoplasms, Experimental; O | 1980 |
Effect of heat combined with polyamines on tumor growth in mice.
Topics: Animals; Cadaverine; Hot Temperature; Melanoma; Mice; Neoplasms, Experimental; Polyamines; Skin Neop | 1980 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Differential cytostatic effects of NO donors and NO producing cells.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Deoxyadenine Nucleotides; Deoxyribonuc | 1999 |
RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes.
Topics: Ammonium Sulfate; Animals; Carcinoma, Hepatocellular; DNA-Directed RNA Polymerases; Enzyme Activatio | 1976 |
Changes in serum putrescine and spermidine levels following local radiation to hepatoma 3924A of the rat.
Topics: Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Neoplasms, Experimental; Putrescine; Ra | 1976 |
Stimulation of ornithine decarboxylase synthesis and its control by polyamines in regenerating rat liver and cultured rat hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomy | 1976 |
Changes in polyamine levels and protein synthesis rate during rat liver carcinogenesis induced by 4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimenta | 1978 |
Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Depression, Chemical; Dose-Response Relatio | 1979 |
Liver ornithine decarboxylase during phenobarbital promotion of nitrosamine carcinogenesis.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; | 1978 |
[Prevention of 3,4-benzpyrene carcinogenesis by naturally occurring and synthetic compounds].
Topics: Aconitic Acid; Animals; Antineoplastic Agents; Benzopyrenes; Cadaverine; Carcinogens; Cysteine; Dica | 1975 |
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne | 1977 |
More sensitive automated detection of polyamines in physiological fluids and tissue extracts with omicron-phthalaldehyde.
Topics: Aldehydes; Amniotic Fluid; Animals; Autoanalysis; Brain Neoplasms; Evaluation Studies as Topic; Fema | 1975 |
Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats.
Topics: Animals; Female; Humans; Leukemia; Lymphoma; Methylnitronitrosoguanidine; Neoplasms; Neoplasms, Expe | 1976 |
Inhibitory action of alpha-difluoromethylornithine on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Drug Administration Schedule; Eflornithine; Male; Neoplasms, | 1989 |
Chain-fluorinated polyamines as tumour markers. III. Determination of geminal difluoropolyamines and their precursor 2,2-difluoroputrescine in normal tissues and experimental tumours by in vitro and in vivo 19F NMR spectroscopy.
Topics: Animals; Biomarkers, Tumor; Liver; Magnetic Resonance Spectroscopy; Mice; Neoplasm Transplantation; | 1988 |
Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats.
Topics: Animals; Colonic Neoplasms; Fibrosarcoma; Hematocrit; Male; Neoplasms, Experimental; Polyamines; Put | 1986 |
Comparison of the effects of polyamines on the activities of RNA polymerases from murine normal tissues and transplantable tumors.
Topics: Animals; DNA-Directed RNA Polymerases; Kidney; Kinetics; Liver; Mice; Neoplasms, Experimental; RNA P | 1986 |
[Effect of blood serum proteins and glucose on the polyamine content of the liver of rats with Guérin's carcinoma].
Topics: Animals; Blood Proteins; Drug Evaluation, Preclinical; Glucose; Liver; Neoplasm Transplantation; Neo | 1986 |
Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Edetic Acid; Hydrogen-Ion Conc | 1966 |
Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.
Topics: Animals; Carboxy-Lyases; Carcinoma, Hepatocellular; Electrophoresis, Paper; Liver; Liver Neoplasms; | 1972 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experim | 1974 |
In-vitro and in-vivo adherence of allergised lymph-node cells to BP8 ascites tumour cells, in the presence of polyamines and quarternary ammonium compounds.
Topics: Animals; Arginine; Bis-Trimethylammonium Compounds; Cell Adhesion; Freund's Adjuvant; Histamine; Imm | 1973 |
Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Carbon Radioisotopes; Carboxy-Lyases; Liver; Male; Neoplasm T | 1974 |
An automated micromethod for the quantitative analysis of di- and polyamines utilizing a sensitive high pressure liquid chromatographic procedure.
Topics: Animals; Autoanalysis; Brain; Brain Chemistry; Brain Neoplasms; Cadaverine; Carbon Radioisotopes; Ch | 1974 |