spermine has been researched along with Experimental Hepatoma in 32 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "MDL 27695 has also been shown to possess significant antimalarial effects both in vitro and in vivo, and it is possible that the marked suppression of polyamine biosynthesis described herein may contribute to its anti-malarial effects as well as its antiproliferative effects in mammalian cells." | 1.28 | Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue. ( Bitonti, AJ; Bush, TL; McCann, PP, 1989) |
| "Putrescine was increased and spermidine was decreased, consistent with the inhibition of spermidine synthase by this compound, which is a potent and specific "transition-state analogue inhibitor" of the isolated enzyme in vitro." | 1.26 | Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. ( Coward, JK; Pegg, AE; Tang, KC, 1982) |
| "Spermine-treated nuclei showed a greater incorporation of ADP-ribose into H1 histones and nonhistone nuclear proteins with isoelectric points between pH 3." | 1.26 | Spermine-induced variations in the adenosine 5'-diphosphate ribosylation patterns of nuclear proteins from rat liver and hepatoma. ( Lea, MA; Perrella, FW, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (68.75) | 18.7374 |
| 1990's | 7 (21.88) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 1 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, SQ | 1 |
| Zhang, LL | 1 |
| Yang, T | 1 |
| Ma, Y | 1 |
| Zhang, YH | 1 |
| Li, Q | 1 |
| Wang, JH | 1 |
| Zhao, J | 1 |
| Wang, CJ | 1 |
| Mitchell, JL | 3 |
| Thane, TK | 1 |
| Sequeira, JM | 1 |
| Marton, LJ | 2 |
| Thokala, R | 1 |
| Pegg, AE | 1 |
| Tang, KC | 1 |
| Coward, JK | 1 |
| Rudkin, BB | 1 |
| Mamont, PS | 5 |
| Seiler, N | 3 |
| Siat, M | 2 |
| Joder-Ohlenbusch, AM | 1 |
| Bernhardt, A | 2 |
| Casara, P | 1 |
| Blair, DG | 1 |
| Byczkowski, JZ | 1 |
| Porter, CW | 1 |
| Comolli, R | 1 |
| Riboni, L | 1 |
| Jacob, ST | 1 |
| Duceman, BW | 1 |
| Rose, KM | 1 |
| Shipe, JR | 1 |
| Savory, J | 1 |
| Wills, MR | 1 |
| Rowley, R | 1 |
| Looney, WB | 1 |
| Hopkins, HA | 1 |
| Beppu, T | 1 |
| Shirahata, A | 1 |
| Takahashi, N | 1 |
| Hosoda, H | 1 |
| Samejima, K | 1 |
| Fedoronchuk, TV | 1 |
| Siatkin, SP | 1 |
| Lulle, IZh | 1 |
| Ianson, IaIa | 1 |
| Lidak, MIu | 1 |
| Berezov, TT | 1 |
| Hawel, L | 1 |
| Tjandrawinata, RR | 1 |
| Byus, CV | 1 |
| Shimpo, K | 1 |
| Takahashi, H | 1 |
| Tsuda, H | 1 |
| Hibino, T | 1 |
| Kawai, K | 1 |
| Kimura, C | 1 |
| Nagatsu, T | 1 |
| Fujita, K | 1 |
| Desiderio, MA | 1 |
| Tacchini, L | 1 |
| Anzon, E | 1 |
| Pogliaghi, G | 1 |
| Radice, L | 1 |
| Bernelli-Zazzera, A | 1 |
| Ashida, Y | 1 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 1 |
| Leyser, A | 1 |
| Holtorff, MS | 1 |
| Bates, JS | 1 |
| Frydman, B | 1 |
| Valasinas, AL | 1 |
| Reddy, VK | 1 |
| Beck, G | 2 |
| Beck, JP | 1 |
| Bollack, C | 1 |
| Belarbi, A | 2 |
| Rether, B | 1 |
| Perrella, FW | 1 |
| Lea, MA | 1 |
| Byers, TL | 1 |
| Bitonti, AJ | 2 |
| McCann, PP | 3 |
| Feo, F | 1 |
| Garcea, R | 1 |
| Daino, L | 1 |
| Pascale, R | 1 |
| Pirisi, L | 1 |
| Frassetto, S | 1 |
| Ruggiu, ME | 1 |
| Baillon, JG | 1 |
| Kolb, M | 1 |
| Bush, TL | 1 |
| Gerner, EW | 2 |
| Berdinskikh, NK | 1 |
| Lialiushko, NM | 1 |
| Sarhan, S | 2 |
| Knodgen, B | 1 |
| Gerhart, F | 1 |
| Murphy, AN | 1 |
| Fiskum, G | 2 |
| Dezeure, F | 1 |
| Mahan, DW | 1 |
| Qasba, P | 1 |
32 other studies available for spermine and Experimental Hepatoma
| Article | Year |
|---|---|
[Acetylsalicylic acid strengthens the effects of ANISpm against hepatocellular carcinoma and its molecular mechanism].
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Caspase 8; Caspase 9; Cell L | 2011 |
Antizyme and antizyme inhibitor activities influence cellular responses to polyamine analogs.
Topics: Animals; Biogenic Polyamines; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Liver Neoplasms, | 2007 |
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism.
Topics: Adenosine; Animals; Cell Transformation, Viral; Cells, Cultured; Fibroblasts; Liver Neoplasms, Exper | 1982 |
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithi | 1984 |
Effects of (2R, 5R)-6-heptyne-2,5-diamine, a potent inhibitor of L-ornithine decarboxylase, on rat hepatoma cells cultured in vitro.
Topics: Adenosylmethionine Decarboxylase; Alkynes; Animals; Cell Division; Cell Survival; Cells, Cultured; D | 1984 |
Stimulation of RNA polymerases I and II from mouse L1210 leukemia and Ehrlich ascites carcinoma cells by spermine and spermidine and its modification by ammonium sulfate.
Topics: Ammonium Sulfate; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Drug Interactions; Kinetics; Leuk | 1984 |
Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria.
Topics: Animals; Antineoplastic Agents; Carbanilides; Dinitrophenols; Drug Interactions; Guanidines; In Vitr | 1983 |
Reassociation of eukaryotic ribosomal subunits and polyamine concentration in Yoshida ascites hepatoma and Ehrlich ascites carcinoma cells during growth.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Liver Neoplasms, Experimental; Mice; Polyamines; Putre | 1980 |
Spermine-mediated phosphorylation of RNA polymerase I and its effect on transcription.
Topics: Animals; Cell Nucleus; DNA-Directed RNA Polymerases; Enzyme Activation; Liver Neoplasms, Experimenta | 1981 |
Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation treatment.
Topics: Animals; Buffers; Erythrocytes; Liver Neoplasms, Experimental; Neoplasm Transplantation; Polyamines; | 1980 |
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Cyclohexylamines; Kinetics; Liver Neo | 1995 |
[The effect of chemically modified polyamine analogs on polyamine and putrescine biosynthesis in a cell-free test system from a rat hepatoma].
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Cell-Free System; Eflornithine; Liver Neoplasms | 1993 |
Selective putrescine export is regulated by insulin and ornithine in Reuber H35 hepatoma cells.
Topics: Animals; Biological Transport; Culture Media; Insulin; Liver Neoplasms, Experimental; Ornithine; Put | 1994 |
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Body Weight; Carcinogens; Erythrocytes; Free Radical S | 1996 |
Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock.
Topics: Animals; Cell Division; Eflornithine; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Imm | 1996 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Antizyme induction by polyamine analogues as a factor of cell growth inhibition.
Topics: Animals; Cell Division; Cell Survival; Enzyme Induction; Kinetics; Liver; Liver Neoplasms, Experimen | 2002 |
Regulation of tyrosine aminotransferase synthesis in vitro by mRNA and soluble factors from hepatoma tissue culture cells.
Topics: Animals; Cell Line; Cytosol; Dexamethasone; Enzyme Induction; Liver Neoplasms, Experimental; Magnesi | 1978 |
Translation of tyrosine aminotransferase mRNA from hepatoma cells in a wheat germ cell-free system.
Topics: Animals; Cell Line; Cell-Free System; Cytosol; Dexamethasone; Kinetics; Liver Neoplasms, Experimenta | 1978 |
Spermine-induced variations in the adenosine 5'-diphosphate ribosylation patterns of nuclear proteins from rat liver and hepatoma.
Topics: Adenosine Diphosphate Sugars; Animals; Cell Division; Histones; In Vitro Techniques; Liver; Liver Ne | 1979 |
bis(benzyl)polyamine analogues are substrates for a mammalian cell-transport system which is distinct from the polyamine-transport system.
Topics: Animals; Benzyl Compounds; Binding, Competitive; Biological Transport; Cricetinae; Eflornithine; Kin | 1990 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin | 1985 |
Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells.
Topics: Animals; Cattle; Cells, Cultured; Diamines; Liver Neoplasms, Experimental; Putrescine; Rats; Spermid | 1989 |
Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue.
Topics: Adenosylmethionine Decarboxylase; Animals; Dexamethasone; Liver Neoplasms, Experimental; Ornithine D | 1989 |
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimen | 1986 |
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation | 1986 |
[Polyamine levels and diamine oxidase activity in the rat liver and kidneys during hepatocarcinogenesis induced by N-nitrosodiethylamine].
Topics: Amine Oxidase (Copper-Containing); Animals; Diethylamines; Diethylnitrosamine; Kidney; Liver; Liver | 1987 |
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Ne | 1987 |
Abnormal Ca2+ transport characteristics of hepatoma mitochondria and endoplasmic reticulum.
Topics: Animals; Calcium; Endoplasmic Reticulum; Intracellular Membranes; Kinetics; Liver Neoplasms, Experim | 1988 |
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
Topics: Animals; Binding Sites; Biomarkers, Tumor; Dose-Response Relationship, Drug; In Vitro Techniques; Li | 1988 |
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.
Topics: Animals; Cell Division; Cells, Cultured; Cyclohexylamines; Liver Neoplasms, Experimental; Mitoguazon | 1985 |
Intracellular levels and distribution of Ca2+ in digitonin-permeabilized cells.
Topics: Animals; Biological Transport; Calcium; Cell Compartmentation; Cell Membrane; Cell Membrane Permeabi | 1985 |