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spermine and Experimental Hepatoma

spermine has been researched along with Experimental Hepatoma in 32 studies

Research Excerpts

ExcerptRelevanceReference
"Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine."7.70Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998)
"Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine."3.70Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998)
"MDL 27695 has also been shown to possess significant antimalarial effects both in vitro and in vivo, and it is possible that the marked suppression of polyamine biosynthesis described herein may contribute to its anti-malarial effects as well as its antiproliferative effects in mammalian cells."1.28Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue. ( Bitonti, AJ; Bush, TL; McCann, PP, 1989)
"Putrescine was increased and spermidine was decreased, consistent with the inhibition of spermidine synthase by this compound, which is a potent and specific "transition-state analogue inhibitor" of the isolated enzyme in vitro."1.26Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. ( Coward, JK; Pegg, AE; Tang, KC, 1982)
"Spermine-treated nuclei showed a greater incorporation of ADP-ribose into H1 histones and nonhistone nuclear proteins with isoelectric points between pH 3."1.26Spermine-induced variations in the adenosine 5'-diphosphate ribosylation patterns of nuclear proteins from rat liver and hepatoma. ( Lea, MA; Perrella, FW, 1979)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199022 (68.75)18.7374
1990's7 (21.88)18.2507
2000's2 (6.25)29.6817
2010's1 (3.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xie, SQ1
Zhang, LL1
Yang, T1
Ma, Y1
Zhang, YH1
Li, Q1
Wang, JH1
Zhao, J1
Wang, CJ1
Mitchell, JL3
Thane, TK1
Sequeira, JM1
Marton, LJ2
Thokala, R1
Pegg, AE1
Tang, KC1
Coward, JK1
Rudkin, BB1
Mamont, PS5
Seiler, N3
Siat, M2
Joder-Ohlenbusch, AM1
Bernhardt, A2
Casara, P1
Blair, DG1
Byczkowski, JZ1
Porter, CW1
Comolli, R1
Riboni, L1
Jacob, ST1
Duceman, BW1
Rose, KM1
Shipe, JR1
Savory, J1
Wills, MR1
Rowley, R1
Looney, WB1
Hopkins, HA1
Beppu, T1
Shirahata, A1
Takahashi, N1
Hosoda, H1
Samejima, K1
Fedoronchuk, TV1
Siatkin, SP1
Lulle, IZh1
Ianson, IaIa1
Lidak, MIu1
Berezov, TT1
Hawel, L1
Tjandrawinata, RR1
Byus, CV1
Shimpo, K1
Takahashi, H1
Tsuda, H1
Hibino, T1
Kawai, K1
Kimura, C1
Nagatsu, T1
Fujita, K1
Desiderio, MA1
Tacchini, L1
Anzon, E1
Pogliaghi, G1
Radice, L1
Bernelli-Zazzera, A1
Ashida, Y1
Ueno, A1
Miwa, Y1
Miyoshi, K1
Inoue, H1
Leyser, A1
Holtorff, MS1
Bates, JS1
Frydman, B1
Valasinas, AL1
Reddy, VK1
Beck, G2
Beck, JP1
Bollack, C1
Belarbi, A2
Rether, B1
Perrella, FW1
Lea, MA1
Byers, TL1
Bitonti, AJ2
McCann, PP3
Feo, F1
Garcea, R1
Daino, L1
Pascale, R1
Pirisi, L1
Frassetto, S1
Ruggiu, ME1
Baillon, JG1
Kolb, M1
Bush, TL1
Gerner, EW2
Berdinskikh, NK1
Lialiushko, NM1
Sarhan, S2
Knodgen, B1
Gerhart, F1
Murphy, AN1
Fiskum, G2
Dezeure, F1
Mahan, DW1
Qasba, P1

Other Studies

32 other studies available for spermine and Experimental Hepatoma

ArticleYear
[Acetylsalicylic acid strengthens the effects of ANISpm against hepatocellular carcinoma and its molecular mechanism].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:9

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Caspase 8; Caspase 9; Cell L

2011
Antizyme and antizyme inhibitor activities influence cellular responses to polyamine analogs.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Animals; Biogenic Polyamines; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Liver Neoplasms,

2007
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism.
    Biochemistry, 1982, Sep-28, Volume: 21, Issue:20

    Topics: Adenosine; Animals; Cell Transformation, Viral; Cells, Cultured; Fibroblasts; Liver Neoplasms, Exper

1982
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
    The Biochemical journal, 1984, Feb-01, Volume: 217, Issue:3

    Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithi

1984
Effects of (2R, 5R)-6-heptyne-2,5-diamine, a potent inhibitor of L-ornithine decarboxylase, on rat hepatoma cells cultured in vitro.
    European journal of biochemistry, 1984, Aug-01, Volume: 142, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Alkynes; Animals; Cell Division; Cell Survival; Cells, Cultured; D

1984
Stimulation of RNA polymerases I and II from mouse L1210 leukemia and Ehrlich ascites carcinoma cells by spermine and spermidine and its modification by ammonium sulfate.
    The International journal of biochemistry, 1984, Volume: 16, Issue:12

    Topics: Ammonium Sulfate; Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Drug Interactions; Kinetics; Leuk

1984
Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria.
    General pharmacology, 1983, Volume: 14, Issue:6

    Topics: Animals; Antineoplastic Agents; Carbanilides; Dinitrophenols; Drug Interactions; Guanidines; In Vitr

1983
Reassociation of eukaryotic ribosomal subunits and polyamine concentration in Yoshida ascites hepatoma and Ehrlich ascites carcinoma cells during growth.
    Cancer biochemistry biophysics, 1980, Volume: 5, Issue:1

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Liver Neoplasms, Experimental; Mice; Polyamines; Putre

1980
Spermine-mediated phosphorylation of RNA polymerase I and its effect on transcription.
    Medical biology, 1981, Volume: 59, Issue:5-6

    Topics: Animals; Cell Nucleus; DNA-Directed RNA Polymerases; Enzyme Activation; Liver Neoplasms, Experimenta

1981
Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation treatment.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 28, Issue:2

    Topics: Animals; Buffers; Erythrocytes; Liver Neoplasms, Experimental; Neoplasm Transplantation; Polyamines;

1980
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.
    Journal of biochemistry, 1995, Volume: 117, Issue:2

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Cyclohexylamines; Kinetics; Liver Neo

1995
[The effect of chemically modified polyamine analogs on polyamine and putrescine biosynthesis in a cell-free test system from a rat hepatoma].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:9

    Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Cell-Free System; Eflornithine; Liver Neoplasms

1993
Selective putrescine export is regulated by insulin and ornithine in Reuber H35 hepatoma cells.
    Biochimica et biophysica acta, 1994, May-26, Volume: 1222, Issue:1

    Topics: Animals; Biological Transport; Culture Media; Insulin; Liver Neoplasms, Experimental; Ornithine; Put

1994
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
    Cancer detection and prevention, 1996, Volume: 20, Issue:2

    Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Body Weight; Carcinogens; Erythrocytes; Free Radical S

1996
Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock.
    Hepatology (Baltimore, Md.), 1996, Volume: 24, Issue:1

    Topics: Animals; Cell Division; Eflornithine; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Imm

1996
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
    Japanese journal of cancer research : Gann, 1998, Volume: 89, Issue:1

    Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell

1998
Antizyme induction by polyamine analogues as a factor of cell growth inhibition.
    The Biochemical journal, 2002, Sep-01, Volume: 366, Issue:Pt 2

    Topics: Animals; Cell Division; Cell Survival; Enzyme Induction; Kinetics; Liver; Liver Neoplasms, Experimen

2002
Regulation of tyrosine aminotransferase synthesis in vitro by mRNA and soluble factors from hepatoma tissue culture cells.
    FEBS letters, 1978, Sep-15, Volume: 93, Issue:2

    Topics: Animals; Cell Line; Cytosol; Dexamethasone; Enzyme Induction; Liver Neoplasms, Experimental; Magnesi

1978
Translation of tyrosine aminotransferase mRNA from hepatoma cells in a wheat germ cell-free system.
    FEBS letters, 1978, Sep-15, Volume: 93, Issue:2

    Topics: Animals; Cell Line; Cell-Free System; Cytosol; Dexamethasone; Kinetics; Liver Neoplasms, Experimenta

1978
Spermine-induced variations in the adenosine 5'-diphosphate ribosylation patterns of nuclear proteins from rat liver and hepatoma.
    Cancer research, 1979, Volume: 39, Issue:4

    Topics: Adenosine Diphosphate Sugars; Animals; Cell Division; Histones; In Vitro Techniques; Liver; Liver Ne

1979
bis(benzyl)polyamine analogues are substrates for a mammalian cell-transport system which is distinct from the polyamine-transport system.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: Animals; Benzyl Compounds; Binding, Competitive; Biological Transport; Cricetinae; Eflornithine; Kin

1990
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
    Carcinogenesis, 1985, Volume: 6, Issue:12

    Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin

1985
Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells.
    European journal of biochemistry, 1989, Jan-15, Volume: 179, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Diamines; Liver Neoplasms, Experimental; Putrescine; Rats; Spermid

1989
Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue.
    The Biochemical journal, 1989, Feb-01, Volume: 257, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Animals; Dexamethasone; Liver Neoplasms, Experimental; Ornithine D

1989
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
    European journal of biochemistry, 1986, Apr-01, Volume: 156, Issue:1

    Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimen

1986
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
    The Biochemical journal, 1986, Oct-15, Volume: 239, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation

1986
[Polyamine levels and diamine oxidase activity in the rat liver and kidneys during hepatocarcinogenesis induced by N-nitrosodiethylamine].
    Eksperimental'naia onkologiia, 1987, Volume: 9, Issue:3

    Topics: Amine Oxidase (Copper-Containing); Animals; Diethylamines; Diethylnitrosamine; Kidney; Liver; Liver

1987
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
    The International journal of biochemistry, 1987, Volume: 19, Issue:9

    Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Ne

1987
Abnormal Ca2+ transport characteristics of hepatoma mitochondria and endoplasmic reticulum.
    Advances in experimental medicine and biology, 1988, Volume: 232

    Topics: Animals; Calcium; Endoplasmic Reticulum; Intracellular Membranes; Kinetics; Liver Neoplasms, Experim

1988
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
    The International journal of biochemistry, 1988, Volume: 20, Issue:11

    Topics: Animals; Binding Sites; Biomarkers, Tumor; Dose-Response Relationship, Drug; In Vitro Techniques; Li

1988
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.
    Biochimica et biophysica acta, 1985, Jul-05, Volume: 840, Issue:3

    Topics: Animals; Cell Division; Cells, Cultured; Cyclohexylamines; Liver Neoplasms, Experimental; Mitoguazon

1985
Intracellular levels and distribution of Ca2+ in digitonin-permeabilized cells.
    Cell calcium, 1985, Volume: 6, Issue:1-2

    Topics: Animals; Biological Transport; Calcium; Cell Compartmentation; Cell Membrane; Cell Membrane Permeabi

1985