spermine has been researched along with Disease Models, Animal in 91 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
Excerpt | Relevance | Reference |
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"To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism." | 7.80 | [Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis]. ( Lyu, W; Qin, W; Shen, W; Sun, B; Wang, X; Zhang, J, 2014) |
"We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats." | 7.80 | The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. ( Dong, H; Liu, Z; Wang, S; Yu, A; Zhang, Z, 2014) |
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
"Acute pancreatitis was induced by infusion of sodium taurodeoxycholate (2%) into the pancreatic duct." | 7.74 | A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. ( Alhonen, L; Grigorenko, N; Herzig, KH; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Räty, S; Sand, J, 2008) |
" After status epilepticus induced by kainic acid (9 mg/kg, i." | 7.71 | Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. ( Camón, L; de Vera, N; Martínez, E, 2002) |
"The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 7.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
"In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)." | 5.42 | Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015) |
"Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 5.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
"The present drugs for treating sepsis act only against either LPS or CpG DNA." | 5.37 | Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011) |
"Experimental pancreatitis is associated with activation of polyamine catabolism." | 5.37 | Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011) |
"The aim of this study was to elucidate the mechanism underlying the effects of Kukoamine A (KuA) treatment on endotoxin-induced lung injury/inflammation." | 4.12 | Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury. ( Jiang, Y; Jiang, Z; Li, W; Liu, X; Song, Y; Wang, M; Xu, B; Zhang, C, 2022) |
"The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia." | 3.96 | Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. ( Cai, WW; Dai, Z; Huang, SQ; Lau, GK; Li, BY; Li, H; Liu, HF; Liu, XQ; Wang, Q; Xu, TT; Zhang, SJ; Zhu, WL, 2020) |
" This study investigated the impact of polyamines (spermidine and spermine) on ischemia/reperfusion injury (IRI) and liver regeneration." | 3.83 | Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats. ( Fujimoto, Y; Iida, T; Kaido, T; Kasahara, N; Masano, Y; Okumura, S; Teratani, T; Tsuruyama, T; Uemoto, S; Uemura, T; Yagi, S; Zhao, X, 2016) |
"We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats." | 3.80 | The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. ( Dong, H; Liu, Z; Wang, S; Yu, A; Zhang, Z, 2014) |
"To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism." | 3.80 | [Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis]. ( Lyu, W; Qin, W; Shen, W; Sun, B; Wang, X; Zhang, J, 2014) |
" Using animal models of pulmonary hypertension, our data showed that CaSR expression and function were both enhanced in PASMC, whereas intraperitoneal injection of the calcilytic NPS 2143 prevented the development of pulmonary hypertension and right ventricular hypertrophy in rats injected with monocrotaline and mice exposed to hypoxia." | 3.78 | Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. ( Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM, 2012) |
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
"Pancreatitis was induced in wild-type rats by 2 or 6% taurodeoxycholate infusion or in transgenic rats by overexpressing spermidine/spermine N(1)-acetyltransferase (SSAT)." | 3.77 | Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis. ( Alhonen, L; Herzig, KH; Hyvönen, MT; Jin, HT; Lämsä, T; Nordback, I; Nordback, PH; Räty, S; Sand, J, 2011) |
"Acute pancreatitis was induced by infusion of sodium taurodeoxycholate (2%) into the pancreatic duct." | 3.74 | A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. ( Alhonen, L; Grigorenko, N; Herzig, KH; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Räty, S; Sand, J, 2008) |
" After status epilepticus induced by kainic acid (9 mg/kg, i." | 3.71 | Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. ( Camón, L; de Vera, N; Martínez, E, 2002) |
"We describe the pharmacological properties of a novel spermine-cholesterol adduct, MSI 1436 (3beta-N-1(spermine)-7alpha, 24R-dihydroxy-5alpha-cholestane 24-sulfate), which causes reversible suppression of food and fluid intake in mammals resulting in profound weight loss, not associated with other signs or symptoms of illness, and which exhibits antidiabetic properties in genetically obese mice." | 3.71 | A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. ( Anderson, M; Chen, Q; Cheshire, K; Holroyd, K; Jones, S; Kinney, W; Maeder, T; McLane, M; Williams, JI; Zasloff, M, 2001) |
"The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension." | 3.69 | Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995) |
"It has been suggested that the induction of ornithine decarboxylase (ODC) activity during pregnancy might contribute to the low ureagenic flux that enables the pregnant mother to spare nitrogen and support growth." | 3.68 | Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes. ( Pastor-Anglada, M; Poveda, B; Soler, C; Soley, M, 1993) |
"Spermine dialdehyde (SDA), an oxidized product of spermine which irreversibly suppresses T cell and NK cell activities, was evaluated as an ex vivo purging agent in the prevention of graft-versus-host disease (GVHD) in mice transplanted with SDA-treated allogeneic bone marrow." | 3.68 | Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. ( Chourmouzis, E; Conant, JM; Lau, C; Li, D; Visconti, V; Wang, E, 1990) |
"DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
"Spermine treatment significantly promoted PASMC proliferation, which was significantly inhibited by U50,488H, p38 inhibitor SB203580, JNK inhibitor SP600125, Erk inhibitor SCH772984, and MEK inhibitor U0126, especially Erk inhibitor (P < 0." | 1.56 | The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development. ( Cao, Z; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Liu, M; Pei, J; Wang, X; Wang, Y; Zhang, S, 2020) |
"Identification of biomarkers for central nervous system disease in MPS patients would facilitate the evaluation of new agents in clinical trials." | 1.46 | Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis. ( Bell, P; Dalla Corte, A; de Souza, CFM; Giugliani, R; Hinderer, C; Katz, N; Louboutin, JP; Lund, TC; Mesaros, C; Nayal, M; Orchard, PJ; Tolar, J; Weng, L; Wilson, JM, 2017) |
"Kukoamine A (KuA) has the ability of anti-oxidative stress and anti-apoptosis in vitro." | 1.43 | Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis. ( Cheng, Z; Ma, H; Meng, W; Wang, C; Zhang, Y; Zhao, Q, 2016) |
"Spermine protects against LPS-induced memory deficits in mice by a mechanism that involves GluN2B receptors." | 1.42 | Spermine reverses lipopolysaccharide-induced memory deficit in mice. ( Duarte, T; Frühauf, PK; Ineu, RP; Mello, CF; Rubin, MA; Tomazi, L, 2015) |
"In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)." | 1.42 | Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015) |
"Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes." | 1.39 | Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013) |
"Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal." | 1.39 | A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury. ( Amendola, R; Bellavia, G; Berger, J; Cavallucci, V; Cecconi, F; Cervelli, M; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Moreno, S; Nardacci, R; Piacentini, M, 2013) |
"The present drugs for treating sepsis act only against either LPS or CpG DNA." | 1.37 | Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011) |
"In the treatment of pulmonary hypertension, this pathway is exogenously activated using inhaled NO or other pharmacological agents." | 1.37 | Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. ( Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C, 2011) |
"Experimental pancreatitis is associated with activation of polyamine catabolism." | 1.37 | Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011) |
"Spermine levels were normal at 6 h and decreased slightly at 24 h, but were normal again by 72 h post-injury." | 1.36 | Polyamine catabolism is enhanced after traumatic brain injury. ( Casero, RA; Huttinger, F; Morrison, R; Murray-Stewart, T; Strauss, KI; Zahedi, K, 2010) |
"The intraluminal suture transient middle cerebral artery occlusion (MCAO) model was used." | 1.33 | The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice. ( Doyle, KM; Henman, MC; Li, J; Shaw, GG; Tatlisumak, T, 2005) |
"In patients with ulcerative colitis, CEC spermidine and N8-acetylspermidine levels were significantly enhanced and spermine levels were reduced compared with healthy controls." | 1.32 | Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease. ( Herfarth, H; Jauch, KW; Obermeier, F; Ouart, J; Rogler, G; Schölmerich, J; Vogl, D; Weiss, TS, 2004) |
"Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60." | 1.28 | Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990) |
"In experimental cardiac hypertrophy induced by aortic constriction of rats, the hypertrophy was established after 5-7 days." | 1.26 | Biochemical aspects of experimental cardiac hypertrophy. ( Matsushita, S, 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (5.49) | 18.7374 |
1990's | 6 (6.59) | 18.2507 |
2000's | 26 (28.57) | 29.6817 |
2010's | 41 (45.05) | 24.3611 |
2020's | 13 (14.29) | 2.80 |
Authors | Studies |
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Solinski, HJ | 1 |
Dranchak, P | 1 |
Oliphant, E | 1 |
Gu, X | 2 |
Earnest, TW | 1 |
Braisted, J | 1 |
Inglese, J | 1 |
Hoon, MA | 1 |
Abrams, RPM | 1 |
Yasgar, A | 1 |
Teramoto, T | 1 |
Lee, MH | 1 |
Dorjsuren, D | 1 |
Eastman, RT | 1 |
Malik, N | 1 |
Zakharov, AV | 1 |
Li, W | 2 |
Bachani, M | 1 |
Brimacombe, K | 1 |
Steiner, JP | 1 |
Hall, MD | 1 |
Balasubramanian, A | 1 |
Jadhav, A | 1 |
Padmanabhan, R | 1 |
Simeonov, A | 1 |
Nath, A | 1 |
Cervetto, C | 1 |
Averna, M | 1 |
Vergani, L | 1 |
Pedrazzi, M | 1 |
Amato, S | 1 |
Pelassa, S | 1 |
Giuliani, S | 1 |
Baldini, F | 1 |
Maura, G | 2 |
Mariottini, P | 2 |
Marcoli, M | 2 |
Cervelli, M | 2 |
Wei, C | 2 |
Song, T | 1 |
Yuan, H | 1 |
Li, X | 1 |
Zhang, X | 2 |
Liang, X | 1 |
Fan, Y | 1 |
Liu, X | 2 |
Wang, M | 2 |
Song, Y | 1 |
Zhang, C | 2 |
Jiang, Y | 1 |
Xu, B | 1 |
Jiang, Z | 1 |
Mao, Y | 1 |
Bajinka, O | 1 |
Tang, Z | 1 |
Qiu, X | 1 |
Tan, Y | 1 |
Fukushima, T | 1 |
Yokooji, T | 1 |
Hirano, T | 1 |
Kataoka, Y | 1 |
Taogoshi, T | 1 |
Matsuo, H | 1 |
Fan, YQ | 1 |
Wang, YH | 1 |
Shao, YY | 1 |
Shao, XT | 1 |
Hu, J | 1 |
Xu, CQ | 1 |
Ricke, KM | 1 |
Cruz, SA | 1 |
Qin, Z | 1 |
Farrokhi, K | 1 |
Sharmin, F | 1 |
Zhang, L | 1 |
Zasloff, MA | 1 |
Stewart, AFR | 1 |
Chen, HH | 1 |
van Veen, S | 1 |
Martin, S | 1 |
Van den Haute, C | 1 |
Benoy, V | 1 |
Lyons, J | 1 |
Vanhoutte, R | 1 |
Kahler, JP | 1 |
Decuypere, JP | 1 |
Gelders, G | 1 |
Lambie, E | 1 |
Zielich, J | 1 |
Swinnen, JV | 1 |
Annaert, W | 1 |
Agostinis, P | 1 |
Ghesquière, B | 1 |
Verhelst, S | 1 |
Baekelandt, V | 1 |
Eggermont, J | 1 |
Vangheluwe, P | 1 |
Li, J | 4 |
Jia, M | 1 |
Liu, M | 2 |
Cao, Z | 1 |
Wang, X | 4 |
Feng, N | 1 |
Zhang, S | 1 |
Fan, R | 1 |
Guo, H | 1 |
Wang, Y | 2 |
Pei, J | 1 |
Xu, TT | 1 |
Li, H | 2 |
Dai, Z | 1 |
Lau, GK | 1 |
Li, BY | 1 |
Zhu, WL | 1 |
Liu, XQ | 1 |
Liu, HF | 1 |
Cai, WW | 1 |
Huang, SQ | 1 |
Wang, Q | 1 |
Zhang, SJ | 1 |
He, YY | 1 |
Yan, Y | 1 |
Jiang, X | 1 |
Zhao, JH | 1 |
Wang, Z | 1 |
Wu, T | 1 |
Guo, SS | 1 |
Ye, J | 1 |
Lian, TY | 1 |
Xu, XQ | 1 |
Zhang, JL | 1 |
Sun, K | 1 |
Peng, FH | 1 |
Zhou, YP | 1 |
Mao, YM | 1 |
Chen, JW | 1 |
Zhang, SY | 1 |
Jing, ZC | 1 |
Minamisawa, M | 1 |
Suzumura, T | 1 |
Bose, S | 1 |
Taniai, T | 1 |
Kawai, G | 1 |
Suzuki, K | 1 |
Yamaguchi, A | 1 |
Yamanaka, S | 1 |
Gaborit, B | 1 |
Govers, R | 1 |
Altié, A | 1 |
Brunel, JM | 1 |
Morange, P | 1 |
Peiretti, F | 1 |
Gassen, NC | 1 |
Papies, J | 1 |
Bajaj, T | 1 |
Emanuel, J | 1 |
Dethloff, F | 1 |
Chua, RL | 1 |
Trimpert, J | 1 |
Heinemann, N | 1 |
Niemeyer, C | 1 |
Weege, F | 1 |
Hönzke, K | 1 |
Aschman, T | 1 |
Heinz, DE | 1 |
Weckmann, K | 1 |
Ebert, T | 1 |
Zellner, A | 1 |
Lennarz, M | 1 |
Wyler, E | 1 |
Schroeder, S | 1 |
Richter, A | 1 |
Niemeyer, D | 1 |
Hoffmann, K | 1 |
Meyer, TF | 1 |
Heppner, FL | 1 |
Corman, VM | 1 |
Landthaler, M | 1 |
Hocke, AC | 1 |
Morkel, M | 1 |
Osterrieder, N | 1 |
Conrad, C | 1 |
Eils, R | 1 |
Radbruch, H | 1 |
Giavalisco, P | 1 |
Drosten, C | 1 |
Müller, MA | 1 |
Thompson, D | 1 |
Morrice, N | 1 |
Grant, L | 1 |
Le Sommer, S | 1 |
Lees, EK | 1 |
Mody, N | 1 |
Wilson, HM | 1 |
Delibegovic, M | 1 |
Hinderer, C | 1 |
Katz, N | 1 |
Louboutin, JP | 1 |
Bell, P | 1 |
Tolar, J | 1 |
Orchard, PJ | 1 |
Lund, TC | 1 |
Nayal, M | 1 |
Weng, L | 1 |
Mesaros, C | 1 |
de Souza, CFM | 1 |
Dalla Corte, A | 1 |
Giugliani, R | 1 |
Wilson, JM | 1 |
Igarashi, K | 4 |
Uemura, T | 2 |
Kashiwagi, K | 4 |
Krych, Ł | 1 |
Kot, W | 1 |
Bendtsen, KMB | 1 |
Hansen, AK | 1 |
Vogensen, FK | 1 |
Nielsen, DS | 1 |
Gaspar, L | 1 |
Coron, RP | 1 |
KongThoo Lin, P | 1 |
Costa, DM | 1 |
Perez-Cabezas, B | 1 |
Tavares, J | 1 |
Roura-Ferrer, M | 1 |
Ramos, I | 1 |
Ronin, C | 1 |
Major, LL | 1 |
Ciesielski, F | 1 |
Pemberton, IK | 1 |
MacDougall, J | 1 |
Ciapetti, P | 1 |
Smith, TK | 1 |
Cordeiro-da-Silva, A | 1 |
Perni, M | 1 |
Flagmeier, P | 1 |
Limbocker, R | 1 |
Cascella, R | 1 |
Aprile, FA | 1 |
Galvagnion, C | 1 |
Heller, GT | 1 |
Meisl, G | 1 |
Chen, SW | 1 |
Kumita, JR | 1 |
Challa, PK | 1 |
Kirkegaard, JB | 1 |
Cohen, SIA | 1 |
Mannini, B | 1 |
Barbut, D | 1 |
Nollen, EAA | 1 |
Cecchi, C | 1 |
Cremades, N | 1 |
Knowles, TPJ | 1 |
Chiti, F | 1 |
Zasloff, M | 2 |
Vendruscolo, M | 1 |
Dobson, CM | 1 |
Condon, KH | 1 |
Ho, J | 1 |
Robinson, CG | 1 |
Hanus, C | 1 |
Ehlers, MD | 1 |
North, ML | 1 |
Grasemann, H | 1 |
Khanna, N | 1 |
Inman, MD | 1 |
Gauvreau, GM | 1 |
Scott, JA | 1 |
Dong, H | 2 |
Wang, S | 2 |
Zhang, Z | 1 |
Yu, A | 1 |
Liu, Z | 1 |
Bellavia, G | 1 |
D'Amelio, M | 1 |
Cavallucci, V | 1 |
Moreno, S | 1 |
Berger, J | 1 |
Nardacci, R | 1 |
Piacentini, M | 1 |
Amendola, R | 1 |
Cecconi, F | 1 |
Lee, BR | 1 |
Ma, YY | 1 |
Huang, YH | 1 |
Otaka, M | 1 |
Ishikawa, M | 1 |
Neumann, PA | 1 |
Graziane, NM | 1 |
Brown, TE | 1 |
Suska, A | 1 |
Guo, C | 1 |
Lobo, MK | 1 |
Sesack, SR | 1 |
Wolf, ME | 1 |
Nestler, EJ | 1 |
Shaham, Y | 1 |
Schlüter, OM | 1 |
Dong, Y | 1 |
Ramani, D | 1 |
De Bandt, JP | 1 |
Cynober, L | 1 |
Liang, N | 1 |
Wang, P | 1 |
Li, S | 1 |
Li, Y | 1 |
Wang, J | 2 |
Hu, YL | 1 |
Miao, PH | 1 |
Huang, B | 1 |
Zhang, TY | 1 |
Hu, ZJ | 1 |
Tabata, Y | 1 |
Gao, JQ | 1 |
Kim, YK | 1 |
Xing, L | 1 |
Chen, BA | 1 |
Xu, F | 1 |
Jiang, HL | 1 |
Zhang, J | 2 |
Qin, W | 2 |
Lyu, W | 2 |
Shen, W | 2 |
Sun, B | 2 |
Sorbara, CD | 1 |
Wagner, NE | 1 |
Ladwig, A | 1 |
Nikić, I | 1 |
Merkler, D | 1 |
Kleele, T | 1 |
Marinković, P | 1 |
Naumann, R | 1 |
Godinho, L | 1 |
Bareyre, FM | 1 |
Bishop, D | 1 |
Misgeld, T | 1 |
Kerschensteiner, M | 1 |
Yan, H | 1 |
Hao, S | 1 |
Sun, X | 1 |
Zhang, D | 1 |
Gao, X | 1 |
Yu, Z | 1 |
Li, K | 1 |
Hang, CH | 1 |
Frühauf, PK | 1 |
Ineu, RP | 1 |
Tomazi, L | 1 |
Duarte, T | 1 |
Mello, CF | 2 |
Rubin, MA | 2 |
Zhang, MM | 1 |
Tu, K | 1 |
Feng, B | 1 |
Zhang, ZN | 1 |
Lei, J | 1 |
Li, YQ | 1 |
Du, JQ | 1 |
Chen, T | 1 |
Royeck, M | 1 |
Kelly, T | 1 |
Opitz, T | 1 |
Otte, DM | 1 |
Rennhack, A | 1 |
Woitecki, A | 1 |
Pitsch, J | 1 |
Becker, A | 1 |
Schoch, S | 1 |
Kaupp, UB | 1 |
Yaari, Y | 1 |
Zimmer, A | 1 |
Beck, H | 1 |
Okumura, S | 1 |
Teratani, T | 1 |
Fujimoto, Y | 1 |
Zhao, X | 1 |
Tsuruyama, T | 1 |
Masano, Y | 1 |
Kasahara, N | 1 |
Iida, T | 1 |
Yagi, S | 1 |
Kaido, T | 1 |
Uemoto, S | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for spermine and Disease Models, Animal
Article | Year |
---|---|
Aliphatic polyamines in physiology and diseases.
Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spe | 2014 |
Skeletal growth in experimental uremia.
Topics: Animals; Bone Development; Calcium; Dietary Proteins; Disease Models, Animal; Dose-Response Relation | 1983 |
Polyamines and the liver.
Topics: Animals; Carboxy-Lyases; Disease Models, Animal; DNA; Liver; Liver Regeneration; Polyamines; Putresc | 1972 |
88 other studies available for spermine and Disease Models, Animal
Article | Year |
---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation.
Topics: Animals; Astrocytes; Calcium; Catalase; Cerebral Cortex; Cytoskeletal Proteins; Disease Models, Anim | 2021 |
Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy.
Topics: Amino Acids; Animals; Computational Biology; Diabetes Mellitus; Diabetic Cardiomyopathies; Disease M | 2022 |
Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Inflammation; Lipopolysaccharides; Lung; Mice; O | 2022 |
Lung-brain axis: Metabolomics and pathological changes in lungs and brain of respiratory syncytial virus-infected mice.
Topics: Animals; Biomarkers; Brain; Cytokines; Disease Models, Animal; Eosine Yellowish-(YS); Estradiol; Hem | 2022 |
Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats.
Topics: Administration, Oral; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Eg | 2019 |
[Exogenous spermine alleviates myocardial injury induced by hyperglycemia by inhibiting golgi stress].
Topics: Animals; Cell Line; Diabetic Cardiomyopathies; Disease Models, Animal; Gene Expression Regulation; G | 2019 |
Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholestanes; Disease Models, Animal; Female; Glyc | 2020 |
ATP13A2 deficiency disrupts lysosomal polyamine export.
Topics: Animals; Biocatalysis; Biological Transport; Caenorhabditis elegans; Cathepsin B; Cytosol; Disease M | 2020 |
The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; C | 2020 |
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
Topics: Animals; Autophagy; Brain; Cellular Senescence; Dementia; Disease Models, Animal; Mice; Mitochondria | 2020 |
Spermine promotes pulmonary vascular remodelling and its synthase is a therapeutic target for pulmonary arterial hypertension.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Glycogen Synthase; Humans; Myocytes, Smooth Mus | 2020 |
Effect of Yuzu (
Topics: Animals; Citrus; Disease Models, Animal; Gastrointestinal Microbiome; Limonins; Mice; RNA, Ribosomal | 2021 |
The aminosterol Claramine inhibits β-secretase 1-mediated insulin receptor cleavage.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cholestanes; Diabetes M | 2021 |
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Topics: Animals; Antinematodal Agents; Autophagosomes; Autophagy; Autophagy-Related Proteins; Cells, Culture | 2021 |
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Blood G | 2017 |
Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis.
Topics: Adolescent; Animals; Biomarkers; Central Nervous System Diseases; Child; Disease Models, Animal; Dog | 2017 |
Acrolein: An Effective Biomarker for Tissue Damage Produced from Polyamines.
Topics: Acrolein; Animals; Biomarkers; Calcium; Cell Line; Disease Models, Animal; Glutathione; Glyceraldehy | 2018 |
Have you tried spermine? A rapid and cost-effective method to eliminate dextran sodium sulfate inhibition of PCR and RT-PCR.
Topics: Animals; Dextran Sulfate; Disease Models, Animal; DNA; Humans; Mice; Polymerase Chain Reaction; Poly | 2018 |
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Enzyme Inhibitors; Mice; Niac | 2018 |
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Topics: alpha-Synuclein; Animals; Caenorhabditis elegans; Cell Line; Cholestanes; Disease Models, Animal; Hu | 2018 |
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation.
Topics: Analysis of Variance; Angelman Syndrome; Animals; Animals, Newborn; Bacterial Proteins; Cells, Cultu | 2013 |
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensi | 2013 |
The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats.
Topics: Animals; Behavior, Animal; Brain; Calcium Channels; Cerebral Infarction; Cytoprotection; Diazoxide; | 2014 |
A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Gene Dosage; HeLa Cells; Humans; Mice; Mice, Inbred | 2013 |
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving.
Topics: Amygdala; Animals; Channelrhodopsins; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopami | 2013 |
Role of mitochondrial calcium uniporter in regulating mitochondrial fission in the cerebral cortexes of living rats.
Topics: Animals; Calcineurin; Calcium; Calcium Channels; Cerebral Cortex; Disease Models, Animal; Dynamins; | 2014 |
Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles.
Topics: Animals; Cell Death; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA; Female; Glucans | 2014 |
Aerosol delivery of programmed cell death protein 4 using polysorbitol-based gene delivery system for lung cancer therapy.
Topics: Aerosols; Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Disease Models, A | 2014 |
[Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis].
Topics: Animals; Caffeic Acids; Disease Models, Animal; Interleukin-1beta; Lung; Male; Mice; Mice, Inbred IC | 2014 |
Pervasive axonal transport deficits in multiple sclerosis models.
Topics: Animals; Axonal Transport; Axons; Disease Models, Animal; Free Radical Scavengers; Functional Neuroi | 2014 |
Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Brain Injuries; Calcium Channels; Disease Models, Animal; Homeostasis; Iron; Mal | 2015 |
Spermine reverses lipopolysaccharide-induced memory deficit in mice.
Topics: Analysis of Variance; Animals; Cytokines; Discrimination, Psychological; Disease Models, Animal; Dos | 2015 |
[Inhibitory effects of Kukoamine B on the inflammatory response of small intestine in lipopolysaccharide-induced septic mice and its potential mechanisms].
Topics: Animals; Caffeic Acids; Cytokines; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interl | 2015 |
The excitatory synaptic transmission of the nucleus of solitary tract was potentiated by chronic myocardial infarction in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Postsyn | 2015 |
Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.
Topics: Action Potentials; Analysis of Variance; Animals; CA1 Region, Hippocampal; Dendrites; Disease Models | 2015 |
Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Pr | 2016 |
Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Injuries; Disease Models, Ani | 2016 |
A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Male; Pancreas; Pancreatitis; Polyamines; Rat | 2008 |
Death and survival of heterozygous Lurcher Purkinje cells in vitro.
Topics: Animals; Cations; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellar Corte | 2009 |
Spermine improves recognition memory deficit in a rodent model of Huntington's disease.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory | 2009 |
Intense correlation between brain infarction and protein-conjugated acrolein.
Topics: Acetylcysteine; Acrolein; Animals; Brain; Carrier Proteins; Disease Models, Animal; Down-Regulation; | 2009 |
Polyamine catabolism is enhanced after traumatic brain injury.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Biomarkers; Brain; Brain Chemistry; Brain Injuries | 2010 |
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Topics: Animals; Appetite; Body Composition; Cholestanes; Diet; Disease Models, Animal; Hep G2 Cells; Humans | 2010 |
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.
Topics: Animals; Arginine; Cationic Amino Acid Transporter 2; Cells, Cultured; Disease Models, Animal; Gastr | 2010 |
Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment.
Topics: Animals; Caffeic Acids; CpG Islands; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Escher | 2011 |
Brain infarction correlates more closely with acrolein than with reactive oxygen species.
Topics: Acrolein; Animals; Brain Infarction; Cell Line, Tumor; Disease Models, Animal; Male; Mice; Mice, Inb | 2011 |
Spermidine delays eye lens opacification in vitro by suppressing transglutaminase-catalyzed crystallin cross-linking.
Topics: Animals; Calcium; Capsule Opacification; Cataract; Crystallins; Disease Models, Animal; Lens, Crysta | 2011 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Use of polyamine metabolites as markers for stroke and renal failure.
Topics: Acrolein; Aged; Animals; Biomarkers; C-Reactive Protein; Cell Line, Tumor; Cell Proliferation; Diagn | 2011 |
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Depen | 2011 |
Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis.
Topics: Acetyltransferases; Animals; Apoptosis; Disease Models, Animal; Enzyme Activation; Male; Oligopeptid | 2011 |
Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.
Topics: Acetyltransferases; Animals; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; K | 2011 |
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosylmethionine Decarboxylase; Animals; Colon; Disease Models, | 2012 |
Amelioration by the natural polyamine spermine of cartilage and bone destruction in rats with collagen-induced arthritis.
Topics: Animals; Arthritis, Experimental; Bone and Bones; Bone Diseases; Cartilage; Disease Models, Animal; | 2012 |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultu | 2012 |
Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage.
Topics: Analysis of Variance; Animals; Ataxia; Biogenic Polyamines; Brain; Disease Models, Animal; Dose-Resp | 2002 |
Therapeutic effects of intracarotid infusion of spermine/nitric oxide complex on cerebral vasospasm.
Topics: Animals; Basilar Artery; Carotid Arteries; Disease Models, Animal; Image Processing, Computer-Assist | 2002 |
Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: a magnetic resonance imaging study.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Brain Infarction; Brain Mapping; D | 2004 |
Molecular mechanisms of nitric oxide-induced growth arrest and apoptosis in fetal pulmonary arterial smooth muscle cells.
Topics: Animals; Apoptosis; Caspases; Cell Cycle; Cells, Cultured; Disease Models, Animal; Fetus; Humans; In | 2003 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cell Count; Dansy | 2004 |
Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease.
Topics: Animals; Antiviral Agents; Case-Control Studies; Colitis; Colitis, Ulcerative; Dextran Sulfate; Dige | 2004 |
The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Damage, Chronic; Brain Ischemia; Dansyl Compo | 2004 |
Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants.
Topics: Amides; Animals; Anti-Bacterial Agents; Binding, Competitive; Cell Line; Cytokines; Disease Models, | 2005 |
Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.
Topics: Acute Disease; Animals; Biomarkers; Disease Models, Animal; Mice; Mice, Transgenic; Pancreatitis; Ra | 2005 |
The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice.
Topics: Animals; Brain; Brain Edema; Dansyl Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Res | 2005 |
A new intranasal influenza vaccine based on a novel polycationic lipid--ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Antibodies, Viral; Bronchoalveolar Lava | 2006 |
Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Cycloo | 2006 |
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Astrocytes; Disease Models, A | 2007 |
Polyamine metabolism in rat myocardial ischemia-reperfusion injury.
Topics: Acetyltransferases; Animals; Coronary Vessels; Disease Models, Animal; Heart Rate; Myocardial Reperf | 2009 |
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
Topics: Animals; Blood Pressure; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Dua | 2008 |
Spermine and endothelial damage during endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Disease Models, Animal; Endothelium, Vasc | 2008 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Psoriasiform dermatosis in a rhesus monkey. Epidermal labeling indexes, polyamines, and histopathologic findings.
Topics: Animals; Disease Models, Animal; DNA; Humans; Infant, Newborn; Macaca mulatta; Psoriasis; Putrescine | 1982 |
Role of polyamines in hypertension induced by angiotensin II.
Topics: Angiotensin II; Animals; Aorta; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension | 1995 |
Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Disease M | 1993 |
Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Bovine papillomavirus 1; Cattle; Disease Models, Anim | 1998 |
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistr | 1999 |
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; E | 2000 |
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis.
Topics: Animals; Cadaverine; Cells, Cultured; Disease Models, Animal; Hypophosphatemia, Familial; Ion Transp | 2000 |
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dose-Response Relatio | 2001 |
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
Topics: Animals; Chromosome Mapping; Diploidy; Disease Models, Animal; Down Syndrome; Evoked Potentials; Fem | 2001 |
A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.
Topics: Animals; Appetite Depressants; Cholestanes; Diabetes Mellitus; Disease Models, Animal; Dogfish; Drin | 2001 |
Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain.
Topics: Animals; Biogenic Polyamines; Biomarkers; Body Weight; Brain; Disease Models, Animal; Epilepsy; Exci | 2001 |
Biochemical aspects of experimental cardiac hypertrophy.
Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Disease Models, Animal; DNA; Myocardial Contractio | 1976 |
Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Chimera; Disease Models, Anima | 1990 |
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv | 1990 |