Page last updated: 2024-10-20

spermine and Disease Models, Animal

spermine has been researched along with Disease Models, Animal in 91 studies

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism."7.80[Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis]. ( Lyu, W; Qin, W; Shen, W; Sun, B; Wang, X; Zhang, J, 2014)
"We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats."7.80The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. ( Dong, H; Liu, Z; Wang, S; Yu, A; Zhang, Z, 2014)
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis."7.77Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011)
"Acute pancreatitis was induced by infusion of sodium taurodeoxycholate (2%) into the pancreatic duct."7.74A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. ( Alhonen, L; Grigorenko, N; Herzig, KH; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Räty, S; Sand, J, 2008)
" After status epilepticus induced by kainic acid (9 mg/kg, i."7.71Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. ( Camón, L; de Vera, N; Martínez, E, 2002)
"The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension."7.69Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995)
"In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)."5.42Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015)
"Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes."5.39Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013)
"The present drugs for treating sepsis act only against either LPS or CpG DNA."5.37Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011)
"Experimental pancreatitis is associated with activation of polyamine catabolism."5.37Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011)
"The aim of this study was to elucidate the mechanism underlying the effects of Kukoamine A (KuA) treatment on endotoxin-induced lung injury/inflammation."4.12Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury. ( Jiang, Y; Jiang, Z; Li, W; Liu, X; Song, Y; Wang, M; Xu, B; Zhang, C, 2022)
"The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia."3.96Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. ( Cai, WW; Dai, Z; Huang, SQ; Lau, GK; Li, BY; Li, H; Liu, HF; Liu, XQ; Wang, Q; Xu, TT; Zhang, SJ; Zhu, WL, 2020)
" This study investigated the impact of polyamines (spermidine and spermine) on ischemia/reperfusion injury (IRI) and liver regeneration."3.83Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats. ( Fujimoto, Y; Iida, T; Kaido, T; Kasahara, N; Masano, Y; Okumura, S; Teratani, T; Tsuruyama, T; Uemoto, S; Uemura, T; Yagi, S; Zhao, X, 2016)
"We investigated the effect of MCU opener spermine on diazoxide against focal cerebral ischemia-reperfusion injury in rats."3.80The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. ( Dong, H; Liu, Z; Wang, S; Yu, A; Zhang, Z, 2014)
"To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism."3.80[Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis]. ( Lyu, W; Qin, W; Shen, W; Sun, B; Wang, X; Zhang, J, 2014)
" Using animal models of pulmonary hypertension, our data showed that CaSR expression and function were both enhanced in PASMC, whereas intraperitoneal injection of the calcilytic NPS 2143 prevented the development of pulmonary hypertension and right ventricular hypertrophy in rats injected with monocrotaline and mice exposed to hypoxia."3.78Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. ( Dong, H; Fernandez, RA; Guo, Q; Makino, A; Pohl, NM; Smith, KA; Yamamura, A; Yamamura, H; Yuan, JX; Zeifman, A; Zimnicka, AM, 2012)
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis."3.77Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011)
"Pancreatitis was induced in wild-type rats by 2 or 6% taurodeoxycholate infusion or in transgenic rats by overexpressing spermidine/spermine N(1)-acetyltransferase (SSAT)."3.77Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis. ( Alhonen, L; Herzig, KH; Hyvönen, MT; Jin, HT; Lämsä, T; Nordback, I; Nordback, PH; Räty, S; Sand, J, 2011)
"Acute pancreatitis was induced by infusion of sodium taurodeoxycholate (2%) into the pancreatic duct."3.74A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate. ( Alhonen, L; Grigorenko, N; Herzig, KH; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Räty, S; Sand, J, 2008)
" After status epilepticus induced by kainic acid (9 mg/kg, i."3.71Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage. ( Camón, L; de Vera, N; Martínez, E, 2002)
"We describe the pharmacological properties of a novel spermine-cholesterol adduct, MSI 1436 (3beta-N-1(spermine)-7alpha, 24R-dihydroxy-5alpha-cholestane 24-sulfate), which causes reversible suppression of food and fluid intake in mammals resulting in profound weight loss, not associated with other signs or symptoms of illness, and which exhibits antidiabetic properties in genetically obese mice."3.71A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties. ( Anderson, M; Chen, Q; Cheshire, K; Holroyd, K; Jones, S; Kinney, W; Maeder, T; McLane, M; Williams, JI; Zasloff, M, 2001)
"The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension."3.69Role of polyamines in hypertension induced by angiotensin II. ( Hughes, AD; Ibrahim, J; Schachter, M; Sever, PS, 1995)
"It has been suggested that the induction of ornithine decarboxylase (ODC) activity during pregnancy might contribute to the low ureagenic flux that enables the pregnant mother to spare nitrogen and support growth."3.68Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes. ( Pastor-Anglada, M; Poveda, B; Soler, C; Soley, M, 1993)
"Spermine dialdehyde (SDA), an oxidized product of spermine which irreversibly suppresses T cell and NK cell activities, was evaluated as an ex vivo purging agent in the prevention of graft-versus-host disease (GVHD) in mice transplanted with SDA-treated allogeneic bone marrow."3.68Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. ( Chourmouzis, E; Conant, JM; Lau, C; Li, D; Visconti, V; Wang, E, 1990)
"DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness."3.66Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983)
"Spermine treatment significantly promoted PASMC proliferation, which was significantly inhibited by U50,488H, p38 inhibitor SB203580, JNK inhibitor SP600125, Erk inhibitor SCH772984, and MEK inhibitor U0126, especially Erk inhibitor (P < 0."1.56The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development. ( Cao, Z; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Liu, M; Pei, J; Wang, X; Wang, Y; Zhang, S, 2020)
"Identification of biomarkers for central nervous system disease in MPS patients would facilitate the evaluation of new agents in clinical trials."1.46Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis. ( Bell, P; Dalla Corte, A; de Souza, CFM; Giugliani, R; Hinderer, C; Katz, N; Louboutin, JP; Lund, TC; Mesaros, C; Nayal, M; Orchard, PJ; Tolar, J; Weng, L; Wilson, JM, 2017)
"Kukoamine A (KuA) has the ability of anti-oxidative stress and anti-apoptosis in vitro."1.43Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis. ( Cheng, Z; Ma, H; Meng, W; Wang, C; Zhang, Y; Zhao, Q, 2016)
"Spermine protects against LPS-induced memory deficits in mice by a mechanism that involves GluN2B receptors."1.42Spermine reverses lipopolysaccharide-induced memory deficit in mice. ( Duarte, T; Frühauf, PK; Ineu, RP; Mello, CF; Rubin, MA; Tomazi, L, 2015)
"In pilocarpine-treated chronically epileptic rats, we describe a novel mechanism that causes an increased proximal dendritic persistent Na(+) current (INaP)."1.42Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. ( Beck, H; Becker, A; Kaupp, UB; Kelly, T; Opitz, T; Otte, DM; Pitsch, J; Rennhack, A; Royeck, M; Schoch, S; Woitecki, A; Yaari, Y; Zimmer, A, 2015)
"Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes."1.39Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. ( Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA, 2013)
"Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal."1.39A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury. ( Amendola, R; Bellavia, G; Berger, J; Cavallucci, V; Cecconi, F; Cervelli, M; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Moreno, S; Nardacci, R; Piacentini, M, 2013)
"The present drugs for treating sepsis act only against either LPS or CpG DNA."1.37Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment. ( Cao, H; Liu, X; Long, Y; Lu, Y; Wang, N; Zhao, K; Zheng, J; Zheng, X; Zhou, H, 2011)
"In the treatment of pulmonary hypertension, this pathway is exogenously activated using inhaled NO or other pharmacological agents."1.37Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. ( Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C, 2011)
"Experimental pancreatitis is associated with activation of polyamine catabolism."1.37Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine. ( Alhonen, L; Grigorenko, N; Hyvönen, MT; Jin, HT; Khomutov, AR; Lämsä, T; Nordback, I; Nordback, PH; Pörsti, I; Räty, S; Sand, J, 2011)
"Spermine levels were normal at 6 h and decreased slightly at 24 h, but were normal again by 72 h post-injury."1.36Polyamine catabolism is enhanced after traumatic brain injury. ( Casero, RA; Huttinger, F; Morrison, R; Murray-Stewart, T; Strauss, KI; Zahedi, K, 2010)
"The intraluminal suture transient middle cerebral artery occlusion (MCAO) model was used."1.33The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice. ( Doyle, KM; Henman, MC; Li, J; Shaw, GG; Tatlisumak, T, 2005)
"In patients with ulcerative colitis, CEC spermidine and N8-acetylspermidine levels were significantly enhanced and spermine levels were reduced compared with healthy controls."1.32Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease. ( Herfarth, H; Jauch, KW; Obermeier, F; Ouart, J; Rogler, G; Schölmerich, J; Vogl, D; Weiss, TS, 2004)
"Putrescine efflux also was altered by hypoxic exposure; T1/2 for loss of diamine from a slowly effluxing pool was increased from 60."1.28Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension. ( Gillespie, MN; Kostenbauder, HB; Olson, JW; Shiao, RT, 1990)
"In experimental cardiac hypertrophy induced by aortic constriction of rats, the hypertrophy was established after 5-7 days."1.26Biochemical aspects of experimental cardiac hypertrophy. ( Matsushita, S, 1976)

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-19905 (5.49)18.7374
1990's6 (6.59)18.2507
2000's26 (28.57)29.6817
2010's41 (45.05)24.3611
2020's13 (14.29)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X2
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W2
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Cervetto, C1
Averna, M1
Vergani, L1
Pedrazzi, M1
Amato, S1
Pelassa, S1
Giuliani, S1
Baldini, F1
Maura, G2
Mariottini, P2
Marcoli, M2
Cervelli, M2
Wei, C2
Song, T1
Yuan, H1
Li, X1
Zhang, X2
Liang, X1
Fan, Y1
Liu, X2
Wang, M2
Song, Y1
Zhang, C2
Jiang, Y1
Xu, B1
Jiang, Z1
Mao, Y1
Bajinka, O1
Tang, Z1
Qiu, X1
Tan, Y1
Fukushima, T1
Yokooji, T1
Hirano, T1
Kataoka, Y1
Taogoshi, T1
Matsuo, H1
Fan, YQ1
Wang, YH1
Shao, YY1
Shao, XT1
Hu, J1
Xu, CQ1
Ricke, KM1
Cruz, SA1
Qin, Z1
Farrokhi, K1
Sharmin, F1
Zhang, L1
Zasloff, MA1
Stewart, AFR1
Chen, HH1
van Veen, S1
Martin, S1
Van den Haute, C1
Benoy, V1
Lyons, J1
Vanhoutte, R1
Kahler, JP1
Decuypere, JP1
Gelders, G1
Lambie, E1
Zielich, J1
Swinnen, JV1
Annaert, W1
Agostinis, P1
Ghesquière, B1
Verhelst, S1
Baekelandt, V1
Eggermont, J1
Vangheluwe, P1
Li, J4
Jia, M1
Liu, M2
Cao, Z1
Wang, X4
Feng, N1
Zhang, S1
Fan, R1
Guo, H1
Wang, Y2
Pei, J1
Xu, TT1
Li, H2
Dai, Z1
Lau, GK1
Li, BY1
Zhu, WL1
Liu, XQ1
Liu, HF1
Cai, WW1
Huang, SQ1
Wang, Q1
Zhang, SJ1
He, YY1
Yan, Y1
Jiang, X1
Zhao, JH1
Wang, Z1
Wu, T1
Guo, SS1
Ye, J1
Lian, TY1
Xu, XQ1
Zhang, JL1
Sun, K1
Peng, FH1
Zhou, YP1
Mao, YM1
Chen, JW1
Zhang, SY1
Jing, ZC1
Minamisawa, M1
Suzumura, T1
Bose, S1
Taniai, T1
Kawai, G1
Suzuki, K1
Yamaguchi, A1
Yamanaka, S1
Gaborit, B1
Govers, R1
Altié, A1
Brunel, JM1
Morange, P1
Peiretti, F1
Gassen, NC1
Papies, J1
Bajaj, T1
Emanuel, J1
Dethloff, F1
Chua, RL1
Trimpert, J1
Heinemann, N1
Niemeyer, C1
Weege, F1
Hönzke, K1
Aschman, T1
Heinz, DE1
Weckmann, K1
Ebert, T1
Zellner, A1
Lennarz, M1
Wyler, E1
Schroeder, S1
Richter, A1
Niemeyer, D1
Hoffmann, K1
Meyer, TF1
Heppner, FL1
Corman, VM1
Landthaler, M1
Hocke, AC1
Morkel, M1
Osterrieder, N1
Conrad, C1
Eils, R1
Radbruch, H1
Giavalisco, P1
Drosten, C1
Müller, MA1
Thompson, D1
Morrice, N1
Grant, L1
Le Sommer, S1
Lees, EK1
Mody, N1
Wilson, HM1
Delibegovic, M1
Hinderer, C1
Katz, N1
Louboutin, JP1
Bell, P1
Tolar, J1
Orchard, PJ1
Lund, TC1
Nayal, M1
Weng, L1
Mesaros, C1
de Souza, CFM1
Dalla Corte, A1
Giugliani, R1
Wilson, JM1
Igarashi, K4
Uemura, T2
Kashiwagi, K4
Krych, Ł1
Kot, W1
Bendtsen, KMB1
Hansen, AK1
Vogensen, FK1
Nielsen, DS1
Gaspar, L1
Coron, RP1
KongThoo Lin, P1
Costa, DM1
Perez-Cabezas, B1
Tavares, J1
Roura-Ferrer, M1
Ramos, I1
Ronin, C1
Major, LL1
Ciesielski, F1
Pemberton, IK1
MacDougall, J1
Ciapetti, P1
Smith, TK1
Cordeiro-da-Silva, A1
Perni, M1
Flagmeier, P1
Limbocker, R1
Cascella, R1
Aprile, FA1
Galvagnion, C1
Heller, GT1
Meisl, G1
Chen, SW1
Kumita, JR1
Challa, PK1
Kirkegaard, JB1
Cohen, SIA1
Mannini, B1
Barbut, D1
Nollen, EAA1
Cecchi, C1
Cremades, N1
Knowles, TPJ1
Chiti, F1
Zasloff, M2
Vendruscolo, M1
Dobson, CM1
Condon, KH1
Ho, J1
Robinson, CG1
Hanus, C1
Ehlers, MD1
North, ML1
Grasemann, H1
Khanna, N1
Inman, MD1
Gauvreau, GM1
Scott, JA1
Dong, H2
Wang, S2
Zhang, Z1
Yu, A1
Liu, Z1
Bellavia, G1
D'Amelio, M1
Cavallucci, V1
Moreno, S1
Berger, J1
Nardacci, R1
Piacentini, M1
Amendola, R1
Cecconi, F1
Lee, BR1
Ma, YY1
Huang, YH1
Otaka, M1
Ishikawa, M1
Neumann, PA1
Graziane, NM1
Brown, TE1
Suska, A1
Guo, C1
Lobo, MK1
Sesack, SR1
Wolf, ME1
Nestler, EJ1
Shaham, Y1
Schlüter, OM1
Dong, Y1
Ramani, D1
De Bandt, JP1
Cynober, L1
Liang, N1
Wang, P1
Li, S1
Li, Y1
Wang, J2
Hu, YL1
Miao, PH1
Huang, B1
Zhang, TY1
Hu, ZJ1
Tabata, Y1
Gao, JQ1
Kim, YK1
Xing, L1
Chen, BA1
Xu, F1
Jiang, HL1
Zhang, J2
Qin, W2
Lyu, W2
Shen, W2
Sun, B2
Sorbara, CD1
Wagner, NE1
Ladwig, A1
Nikić, I1
Merkler, D1
Kleele, T1
Marinković, P1
Naumann, R1
Godinho, L1
Bareyre, FM1
Bishop, D1
Misgeld, T1
Kerschensteiner, M1
Yan, H1
Hao, S1
Sun, X1
Zhang, D1
Gao, X1
Yu, Z1
Li, K1
Hang, CH1
Frühauf, PK1
Ineu, RP1
Tomazi, L1
Duarte, T1
Mello, CF2
Rubin, MA2
Zhang, MM1
Tu, K1
Feng, B1
Zhang, ZN1
Lei, J1
Li, YQ1
Du, JQ1
Chen, T1
Royeck, M1
Kelly, T1
Opitz, T1
Otte, DM1
Rennhack, A1
Woitecki, A1
Pitsch, J1
Becker, A1
Schoch, S1
Kaupp, UB1
Yaari, Y1
Zimmer, A1
Beck, H1
Okumura, S1
Teratani, T1
Fujimoto, Y1
Zhao, X1
Tsuruyama, T1
Masano, Y1
Kasahara, N1
Iida, T1
Yagi, S1
Kaido, T1
Uemoto, S1
Zhang, Y1
Cheng, Z1
Wang, C1
Ma, H1
Meng, W1
Zhao, Q1
Jin, HT3
Lämsä, T3
Hyvönen, MT3
Sand, J3
Räty, S3
Grigorenko, N2
Khomutov, AR2
Herzig, KH4
Alhonen, L5
Nordback, I3
Zanjani, HS1
McFarland, R1
Cavelier, P1
Blokhin, A1
Gautheron, V1
Levenes, C1
Bambrick, LL1
Mariani, J1
Vogel, MW1
Velloso, NA1
Dalmolin, GD1
Gomes, GM1
Canas, PM1
Cunha, RA1
Saiki, R2
Nishimura, K2
Ishii, I2
Omura, T1
Okuyama, S1
Zahedi, K1
Huttinger, F1
Morrison, R1
Murray-Stewart, T1
Casero, RA2
Strauss, KI1
Lantz, KA1
Hart, SG1
Planey, SL1
Roitman, MF1
Ruiz-White, IA1
Wolfe, HR1
McLane, MP1
Chaturvedi, R1
Asim, M1
Hoge, S1
Lewis, ND1
Singh, K1
Barry, DP1
de Sablet, T1
Piazuelo, MB1
Sarvaria, AR1
Cheng, Y1
Closs, EI1
Gobert, AP1
Wilson, KT1
Zheng, X1
Wang, N1
Cao, H2
Lu, Y1
Long, Y1
Zhao, K1
Zhou, H1
Zheng, J1
Park, H1
Yoshida, M1
Toida, T1
Tatsukawa, H1
Kojima, S1
Ikeguchi, Y1
Pegg, AE2
Lentini, A1
Tabolacci, C1
Mattioli, P1
Provenzano, B1
Beninati, S1
Duan, B1
Wang, YZ1
Yang, T1
Chu, XP1
Yu, Y1
Huang, Y1
Hansen, J1
Simon, RP1
Zhu, MX1
Xiong, ZG1
Xu, TL1
Aggarwal, S1
Gross, CM1
Kumar, S1
Datar, S1
Oishi, P1
Kalkan, G1
Schreiber, C1
Fratz, S1
Fineman, JR1
Black, SM2
Nordback, PH2
Pörsti, I1
Welsh, PA1
Sass-Kuhn, S1
Prakashagowda, C1
McCloskey, D1
Feith, D1
Iezaki, T1
Hinoi, E1
Yamamoto, T1
Ishiura, R1
Ogawa, S1
Yoneda, Y1
Yamamura, A1
Guo, Q1
Yamamura, H1
Zimnicka, AM1
Pohl, NM1
Smith, KA1
Fernandez, RA1
Zeifman, A1
Makino, A1
Yuan, JX1
de Vera, N2
Camón, L2
Martínez, E2
Sönmez, OF1
Unal, B1
Inalöz, S1
Sahin, B1
Yilmaz, M1
Aydin, A1
Kaplan, S1
Shirhan, MD1
Moochhala, SM1
Ng, PY1
Lu, J1
Ng, KC1
Teo, AL1
Yap, E1
Ng, I1
Hwang, P1
Lim, T1
Sitoh, YY1
Rumpel, H1
Jose, R1
Ling, E1
Wedgwood, S1
Kirby, BP2
Shaw, GG3
Weiss, TS1
Herfarth, H1
Obermeier, F1
Ouart, J1
Vogl, D1
Schölmerich, J1
Jauch, KW1
Rogler, G1
Henman, MC2
Doyle, KM2
Strbian, D1
Tatlisumak, T2
Burns, MR1
Wood, SJ1
Miller, KA1
Nguyen, T1
Cromer, JR1
David, SA1
Jänne, J2
Joseph, A1
Itskovitz-Cooper, N1
Samira, S1
Flasterstein, O1
Eliyahu, H1
Simberg, D1
Goldwaser, I1
Barenholz, Y1
Kedar, E1
Ignatenko, NA1
Besselsen, DG1
Roy, UK1
Stringer, DE1
Blohm-Mangone, KA1
Padilla-Torres, JL1
Guillen-R, JM1
Gerner, EW1
Yin, HZ1
Tang, DT1
Weiss, JH1
Han, L1
Xu, C1
Guo, Y1
Jiang, C1
Zhao, Y1
Calvert, TJ1
Chicoine, LG1
Liu, Y1
Nelin, LD1
Peter, C1
Barth, C1
Petri, E1
Martin, E1
Walther, A1
Clarkson, AB1
Bacchi, CJ1
Mellow, GH1
Nathan, HC1
McCann, PP1
Sjoerdsma, A1
Mehls, O1
Ritz, E1
Lowe, NJ1
Chalet, M1
Breeding, J1
Kean, C1
Russell, DH1
Ibrahim, J1
Schachter, M1
Hughes, AD1
Sever, PS1
Poveda, B1
Soler, C1
Soley, M1
Pastor-Anglada, M1
Imaoka, T1
Date, I1
Ohmoto, T1
Nagatsu, T1
ter Steege, JC1
Forget, PP1
Buurman, WA1
Parkkinen, JJ1
Keinanen, T1
Sinervirta, R1
Lopatin, AN1
Shantz, LM1
Mackintosh, CA1
Nichols, CG1
Hussain, MB1
MacAllister, RJ1
Hobbs, AJ1
Klein, RC1
Siarey, RJ1
Caruso, A1
Rapoport, SI1
Castellino, FJ1
Galdzicki, Z1
Williams, JI1
Chen, Q1
Anderson, M1
Maeder, T1
Holroyd, K1
Jones, S1
Kinney, W1
Cheshire, K1
McLane, M1
Matsushita, S1
Wang, E1
Conant, JM1
Li, D1
Visconti, V1
Chourmouzis, E1
Lau, C1
Shiao, RT1
Kostenbauder, HB1
Olson, JW1
Gillespie, MN1
Domschke, S1
Domschke, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369]Phase 10 participants (Actual)Interventional2014-12-31Withdrawn (stopped due to Changes to cardiac surgery program)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for spermine and Disease Models, Animal

ArticleYear
Aliphatic polyamines in physiology and diseases.
    Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:1

    Topics: Agmatine; Animals; Disease Models, Animal; Humans; Neoplasms; Ornithine; Putrescine; Spermidine; Spe

2014
Skeletal growth in experimental uremia.
    Kidney international. Supplement, 1983, Volume: 15

    Topics: Animals; Bone Development; Calcium; Dietary Proteins; Disease Models, Animal; Dose-Response Relation

1983
Polyamines and the liver.
    Acta hepato-gastroenterologica, 1972, Volume: 19, Issue:3

    Topics: Animals; Carboxy-Lyases; Disease Models, Animal; DNA; Liver; Liver Regeneration; Polyamines; Putresc

1972

Other Studies

88 other studies available for spermine and Disease Models, Animal

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation.
    Biomolecules, 2021, 08-25, Volume: 11, Issue:9

    Topics: Animals; Astrocytes; Calcium; Catalase; Cerebral Cortex; Cytoskeletal Proteins; Disease Models, Anim

2021
Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Amino Acids; Animals; Computational Biology; Diabetes Mellitus; Diabetic Cardiomyopathies; Disease M

2022
Kukoamine A inhibits C-C motif chemokine receptor 5 to attenuate lipopolysaccharide-induced lung injury.
    Drug development research, 2022, Volume: 83, Issue:6

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Inflammation; Lipopolysaccharides; Lung; Mice; O

2022
Lung-brain axis: Metabolomics and pathological changes in lungs and brain of respiratory syncytial virus-infected mice.
    Journal of medical virology, 2022, Volume: 94, Issue:12

    Topics: Animals; Biomarkers; Brain; Cytokines; Disease Models, Animal; Eosine Yellowish-(YS); Estradiol; Hem

2022
Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats.
    PloS one, 2019, Volume: 14, Issue:12

    Topics: Administration, Oral; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Eg

2019
[Exogenous spermine alleviates myocardial injury induced by hyperglycemia by inhibiting golgi stress].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2019, Volume: 35, Issue:5

    Topics: Animals; Cell Line; Diabetic Cardiomyopathies; Disease Models, Animal; Gene Expression Regulation; G

2019
Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 02-12, Volume: 40, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholestanes; Disease Models, Animal; Female; Glyc

2020
ATP13A2 deficiency disrupts lysosomal polyamine export.
    Nature, 2020, Volume: 578, Issue:7795

    Topics: Animals; Biocatalysis; Biological Transport; Caenorhabditis elegans; Cathepsin B; Cytosol; Disease M

2020
The effect of activated κ-opioid receptor (κ-OR) on the role of calcium sensing receptor (CaSR) in preventing hypoxic pulmonary hypertension development.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; C

2020
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
    Aging, 2020, 04-08, Volume: 12, Issue:7

    Topics: Animals; Autophagy; Brain; Cellular Senescence; Dementia; Disease Models, Animal; Mice; Mitochondria

2020
Spermine promotes pulmonary vascular remodelling and its synthase is a therapeutic target for pulmonary arterial hypertension.
    The European respiratory journal, 2020, Volume: 56, Issue:5

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Glycogen Synthase; Humans; Myocytes, Smooth Mus

2020
Effect of Yuzu (
    Medical sciences (Basel, Switzerland), 2021, 03-11, Volume: 9, Issue:1

    Topics: Animals; Citrus; Disease Models, Animal; Gastrointestinal Microbiome; Limonins; Mice; RNA, Ribosomal

2021
The aminosterol Claramine inhibits β-secretase 1-mediated insulin receptor cleavage.
    The Journal of biological chemistry, 2021, Volume: 297, Issue:1

    Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cholestanes; Diabetes M

2021
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
    Nature communications, 2021, 06-21, Volume: 12, Issue:1

    Topics: Animals; Antinematodal Agents; Autophagosomes; Autophagy; Autophagy-Related Proteins; Cells, Culture

2021
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR
    Clinical science (London, England : 1979), 2017, Oct-01, Volume: 131, Issue:20

    Topics: AMP-Activated Protein Kinases; Animals; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Blood G

2017
Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis.
    Human molecular genetics, 2017, 10-01, Volume: 26, Issue:19

    Topics: Adolescent; Animals; Biomarkers; Central Nervous System Diseases; Child; Disease Models, Animal; Dog

2017
Acrolein: An Effective Biomarker for Tissue Damage Produced from Polyamines.
    Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1694

    Topics: Acrolein; Animals; Biomarkers; Calcium; Cell Line; Disease Models, Animal; Glutathione; Glyceraldehy

2018
Have you tried spermine? A rapid and cost-effective method to eliminate dextran sodium sulfate inhibition of PCR and RT-PCR.
    Journal of microbiological methods, 2018, Volume: 144

    Topics: Animals; Dextran Sulfate; Disease Models, Animal; DNA; Humans; Mice; Polymerase Chain Reaction; Poly

2018
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:1

    Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Enzyme Inhibitors; Mice; Niac

2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
    ACS chemical biology, 2018, 08-17, Volume: 13, Issue:8

    Topics: alpha-Synuclein; Animals; Caenorhabditis elegans; Cell Line; Cholestanes; Disease Models, Animal; Hu

2018
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Feb-27, Volume: 33, Issue:9

    Topics: Analysis of Variance; Angelman Syndrome; Animals; Animals, Newborn; Bacterial Proteins; Cells, Cultu

2013
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
    American journal of respiratory cell and molecular biology, 2013, Volume: 48, Issue:6

    Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensi

2013
The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:2

    Topics: Animals; Behavior, Animal; Brain; Calcium Channels; Cerebral Infarction; Cytoprotection; Diazoxide;

2014
A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Brain Injuries; Disease Models, Animal; Gene Dosage; HeLa Cells; Humans; Mice; Mice, Inbred

2013
Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving.
    Nature neuroscience, 2013, Volume: 16, Issue:11

    Topics: Amygdala; Animals; Channelrhodopsins; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopami

2013
Role of mitochondrial calcium uniporter in regulating mitochondrial fission in the cerebral cortexes of living rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:6

    Topics: Animals; Calcineurin; Calcium; Calcium Channels; Cerebral Cortex; Disease Models, Animal; Dynamins;

2014
Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles.
    Journal of biomedical nanotechnology, 2014, Volume: 10, Issue:2

    Topics: Animals; Cell Death; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA; Female; Glucans

2014
Aerosol delivery of programmed cell death protein 4 using polysorbitol-based gene delivery system for lung cancer therapy.
    Journal of drug targeting, 2014, Volume: 22, Issue:9

    Topics: Aerosols; Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Disease Models, A

2014
[Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis].
    Zhonghua wei zhong bing ji jiu yi xue, 2014, Volume: 26, Issue:7

    Topics: Animals; Caffeic Acids; Disease Models, Animal; Interleukin-1beta; Lung; Male; Mice; Mice, Inbred IC

2014
Pervasive axonal transport deficits in multiple sclerosis models.
    Neuron, 2014, Dec-17, Volume: 84, Issue:6

    Topics: Animals; Axonal Transport; Axons; Disease Models, Animal; Free Radical Scavengers; Functional Neuroi

2014
Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage.
    Biochemical and biophysical research communications, 2015, Jan-24, Volume: 456, Issue:4

    Topics: Animals; Apoptosis; Brain Injuries; Calcium Channels; Disease Models, Animal; Homeostasis; Iron; Mal

2015
Spermine reverses lipopolysaccharide-induced memory deficit in mice.
    Journal of neuroinflammation, 2015, Jan-09, Volume: 12

    Topics: Analysis of Variance; Animals; Cytokines; Discrimination, Psychological; Disease Models, Animal; Dos

2015
[Inhibitory effects of Kukoamine B on the inflammatory response of small intestine in lipopolysaccharide-induced septic mice and its potential mechanisms].
    Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:2

    Topics: Animals; Caffeic Acids; Cytokines; Disease Models, Animal; Intercellular Adhesion Molecule-1; Interl

2015
The excitatory synaptic transmission of the nucleus of solitary tract was potentiated by chronic myocardial infarction in rats.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Postsyn

2015
Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Nov-18, Volume: 35, Issue:46

    Topics: Action Potentials; Analysis of Variance; Animals; CA1 Region, Hippocampal; Dendrites; Disease Models

2015
Oral administration of polyamines ameliorates liver ischemia/reperfusion injury and promotes liver regeneration in rats.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2016, Volume: 22, Issue:9

    Topics: Administration, Oral; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Cell Pr

2016
Neuroprotective Effects of Kukoamine a against Radiation-induced Rat Brain Injury through Inhibition of Oxidative Stress and Neuronal Apoptosis.
    Neurochemical research, 2016, Volume: 41, Issue:10

    Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Brain Injuries; Disease Models, Ani

2016
A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.
    Surgery, 2008, Volume: 144, Issue:1

    Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Male; Pancreas; Pancreatitis; Polyamines; Rat

2008
Death and survival of heterozygous Lurcher Purkinje cells in vitro.
    Developmental neurobiology, 2009, Volume: 69, Issue:8

    Topics: Animals; Cations; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellar Corte

2009
Spermine improves recognition memory deficit in a rodent model of Huntington's disease.
    Neurobiology of learning and memory, 2009, Volume: 92, Issue:4

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory

2009
Intense correlation between brain infarction and protein-conjugated acrolein.
    Stroke, 2009, Volume: 40, Issue:10

    Topics: Acetylcysteine; Acrolein; Animals; Brain; Carrier Proteins; Disease Models, Animal; Down-Regulation;

2009
Polyamine catabolism is enhanced after traumatic brain injury.
    Journal of neurotrauma, 2010, Volume: 27, Issue:3

    Topics: Acetyltransferases; Animals; Biogenic Polyamines; Biomarkers; Brain; Brain Chemistry; Brain Injuries

2010
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
    Obesity (Silver Spring, Md.), 2010, Volume: 18, Issue:8

    Topics: Animals; Appetite; Body Composition; Cholestanes; Diet; Disease Models, Animal; Hep G2 Cells; Humans

2010
Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.
    Gastroenterology, 2010, Volume: 139, Issue:5

    Topics: Animals; Arginine; Cationic Amino Acid Transporter 2; Cells, Cultured; Disease Models, Animal; Gastr

2010
Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment.
    British journal of pharmacology, 2011, Volume: 162, Issue:6

    Topics: Animals; Caffeic Acids; CpG Islands; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Escher

2011
Brain infarction correlates more closely with acrolein than with reactive oxygen species.
    Biochemical and biophysical research communications, 2011, Jan-28, Volume: 404, Issue:4

    Topics: Acrolein; Animals; Brain Infarction; Cell Line, Tumor; Disease Models, Animal; Male; Mice; Mice, Inb

2011
Spermidine delays eye lens opacification in vitro by suppressing transglutaminase-catalyzed crystallin cross-linking.
    The protein journal, 2011, Volume: 30, Issue:2

    Topics: Animals; Calcium; Capsule Opacification; Cataract; Crystallins; Disease Models, Animal; Lens, Crysta

2011
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-09, Volume: 31, Issue:6

    Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju

2011
Use of polyamine metabolites as markers for stroke and renal failure.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 720

    Topics: Acrolein; Aged; Animals; Biomarkers; C-Reactive Protein; Cell Line, Tumor; Cell Proliferation; Diagn

2011
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
    Journal of cellular physiology, 2011, Volume: 226, Issue:12

    Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Depen

2011
Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2011, Volume: 11, Issue:2

    Topics: Acetyltransferases; Animals; Apoptosis; Disease Models, Animal; Enzyme Activation; Male; Oligopeptid

2011
Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:4

    Topics: Acetyltransferases; Animals; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; K

2011
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
    Cancer biology & therapy, 2012, Volume: 13, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosylmethionine Decarboxylase; Animals; Colon; Disease Models,

2012
Amelioration by the natural polyamine spermine of cartilage and bone destruction in rats with collagen-induced arthritis.
    Journal of pharmacological sciences, 2012, Volume: 119, Issue:1

    Topics: Animals; Arthritis, Experimental; Bone and Bones; Bone Diseases; Cartilage; Disease Models, Animal;

2012
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
    Circulation research, 2012, Aug-03, Volume: 111, Issue:4

    Topics: Aniline Compounds; Animals; Calcimimetic Agents; Calcium Signaling; Cell Proliferation; Cells, Cultu

2012
Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:5

    Topics: Analysis of Variance; Animals; Ataxia; Biogenic Polyamines; Brain; Disease Models, Animal; Dose-Resp

2002
Therapeutic effects of intracarotid infusion of spermine/nitric oxide complex on cerebral vasospasm.
    Acta neurochirurgica, 2002, Volume: 144, Issue:9

    Topics: Animals; Basilar Artery; Carotid Arteries; Disease Models, Animal; Image Processing, Computer-Assist

2002
Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: a magnetic resonance imaging study.
    Neuroscience, 2004, Volume: 124, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Brain Infarction; Brain Mapping; D

2004
Molecular mechanisms of nitric oxide-induced growth arrest and apoptosis in fetal pulmonary arterial smooth muscle cells.
    Nitric oxide : biology and chemistry, 2003, Volume: 9, Issue:4

    Topics: Animals; Apoptosis; Caspases; Cell Cycle; Cells, Cultured; Disease Models, Animal; Fetus; Humans; In

2003
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia.
    Brain research, 2004, Jun-11, Volume: 1011, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Brain Ischemia; Cell Count; Dansy

2004
Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease.
    Inflammatory bowel diseases, 2004, Volume: 10, Issue:5

    Topics: Animals; Antiviral Agents; Case-Control Studies; Colitis; Colitis, Ulcerative; Dextran Sulfate; Dige

2004
The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice.
    Brain research, 2004, Dec-10, Volume: 1029, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Damage, Chronic; Brain Ischemia; Dansyl Compo

2004
Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants.
    Bioorganic & medicinal chemistry, 2005, Apr-01, Volume: 13, Issue:7

    Topics: Amides; Animals; Anti-Bacterial Agents; Binding, Competitive; Cell Line; Cytokines; Disease Models,

2005
Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:1

    Topics: Acute Disease; Animals; Biomarkers; Disease Models, Animal; Mice; Mice, Transgenic; Pancreatitis; Ra

2005
The pre-ischaemic neuroprotective effects of N1-dansyl-spermine in a transient focal cerebral ischaemia model in mice.
    Brain research, 2005, Sep-07, Volume: 1055, Issue:1-2

    Topics: Animals; Brain; Brain Edema; Dansyl Compounds; Disease Models, Animal; Dizocilpine Maleate; Dose-Res

2005
A new intranasal influenza vaccine based on a novel polycationic lipid--ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice.
    Vaccine, 2006, May-01, Volume: 24, Issue:18

    Topics: Adjuvants, Immunologic; Administration, Intranasal; Animals; Antibodies, Viral; Bronchoalveolar Lava

2006
Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis.
    Nutrition and cancer, 2006, Volume: 56, Issue:2

    Topics: Adenomatous Polyposis Coli; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Cycloo

2006
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.
    Experimental neurology, 2007, Volume: 207, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Astrocytes; Disease Models, A

2007
Polyamine metabolism in rat myocardial ischemia-reperfusion injury.
    International journal of cardiology, 2009, Feb-06, Volume: 132, Issue:1

    Topics: Acetyltransferases; Animals; Coronary Vessels; Disease Models, Animal; Heart Rate; Myocardial Reperf

2009
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4

    Topics: Animals; Blood Pressure; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Dua

2008
Spermine and endothelial damage during endotoxemia.
    Inflammation, 2008, Volume: 31, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Disease Models, Animal; Endothelium, Vasc

2008
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
    Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:18

    Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati

1983
Psoriasiform dermatosis in a rhesus monkey. Epidermal labeling indexes, polyamines, and histopathologic findings.
    Archives of dermatology, 1982, Volume: 118, Issue:12

    Topics: Animals; Disease Models, Animal; DNA; Humans; Infant, Newborn; Macaca mulatta; Psoriasis; Putrescine

1982
Role of polyamines in hypertension induced by angiotensin II.
    Cardiovascular research, 1995, Volume: 29, Issue:1

    Topics: Angiotensin II; Animals; Aorta; Cardiomegaly; Disease Models, Animal; Heart Ventricles; Hypertension

1995
Ornithine decarboxylase activity and urea in liver of late-pregnant rats. Effect of streptozotocin-induced diabetes.
    Biology of the neonate, 1993, Volume: 63, Issue:1

    Topics: Animals; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabetes Mellitus, Experimental; Disease M

1993
Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex.
    Human gene therapy, 1998, May-01, Volume: 9, Issue:7

    Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Bovine papillomavirus 1; Cattle; Disease Models, Anim

1998
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2

    Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistr

1999
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Jul-18, Volume: 97, Issue:15

    Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; E

2000
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:11

    Topics: Animals; Cadaverine; Cells, Cultured; Disease Models, Animal; Hypophosphatemia, Familial; Ion Transp

2000
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:3

    Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dose-Response Relatio

2001
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons.
    Journal of neurochemistry, 2001, Volume: 76, Issue:6

    Topics: Animals; Chromosome Mapping; Diploidy; Disease Models, Animal; Down Syndrome; Evoked Potentials; Fem

2001
A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:5

    Topics: Animals; Appetite Depressants; Cholestanes; Diabetes Mellitus; Disease Models, Animal; Dogfish; Drin

2001
Polyamine metabolism and glutamate receptor agonists-mediated excitotoxicity in the rat brain.
    Journal of neuroscience research, 2001, Dec-15, Volume: 66, Issue:6

    Topics: Animals; Biogenic Polyamines; Biomarkers; Body Weight; Brain; Disease Models, Animal; Epilepsy; Exci

2001
Biochemical aspects of experimental cardiac hypertrophy.
    Japanese circulation journal, 1976, Volume: 40, Issue:10

    Topics: Adenosine Triphosphatases; Animals; Cardiomegaly; Disease Models, Animal; DNA; Myocardial Contractio

1976
Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model.
    Bone marrow transplantation, 1990, Volume: 6, Issue:4

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Chimera; Disease Models, Anima

1990
Mechanisms of lung polyamine accumulation in chronic hypoxic pulmonary hypertension.
    The American journal of physiology, 1990, Volume: 259, Issue:6 Pt 1

    Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Liv

1990