spermine has been researched along with Central Nervous System Diseases in 5 studies
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| "Identification of biomarkers for central nervous system disease in MPS patients would facilitate the evaluation of new agents in clinical trials." | 1.46 | Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis. ( Bell, P; Dalla Corte, A; de Souza, CFM; Giugliani, R; Hinderer, C; Katz, N; Louboutin, JP; Lund, TC; Mesaros, C; Nayal, M; Orchard, PJ; Tolar, J; Weng, L; Wilson, JM, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hinderer, C | 1 |
| Katz, N | 1 |
| Louboutin, JP | 1 |
| Bell, P | 1 |
| Tolar, J | 1 |
| Orchard, PJ | 1 |
| Lund, TC | 1 |
| Nayal, M | 1 |
| Weng, L | 1 |
| Mesaros, C | 1 |
| de Souza, CFM | 1 |
| Dalla Corte, A | 1 |
| Giugliani, R | 1 |
| Wilson, JM | 1 |
| Clarkson, AB | 1 |
| Bacchi, CJ | 1 |
| Mellow, GH | 1 |
| Nathan, HC | 1 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Bernstein, HG | 1 |
| Müller, M | 1 |
| Marton, LJ | 1 |
| Heby, O | 1 |
| Levin, VA | 1 |
| Lubich, WP | 1 |
| Crafts, DC | 1 |
| Wilson, CB | 1 |
1 review available for spermine and Central Nervous System Diseases
| Article | Year |
|---|---|
The cellular localization of the L-ornithine decarboxylase/polyamine system in normal and diseased central nervous systems.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Humans; Neurons; Ornithine Decarbo | 1999 |
1 trial available for spermine and Central Nervous System Diseases
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
3 other studies available for spermine and Central Nervous System Diseases
| Article | Year |
|---|---|
Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis.
Topics: Adolescent; Animals; Biomarkers; Central Nervous System Diseases; Child; Disease Models, Animal; Dog | 2017 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
The relationship of polyamines in cerebrospinal fluid to the presence of central nervous system tumors.
Topics: Adenoma; Astrocytoma; Brain Neoplasms; Central Nervous System Diseases; Glioma; Humans; Medulloblast | 1976 |