spermine has been researched along with Carcinoma, Hepatocellular in 19 studies
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study reveals the crucial function of spermine in establishing immune privilege by increasing the expression and N-glycosylation of PD-L1, providing a potential strategy for the treatment of hepatocellular carcinoma." | 8.12 | Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma. ( Cao, JL; Fang, D; Gao, ZX; Li, YY; Liang, C; Qin, J; Shi, HX; Sun, H; Wang, MQ; Xie, SQ; Yao, CY; Zhang, MZ, 2022) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| " Drug levels in plasma decayed rapidly immediately after the infusion but remained above 10 nM for several days after dosing at the MTD." | 6.78 | Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. ( Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX, 2013) |
| "This study reveals the crucial function of spermine in establishing immune privilege by increasing the expression and N-glycosylation of PD-L1, providing a potential strategy for the treatment of hepatocellular carcinoma." | 4.12 | Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma. ( Cao, JL; Fang, D; Gao, ZX; Li, YY; Liang, C; Qin, J; Shi, HX; Sun, H; Wang, MQ; Xie, SQ; Yao, CY; Zhang, MZ, 2022) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| " Drug levels in plasma decayed rapidly immediately after the infusion but remained above 10 nM for several days after dosing at the MTD." | 2.78 | Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. ( Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX, 2013) |
| "Polyamines as a vector to ferry toxic agents have attracted attention, and naphthalimide-polyamine conjugates show potent activity and tumor cell selectivity." | 1.39 | Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. ( Li, M; Li, Q; Ma, HX; Tian, ZY; Wang, CJ; Xie, SQ; Zhang, YH; Zhao, J, 2013) |
| "Treatment of human hepatoma cells (HepG2) with NO-donors for 24 h inhibited hypoxia-induced erythropoietin (EPO) gene activation." | 1.31 | Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing. ( Fandrey, J; Genius, J, 2000) |
| "In the hepatomas, evidence was obtained for the preexistence of considerable amounts of the smaller, RNase-containing subunits in the cell." | 1.24 | Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas. ( Roth, JS; Utsunomiya, T, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, HX | 1 |
| Liang, C | 1 |
| Yao, CY | 1 |
| Gao, ZX | 1 |
| Qin, J | 1 |
| Cao, JL | 1 |
| Zhang, MZ | 1 |
| Li, YY | 1 |
| Wang, MQ | 1 |
| Sun, H | 1 |
| Xie, SQ | 2 |
| Fang, D | 1 |
| Goyal, L | 1 |
| Supko, JG | 1 |
| Berlin, J | 1 |
| Blaszkowsky, LS | 1 |
| Carpenter, A | 1 |
| Heuman, DM | 1 |
| Hilderbrand, SL | 1 |
| Stuart, KE | 1 |
| Cotler, S | 1 |
| Senzer, NN | 1 |
| Chan, E | 1 |
| Berg, CL | 1 |
| Clark, JW | 1 |
| Hezel, AF | 1 |
| Ryan, DP | 1 |
| Zhu, AX | 1 |
| Li, M | 1 |
| Li, Q | 1 |
| Zhang, YH | 1 |
| Tian, ZY | 1 |
| Ma, HX | 1 |
| Zhao, J | 1 |
| Wang, CJ | 1 |
| Santos, AA | 1 |
| Stubbs, AP | 1 |
| Maghsoudloo, M | 1 |
| Murphy, GM | 1 |
| Wilkinson, ML | 1 |
| Mack, KD | 1 |
| Walzem, R | 1 |
| Zeldis, JB | 1 |
| Ashida, Y | 1 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 1 |
| Genius, J | 1 |
| Fandrey, J | 1 |
| Theoharides, TC | 2 |
| Cannelakis, ZN | 1 |
| Rose, KM | 1 |
| Ruch, PA | 1 |
| Morris, HP | 3 |
| Jacob, ST | 1 |
| Russell, DH | 2 |
| Looney, WB | 2 |
| Kovacs, CJ | 2 |
| Hopkins, HA | 2 |
| Dattilo, JW | 1 |
| Katsuta, H | 1 |
| Takaoka, T | 1 |
| Nose, K | 1 |
| Nagai, Y | 1 |
| Canellakis, ZN | 1 |
| McCann, PP | 1 |
| Tardif, C | 1 |
| Mamont, PS | 1 |
| Perin, A | 1 |
| Sessa, A | 1 |
| Utsunomiya, T | 1 |
| Roth, JS | 1 |
| Williams-Ashman, HG | 2 |
| Coppoc, GL | 2 |
| Weber, G | 1 |
| Cavia, E | 1 |
| Webb, TE | 1 |
| Jänne, J | 1 |
| Geroch, ME | 1 |
| Schenone, A | 1 |
| Marton, LJ | 1 |
| LeGendre, SM | 1 |
1 review available for spermine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
New aspects of polyamine biosynthesis in eukaryotic organisms.
Topics: Animals; Azotobacter; Carboxy-Lyases; Carcinoma, Hepatocellular; Catalysis; Chickens; Escherichia co | 1972 |
1 trial available for spermine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Humans; In | 2013 |
17 other studies available for spermine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma.
Topics: Animals; B7-H1 Antigen; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neo | 2022 |
Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; | 2013 |
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liv | 1994 |
Cationic lipid enhances in vitro receptor-mediated transfection.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Binding, Competitive; Carcinoma, Hepatocellular; C | 1994 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Nitric oxide affects the production of reactive oxygen species in hepatoma cells: implications for the process of oxygen sensing.
Topics: Acridines; Anaerobiosis; Carcinoma, Hepatocellular; DNA-Binding Proteins; Erythropoietin; Gene Expre | 2000 |
Spermine inhibits induction of ornithine decarboxylase by cyclic AMP but not by dexamethasone in rat hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cyclic AMP; Cycloheximid | 1975 |
RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes.
Topics: Ammonium Sulfate; Animals; Carcinoma, Hepatocellular; DNA-Directed RNA Polymerases; Enzyme Activatio | 1976 |
Changes in serum putrescine and spermidine levels following local radiation to hepatoma 3924A of the rat.
Topics: Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Neoplasms, Experimental; Putrescine; Ra | 1976 |
Effects of polyamines on the proliferation of mammalian cells in tissue culture.
Topics: Agmatine; Animals; Carcinoma, Hepatocellular; Cell Division; Culture Techniques; Fibroblasts; Liver; | 1975 |
Stimulation of ornithine decarboxylase synthesis and its control by polyamines in regenerating rat liver and cultured rat hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomy | 1976 |
Regulation of ornithine decarboxylase by ODC-antizyme in HTC cells.
Topics: Cadaverine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomycin; Dose- | 1977 |
Changes in polyamine levels and protein synthesis rate during rat liver carcinogenesis induced by 4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimenta | 1978 |
Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Edetic Acid; Hydrogen-Ion Conc | 1966 |
Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.
Topics: Animals; Carboxy-Lyases; Carcinoma, Hepatocellular; Electrophoresis, Paper; Liver; Liver Neoplasms; | 1972 |
The polyamine content in two slow-growing rat hepatomas.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Ornithin | 1972 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experim | 1974 |