spermine has been researched along with Carcinoma, Anaplastic in 23 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the in vitro and in vivo antitumor potential of the polyamine analog N(1), N(11)-diethylnorspermine (DENSpm) in human prostate carcinoma cells was examined." | 7.70 | Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. ( Deli, G; Deloyer, P; Lange, WP; Schalken, JA; Schipper, RG; Verhofstad, AA, 2000) |
| "The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)." | 7.68 | High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. ( Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L, 1990) |
| "Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1." | 7.65 | Compartmentalization of spermine and spermidine in the herpes simplex virion. ( Gibson, W; Roizman, B, 1971) |
| " Detailed studies with estrogen receptor-positive MCF-7 and estrogen receptor- negative Hs578t cells show a similar dose-response curve with concentrations of 1-10 microM resulting in maximal growth inhibition." | 5.29 | Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine. ( Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ, 1993) |
| "Cisplatin (DDP)-resistance confers a deficient expression of spermidine/spermine N(1)-acetyltransferase (SSAT) gene in response to the spermine analog N(1),N(12)-bis(ethyl)spermine (BESpm) in the DDP-resistant human ovarian carcinoma cell line (C13*), compared with their parental DDP-sensitive 2008 cells." | 3.72 | Cisplatin-resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N(1)-acetyltransferase expression. ( Astancolle, S; Bettuzzi, S; Caporali, A; Marverti, G; Monti, MG; Moruzzi, MS, 2004) |
| " In this study, the in vitro and in vivo antitumor potential of the polyamine analog N(1), N(11)-diethylnorspermine (DENSpm) in human prostate carcinoma cells was examined." | 3.70 | Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. ( Deli, G; Deloyer, P; Lange, WP; Schalken, JA; Schipper, RG; Verhofstad, AA, 2000) |
| "The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)." | 3.68 | High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. ( Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L, 1990) |
| "Urinary excretion of the basic polyamine, spermidine, was significantly elevated in patients with prostatic carcinoma as compared to a control group of patients, Of 44 urine specimens from patients with prostatic malignancy 31 had spermidine levels more than 2 mg." | 3.65 | Urinary polyamine levels in the diagnosis of carcinoma of the prostate. ( Brorsson, U; Fair, WR; Wehner, N, 1975) |
| "Enveloped particles of herpes simplex virus produced in human cells in culture contained spermidine and spermine, in a molar ratio of 1." | 3.65 | Compartmentalization of spermine and spermidine in the herpes simplex virion. ( Gibson, W; Roizman, B, 1971) |
| " Detailed studies with estrogen receptor-positive MCF-7 and estrogen receptor- negative Hs578t cells show a similar dose-response curve with concentrations of 1-10 microM resulting in maximal growth inhibition." | 1.29 | Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine. ( Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ, 1993) |
| "The presence of GR in human colon cancers has been previously reported." | 1.27 | Polyamine levels and gastrin receptors in colon cancers. ( Barranco, SC; Saydjari, R; Singh, P; Thompson, JC; Townsend, CM; Upp, JR, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (60.87) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johansson, VM | 1 |
| Miniotis, MF | 1 |
| Hegardt, C | 1 |
| Jönsson, G | 1 |
| Staaf, J | 1 |
| Berntsson, PS | 1 |
| Oredsson, SM | 1 |
| Alm, K | 1 |
| Tummala, R | 1 |
| Diegelman, P | 1 |
| Fiuza, SM | 1 |
| Batista de Carvalho, LA | 1 |
| Marques, MP | 1 |
| Kramer, DL | 1 |
| Clark, K | 1 |
| Vujcic, S | 1 |
| Porter, CW | 1 |
| Pendyala, L | 1 |
| ARDIZZONE, G | 1 |
| RICCI, P | 1 |
| GOLDSTEIN, J | 1 |
| Marverti, G | 1 |
| Monti, MG | 1 |
| Bettuzzi, S | 1 |
| Caporali, A | 1 |
| Astancolle, S | 1 |
| Moruzzi, MS | 1 |
| Colella, G | 1 |
| Cianciulli, S | 1 |
| De Santis, A | 1 |
| Martin, A | 1 |
| Maione, F | 1 |
| Della Pietra, F | 1 |
| Stroffolini, F | 1 |
| Tanaka, T | 1 |
| Kojima, T | 1 |
| Hara, A | 1 |
| Sawada, H | 1 |
| Mori, H | 1 |
| Davidson, NE | 1 |
| Mank, AR | 1 |
| Prestigiacomo, LJ | 1 |
| Bergeron, RJ | 2 |
| Casero, RA | 3 |
| Evans, CH | 1 |
| Lee, TS | 1 |
| Flugelman, AA | 1 |
| Schipper, RG | 1 |
| Deli, G | 1 |
| Deloyer, P | 1 |
| Lange, WP | 1 |
| Schalken, JA | 1 |
| Verhofstad, AA | 1 |
| Fair, WR | 1 |
| Wehner, N | 1 |
| Brorsson, U | 1 |
| Celano, P | 2 |
| Ervin, SJ | 2 |
| Wiest, L | 1 |
| Pegg, AE | 1 |
| Dunzendorfer, U | 1 |
| Knöner, M | 1 |
| Baylin, SB | 1 |
| Yamamoto, O | 1 |
| Upp, JR | 1 |
| Saydjari, R | 1 |
| Townsend, CM | 1 |
| Singh, P | 1 |
| Barranco, SC | 1 |
| Thompson, JC | 1 |
| Romano, M | 1 |
| Bonelli, P | 1 |
| Nishioka, K | 1 |
| Romsdahl, MM | 1 |
| Israel, M | 1 |
| Zoll, EC | 1 |
| Muhammad, N | 1 |
| Modest, EJ | 1 |
| Dawson, M | 1 |
| Dryden, WF | 1 |
| Russell, DH | 1 |
| Gibson, W | 1 |
| Roizman, B | 1 |
| Higgins, ML | 1 |
| Tillman, MC | 1 |
| Rupp, JP | 1 |
| Leach, FR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| To Evaluate the Performance of a Urine Spermine Measuring Device in Predicting Prostate Biopsy Result[NCT04339920] | 0 participants (Actual) | Observational | 2021-09-01 | Withdrawn (stopped due to No funding) | |||
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| To Identify Potential New Urine Marker Panel for Cancer Screening[NCT04689802] | 2,500 participants (Anticipated) | Observational | 2021-01-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 other studies available for spermine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Line, Tumor; | 2008 |
Characterization of Pt-, Pd-spermine complexes for their effect on polyamine pathway and cisplatin resistance in A2780 ovarian carcinoma cells.
Topics: Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cisplatin; Drug Evaluation, Preclinical; Drug Re | 2010 |
[Seroreaction to spermine for diagnosis of genital carcinoma].
Topics: Carcinoma; Genitalia; Genitalia, Female; Neoplasms; Spermine; Urogenital System | 1955 |
THE EFFECT OF SPERMINE ON THE ACCUMULATION OF NUCLEIC ACIDS AND PROTEIN IN MAMMALIAN CELLS.
Topics: Carbon Isotopes; Carcinoma; Carcinoma 256, Walker; DNA; DNA, Neoplasm; Metabolism; Neoplasm Proteins | 1965 |
Cisplatin-resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N(1)-acetyltransferase expression.
Topics: Acetyltransferases; Anisomycin; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cisplatin; Cyclo | 2004 |
[The determination of polyamines in tumors of the maxillofacial area].
Topics: Carcinoma; Chromatography, High Pressure Liquid; Facial Neoplasms; Humans; Jaw Neoplasms; Parotid Ne | 1994 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine.
Topics: Acetyltransferases; Breast Neoplasms; Carcinoma; Cell Division; Drug Resistance; Enzyme Induction; F | 1993 |
Spermine-directed immunosuppression of cervical carcinoma cell sensitivity to a majority of lymphokine-activated killer lymphocyte cytotoxicity.
Topics: Carcinoma; Cytotoxicity, Immunologic; Female; Humans; Immunity, Innate; Immunosuppressive Agents; Ki | 1995 |
Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells.
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Biogenic Polyamines; Carcinoma; Cell Division; D | 2000 |
Urinary polyamine levels in the diagnosis of carcinoma of the prostate.
Topics: Aged; Carcinoma; Diagnosis, Differential; Electrophoresis, Paper; Humans; Male; Middle Aged; Polyami | 1975 |
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
Topics: Acetyltransferases; Amino Acid Sequence; Amino Acids; Blotting, Western; Carcinoma; Enzyme Induction | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Topics: Adenosylmethionine Decarboxylase; Carcinoma; Carcinoma, Small Cell; Cells, Cultured; Humans; Lung Ne | 1989 |
[Ornithine decarboxylase activity and polyamine levels in human thyroid tumor tissue].
Topics: Adenoma; Adolescent; Adult; Aged; Biogenic Polyamines; Carcinoma; Carcinoma, Papillary; Child; Femal | 1989 |
Polyamine levels and gastrin receptors in colon cancers.
Topics: Carcinoma; Colonic Neoplasms; Humans; Intestinal Mucosa; Neoplasm Staging; Polyamines; Putrescine; R | 1988 |
Polyamine oxidase activity in carcinoma-bearing human breast: significant decreased activity in carcinomatous tissue.
Topics: Breast; Breast Neoplasms; Carcinoma; Female; Humans; Oxidoreductases Acting on CH-NH Group Donors; P | 1986 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |
Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N'-bis(3-aminopropyl)nonane-1,9-diamine.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Line; Dose-Response Relationship, Drug; Humans; Leuk | 1973 |
The toxicity of spermine and spermidine to cells in culture.
Topics: Amines; Anti-Bacterial Agents; Carcinoma; Cell Division; Cell Line; Culture Media; Culture Technique | 1969 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Increased polyamine concentrations in the urine of human cancer patients.
Topics: Carcinoma; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; N | 1971 |
Compartmentalization of spermine and spermidine in the herpes simplex virion.
Topics: Carcinoma; Cell Line; Detergents; DNA, Viral; Herpes Simplex; Herpesviridae; Humans; Ornithine; Poly | 1971 |
The effect of polyamines on cell culture cells.
Topics: Amines; Animals; Carcinoma; Cattle; Cell Division; Cell Line; Culture Media; Culture Techniques; Hor | 1969 |