spermine has been researched along with Cancer of Lung in 56 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)." | 7.68 | High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. ( Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L, 1990) |
| "The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)." | 3.68 | High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. ( Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L, 1990) |
| "Twenty-nine patients were treated with DENSPM using a dosing schedule of once daily for 5 days." | 2.70 | Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer. ( Bowling, K; Casero, RA; Chen, TL; Ettinger, DS; Hahm, HA; Hoker, B; Zabelina, Y, 2002) |
| "Fifteen patients with advanced solid tumors were entered into a phase I study of DENSPM given by a 1 h i." | 2.68 | Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy. ( Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D, 1997) |
| "Lung cancer has been a leading cause of cancer mortality worldwide and aerosol-mediated gene therapy endows numerous advantages compared to other traditional modalities." | 1.43 | Aerosol delivery of folate-decorated hyperbranched polyspermine complexes to suppress lung tumorigenesis via Akt signaling pathway. ( Cho, MH; Cui, PF; Jang, Y; Jiang, HL; Kim, HJ; Lee, AY; Luo, CQ; Qiao, JB; Xing, L, 2016) |
| "Spermine-BBI was considerably more effective than pBBI at affecting heart-disease-related parameters." | 1.32 | Effects of spermine-conjugated Bowman-Birk inhibitor (spermine-BBI) on carcinogenesis and cholesterol biosynthesis in mice. ( Kennedy, AR; Kritchevsky, D; Shen, WC, 2003) |
| "Selenomethionine treatment induced apoptosis in both cancer cell lines." | 1.30 | Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells. ( Clark, LC; Nelson, MA; Payne, C; Peng, YM; Redman, C; Scott, JA; Xu, MJ, 1997) |
| "The SF-767 brain tumors were extremely responsive to BE-4-4-4-4 alone (3 of 8 complete regressions after 2 cycles); however, the growth of the U-87 MG brain tumor was only slightly inhibited by BE-4-4-4-4 treatment." | 1.29 | Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts. ( Basu, HS; Casero, RA; Dolan, ME; Feuerstein, BG; Fleig, MJ; Luk, GD; Marton, LJ, 1994) |
| " In vitro studies indicated that the growth sensitivity of most tumor cell lines to DENSPM was similar, with characteristically flat dose-response curves and IC50s ranging between 0." | 1.29 | Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. ( Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE, 1995) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (16.07) | 18.7374 |
| 1990's | 20 (35.71) | 18.2507 |
| 2000's | 5 (8.93) | 29.6817 |
| 2010's | 20 (35.71) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Sil, D | 1 |
| Panja, S | 1 |
| Jogdeo, CM | 1 |
| Kumar, R | 1 |
| Yu, A | 1 |
| Holbert, CE | 1 |
| Ding, L | 1 |
| Foley, JR | 1 |
| Stewart, TM | 1 |
| Casero, RA | 17 |
| Oupický, D | 1 |
| Jin, Y | 1 |
| Adams, F | 1 |
| Isert, L | 1 |
| Baldassi, D | 1 |
| Merkel, OM | 2 |
| Xie, L | 1 |
| Yang, Y | 1 |
| Meng, J | 1 |
| Wen, T | 1 |
| Liu, J | 1 |
| Xu, H | 1 |
| Wang, K | 1 |
| Huang, Q | 1 |
| Zhao, G | 1 |
| Yang, J | 2 |
| Yang, K | 1 |
| Huang, Y | 1 |
| Kim, YK | 5 |
| Cho, CS | 5 |
| Cho, MH | 7 |
| Jiang, HL | 8 |
| Murray-Stewart, T | 2 |
| Hanigan, CL | 1 |
| Woster, PM | 5 |
| Marton, LJ | 3 |
| Elsayed, M | 1 |
| Corrand, V | 1 |
| Kolhatkar, V | 1 |
| Xie, Y | 1 |
| Kim, NH | 1 |
| Kolhatkar, R | 1 |
| Hu, YL | 1 |
| Miao, PH | 1 |
| Huang, B | 1 |
| Zhang, TY | 1 |
| Hu, ZJ | 1 |
| Tabata, Y | 1 |
| Gao, JQ | 1 |
| Kato, M | 2 |
| Onishi, H | 1 |
| Matsumoto, K | 1 |
| Motoshita, J | 1 |
| Tsuruta, N | 1 |
| Higuchi, K | 1 |
| Katano, M | 1 |
| Xing, L | 3 |
| Chen, BA | 1 |
| Xu, F | 1 |
| Zhang, C | 1 |
| Xie, RL | 1 |
| Jang, YJ | 1 |
| Zhang, BF | 1 |
| Wang, FZ | 1 |
| Cui, PF | 2 |
| Takahashi, Y | 2 |
| Horio, H | 2 |
| Sakaguchi, K | 2 |
| Hiramatsu, K | 2 |
| Kawakita, M | 3 |
| Min, JZ | 1 |
| Morota, Y | 1 |
| Jiang, YZ | 1 |
| Li, G | 1 |
| Kang, D | 1 |
| Yu, HF | 1 |
| Inoue, K | 1 |
| Todoroki, K | 1 |
| Toyo'oka, T | 1 |
| Wikoff, WR | 1 |
| Hanash, S | 1 |
| DeFelice, B | 1 |
| Miyamoto, S | 1 |
| Barnett, M | 1 |
| Zhao, Y | 1 |
| Goodman, G | 1 |
| Feng, Z | 1 |
| Gandara, D | 1 |
| Fiehn, O | 1 |
| Taguchi, A | 1 |
| Peled, N | 1 |
| Ilouze, M | 1 |
| Moriya, S | 1 |
| Takahashi, K | 1 |
| Wang, Z | 2 |
| Zou, H | 1 |
| Wu, J | 1 |
| Xia, Z | 1 |
| Feng, M | 1 |
| Luo, CQ | 1 |
| Jang, Y | 1 |
| Qiao, JB | 1 |
| Lee, AY | 1 |
| Kim, HJ | 3 |
| Gankhuyag, N | 1 |
| Yu, KN | 1 |
| Davaadamdin, O | 1 |
| Lee, S | 1 |
| Cho, WY | 1 |
| Park, C | 1 |
| Singh, B | 1 |
| Chae, CH | 1 |
| Jere, D | 1 |
| Kim, JE | 2 |
| Arote, R | 1 |
| Choi, YJ | 2 |
| Yun, CH | 1 |
| Fraser, AV | 2 |
| Goodwin, AC | 1 |
| Hacker-Prietz, A | 1 |
| Sugar, E | 1 |
| Hong, SH | 2 |
| Islam, MA | 1 |
| Nah, JW | 1 |
| Lee, KH | 1 |
| Han, KW | 1 |
| Chae, C | 2 |
| Minai-Tehrani, A | 1 |
| Shin, JY | 1 |
| Kang, B | 1 |
| Kennedy, AR | 2 |
| Kritchevsky, D | 1 |
| Shen, WC | 2 |
| Wang, Y | 1 |
| Hacker, A | 1 |
| Frydman, B | 1 |
| Valasinas, A | 1 |
| Yamaguchi, K | 1 |
| Kaku, T | 1 |
| Enjoji, M | 1 |
| Anai, M | 1 |
| Hamasaki, N | 1 |
| Tanaka, M | 1 |
| Moulinoux, JP | 1 |
| Quemener, V | 1 |
| Larzul, JJ | 1 |
| Le Calve, M | 1 |
| Roch, AM | 2 |
| Toujas, L | 1 |
| Quash, G | 2 |
| Woo, KB | 1 |
| Waalkes, TP | 1 |
| Abeloff, MD | 1 |
| Lenhard, RE | 1 |
| Gehrke, CW | 1 |
| Kuo, KC | 1 |
| Gutman, M | 1 |
| Beltran, PJ | 1 |
| Fan, D | 1 |
| Delworth, MG | 1 |
| Singh, RK | 1 |
| Wilson, MR | 1 |
| Fidler, IJ | 1 |
| Igarashi, K | 1 |
| Koga, K | 1 |
| He, Y | 1 |
| Shimogori, T | 1 |
| Ekimoto, H | 1 |
| Kashiwagi, K | 1 |
| Shirahata, A | 1 |
| Gabrielson, EW | 2 |
| Pegg, AE | 4 |
| Dolan, ME | 1 |
| Fleig, MJ | 1 |
| Feuerstein, BG | 1 |
| Basu, HS | 1 |
| Luk, GD | 1 |
| Ekrami, H | 1 |
| Witschi, H | 1 |
| Shao, D | 1 |
| Xiao, L | 4 |
| Ha, HC | 1 |
| Wu, R | 1 |
| Saab, NH | 1 |
| Huang, H | 1 |
| Wiest, L | 2 |
| Redman, C | 1 |
| Xu, MJ | 1 |
| Peng, YM | 1 |
| Scott, JA | 1 |
| Payne, C | 1 |
| Clark, LC | 1 |
| Nelson, MA | 1 |
| Creaven, PJ | 1 |
| Perez, R | 1 |
| Pendyala, L | 1 |
| Meropol, NJ | 1 |
| Loewen, G | 1 |
| Levine, E | 1 |
| Berghorn, E | 1 |
| Raghavan, D | 1 |
| Felschow, DM | 1 |
| Mi, Z | 1 |
| Stanek, J | 1 |
| Frei, J | 1 |
| Porter, CW | 2 |
| Barr, LF | 1 |
| Campbell, SE | 1 |
| Tamez, P | 1 |
| Mank-Seymour, AR | 1 |
| Murray, TR | 1 |
| Berkey, KA | 1 |
| Kern, S | 1 |
| Bernacki, RJ | 1 |
| Oberman, EJ | 1 |
| Seweryniak, KE | 1 |
| Atwood, A | 1 |
| Bergeron, RJ | 3 |
| McCloskey, DE | 1 |
| Davidson, NE | 1 |
| Hahm, HA | 1 |
| Ettinger, DS | 1 |
| Bowling, K | 1 |
| Hoker, B | 1 |
| Chen, TL | 1 |
| Zabelina, Y | 1 |
| Lipton, A | 2 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Sheehan, L | 1 |
| Mortel, R | 1 |
| Harvey, HA | 1 |
| Twentyman, PR | 1 |
| Wright, KA | 1 |
| Wallace, HM | 1 |
| Mank, AR | 1 |
| Smith, J | 1 |
| Celano, P | 3 |
| Delcros, JG | 1 |
| Ripoll, JP | 1 |
| Thomas, V | 1 |
| Richard, J | 1 |
| Ervin, SJ | 2 |
| Baylin, SB | 1 |
| Sarhan, S | 2 |
| Knodgen, B | 1 |
| Gerhart, F | 1 |
| Seiler, N | 2 |
| Dezeure, F | 1 |
| Hibasami, H | 1 |
| Tsukada, T | 1 |
| Nakashima, K | 1 |
| Russell, DH | 1 |
| Levy, CC | 1 |
2 reviews available for spermine and Cancer of Lung
| Article | Year |
|---|---|
[Urine diacetylspermine as a novel tumor marker].
Topics: Biliary Tract Neoplasms; Biomarkers, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Genital Neopl | 2005 |
[Cancer metastasis and polyamines].
Topics: Adenosylmethionine Decarboxylase; Animals; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; | 1985 |
2 trials available for spermine and Cancer of Lung
| Article | Year |
|---|---|
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Centr | 1997 |
Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response | 2002 |
52 other studies available for spermine and Cancer of Lung
| Article | Year |
|---|---|
Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Lung Neoplasms; Nanoparticles; Polyamines; Spermine | 2022 |
Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
Topics: Humans; Lung Neoplasms; Polyethyleneimine; Polymers; Proto-Oncogene Proteins p21(ras); RNA, Small In | 2023 |
Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression.
Topics: Animals; Cations; Cell Line, Tumor; Cell Polarity; Disease Progression; Female; Glucans; Lectins, C- | 2019 |
Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients.
Topics: Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell | 2019 |
Spermine-alt-poly(ethylene glycol) polyspermine as a safe and efficient aerosol gene carrier for lung cancer therapy.
Topics: Aerosols; Animals; Biocompatible Materials; DNA; Female; Genetic Vectors; Humans; Lung Neoplasms; Mi | 2014 |
Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism.
Topics: Acetyltransferases; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Humans; | 2013 |
Influence of oligospermines architecture on their suitability for siRNA delivery.
Topics: Anions; Binding, Competitive; Carcinoma, Non-Small-Cell Lung; Chemistry Techniques, Synthetic; Flow | 2014 |
Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles.
Topics: Animals; Cell Death; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA; Female; Glucans | 2014 |
Prognostic significance of urine N1, N12-diacetylspermine in patients with non-small cell lung cancer.
Topics: Adenocarcinoma; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; F | 2014 |
Aerosol delivery of programmed cell death protein 4 using polysorbitol-based gene delivery system for lung cancer therapy.
Topics: Aerosols; Animals; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Disease Models, A | 2014 |
A novel potential biocompatible hyperbranched polyspermine for efficient lung cancer gene therapy.
Topics: Animals; Cell Line, Tumor; Cell Survival; Citric Acid; DNA; Erythrocytes; Gene Transfer Techniques; | 2015 |
Significant correlation between urinary N(1), N(12)-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Creatinine; Femal | 2015 |
Rapid and sensitive determination of diacetylpolyamines in human fingernail by ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Diamines; Female; Humans; Limi | 2014 |
Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non-Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B.
Topics: Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Chromatography, Liqui | 2015 |
Screening for Lung Cancer: What Comes Next?
Topics: Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Early Detection of Cancer; Female; Humans; Lung N | 2015 |
Urinary N1, N12-diacetylspermine is a non-invasive marker for the diagnosis and prognosis of non-small-cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Early Detection o | 2015 |
Highly stable polyglutamate derivatives/siRNA polyplex efficiently down-relegate survivin expression and augment the efficacy of cisplatin.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; | 2016 |
Aerosol delivery of folate-decorated hyperbranched polyspermine complexes to suppress lung tumorigenesis via Akt signaling pathway.
Topics: Aerosols; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; DNA; Folic Acid; Folic Ac | 2016 |
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Topics: Administration, Inhalation; Aerosols; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogenesis | 2017 |
Akt1 silencing efficiencies in lung cancer cells by sh/si/ssiRNA transfection using a reductable polyspermine carrier.
Topics: Animals; Apoptosis; Biological Transport; Cell Count; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2009 |
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.
Topics: Base Sequence; Blotting, Northern; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lung Neoplas | 2012 |
Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy.
Topics: Acrylates; Adenocarcinoma; Adenocarcinoma of Lung; Aerosols; Animals; Cell Line, Tumor; Cross-Linkin | 2011 |
Suppression of lung cancer progression by biocompatible glycerol triacrylate-spermine-mediated delivery of shAkt1.
Topics: Aerosols; Animals; Cell Line, Tumor; Disease Progression; Drug Carriers; Female; Genetic Therapy; Gl | 2012 |
Effects of spermine-conjugated Bowman-Birk inhibitor (spermine-BBI) on carcinogenesis and cholesterol biosynthesis in mice.
Topics: Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Carcinogens; Cholesterol; Heart Diseases | 2003 |
Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity.
Topics: Drug Resistance, Neoplasm; Homeostasis; Humans; Lung Neoplasms; Oxidation-Reduction; Oxidoreductases | 2005 |
Red blood cell polyamines in mice bearing the Lewis lung carcinoma (3LL) and in patients with bronchopulmonary cancers.
Topics: Adenocarcinoma; Adult; Aged; Animals; Bronchial Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamou | 1984 |
Urinary polyamines for evaluating the course of disease for patients with small cell carcinoma of the lung.
Topics: Carcinoma, Small Cell; Creatinine; Humans; Lung Neoplasms; Neoplasm Metastasis; Polyamines; Putresci | 1983 |
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Cell Division; Culture Media; Dose-Response Rel | 1995 |
Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Breast Neoplas | 1995 |
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Topics: Acetyltransferases; Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Drug Screening Assay | 1994 |
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
Topics: Animals; Body Weight; Brain Neoplasms; Carmustine; Cell Division; Colonic Neoplasms; Drug Screening | 1994 |
Cationized Bowman-Birk protease inhibitor as a targeted cancer chemopreventive agent.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Survival; Chromatography, Gel; Chymotrypsin; Inj | 1993 |
Isolation of a polyamine transport deficient cell line from the human non-small cell lung carcinoma line NCI H157.
Topics: Acetyltransferases; Antineoplastic Agents; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cel | 1996 |
Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.
Topics: Acetyltransferases; Base Sequence; Carcinoma, Small Cell; Cloning, Molecular; Deoxyribonuclease I; H | 1996 |
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.
Topics: Acetyltransferases; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Humans; Lung Neoplasms; Magne | 1996 |
Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Cell Division; HT29 Cells; Humans; Lung Neopl | 1997 |
Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe.
Topics: Animals; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Cross-Linking | 1997 |
The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes.
Topics: Acetyltransferases; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Genes, myc; Genes, | 1998 |
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Topics: Acetyltransferases; Alleles; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Cell Surviva | 1998 |
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administratio | 1995 |
Polyamine analogue induction of programmed cell death in human lung tumor cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; DNA Fragmentation; Humans; Lung Ne | 1996 |
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.
Topics: Acetyltransferases; Antineoplastic Agents; Biomarkers; Carcinoma, Small Cell; Clinical Trials, Phase | 1999 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
Urinary polyamine levels in patients with localized malignancy.
Topics: Adolescent; Adult; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Humans; Lung Neopl | 1976 |
Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cel | 1992 |
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.
Topics: Acetyltransferases; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Ce | 1992 |
A novel covalent enzyme-linked immunoassay (CELIA) for simultaneously measuring free and immune complex bound antibodies of defined specificity. I. Application to naturally occurring antipolyamine antibodies in human sera.
Topics: Animals; Antibodies; Antibody Specificity; Antigen-Antibody Complex; Goats; Humans; Hydrogen-Ion Con | 1990 |
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
Topics: Acetyltransferases; Amino Acid Sequence; Amino Acids; Blotting, Western; Carcinoma; Enzyme Induction | 1990 |
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Topics: Adenosylmethionine Decarboxylase; Carcinoma; Carcinoma, Small Cell; Cells, Cultured; Humans; Lung Ne | 1989 |
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Ne | 1987 |
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
Topics: Animals; Binding Sites; Biomarkers, Tumor; Dose-Response Relationship, Drug; In Vitro Techniques; Li | 1988 |
Measurement of putrescine, spermidine, and spermine in physiological fluids by use of an amino acid analyzer.
Topics: Autoanalysis; Carbon Isotopes; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Humans; Lung | 1973 |