spermine has been researched along with Cancer of Liver in 32 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study reveals the crucial function of spermine in establishing immune privilege by increasing the expression and N-glycosylation of PD-L1, providing a potential strategy for the treatment of hepatocellular carcinoma." | 8.12 | Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma. ( Cao, JL; Fang, D; Gao, ZX; Li, YY; Liang, C; Qin, J; Shi, HX; Sun, H; Wang, MQ; Xie, SQ; Yao, CY; Zhang, MZ, 2022) |
| "N (1),N (12)-Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorectal cancer, but where and how DiAcSpm is made remains unclear." | 7.79 | Increase of N1, N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis. ( Hiramatsu, K; Horiguchi, S; Iwasaki, K; Kawakita, M; Kobayashi, M; Koizumi, K; Kuwata, G; Moriya, SS; Samejima, K; Takahashi, K, 2013) |
| " Drug levels in plasma decayed rapidly immediately after the infusion but remained above 10 nM for several days after dosing at the MTD." | 6.78 | Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. ( Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX, 2013) |
| "This study reveals the crucial function of spermine in establishing immune privilege by increasing the expression and N-glycosylation of PD-L1, providing a potential strategy for the treatment of hepatocellular carcinoma." | 4.12 | Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma. ( Cao, JL; Fang, D; Gao, ZX; Li, YY; Liang, C; Qin, J; Shi, HX; Sun, H; Wang, MQ; Xie, SQ; Yao, CY; Zhang, MZ, 2022) |
| "N (1),N (12)-Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorectal cancer, but where and how DiAcSpm is made remains unclear." | 3.79 | Increase of N1, N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis. ( Hiramatsu, K; Horiguchi, S; Iwasaki, K; Kawakita, M; Kobayashi, M; Koizumi, K; Kuwata, G; Moriya, SS; Samejima, K; Takahashi, K, 2013) |
| " Drug levels in plasma decayed rapidly immediately after the infusion but remained above 10 nM for several days after dosing at the MTD." | 2.78 | Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. ( Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX, 2013) |
| "Polyamines as a vector to ferry toxic agents have attracted attention, and naphthalimide-polyamine conjugates show potent activity and tumor cell selectivity." | 1.39 | Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. ( Li, M; Li, Q; Ma, HX; Tian, ZY; Wang, CJ; Xie, SQ; Zhang, YH; Zhao, J, 2013) |
| "Polyamine content of colorectal cancers was independent of tumour site, Dukes' stage, histological grade and the presence of palpable liver metastases at laparotomy." | 1.27 | Polyamines in colorectal cancer. ( Kingsnorth, AN; Lumsden, AB; Wallace, HM, 1984) |
| "(c) Spermine levels were significantly lowered, with 3 minima corresponding to the putrescine maxima." | 1.26 | Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide. ( Aussel, C; Lafaurie, M; Lalanne, CM; Milano, G; Soula, G; Stora, C, 1981) |
| "All 6 patients with localized malignant tumors had elevated urinary polyamine levels." | 1.25 | Urinary polyamine levels in human cancer. ( Kessler, GF; Lipton, A; Sheehan, LM, 1975) |
| "In the hepatomas, evidence was obtained for the preexistence of considerable amounts of the smaller, RNase-containing subunits in the cell." | 1.24 | Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas. ( Roth, JS; Utsunomiya, T, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (59.38) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, HX | 1 |
| Liang, C | 1 |
| Yao, CY | 1 |
| Gao, ZX | 1 |
| Qin, J | 1 |
| Cao, JL | 1 |
| Zhang, MZ | 1 |
| Li, YY | 1 |
| Wang, MQ | 1 |
| Sun, H | 1 |
| Xie, SQ | 2 |
| Fang, D | 1 |
| Xie, L | 1 |
| Yang, Y | 1 |
| Meng, J | 1 |
| Wen, T | 1 |
| Liu, J | 1 |
| Xu, H | 1 |
| Kuwata, G | 1 |
| Hiramatsu, K | 1 |
| Samejima, K | 1 |
| Iwasaki, K | 1 |
| Takahashi, K | 1 |
| Koizumi, K | 1 |
| Horiguchi, S | 1 |
| Moriya, SS | 1 |
| Kobayashi, M | 1 |
| Kawakita, M | 2 |
| Goyal, L | 1 |
| Supko, JG | 1 |
| Berlin, J | 1 |
| Blaszkowsky, LS | 1 |
| Carpenter, A | 1 |
| Heuman, DM | 1 |
| Hilderbrand, SL | 1 |
| Stuart, KE | 1 |
| Cotler, S | 1 |
| Senzer, NN | 1 |
| Chan, E | 1 |
| Berg, CL | 1 |
| Clark, JW | 1 |
| Hezel, AF | 1 |
| Ryan, DP | 1 |
| Zhu, AX | 1 |
| Leblond, P | 1 |
| Boulet, E | 1 |
| Bal-Mahieu, C | 1 |
| Pillon, A | 1 |
| Kruczynski, A | 1 |
| Guilbaud, N | 1 |
| Bailly, C | 1 |
| Sarrazin, T | 1 |
| Lartigau, E | 1 |
| Lansiaux, A | 1 |
| Meignan, S | 1 |
| Kim, JH | 2 |
| Minai-Tehrani, A | 1 |
| Kim, YK | 2 |
| Shin, JY | 1 |
| Hong, SH | 2 |
| Kim, HJ | 1 |
| Lee, HD | 1 |
| Chang, SH | 1 |
| Yu, KN | 1 |
| Bang, YB | 2 |
| Cho, CS | 2 |
| Yoon, TJ | 1 |
| Yu, DY | 2 |
| Jiang, HL | 2 |
| Cho, MH | 2 |
| Arash, MT | 1 |
| Lee, JH | 1 |
| Kang, BN | 1 |
| Li, M | 1 |
| Li, Q | 1 |
| Zhang, YH | 1 |
| Tian, ZY | 1 |
| Ma, HX | 1 |
| Zhao, J | 1 |
| Wang, CJ | 1 |
| Yamaguchi, K | 1 |
| Kaku, T | 1 |
| Enjoji, M | 1 |
| Kato, M | 1 |
| Anai, M | 1 |
| Hamasaki, N | 1 |
| Tanaka, M | 1 |
| Kingsnorth, AN | 1 |
| Lumsden, AB | 1 |
| Wallace, HM | 1 |
| Milano, G | 1 |
| Aussel, C | 1 |
| Stora, C | 1 |
| Lafaurie, M | 1 |
| Soula, G | 1 |
| Lalanne, CM | 1 |
| Santos, AA | 1 |
| Stubbs, AP | 1 |
| Maghsoudloo, M | 1 |
| Murphy, GM | 1 |
| Wilkinson, ML | 1 |
| Kichler, A | 1 |
| Remy, JS | 1 |
| Boussif, O | 1 |
| Frisch, B | 1 |
| Boeckler, C | 1 |
| Behr, JP | 1 |
| Schuber, F | 1 |
| Mack, KD | 1 |
| Walzem, R | 1 |
| Zeldis, JB | 1 |
| Taguchi, T | 1 |
| Kurata, S | 1 |
| Ohashi, M | 1 |
| Lipton, A | 1 |
| Sheehan, LM | 1 |
| Kessler, GF | 1 |
| Theoharides, TC | 2 |
| Cannelakis, ZN | 1 |
| Rose, KM | 1 |
| Ruch, PA | 1 |
| Morris, HP | 3 |
| Jacob, ST | 1 |
| Russell, DH | 2 |
| Looney, WB | 2 |
| Kovacs, CJ | 2 |
| Hopkins, HA | 2 |
| Dattilo, JW | 1 |
| Katsuta, H | 1 |
| Takaoka, T | 1 |
| Nose, K | 1 |
| Nagai, Y | 1 |
| Canellakis, ZN | 1 |
| McCann, PP | 1 |
| Tardif, C | 1 |
| Mamont, PS | 1 |
| Perin, A | 1 |
| Sessa, A | 1 |
| Farwell, DC | 1 |
| Nolan, CE | 1 |
| Herbst, EJ | 1 |
| Jänne, J | 2 |
| Hölttä, E | 1 |
| Guha, SK | 1 |
| Oka, T | 1 |
| Utsunomiya, T | 1 |
| Roth, JS | 1 |
| Williams-Ashman, HG | 2 |
| Coppoc, GL | 2 |
| Weber, G | 1 |
| Cavia, E | 1 |
| Webb, TE | 1 |
| Geroch, ME | 1 |
| Schenone, A | 1 |
| Marton, LJ | 1 |
| LeGendre, SM | 1 |
| Andersson, G | 1 |
| Heby, O | 1 |
4 reviews available for spermine and Cancer of Liver
| Article | Year |
|---|---|
[Urine diacetylspermine as a novel tumor marker].
Topics: Biliary Tract Neoplasms; Biomarkers, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Genital Neopl | 2005 |
Polyamines in mammalian liver during growth and development.
Topics: Animals; Chick Embryo; Hormones; Humans; Liver; Liver Neoplasms; Liver Regeneration; Mammals; Ornith | 1976 |
[Some new aspects of the function of spermidine in animal cells].
Topics: Adenosylmethionine Decarboxylase; Animals; Breast; Cell Division; Chick Embryo; Female; Glucocortico | 1975 |
New aspects of polyamine biosynthesis in eukaryotic organisms.
Topics: Animals; Azotobacter; Carboxy-Lyases; Carcinoma, Hepatocellular; Catalysis; Chickens; Escherichia co | 1972 |
1 trial available for spermine and Cancer of Liver
| Article | Year |
|---|---|
Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Humans; In | 2013 |
27 other studies available for spermine and Cancer of Liver
| Article | Year |
|---|---|
Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma.
Topics: Animals; B7-H1 Antigen; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neo | 2022 |
Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression.
Topics: Animals; Cations; Cell Line, Tumor; Cell Polarity; Disease Progression; Female; Glucans; Lectins, C- | 2019 |
Increase of N1, N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Colorectal | 2013 |
Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.
Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Line, Tumor; Cell Survival; Cisplatin; Etoposide; | 2014 |
Suppression of tumor growth in H-ras12V liver cancer mice by delivery of programmed cell death protein 4 using galactosylated poly(ethylene glycol)-chitosan-graft-spermine.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chitosan; Drug Delivery Systems; Endosomes | 2012 |
Galactosylation of chitosan-graft-spermine as a gene carrier for hepatocyte targeting in vitro and in vivo.
Topics: Animals; Cell Line, Tumor; Chitosan; DNA; Drug Carriers; Humans; Liver Neoplasms; Male; Mice; Mice, | 2012 |
Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; | 2013 |
Polyamines in colorectal cancer.
Topics: Aged; Colonic Neoplasms; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Polya | 1984 |
Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Female; Liver Neoplasms; Neoplasms, Experimental; Organ | 1981 |
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liv | 1994 |
Efficient gene delivery with neutral complexes of lipospermine and thiol-reactive phospholipids.
Topics: 3T3 Cells; Animals; Gene Transfer Techniques; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Ph | 1995 |
Cationic lipid enhances in vitro receptor-mediated transfection.
Topics: Asialoglycoprotein Receptor; Asialoglycoproteins; Binding, Competitive; Carcinoma, Hepatocellular; C | 1994 |
Effects of polyamines on DNA synthesis using various subcellular DNA polymerases extracted from normal rat liver, tumour-bearing rat liver, and tumour cells.
Topics: Animals; Cadaverine; Cytoplasm; DNA; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; | 2001 |
Urinary polyamine levels in human cancer.
Topics: Adenocarcinoma; Adenoma; Bone Neoplasms; Breast Neoplasms; Bronchial Neoplasms; Carcinoma, Squamous | 1975 |
Spermine inhibits induction of ornithine decarboxylase by cyclic AMP but not by dexamethasone in rat hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cyclic AMP; Cycloheximid | 1975 |
RNA polymerases from a rat hepatoma. Partial purification and comparison of properties with corresponding liver enzymes.
Topics: Ammonium Sulfate; Animals; Carcinoma, Hepatocellular; DNA-Directed RNA Polymerases; Enzyme Activatio | 1976 |
Changes in serum putrescine and spermidine levels following local radiation to hepatoma 3924A of the rat.
Topics: Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Neoplasms, Experimental; Putrescine; Ra | 1976 |
Effects of polyamines on the proliferation of mammalian cells in tissue culture.
Topics: Agmatine; Animals; Carcinoma, Hepatocellular; Cell Division; Culture Techniques; Fibroblasts; Liver; | 1975 |
Stimulation of ornithine decarboxylase synthesis and its control by polyamines in regenerating rat liver and cultured rat hepatoma cells.
Topics: Animals; Bucladesine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomy | 1976 |
Regulation of ornithine decarboxylase by ODC-antizyme in HTC cells.
Topics: Cadaverine; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dactinomycin; Dose- | 1977 |
Changes in polyamine levels and protein synthesis rate during rat liver carcinogenesis induced by 4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimenta | 1978 |
Liver ornithine decarboxylase during phenobarbital promotion of nitrosamine carcinogenesis.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; | 1978 |
Studies on the function of intracellular ribonucleases. V. Ribonuclease activity in ribosomes and polysomes prepared from rat liver and hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Edetic Acid; Hydrogen-Ion Conc | 1966 |
Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.
Topics: Animals; Carboxy-Lyases; Carcinoma, Hepatocellular; Electrophoresis, Paper; Liver; Liver Neoplasms; | 1972 |
The polyamine content in two slow-growing rat hepatomas.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Ornithin | 1972 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experim | 1974 |
Polyamine and nucleic acid concentrations in Ehrlich ascites carcinoma cells and liver of tumor-bearing mice at various stages of tumor growth.
Topics: Animals; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred S | 1972 |